September 17, 2025
New Orleans Saints rookie running back
Devin Neal did not record a touch in Week 2 and appears to be the clear RB3 in New Orleans behind
Alvin Kamara and
Kendre Miller. The Saints are averaging 114 rushing yards per game as a team through the first two weeks of the season, but it does not appear that Neal will be a regular contributor in the run game without an injury to one of the backs ahead of him on the depth chart. Neal still has some value as a stash play in dynasty leagues, but he should not be on the radar of redraft managers for the time being.
--Will BradySource: RotoBaller
September 17, 2025
Washington Commanders quarterback
Jayden Daniels (knee) suffered a knee sprain in the team's Week 2 loss to the Green Bay Packers, and his status for the team's Week 3 matchup against the Las Vegas Raiders is in question as a result. Commanders head coach Dan Quinn said earlier this week that Daniels should be considered day-to-day. Quinn also said he would have more to share on Wednesday, so fantasy managers should be on the lookout for updates from the team as the Commanders' initial Week 3 injury report gets released later today. If Daniels is unable to play, veteran quarterback
Marcus Mariota would be in line to start against the Raiders. Mariota appeared in three games for Washington in 2024, completing 34 of 44 passes for 364 yards and four touchdowns while also rushing for 92 yards and a score on 18 attempts. The 31-year-old could be a worthy fantasy option as a QB streamer/injury replacement in Week 3, particularly in two-quarterback formats.
--Will BradySource: RotoBaller
September 17, 2025
The Houston Texans have been worringly vague when providing updates on the status of running back
Joe Mixon (ankle, foot), who did not participate in any team offseason activities while recovering from an ankle/foot injury. Mixon was placed on the non-football injury list before the start of the regular season, meaning his earliest possible return date is Week 5 against the Baltimore Ravens. However, it appears as though Mixon will likely be out significantly longer and could even miss the entirety of 2025. The 29-year-old was a huge piece of Houston's offense in 2024, totaling 1,325 yards from scrimmage and 12 touchdowns in 14 games. In Mixon's absence so far, the Texans have turned to veteran running back
Nick Chubb, who has 103 rushing yards and a touchdown on 25 carries through the team's first two games. Mixon may be worth stashing in an IR spot for fantasy managers, but the lack of updates from the team is a concerning sign.
--Will BradySource: RotoBaller
September 17, 2025
Seattle Seahawks rookie quarterback
Jalen Milroe served as the team's emergency quarterback in the 31-17 win over the Pittsburgh Steelers. With
Sam Darnold locked in as the starter and
Drew Lock currently operating as QB2, Milroe has opened his career as the third-string option and has only seen the field as a change-of-pace option. The 2025 third-round pick brings an element of explosiveness that neither Darnold nor Lock can match, with elite rushing ability that could eventually add a unique wrinkle to Seattle's offense. For now, the organization's priority is letting Milroe develop behind the veterans, with the hope that he can leapfrog Lock on the depth chart later this season. Until he earns meaningful snaps, Milroe remains off the fantasy radar.
--Nathan HarveySource: Pro Football Reference
September 17, 2025
Buffalo Bills cornerback Taron Johnson (quadriceps) is expected to play Thursday night against the Miami Dolphins, per Cameron Wolfe. Johnson sat out last week's game against the New York Jets with the injury, but returned to practice late last week and has been limited in sessions leading up to this matchup. His return is a crucial boost for Buffalo's secondary as they prepare to face
Tyreek Hill and
Jaylen Waddle. With defensive anchors Ed Oliver and Matt Milano already ruled out, Johnson's presence becomes even more important as the Bills look to slow down Miami's explosive offense.
--Nathan HarveySource: Cameron Wolfe - ESPN
September 17, 2025
Buffalo Bills defensive tackle Ed Oliver (ankle) has been ruled out for Thursday night's matchup against the Miami Dolphins. Oliver also missed last week's win over the New York Jets after suffering the injury in practice when he was stepped on. The veteran was a difference-maker in Week 1, forcing a fumble on
Derrick Henry and earning a team-best 92.7 defensive grade from PFF. In his absence, rookie second-round pick T.J. Sanders is expected to draw the start against a shaky Dolphins offensive line. With both Oliver and linebacker Matt Milano sidelined, Miami's star running back
De'Von Achane gets a significant boost.
--Nathan HarveySource: Adam Schefter - ESPN
September 17, 2025
Buffalo Bills linebacker Matt Milano (pectoral) has been ruled out for Thursday night's matchup against the Miami Dolphins. Milano suffered the injury during Sunday's blowout win over the New York Jets and, on a short week, won't be ready to play. The veteran has dealt with his share of major injuries in recent years, including a fractured leg and torn biceps. In his absence, third-year linebacker Dorian Williams is expected to step into the starting role. Milano's absence is a notable boost for Miami's ground game, particularly
De'Von Achane, who should find more running lanes against a weakened Buffalo front seven.
--Nathan HarveySource: Adam Schefter - ESPN
September 17, 2025
Indianapolis Colts quarterback
Anthony Richardson Sr. could emerge as a trade candidate in the coming weeks. Through his first two seasons, Richardson has completed just 50.6% of his passes with more interceptions than touchdowns, but the former top-five pick is still viewed as an unpolished talent with untapped potential. After the Colts named
Daniel Jones their starting quarterback at the end of training camp, speculation grew that Richardson might seek a fresh start elsewhere. With teams like the Cincinnati Bengals, Minnesota Vikings, and Washington Commanders already battling quarterback injuries, Richardson could draw interest as a developmental option or insurance plan. While his playing style doesn't seamlessly fit every system, it wouldn't be surprising to see him land a new role before season's end.
--Nathan HarveySource: Pro Football Reference
September 17, 2025
Los Angeles Chargers edge rusher Khalil Mack (elbow) is expected to miss a few weeks after dislocating his elbow in Monday night's matchup against the Las Vegas Raiders. Mack exited early with what initially appeared to be a serious injury, but NFL Network's Ian Rapoport reports it is not season-ending, and he should return later this season. It remains unclear whether the Chargers will place him on injured reserve, but the news is still encouraging, given that the team feared a much longer absence for the veteran pass rusher. In the meantime, veteran Bud Dupree is expected to step into an expanded role off the edge.
--Nathan HarveySource: Ian Rapoport - NFL Network
September 17, 2025
Tampa Bay Buccaneers quarterback
Baker Mayfield is on track to start in Week 3 against the New York Jets. Mayfield appeared shaken up during Monday night's win over the Houston Texans but avoided any structural damage and did not require further testing. While he may scale back practice reps on the short week, there are no concerns about his availability for Sunday. With elite weapons at his disposal and improved consistency as a passer, Mayfield remains firmly in the QB1 mix for fantasy managers.
--Nathan HarveySource: Ian Rapoport - NFL Network
September 17, 2025
Green Bay Packers wide receiver
Jayden Reed (foot, collarbone) underwent successful surgeries on both his shoulder and foot on Tuesday. Reed broke his clavicle in Week 2 while also playing through a Jones fracture, and with surgery already needed for his shoulder, he opted to address both issues at once. The second-year wideout is expected to return before the end of the season, but his fantasy outlook is murky.
Matthew Golden might begin to emerge,
Christian Watson (knee) is nearing a full return, and Green Bay could explore a trade before the deadline. For now, Reed is best stashed on injured reserve in fantasy leagues, with no guarantee he regains a significant role down the stretch.
--Nathan HarveySource: Adam Schefter - ESPN
September 17, 2025
Buffalo Bills running back
Ray Davis could see an increased role on Thursday night against the Miami Dolphins. Through the first two weeks, Davis has logged just 10 carries for 26 yards, while starter
James Cook has dominated the backfield touches. However, with a quick turnaround on a short week, the Bills may look to lighten Cook's workload. Historically, Cook hasn't handled a heavy rushing volume in Thursday games, recording just 42 carries across five career appearances. While Cook remains a locked-in fantasy starter and Davis isn't on the fantasy radar yet, he could make a sneaky impact for Buffalo in this divisional matchup.
--Nathan HarveySource: Pro Football Reference
September 17, 2025
Tampa Bay Buccaneers wide receiver
Jalen McMillan (neck) is currently on the Injured Reserve and eligible to return on Oct. 5, when the Buccaneers will travel to take on the Seattle Seahawks. McMillan left Tampa Bay's exhibition in Pittsburgh on August 16 with what eventually was termed a strained neck. This injury has opened the door for rookie wide receiver
Emeka Egbuka to be involved early on in the season, and he has not disappointed, hauling in three touchdowns in his first two career NFL games. McMillan had a nice rookie campaign in 2024, hauling in 37 of his 58 targets for 461 receiving yards and eight touchdowns. Before the draft, McMillan was lined up to be in the WR2 spot on the Bucs offense with
Chris Godwin (foot) recovering from his injury. At this time, McMillan remains a dynasty stash and can be picked up off the waivers in leagues with deeper benches once he returns.
--Nicho RoesslerSource: RotoBaller
September 17, 2025
Kansas City Chiefs running back
Brashard Smith logged his first NFL carry on Sunday against the Philadelphia Eagles and turned that into two yards. He also saw a target in the pass game, although he didn't come down with it. Smith is currently listed as the No. 3 running back on the depth chart; however, with
Isiah Pacheco (3.13 YPC) and
Kareem Hunt (3.62 YPC) both struggling to break out, it stands to reason that the Chiefs may give the rookie out of SMU a chance for some more carries in the coming weeks. At this time, Smith remains a decent dynasty stash and someone to keep an eye on in leagues with deeper bench spots. Until then, Smith will likely serve primarily as a returner on special teams and try to make his impact that way.
--Nicho RoesslerSource: RotoBaller
September 17, 2025
The Los Angeles Rams' second-round rookie tight end,
Terrance Ferguson, played a few snaps on Sunday and was not targeted against the Tennessee Titans after not seeing the field in Week 1 against the Houston Texans. Ferguson is listed second on the depth chart behind
Tyler Higbee, with
Colby Parkinson (shoulder) dealing with an injury. At this time, it's unclear what Ferguson's role will be in the offense, as he has not gotten many opportunities in the offense to this point. In his career with the Oregon Ducks, he had 134 receptions, 16 receiving touchdowns, and 1,537 career receiving yards. In his senior year in 2024, he recorded 43 catches for 591 yards and three touchdowns. He set school records for tight ends in career receptions and receiving touchdowns.
--Nicho RoesslerSource: RotoBaller
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