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San Francisco 49ers running back Isaac Guerendo recorded 572 yards from scrimmage and four touchdowns on 99 total touches as a rookie in 2024. However, through five games in 2025, the 25-year-old has not played a single offensive snap. Guerendo is buried on the 49ers running back depth chart behind Christian McCaffrey and Brian Robinson Jr. As long as both McCaffrey and Robinson Jr. remain healthy, it appears unlikely that Guerendo's role in San Francisco's offense is going to change. Guerendo maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.--Will Brady
Source: RotoBaller
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Lamar Jackson

Status for Week 6 "in Doubt"
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Sustains Hamstring Injury in Preseason Opener
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Available Wednesday
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Rejoins Practice
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Considered Day-to-Day
Sahith Theegala

Still Uneven Heading to Japan
Darius Garland

Goes Through Light Workout
Nicolai Hojgaard

Trying to Pick Up Pieces After Last Three Efforts
LeBron James

Likely to Sit Out Preseason
Vince Whaley

Tries to Add on From Sanderson Farms Performance
Adam Scott

Struggling Some Heading to Baycurrent Classic
PIT

Arturs Silovs Posts First Career Shutout in Penguins Debut
PGA

Chris Gotterup Expects to Contend at Baycurrent Classic
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Primed for Baycurrent Classic
Martin Necas

Nets Two Goals in Tuesday's Win
Nathan MacKinnon

Becomes Avalanche's All-Time Top Scorer
Sergei Bobrovsky

Stops 17 Shots in Season-Opening Win
Barrett Hayton

Considered Day-to-Day
Teddy Blueger

to Miss at Least Three Games
Garrick Higgo

Finishes Second at Sanderson Farms Championship
Max Homa

Finishes Tied for 18th at Sanderson Farms Championship
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Misses The Cut at Omega European Masters
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Finishes Tied for 13th at BMW PGA Championship
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Available Against Bruins
Pavel Dorofeyev

to Be Game-Time Call Wednesday
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on Injured Reserve to Start the Season
Tyrone Tracy Jr.

Giants Optimistic Tyrone Tracy Jr. Will Return on Thursday Night
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Signs With Mavericks
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Daniel Gafford

is Trending in the Right Direction
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Starting for Mariners in Game 3 of ALDS
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Participates in Non-Contact Part of Practice on Monday
Joe Flacco

Bengals Acquiring Joe Flacco From Browns
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a "Long Shot" to Play in Week 6
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John Mateer Likely to Play Against Texas?
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Nursing Shoulder Injury
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Day-to-Day With Sore Hamstring
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Dealing With Back Issue
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Misses Preseason Action for Maintenance Purposes
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Receives Stitches for Chin Laceration
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Close to Returning
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Placed on Injured Reserve
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Begins Season on Injured Reserve
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Suspended for Two Games
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on Track to Play Against Avalache
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Out on Tuesday
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Unavailable Tuesday
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Gives Shane van Gisbergen a Brief Challenge
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Improved Pace Continues at Charlotte Roval
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Pulls Off His First Victory at the Charlotte Roval
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Competitive Effort Leads to Runner-Up Finish at Charlotte Roval
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Sneaks Into the Round of Eight After the Charlotte Roval
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Scores a Strong Top-Five Finish at Charlotte Roval
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Ready for Opening Night
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in Starting Lineup for NLDS Game 2
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Active on Monday Night
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Jermod McCoy Unlikely to Play Against Arkansas
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Conner Weigman in Concussion Protocol
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Florida State's Quindarrius Jones Set for Season-Ending Surgery
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Mark Gronowski Viewed as Day-to-Day with Knee Injury
Xavier Worthy

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