October 12, 2025
Arizona Cardinals running back
Bam Knight will take over as the team's lead back in Week 6 against the Indianapolis Colts, according to ESPN's Adam Schefter.
Michael Carter will be relegated to the backup role while
Emari Demercado handles the bulk of the third-down snaps. This represents a personnel change after Carter led the backfield with 18 touches last Sunday. Carter scored a touchdown in that game, but he was inefficient with just 2.8 yards per carry, which could be why Arizona is switching to Knight for Week 6. Fantasy managers should adjust their lineups accordingly. Knight is suddenly a solid RB3/flex option against the Colts, while Carter and Demercado should be benched in most leagues. All three have relatively low floors given the state of the Cardinals' offense, which will be led by
Jacoby Brissett and not
Kyler Murray (foot) in Week 6.
--Andersen PickardSource: Adam Schefter
October 11, 2025
According to ESPN's Adam Schefter, Arizona Cardinals quarterback
Jacoby Brissett is expected to start in Sunday's clash with the Colts.
Kyler Murray (foot) still has a chance to play. However, that's unlikely, although NFL Media's Ian Rapoport reported that a final decision won't come until Sunday morning. Unfortunately, there's belief Murray might miss extended time due to a mid-foot sprain, meaning Brissett could be under center in Week 6 and beyond. The signal-caller has been a reliable fantasy quarterback (at times) over the years. In 89 regular-season appearances, he has thrown for 11,400 yards, 53 touchdowns, and 24 picks, adding 15 scores on the ground. While Brissett potentially has a tough matchup on tap against a capable Colts' defense, the potential for Murray to be sidelined for more than a game makes him worth adding to fantasy rosters, mostly by those participating in deeper Superflex formats.
--Dennis ClausenSource: Adam Schefter
October 11, 2025
According to NFL Media's Ian Rapoport, the Arizona Cardinals "are leaving the door open" for quarterback
Kyler Murray (foot) to suit up on Sunday versus the Colts. However, the team is realistically "preparing" for
Jacoby Brissett to start in Week 6, although a final decision won't come until Sunday morning. The signal-caller is reportedly dealing with a "mid-foot sprain," with Rapoport adding that it's "a version of a Lisfranc injury." Unfortunately, that could sideline Murray for more than just one week. As far as Brissett is concerned, he's had some quality performances over the years. In 89 regular-season games, he's thrown for 11,400 yards, 53 touchdowns, and 24 interceptions, adding 15 more scores on the ground. With that said, Brissett has some value for managers in deeper superflex formats despite a tough matchup on the horizon, especially with injuries at the QB position and a few teams getting the week off.
--Dennis ClausenSource: Ian Rapoport
October 11, 2025
The Arizona Cardinals signed quarterback
Kedon Slovis off of the practice squad on Saturday. The 24-year-old has bounced around the league, suiting up for various practice squads in the last few years. While the signing won't directly impact fantasy managers, it could mean that
Kyler Murray (foot), who is still questionable, won't be out there in Week 6 versus the Indianapolis Colts. However, it's still too early to speculate. If Murray ends up suiting up on Sunday, Slovis may still stick around as an emergency quarterback. On the other hand,
Jacoby Brissett is in line to start if Murray gets ruled out. Either way, Slovis isn't worth adding to any fantasy roster.
--Dennis ClausenSource: Mike Garafolo
October 11, 2025
Arizona Cardinals running back
Emari Demercado had a Week 5 to forget, as he dropped the ball for a fumble just before crossing the goal line on what should have been a long touchdown run. Cardinals head coach Jonathan Gannon said that Demercado will maintain his role in the offense despite the error. Still, Demercado appears to be limited to a third-down role in the Cardinals' backfield. Veteran back
Michael Carter assumed lead rushing responsibilities in Week 5, the team's first full game without top running backs
James Conner (ankle) and
Trey Benson (knee). Arizona takes on the Indianapolis Colts in Week 6, who are tied for first in the NFL in fewest rushing touchdowns allowed (two). Demercado recorded just three total touches in Week 5 and should not be expected to see significantly more work in Week 6. Demercado profiles as a low-end flex option in deep leagues in Week 6 against the Colts.
--Will BradySource: RotoBaller
October 11, 2025
Arizona Cardinals tight end
Trey McBride still sits atop the mountain at the position as the No. 1 option in the team's offense. He's still quarterback
Kyler Murray's (foot) favorite target, and even if backup
Jacoby Brissett gets the start, McBride plays a great security-blanket role. The Indianapolis Colts are ranked as the 10th-toughest defense against the position, allowing 11.66 fantasy points per game, but McBride has been matchup-proof for the past couple of seasons. It goes without saying that McBride is a set-it-and-forget-it type of play.
--Alex Fischbein - RotoBallerSource: RotoBaller
October 11, 2025
Arizona Cardinals wide receiver
Marvin Harrison Jr. has had his fair share of issues with drops so far this season, but he seems to be trending in a better direction over the last two weeks. He registered finishes of WR21 and WR14 in half-PPR formats against the Tennessee Titans and Seattle Seahawks. The coaches even talked about getting Harrison some more targets moving forward. On the flip side,
Kyler Murray (foot) is considered questionable, so Brissett may be under center. Usually, backup quarterbacks target their number-one receiver more often, so that could play into Harrison's favor. With that being said, he's currently projected as a low-end WR2 with a higher ceiling since the Indianapolis Colts are ranked 28th against opposing receiver groups, giving up 38.02 fantasy points per outing.
--Alex Fischbein - RotoBallerSource: RotoBaller
October 11, 2025
Arizona Cardinals running back
Michael Carter leap-frogged the rest of the depth chart when he was elevated from the practice squad last week. After
James Conner (ankle) and
Trey Benson (knee) both went down for extended periods of time, Carter saw 23 touches and 57.4% of the offensive snaps. Leaving
Emari Demercado and
Bam Knight to pick up the scraps. He seems to be in line for a similar workload, especially if
Kyler Murray (foot) can't play, but Week 6 presents a tough matchup. The Indianapolis Colts are ranked as the sixth-toughest unit against opposing backfields, allowing just 18.12 fantasy points per game. Carter seems to have a ceiling of a low-end RB2, which could be a decent flex play in deeper leagues.
--Alex Fischbein - RotoBallerSource: RotoBaller
October 11, 2025
Arizona Cardinals quarterback
Jacoby Brissett has had a handful of solid games as a starter throughout his career. He's not going to do anything flashy or out of this world, but he's been able to manage the game for a few different teams when the starter has gone down.
Kyler Murray (foot) is currently considered questionable, and it looks like the team won't make a decision until gameday. If Murray can't suit up, Brissett takes over an offense that doesn't have much of a run game and has to go up against the sixth-toughest defense against opposing QBs in the Indianapolis Colts. The last time Brissett started was in Week 5 of last season with the New England Patriots when he was unable to register any touchdowns and lost 10-15 to the Miami Dolphins. Fantasy managers will want to avoid Brissett if he does play, as long as they can afford to.
--Alex Fischbein - RotoBallerSource: RotoBaller
October 11, 2025
Arizona Cardinals quarterback
Kyler Murray (foot) has officially received a questionable tag heading into the Week 6 matchup against the Indianapolis Colts. Let's say Murray does play in this one, the veteran would still present a risky option since a hurt foot would affect his scrambling ability, which is part of what makes him valuable in fantasy football. On top of that, the Colts are the sixth-toughest team against opposing QBs, allowing just 14.47 fantasy points per matchup. They have also accrued six interceptions versus eight passing touchdowns against them through five weeks. The Colts also don't have to worry much about a run game, so Murray's projections come in as a low-end QB2 if he can suit up. Otherwise,
Jacoby Brissett will be under center for his first start of the season.
--Alex Fischbein - RotoBallerSource: RotoBaller
October 10, 2025
Arizona Cardinals quarterback
Kyler Murray (foot) is listed as questionable for Sunday's game against the Colts, according to Tyler Drake of AZSports. Murray was able to get a limited practice in on Friday after missing Wednesday and Thursday, which will give him a chance to play on Sunday. He suffered the injury in the second half of Arizona's disappointing home loss to the Titans in Week 5, but he later returned and finished the game. Murray has been up and down this season for fantasy managers, but the Cardinals' offense would take a hit if he were to miss Sunday's game. Journeyman
Jacoby Brissett would be in line to make the start in that case, but he's not an option to consider starting in Week 6.
--Kyle McCarthySource: Tyler Drake
October 10, 2025
Arizona Cardinals head coach Jonathan Gannon said that quarterback
Kyler Murray (foot) will practice on Friday, according to Dani Sureck of AZCardinals.com. Murray injured his foot in the Week 5 loss to the Tennessee Titans in the second half, but he was able to return and finish out the game. The 28-year-old then missed the first two practices of the week on Wednesday and Thursday, putting his availability in doubt for this Sunday's game on the road against the Indianapolis Colts. Murray has a shot to play in Week 6 after returning to practice on Friday, but he could draw a questionable tag for Sunday's contest. Whether he plays this weekend will depend on how he looks the next couple days. Murray has been pretty mediocre through the first five weeks of the 2025 season, but Arizona's offense would lose a lot of explosiveness if backup
Jacoby Brissett were forced to start against Indy.
--Keith HernandezSource: AZCardinals.com - Dani Sureck
October 10, 2025
Arizona Cardinals head coach Jonathan Gannon reported on Thursday that running back
Emari Demercado will not be punished for costing the team a touchdown in their loss to the Tennessee Titans in Week 5. "It's the best thing for the team," said Gannon. Demercado egregiously lost a handle on the football last weekend as he pulled up early before crossing the goal line on a breakaway run. However, it doesn't appear that the head coach will dock him playing time, despite his visible frustration on the sideline following the blunder. In somewhat of a surprise, backfield mate
Michael Carter seized the team's primary rushing role following
Trey Benson's (knee) injury, and that should be the case again in Week 6. Demercado will operate on third downs and as a change-of-pace option.
--Alex CiullaSource: Theo Mackie
October 10, 2025
Arizona Cardinals running back
Michael Carter appears poised to shoulder a significant portion of the team's backfield workload for the foreseeable future. The Cardinals are without veteran
James Conner (ankle) for the remainder of the season, and second-year back
Trey Benson (knee) is on Injured Reserve due to a knee injury. In the team's first full game without both players in Week 5, Carter logged 73 scrimmage yards and a touchdown on 23 total touches. In contrast, fellow Arizona running backs
Emari Demercado and
Bam Knight combined for just eight touches. The Cardinals could be without starting quarterback
Kyler Murray (foot) in Week 6 against the Indianapolis Colts, potentially leading to a run-heavy game plan for the team. Carter profiles as a low-end fantasy RB2 in Week 6.
--Will BradySource: RotoBaller
October 9, 2025
Arizona Cardinals quarterback
Kyler Murray (foot) missed Thursday's practice, marking his second straight absence and casting serious doubt on his availability for Sunday's matchup against the Indianapolis Colts. Head coach Jonathan Gannon told reporters Wednesday that Murray remains "day-to-day," but his limited mobility could make it difficult for him to suit up against a Colts defense that ranks among the league's best at sacking quarterbacks and forcing takeaways. If Murray is unable to go, veteran
Jacoby Brissett would draw the start and lead the offense on the road. Fantasy managers should prepare for Murray to be inactive and look to other streaming options in Week 6, as Brissett offers limited fantasy upside against a strong Indianapolis defense.
--Shaun AlbinSource: Adam Schefter
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