October 9, 2025
Arizona Cardinals quarterback
Jacoby Brissett took first-team reps during Thursday's practice as
Kyler Murray (foot) missed his second straight session. Murray's injury appears to be affecting his mobility, and the team may be preparing to roll with Brissett under center for Sunday's matchup against the surging Indianapolis Colts. Brissett last started in 2024 with the New England Patriots, going 1-4 while averaging 5.1yards per attempt. While the veteran brings stability and experience, he lacks the dynamic upside Murray provides both as a passer and runner. Fantasy managers should avoid Brissett outside of deep superflex leagues, as the Cardinals offense faces a difficult challenge on the road against an Indianapolis defense that ranks near the top of the league in takeaways and sacks.
--Shaun AlbinSource: Tyler Drake
October 8, 2025
Arizona Cardinals head coach Jonathan Gannon said that quarterback
Kyler Murray (foot) will not practice on Wednesday, according to Darren Urban of AZCardinals.com. Gannon added that the team will see how the week goes for Murray. The 28-year-old signal-caller injured his foot in the second half of the Week 5 loss to the Tennessee Titans, but he only ended up missing three snaps and was able to finish out the game. The fact that Murray was able to come back and finish Sunday's game was encouraging, but a missed practice on Wednesday could mean that his status for Week 6 against the Indianapolis Colts is up in the air. Murray's performance early in 2025 has left a lot to be desired from his fantasy managers, and now they could be without him this weekend. Start searching for backup plans if you don't already have one. If Murray is unavailable against the Colts, veteran
Jacoby Brissett would be forced into starting duties at QB.
--Keith HernandezSource: AZCardinals.com - Darren Urban
October 7, 2025
Arizona Cardinals running back
Michael Carter is listed as the RB1 on the team's depth chart going into a Week 6 clash against the Indianapolis Colts on the road on Sunday.
Emari Demercado is listed as the No. 2, with
Bam Knight following him.
James Conner (ankle) is out for the rest of the season, while
Trey Benson (knee) is out four to six weeks due to a knee injury. In Arizona's new-look backfield in the Week 5 loss to the Tennessee Titans, Carter operated as the clear lead back, carrying the ball 18 times for 51 yards and a touchdown and catching all five of his targets for another 22 yards. Demercado and Knight combined for only nine touches, with Demercado botching what would have been a 70-plus-yard touchdown. Even though Carter wasn't very efficient with his 23 touches, it's clear the Cardinals are going to lean heavily on him with Benson out. Carter should be scooped up off waivers this week if he's still available in your league.
--Keith HernandezSource: AZCardinals.com
October 7, 2025
After rewatching the tape of the Week 5 loss to the Tennessee Titans on Sunday, Arizona Cardinals offensive coordinator Drew Petzing said he felt like he didn't do enough to get wide receiver
Marvin Harrison Jr. the ball down the stretch, according to Theo Mackie of The Arizona Republic. "Going back and looking at it, I think there's maybe a couple of things I could've done differently," Petzing said. Harrison had only five targets on the day, which tied for a season low, but he caught four of them to finish two yards shy of the century mark for the first time in 2025. He caught a season-high six passes on 10 targets in Week 4 for 66 yards and his second touchdown of the year. The 23-year-old former first-rounder nearly had a 44-yard TD early in the game on Sunday and did most of his damage in the first half before Arizona's offense sat on their lead after halftime. Look for Arizona to feature Harrison early and often in Week 6 on the road against the Indianapolis Colts.
--Keith HernandezSource: The Arizona Republic - Theo Mackie
October 7, 2025
Arizona Cardinals running back
Michael Carter dominated backfield touches in Week 5, the team's first full game without running backs
James Conner (ankle) and
Trey Benson (knee). Carter recorded 73 yards from scrimmage and a touchdown on 23 total touches in Week 5, while fellow Arizona backs
Emari Demercado and
Bam Knight combined for just eight total touches. With Conner out for the season and Benson currently on Injured Reserve, Carter could have an extended window as the Cardinals' clear RB1. Carter is a priority waiver-wire addition in any league where he's not already rostered. He profiles as a low-end RB2/high-end RB3/flex option in Week 6 against the Indianapolis Colts.
--Will BradySource: RotoBaller
October 6, 2025
Arizona Cardinals head coach Jonathan Gannon said that quarterback
Kyler Murray (foot) will be monitored this week after briefly leaving the Week 5 loss to the Tennessee Titans on Sunday to have his foot evaluated in the locker room, according to Darren Urban of AZCardinals.com. The fact that Murray returned and finished out Sunday's game should give fantasy managers hope that he'll be able to play in Week 6 against the Indianapolis Colts. However, Gannon is leaving things up in the air early in the week, so we'll have to pay close attention to the 28-year-old signal-caller's practice status later in the week. Murray had another middling fantasy outing against the Titans, throwing for 220 yards, no touchdowns, and no interceptions. He added a rushing touchdown but also lost a fumble. If Murray is unable to play in Week 6, veteran
Jacoby Brissett would make the start against the one-loss Colts.
--Keith HernandezSource: AZCardinals.com - Darren Urban
October 6, 2025
Arizona Cardinals running back
Michael Carter recorded 18 carries for 51 yards and a touchdown as well as five catches for 22 yards in his team's 22-21 Week 5 loss to the Tennessee Titans. In Arizona's first full game without both running backs
James Conner (ankle) and
Trey Benson (knee), Carter recorded 23 touches, compared to eight combined touches for fellow Cardinals backs
Emari Demercado and
Bam Knight. While Carter did not have his most efficient day as a rusher in Week 5, he looks like the clear number one option in the run game for Arizona. Additionally, Demercado broke a long run that should have been a touchdown but dropped the ball just before crossing the goal line, which could put him in the dog house with Cardinals head coach Jonathan Gannon. With Conner out for the season and Benson on Injured Reserve, Carter should be a priority waiver-wire addition in any league where he is not already rostered.
--Will BradySource: RotoBaller
October 6, 2025
Arizona Cardinals running back
Michael Carter rushed for 51 yards and a touchdown on 18 carries during Sunday's Week 5 loss to the Tennessee Titans. He also caught all five of his targets for an additional 22 receiving yards. After plenty of speculation about the backfield roles in Arizona, Carter handled early-down work,
Emari Demercado played third downs, and
Bam Knight rotated in occasionally. Carter easily saw the bulk of the workload, totaling 23 touches while staying involved both on the ground and through the air. His lack of yardage efficiency could leave the backfield in a by-committee state ahead of Week 6, but Carter has the early advantage in the competition. He'll continue to rank as a high-end RB3/flex for next week's clash in Indianapolis.
--Andersen PickardSource: RotoBaller
October 5, 2025
Arizona Cardinals tight end
Tip Reiman (right leg) was carted to the locker room during the second half of Sunday's Week 5 contest against the Tennessee Titans. He suffered the injury after failing to haul in his first and only target of the game. Given the urgency of the Cardinals' medical personnel to get the cart on the field for Reiman, this could be a very serious injury, and it's likely one that will keep him sidelined for the remainder of the contest. He has merely occupied a depth role in Arizona this season, catching just three passes for 18 yards.
Elijah Higgins will step up as the No. 2 tight end behind
Trey McBride.
--Andersen PickardSource: Josh Weinfuss
October 5, 2025
Arizona Cardinals wide receiver
Greg Dortch (collarbone) and cornerback Will Johnson (groin) are active for Sunday's Week 5 contest against the Tennessee Titans. Both players had been listed as questionable after being limited in practice this past week. Dortch has been a contributor in all four games this year, catching a total of eight passes while returning nine kicks and six punts. He's off the fantasy radar but could eventually have streaming appeal if
Marvin Harrison Jr. or
Michael Wilson were to get injured. Meanwhile, Johnson is returning from a two-game absence. He last played in Week 2 when he logged a 62 percent snap share and made three tackles. He'll look to make an impact against a subpar Titans offense.
--Andersen PickardSource: Arizona Cardinals
October 5, 2025
ESPN's Adam Schefter reports that Arizona Cardinals running back
Emari Demercado "will stay in the same role" on third downs. Meanwhile,
Michael Carter will take over on first and second downs with
Trey Benson (knee) out four to six weeks after having surgery on his meniscus.
James Conner (ankle) has already been lost for the year, so the Cardinals' backfield depth is being tested early on. Arizona could plan more designed runs for slippery quarterback
Kyler Murray, too. Demercado had two carries for eight yards and caught both of his targets for 13 yards and a touchdown in the Week 4 loss to the Seattle Seahawks. While the 26-year-old will be more involved with Benson out, it's Carter that should see more volume, and thus be a better flex play in fantasy lineups, starting this Sunday against the winless Tennessee Titans. Demercado is a better flex option in PPR formats.
--Keith HernandezSource: ESPN - Adam Schefter
October 5, 2025
Rookie cornerback Will Johnson (groin) is likely to be in the Arizona Cardinals' lineup on Sunday against the Tennessee Titans, according to Ian Rapoport of NFL Network. The second-round pick from Michigan has not played since last month due to the injury, but appears set to go on Sunday. That should be a boost to Arizona, which will play host to one of the worst offenses in the NFL this week. Through four games, nobody has scored fewer points than Tennessee, which is still looking for its first win of 2025.
--Nick PiotrowiczSource: NFL Network
October 5, 2025
NFL Network's Ian Rapoport reports that Arizona Cardinals defensive back Will Johnson (groin) is likely to be active for Sunday's home meeting with the Tennessee Titans. The University of Michigan alum has been on the shelf since picking up a groin injury in Arizona's win over the Panthers in Week 2. Johnson finally returned to practice this week, albeit in a limited fashion, but his return comes at a good time. Teammate Denzel Burke (knee) was a late addition to the injury report with a knee issue and may not be able to play. With the rookie trending in the right direction, he'll be a boon in an already excellent matchup for the Cardinals' D/ST.
--Alex CiullaSource: Ian Rapoport
October 4, 2025
According to Jeremy Fowler, the Arizona Cardinals plan to ride the hot hand in the backfield during Sunday's game against the Tennessee Titans. This backfield has been crushed by injuries early in the season. That being said, the plan is to use
Michael Carter and
Bam Knight on base downs and
Emari Demercado on third downs. It sounds like all three backs are going to have a role this weekend. That being said, this seems like an extremely messy situation for fantasy managers. These backs should probably be avoided unless you have no other options.
--Andy WebbSource: Jeremy Fowler
October 4, 2025
Facing likely the worst roster in the NFL, the Arizona Cardinals D/ST is a fantasy must-start in Week 5 against the struggling Tennessee Titans. Independently of the matchup, the Cards have been solid defensively in 2025, ranking sixth in points allowed, sixth in first downs allowed, and 11th in passer rating against, and now they take on Titans team that borders on helpless offensively. Tennessee is at or near the bottom of the league in points scored (32nd), scoring percentage (30th), net yards per passing attempt (32nd), first downs (29th), and offensive penalties (30th). Until rookie quarterback
Cameron Ward and the Titans turn the corner, betting against them with an above average defense is a smart lineup decision.
--Nick PiotrowiczSource: RotoBaller
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