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DraftKings Daily Fantasy Baseball Picks (9/22/19): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on September 22nd, 2019. Austyn Varney's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome to Sunday baseball! The NFL is kicking off at 1 PM today, but so is baseball! DraftKings is still giving us big tournaments and the edge remains with a ton of fresh money on the sites. You have options no matter your price point, and the prize pools are all still huge. This is a fun slate. Runs will be scored and plenty of pitchers will have solid outings.

We'll be looking for the best play at each position. I'll be putting together a value article as well, so make sure to check that out as well. Let's dive in and find a top play at each position.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 9/22/19. The lineup picks will range from some of the elite players to mid-priced options and value plays. Be sure to also check out all the MLB Rosters for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. .

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DraftKings DFS Starting Pitchers

Yu Darvish - CHC vs. STL - $11,600

The Cubs are in dire need of a win at this point and it will be on the shoulders of Yu Darvish. He’s been playing the best baseball of his Cubs career, striking out 14 and 13 in back to back games. He now gets a Cardinals team that’s middle of the road against righties and strikeout 22% of the time. It looks like Verlander will be the chalk on this slate, and while he’s a bit safer than Darvish, I don’t think the Astros will stretch him all the way out at this point. Darvish will go over 100 pitches if pitching well and Madden will get all he can out of Darvish after the bullpen has blown it back to back nights.

Reynaldo Lopez - CWS @ DET - $7,400

Reynaldo Lopez is extremely unreliable and up and down, but this is the best match-up he can possibly have and if there’s ever a time for his ceiling to poke through it’s here. The Tigers rank dead last in baseball against righties with a team .280 wOBA and 25% strikeout rate. We’ve seen Lopez go for seven innings and strikeout 10 before, so it really just comes down to whether or not he can locate his pitches. We’re hoping for five or six dominant innings, but there is upside for a lot more.

 

DraftKings DFS Infielders

C - Tom Murphy - SEA @ BAL (Means) - $4,200

When the Mariners face off with a lefty, Tom Murphy brings a big bat to the lineup. He’s sported a .400+ wOBA against southpaws on the season and is averaging nearly a home run every 12 at-bats. The Mariners face off with John Means today, who’s given up a .336 wOBA to opposing right-handers. There’s a reason Murphy is priced up. He’s proven himself as a real threat when in the lineup against a lefty.

1B - Freddie Freeman - ATL vs. SF (Webb) - $4,700

With the Braves holding an expected run total of six, Vegas obviously expects Logan Webb to struggle on the road here. He’s had trouble with both sides of the plate on the season, giving up a combined .368 wOBA. Freeman is the heart of this Braves lineup and he’ll be involved in at least a couple of those runs one way or another. Against righties, his wOBA remains over .380. Logan Webb has looked reverse splits a bit, but the 25 inning sample size is nowhere near enough to judge that.

2B - Whit Merrifield - KC @ MIN (Perez) - $4,300

Whit Merrifield flies under the radar on most slates as the Royals really aren’t too exciting of an offense. They face off with Martin Pérez today, who’s always had some HR Issues with righties. He’s only getting worse and worse at this point and his combined wOBA is up to .341. The Royals are a team I like today that will go completely un-owned. I’m a believer that if Martin Pérez these guys can hit a ton of home runs. Whit, Soler, and Dozier are a great mini stack on all sites.

Renato Nunez - BAL vs. SEA (Gonzalez) - $3,900

Marco Gonzales is already a bit shaky with the long ball, and now he moves to Camden Yards. Renato Nunez is back in the lineup and he’s been a lefty masher all year long. He’s fallen off a bit of late, but is still sporting a .339 wOBA against lefties with double digit home runs. The Orioles can put up a ton of runs, and they’re very rarely popular. This is another slate where you can get a low-owned Orioles stack in Camden Yards at an affordable price.

Alex Bregman - HOU vs. LAA (Rodriguez) - $5,400

Jose Rodriguez will get around 50 pitches before Jose Suarez takes over in this one. It’s really all semantics against this offense who’s going to rough up whoever is on the mound. If you’d like to know, Rodriguez is actually pretty good, but he’s also been very lucky. Jose Suarez on the other hand, has been one of the worst pitchers in all of baseball against opposing righties. They’re all pretty expensive on DraftKings, but rightfully so. Vegas expects another six plus runs and you know generally where the production is coming from. Bregman has been great against both sides of the plate, posting a .382 wOBA on the season with 38 home runs and a 13% strikeout rate. Bregman is safe with a ton of upside.

 

DraftKings DFS Outfielders

Giancarlo Stanton - NYY vs. TOR (Tepera) - $4,000

Stanton has been good since returning from injury, and he’s still too cheap. Make sure he’s in there as this is a day game, but he should be after homering last night. Ryan Tepera isn’t very good himself and the bullpen will follow after just a few innings. It’s always tough to predict bullpen games, but it’s clear to me that I’d rather have Stanton than any Blue Jays bullpen arm and I’m willing to take my chances that he connects on one at that price on DK.

Jason Heyward - CHC vs. STL (Mikolas) - $3,900

Jason Heyward is too cheap on DraftKings for a guy that should be leading off. Mikolas has struggled with lefties all season long and the Cubs have hit him around a few times themselves. Heyward has sported a .356 wOBA against righties and he’s only gotten better as the year has aged. I don’t love this entire game for offense, but I don’t mind taking a flier on a cheap Jason Heyward.

Things change quickly as lineups come out. If you have any questions, hit me up on Twitter @VarneyDFS and I'd be more than happy to help.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

David Montgomery

Dynasty Stock Rising Following Move to Houston
Chris Godwin Jr.

Can Chris Godwin Jr. Re-Establish His Dynasty Value in 2026?
Malik Willis

Not Set Up for Immediate Success in Miami
Terrance Ferguson

has Promising Receiving Skills in Crowded TE Room in L.A.
Brenton Strange

Is Brenton Strange a Top-15 Dynasty Tight End?
T.J. Watt

Steelers Ready to Move on From T.J. Watt?
Jacory Croskey-Merritt

Must Make Gains as Pass-Catcher to Take the Next Step
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Kaytron Allen

Could Kaytron Allen Take on a Big Role Right Away?
Demond Claiborne

Has Long-Term Appeal in Minnesota
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Adam Randall

to Contribute as a Pass-Catcher Right Away?
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Nicholas Singleton

Could Contribute Right Away
Bryce Lance

a Perfect Fit in New Orleans?
Mike Washington Jr.

Can Mike Washington Jr. Force a Backfield Split in Vegas?
Paul Reed

Makes Big Impact Off the Bench Wednesday
Adonai Mitchell

Unlikely to be Phased Out of Jets Offense
Daniss Jenkins

Contributes 19 Points As Starter
Cade Cunningham

Tallies 39 Points in Losing Effort
Tony Pollard

an Affordable Add for Contending Dynasty Managers
Max Strus

Notches 20 Points With Six Triples
Evan Mobley

Close to Triple-Double Wednesday
Mason Taylor

How Much Dynasty Value Will Mason Taylor Hold After Offensive-Heavy Draft?
Jarrett Allen

Records Double-Double in Game 5 Win
De'Von Achane

a Dynasty Cornerstone
James Harden

Leads the Way for Cavaliers in Game 5 Victory
Quinn Hughes

Finishes Postseason With 15 Points
Matt Boldy

Posts Two Assists in Season-Ending Loss
Scott Wedgewood

Perfect in Relief Effort
Martin Necas

Records Another Multi-Point Game
Brett Kulak

Sends Avalanche Into Conference Finals
Brayden McNabb

Suspended for One Game
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Tim Patrick

Jets Agree to Terms With Veteran Receiver Tim Patrick
Malik Nabers

Undergoes Second Knee Surgery
De'Von Achane

Dolphins, De'Von Achane Agree to Four-Year Contract Extension
Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF