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DraftKings Daily Fantasy Baseball Picks (9/22/19): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on September 22nd, 2019. Austyn Varney's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome to Sunday baseball! The NFL is kicking off at 1 PM today, but so is baseball! DraftKings is still giving us big tournaments and the edge remains with a ton of fresh money on the sites. You have options no matter your price point, and the prize pools are all still huge. This is a fun slate. Runs will be scored and plenty of pitchers will have solid outings.

We'll be looking for the best play at each position. I'll be putting together a value article as well, so make sure to check that out as well. Let's dive in and find a top play at each position.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 9/22/19. The lineup picks will range from some of the elite players to mid-priced options and value plays. Be sure to also check out all the MLB Rosters for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. .

 

DraftKings DFS Starting Pitchers

Yu Darvish - CHC vs. STL - $11,600

The Cubs are in dire need of a win at this point and it will be on the shoulders of Yu Darvish. He’s been playing the best baseball of his Cubs career, striking out 14 and 13 in back to back games. He now gets a Cardinals team that’s middle of the road against righties and strikeout 22% of the time. It looks like Verlander will be the chalk on this slate, and while he’s a bit safer than Darvish, I don’t think the Astros will stretch him all the way out at this point. Darvish will go over 100 pitches if pitching well and Madden will get all he can out of Darvish after the bullpen has blown it back to back nights.

Reynaldo Lopez - CWS @ DET - $7,400

Reynaldo Lopez is extremely unreliable and up and down, but this is the best match-up he can possibly have and if there’s ever a time for his ceiling to poke through it’s here. The Tigers rank dead last in baseball against righties with a team .280 wOBA and 25% strikeout rate. We’ve seen Lopez go for seven innings and strikeout 10 before, so it really just comes down to whether or not he can locate his pitches. We’re hoping for five or six dominant innings, but there is upside for a lot more.

 

DraftKings DFS Infielders

C - Tom Murphy - SEA @ BAL (Means) - $4,200

When the Mariners face off with a lefty, Tom Murphy brings a big bat to the lineup. He’s sported a .400+ wOBA against southpaws on the season and is averaging nearly a home run every 12 at-bats. The Mariners face off with John Means today, who’s given up a .336 wOBA to opposing right-handers. There’s a reason Murphy is priced up. He’s proven himself as a real threat when in the lineup against a lefty.

1B - Freddie Freeman - ATL vs. SF (Webb) - $4,700

With the Braves holding an expected run total of six, Vegas obviously expects Logan Webb to struggle on the road here. He’s had trouble with both sides of the plate on the season, giving up a combined .368 wOBA. Freeman is the heart of this Braves lineup and he’ll be involved in at least a couple of those runs one way or another. Against righties, his wOBA remains over .380. Logan Webb has looked reverse splits a bit, but the 25 inning sample size is nowhere near enough to judge that.

2B - Whit Merrifield - KC @ MIN (Perez) - $4,300

Whit Merrifield flies under the radar on most slates as the Royals really aren’t too exciting of an offense. They face off with Martin Pérez today, who’s always had some HR Issues with righties. He’s only getting worse and worse at this point and his combined wOBA is up to .341. The Royals are a team I like today that will go completely un-owned. I’m a believer that if Martin Pérez these guys can hit a ton of home runs. Whit, Soler, and Dozier are a great mini stack on all sites.

Renato Nunez - BAL vs. SEA (Gonzalez) - $3,900

Marco Gonzales is already a bit shaky with the long ball, and now he moves to Camden Yards. Renato Nunez is back in the lineup and he’s been a lefty masher all year long. He’s fallen off a bit of late, but is still sporting a .339 wOBA against lefties with double digit home runs. The Orioles can put up a ton of runs, and they’re very rarely popular. This is another slate where you can get a low-owned Orioles stack in Camden Yards at an affordable price.

Alex Bregman - HOU vs. LAA (Rodriguez) - $5,400

Jose Rodriguez will get around 50 pitches before Jose Suarez takes over in this one. It’s really all semantics against this offense who’s going to rough up whoever is on the mound. If you’d like to know, Rodriguez is actually pretty good, but he’s also been very lucky. Jose Suarez on the other hand, has been one of the worst pitchers in all of baseball against opposing righties. They’re all pretty expensive on DraftKings, but rightfully so. Vegas expects another six plus runs and you know generally where the production is coming from. Bregman has been great against both sides of the plate, posting a .382 wOBA on the season with 38 home runs and a 13% strikeout rate. Bregman is safe with a ton of upside.

 

DraftKings DFS Outfielders

Giancarlo Stanton - NYY vs. TOR (Tepera) - $4,000

Stanton has been good since returning from injury, and he’s still too cheap. Make sure he’s in there as this is a day game, but he should be after homering last night. Ryan Tepera isn’t very good himself and the bullpen will follow after just a few innings. It’s always tough to predict bullpen games, but it’s clear to me that I’d rather have Stanton than any Blue Jays bullpen arm and I’m willing to take my chances that he connects on one at that price on DK.

Jason Heyward - CHC vs. STL (Mikolas) - $3,900

Jason Heyward is too cheap on DraftKings for a guy that should be leading off. Mikolas has struggled with lefties all season long and the Cubs have hit him around a few times themselves. Heyward has sported a .356 wOBA against righties and he’s only gotten better as the year has aged. I don’t love this entire game for offense, but I don’t mind taking a flier on a cheap Jason Heyward.

Things change quickly as lineups come out. If you have any questions, hit me up on Twitter @VarneyDFS and I'd be more than happy to help.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Tarik Skubal

Dominates in Rehab Start; Return Appears Imminent
Mitchell Robinson

Available for Game 3
Chicago Bulls

Bulls Hire Alex Kaufman as Windy City Bulls General Manager
E.J. Liddell

Agrees to Two-Year Deal with Greek Club Aris
Konnor Griffin

is Looking at Extended Absence
Matas Buzelis

Will Play for Lithuania This Summer
Kenley Jansen

to Begin Rehab Assignment on Tuesday
Giannis Antetokounmpo

Has Concerns About Heat Roster If Traded to Miami
Casey Mize

to Make Rehab Start on Tuesday
Bobby Witt Jr.

Exits Early with Knee Soreness
Mitchell Robinson

Has Technical Foul Rescinded After Game 2 Win
Jarquez Hunter

Is it Time for Dynasty Managers to Move on From Jarquez Hunter?
Elijah Arroyo

Worth Buying Low on in Dynasty Formats?
Tre Tucker

Profiles as a Dynasty Sell-High Candidate Entering 2026
Jack Bech

Should Dynasty Managers Target Jack Bech as a Buy-Low Candidate?
Jaydon Blue

a Dynasty Buy-Low Candidate After Underwhelming Rookie Year?
Saquon Barkley

in Line for Larger Pass-Catching Role in 2026?
Max Fried

Nearing Return to Mound Work?
Karl-Anthony Towns

Eligible for Massive Extension
Isaiah Stewart

Could Draw Trade Interest
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Michigan?
Philadelphia 76ers

Jameer Nelson Promoted to Executive Vice President
Domantas Sabonis

Could be Traded This Summer
Ty Gibbs

Is Ty Gibbs Worth Rostering at Michigan This Week for DFS?
William Byron

Will Start at the Rear at Michigan After Unapproved Adjustments
NASCAR

Should DFS Managers Roster Bubba Wallace at Michigan?
Joey Logano

Is Joey Logano Worth Rostering In DFS Lineups for Michigan
Daniel Suarez

Might Have Tournament Appeal for Michigan DFS Lineups
Jonah Coleman

Is Jonah Coleman the Most Valuable Broncos Running Back in Dynasty Leagues?
William Carrier

Suffers Upper-Body Injury in Game 3 Versus Golden Knights
Darius Slayton

Will Darius Slayton Be Phased Out of New-Look Giants Offense?
Sebastian Aho

Records Two Assists in Losing Effort
Alex Lange

Earns Third Save, Quickly Entering Must-Roster Status
Keaton Mitchell

Can Keaton Mitchell Carve Out a Large Enough Role for a Fantasy Breakout?
Jordan Staal

Scores in Third Consecutive Game
Shea Theodore

Caps Multi-Point Effort With Game-Winning Goal Saturday
Kayshon Boutte

Will Attend Mandatory Minicamp
Denny Hamlin

Puts DFS Managers in Tough Spot for Michigan
Chase Elliott

Can Chase Elliott Get Back to His Old Ways at Michigan?
Chris Buescher

Looking for Another Solid Run at Michigan
Tomas Hertl

Collects Two Points in Overtime Win
Jonathon Brooks

to Be Carolina's Lead Back in 2026?
Carson Hocevar

Qualifies Second, Seeking Redemption at Michigan
Ross Chastain

Can DFS Managers Trust Ross Chastain at Michigan?
Mitch Marner

Scores Fastest Hat Trick in Finals History
Brad Keselowski

Has Been Solid at Michigan
Will Smith

Scratched With Neck Stiffness, Expected to Return on Sunday
Kenneth Gainwell

Standing Out at OTAs
Bhayshul Tuten

"Picking Up Steam," More in-Tune With New Scheme
Auston Matthews

Maple Leafs Confident of Keeping Auston Matthews
Andrei Vasilevskiy

Wins Second Vezina Trophy
Brayden McNabb

Uncertain for Game 3 Against Hurricanes
Jadarian Price

Is Jadarian Price Still Undervalued in Dynasty Formats?
Isaiah Bond

Is Isaiah Bond Still Worthy of a Dynasty Roster Spot?
Michael Pittman Jr.

Dynasty Outlook Clouded by Long-Term QB Uncertainty
Stefon Diggs

Win-Now Dynasty Managers Have a Buy-Low Window on Stefon Diggs
Will Howard

Is it Time for Dynasty Managers to Drop Will Howard?
DK Metcalf

Dynasty Stock is Declining Rapidly Entering 2026
Hunter Greene

Could Return Before the All-Star Break
Isaac TeSlaa

How Will Isaac TeSlaa Follow Up on a Strong 2025 Finish?
Troy Franklin

a Dynasty Hold with Potentially Rough Times Ahead
Dylan Harper

Remains a Bright Spot for San Antonio
De'Aaron Fox

Shoots Well in a Loss to the Knicks
Victor Wembanyama

Scores 29 Points in Game 2 Loss
OG Anunoby

Anchors Knicks' Defense in Finals Game 2
Mikal Bridges

Helps Knicks Secure a Game 2 Victory
Karl-Anthony Towns

Records Another Finals Double-Double
Jalen Brunson

Overcomes Cold Night to Seal Game 2
Michael Harris II

Dealing With Back Tightness, Not Believed to be Serious
Byron Buxton

Suffers Shoulder Contusion After Colliding With the Wall
Sacramento Kings

Kings Want to Trade Their Larger Contracts
Chicago Bulls

Darius Acuff Jr. Works Out for Bulls
Jaime Jaquez Jr.

Could Get Traded
MIN

Marcus Johansson Returning to Europe
Thomas White

Likely to Miss Rest of Season With Shoulder Capsular Sprain
Mitchell Robinson

is Upgraded to Available for Game 2
Cole Caufield

Earns Lady Byng Trophy
Nick Suzuki

Lands Selke Trophy
Jose Altuve

Astros Reinstate Jose Altuve From the Injured List
CFB

Reed Harris Hoping to Fill Void in Arizona State Receiving Room
CFB

Nick Marsh Gearing Up for Breakout
CFB

Drew Mestemaker Looking to Catapult Oklahoma State Offense in 2026
CFB

Rocco Becht Brings Experience to New-Look Nittany Lions
CFB

Can Trey White, Adam Trick Keep Texas Tech's Defensive Front Elite?
CFB

Devon Dampier is Key to Success for Morgan Scalley in Year 1
Aaron Judge

Yankees Officially Place Aaron Judge on Injured List With Fractured Rib
Francisco Lindor

Expected to Return in "About a Couple Weeks"
Corey Seager

Rangers Activate Corey Seager From the Injured List
Gabriel Bonfim

Set For UFC Vegas 118 Main Event
Belal Muhammad

In Dire Need Of Win
Edmen Shahbazyan

An Underdog At UFC Vegas 118
Shayne Gostisbehere

Dishes Out Two Power-Play Assists in Comeback Win
Brendan Allen

Looks For His Third Win In A Row
Seth Jarvis

Ties Finals With Power-Play Goal
Mark Stone

Scores Sixth Playoff Goal in Overtime Defeat
Tom Nolan

Searches For His Fifth Consecutive Win
Mitch Marner

Records Two Assists in Game 2 Loss
Farés Ziam

Fares Ziam A Favorite At UFC Vegas 118
Brett Howden

Matches Franchise Record With Another Productive Outing
Brayden McNabb

Hospitalized After Taking Puck to Face
Aaron Judge

Diagnosed with Stress Fracture, Out 4-6 Weeks
Shohei Ohtani

has "Small" Blister, a "Non-Issue" for his Pitching Starts
Brent Rooker

Out on Thursday Due to Knee Soreness
Frederik Andersen

Hurricanes Retain Confidence in Frederik Andersen
Vincent Trocheck

Maple Leafs Interested in Vincent Trocheck
Dylan Larkin

Requests Trade From Red Wings
Corey Seager

Expected to Return This Weekend
Lucas Erceg

Royals to Mix and Match in Ninth With Lucas Erceg Struggling
Rickie Fowler

Looks To Continue Resurgent Season At Memorial
CFB

Can Eric Singleton Jr. Fully Break Out at Third School?
CFB

Katin Houser Steps into QB1 Role for Illinois
CFB

Savion Hiter an Immediate Impact Freshman for Michigan
CFB

Isaiah Horton Set to Take Over KC Concepcion's Role
CFB

UCLA Transfer Karson Gordon Signs with Austin Peay
CFB

Will Muschamp Bringing New Intensity to Texas Practices
Gary Woodland

Brings Boom-or-Bust Potential to Memorial
Jordan Spieth

Still Searching for a Breakthrough
Alex Smalley

Brings Elite Form to Memorial Tournament
Justin Rose

Looks to Recapture Memorial Tournament Success
Cameron Young

Looks to Get Back to His Contending Ways at Murifield Village
Chris Gotterup

Needs to Find Fairways at Muirfield Village
Si Woo Kim

Looks to Stay Hot at Memorial Tournament
Matt Fitzpatrick

Positioned for Success at Muirfield Village
Keegan Bradley

Looking for Another Strong Finish at Muirfield
Justin Thomas

is an Exciting Play This Week in Ohio
Scottie Scheffler

Looks to Win Memorial Tournament for Third Consecutive Year
Rory McIlroy

Looking for Better Performance at Muirfield Village
Russell Henley

Coming to Ohio on the Heels of Latest Victory
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
CFB

SEC Coach Calls Buster Faulkner a "Home-Run Hire"
CFB

Auburn a Sleeper in the SEC Under Alex Golesh?
CFB

Noah Fifita Primed for Strong 2026 Campaign
CFB

Oregon Assistant Coach Charged with DUII, Reckless Driving
CFB

Tight End Nick Pollack Commits to Clemson
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF