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Frank Ammirante's five fantasy football bold predictions for Week 5 of the 2025 NFL season. Expert predictions for De'Von Achane, Garrett Wilson, Tetairoa McMillan, and more.
Welcome to my weekly bold predictions column, where I attempt to predict spike weeks for five players whom I'm above consensus in fantasy football rankings.
I was shut out on my Week 4 bold predictions, but I correctly called a big game for Quinshon Judkins; it's just that he didn't get to 100+ yards (finished with 82). I'll try to be more accurate this time around.
With that in mind, let's dive into my Week 5 bold predictions on De'Von Achane, Garrett Wilson, Tetairoa McMillan, Jakobi Meyers, and Justin Herbert.
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De'Von Achane Puts Up 150+ Total Yards
With Tyreek Hill now out for the season, Achane is the focal point of the Dolphins' offense. Expect to see massive usage for this explosive running back, especially in the passing game.
Achane hasn't gotten close to 150+ total yards just yet:
- 101 total yards
- 91 total yards
- 122 total yards
- 75 total yards
But when you consider the likely uptick in usage in Hill's absence, it wouldn't surprise me to see him get there in Week 5.
This is a great spot against the Panthers, who rank 24th in Rush EPA this season. Let's take a look at what opposing running backs have done against them this year:
- TreVeyon Henderson: 46 total yards
- Bijan Robinson: 111 total yards
- James Conner: 52 total yards
- Travis Etienne: 156 total yards
Etienne is the only back to get to 150+, but Bijan likely could have gotten there if it wasn't a blowout.
Achane has the ability to take it to the house on any play while being a volume target-earner in the passing game.
De’Von Achane eludes defenders on his way for six 🔥
NYJvsMIA on ESPN
Stream on @NFLPlus and ESPN App pic.twitter.com/ATlX9WQW9s— NFL (@NFL) September 30, 2025
This projects as a close game with the Dolphins as short road favorites, which bodes well for Achane's usage here. I can already see it: the Dolphins are down three, trying to tie it with a last-minute field goal. Tua Tagovailoa marches down the field by checking it down to Achane. This feels like an attainable scenario.
Now, obviously, you're starting Achane. The actionable move with this bold prediction is to make sure Achane is a fixture in your DFS lineups this week. You can also take alternate lines on Achane if you're into player props.
Garrett Wilson Gets 100+ Receiving Yards
Wilson is having a terrific season despite erratic quarterback play from Justin Fields and Tyrod Taylor. The fourth-year wideout is dominating usage for the Jets, leading the team with an impressive 36.5% target share.
The former Buckeyes standout has been the model of consistency so far. Just take a look at his game log:
- 7 receptions, 95 yards, 1 TD
- 4 receptions, 50 yards
- 10 receptions, 84 yards, 1 TD
- 6 receptions, 82 yards, 1 TD
Despite the strong start, Wilson has yet to eclipse the century mark in yardage. I'm betting that this changes this week.
It's a fantastic spot against the Cowboys, who rank 32nd in Pass EPA. Take a look at the big games they've allowed to opposing wideouts:
- Romeo Doubs: 6 receptions, 58 yards, 3 TD
- Luther Burden III: 3 receptions, 101 yards, 1 TD
- Malik Nabers: 9 receptions, 167 yards, 2 TD
- Wan'Dale Robinson: 8 receptions, 142 yards, 1 TD
With that in mind, you're likely to see Fields have one of his best games of the year. With Wilson earning almost 40% of the team's target share, expect him to reap the rewards of this smash spot.
Tetairoa McMillan Puts Up 100+ Receiving Yards
McMillan hasn't had a breakout game yet, but you have to like the usage so far, as highlighted by an impressive 24% target share and 41% air yard share. This is a true alpha WR1, so it's only a matter of time before he has a spike week.
So far, the production has been dependable:
- 4 receptions, 62 yards
- 3 receptions, 48 yards
- 6 receptions, 100 yards
- 5 receptions, 68 yards
I like McMillan's chances of getting to 100+ receiving yards for the second time in his rookie season. It's a great spot against the Dolphins, who rank 31st in Pass EPA. McMillan has a 10.6 average depth of target, so he's consistently targeted downfield, which also bodes well for this prop.
We also have to acknowledge that this game has sneaky shootout potential, as reflected in the 44.5-point game total.
With Bryce Young likely able to have more success given the state of the Dolphins' pass defense, we should see a big game from McMillan here. It helps that this game projects to be close, so Young will have to consistently air it out.
I recommend pairing McMillan with Achane if you're building a DFS lineup this week. That gives you some correlation if this game does turn into a shootout.
Jakobi Meyers Gets 100+ Receiving Yards
Meyers has established himself as one of the most underrated wideouts in the NFL. So far, the dependable veteran is off to a rock-solid start, catching 21-of-33 targets for 258 yards, including 97 yards against the Patriots in Week 1.
There are a couple of factors to consider with this matchup vs. the Colts. For one, it's a projected shootout with a 47.5-point total, which is one of the highest of the slate. In an indoor environment with two underwhelming defenses, this could be a high-scoring affair, meaning more looks for Meyers.
On top of that, Brock Bowers remains banged up with a knee injury, putting his status in question for this game. Even if Bowers plays, he's clearly not at 100%, so Meyers is the top target in this offense.
We should note that the Colts have struggled in the slot this season, giving up big production to Puka Nacua (170 yards) last week. The Rams' star wideout plays in the slot 27% of the time, while Meyers (51%) is used there even more.
With the Raiders as six-point underdogs, it's likely that they're forced to play from behind, which means more passing volume and opportunities for Meyers.
I like using Meyers in DFS, too, because most of your opponents will focus on Ashton Jeanty in this game. Meyers is always underappreciated, so firing him up gives you some leverage on the field.
Justin Herbert Throws For 275 Yards and 3+ Touchdowns
Herbert has been playing like an MVP candidate this season, averaging 265.8 passing yards per game in what has surprisingly been a pass-heavy Chargers offense. I like Herbert to go nuclear this week.
For one, it's a great spot at home in an indoor environment. Herbert has eclipsed 300 passing yards in each of his home games this season.
Secondly, the Commanders' defense has been highly vulnerable against the pass, getting shredded by Michael Penix Jr. for 313 passing yards on 12.0 yards per attempt last week.
The Chargers have a 25-point implied total this week, which is tied for fifth-most on the slate. There's a legitimate chance that they put up 30+ against this defense, with most of the damage coming from Herbert.
We should also note that the Commanders have been tougher in run defense, ranking eighth in Rush EPA. If Washington is able to slow down Omarion Hampton, it could mean more pass attempts for Herbert, allowing him to get to these numbers.
I have Herbert as a top-3 quarterback this week, with only Josh Allen and Fields ahead. I have no issue starting him over a bona fide fantasy stud like Jalen Hurts, who has a much tougher matchup against an elite Broncos defense. Fire up Herbert with confidence this week.
