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Top MLB Betting Picks for Today's Slate (5/21/19)

Nate Duffett's MLB betting picks for 5/21/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Tuesday, May 21st, we see a huge 15 game MLB slate. The day starts with a 6:10 PM game between the Oakland Athletics and Cleveland Indians, and ends with a 10:10 PM game between the Arizona Diamondbacks and San Diego Padres.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Tuesday, May 21st. Good luck!

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Boston Red Sox (-150) @ Toronto Blue Jays | O/U: 9

We see a considerable change in the odds from yesterday's game, as the Red Sox drop to only -150 favorites against the Blue Jays. This is due in part to Marcus Stroman's 2.95 ERA and Ace status in the Blue Jays rotation. I will look to the numbers to see that this could be a bit of mispricing, as the Blue Jays have been 2-8 straight up when Stroman starts the game.

These results make Stroman the fifth-least profitable pitcher in the Majors. When it comes to recent form, the Blue Jays have only managed four wins over their last 10 games, while the Red Sox have been hot with seven wins in their last 10. Oddly enough, the Blue Jays have also struggled at the Rogers Centre this season, coming in with an abysmal 6-15 record.

My Picks: Red Sox (-150)

 

Cincinnati Reds @ Milwaukee Brewers (-135) | O/U: 8.5

We have another mispricing here in this game with the Brewers coming in at -135 favorites against the Cincinnati Reds. For starters, the Brewers have Gio Gonzalez taking the mound with his 2-0 record and 1.69 ERA, while the Reds counter with Sonny Gray and his 0-4 record and 4.30 ERA.

The Brewers have played their best baseball at home, boasting a 16-7 record, while the Reds have struggled outside of Cincinnati, putting up a 9-15 record. There isn't much else to say here except lock in the Brewers while these odds still exist.

My Picks: Brewers (-135), Brewers -1.5 

 

Colorado Rockies (-116) @ Pittsburgh Pirates | O/U: 7.5

This number seems too good to be true in this matchup. German Marquez has struggled in his last two starts on the road, allowing nine runs over 13 innings. Chris Archer has been a shell of his former self, allowing six earned runs in each of his last two starts, and failing to make it past the fourth inning in either outing.

Rockies games have gone over in seven of the last ten games, while the Pirates have gone over in four of their last five. This total number could hit before the starters even come out of the game, so I will be locking in the Over. Both teams have team totals of 3.5, so I would be interested in sprinkling a bit of cash on both of these numbers as well considering the struggles that each starting pitcher have had in the past month.

My Picks:  Over 7.5, Rockies Team Total O3.5, Pirates Team Total O3.5

 

Miami Marlins @ Detroit Tigers (-107) | O/U: 7.5

There's nothing I hate more than betting the under and rooting for a pitching duel, so if you see me picking an under, you should know that the numbers are there to back it up. Betting the under on a 7.5 total is one of the worst feelings ever, but you have to consider it when two of the worst offences in baseball face off. Spencer Turnbull has had some outstanding outings against teams that are a lot better than the Marlins, so I can't see them getting much off of him in this matchup.

The Marlins will send their best starter, Caleb Smith, who hasn't given up more than 2 earned runs since early April. The Tigers have scored 11 runs in their last five games, while the Marlins have only managed 13 in their last five, with eight of those runs coming in one outlier of a game against the Mets. This could be a snoozefest of a game unless you like watching hitters fail, so my suggestion is to lock in this bet and check the score when it's over.

My Pick: Under 7.5

 

Arizona Diamondbacks @ San Diego Padres (-107) | O/U: 7

The oddsmakers have this game billed as a toss-up which is understandable since both of these teams have been struggling with identical 3-7 records in their last 10 games. The thing that stands out to me is that the Diamondbacks 14-10 away from home while the Padres are 11-14 at Petco Park.

Zack Greinke takes the hill for the Diamondbacks, and he has been dealing in his past six starts, allowing one or fewer runs in all except for a three-run game at Coors Field. Meanwhile, Matt Strahm has been doing good as well allowing two runs in each of his last four starts, but I will take the more experienced Greinke here who will be determined to get his team back on the winning track.

My Pick: Diamondbacks (-101)

More Fantasy Baseball Analysis




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REAL-TIME FANTASY NEWS

CFB

Alberto Mendoza Entering Transfer Portal
Tennessee Titans

Titans Set to Hire Robert Saleh as Next Head Coach
Josh Giddey

Could Return Tuesday
Zaccharie Risacher

Ruled Out for the Week
Kristaps Porzingis

to Sit Out at Least One More Week
Jalen Williams

to Be Re-Evaluated in Two Weeks
Tyler Herro

Out Indefinitely With Ribs Issue
Jimmy Butler III

Out for Season With ACL Tear
Ludvig Aberg

Making Season Debut at American Express
Ryan Gerard

Heads to PGA West With Momentum After Strong Week in Hawaii
Naz Reid

Holds Questionable Tag for Tuesday
Rudy Gobert

is Cleared for Tuesday's Game
Christian Braun

to Remain Out on Tuesday
Ron Holland II

is Available to Play on Monday
Joel Embiid

Slated to Suit Up Monday
Miami Dolphins

Dolphins Expected to Hire Jeff Hafley as Next Head Coach
Day'Ron Sharpe

Ruled Out on Monday
Jalen Green

to Return on Tuesday
Draymond Green

Ruled Out for Monday's Game
Egor Demin

Ruled Out on Monday
Ondrej Palat

Ready to Face Flames
Devin Booker

Active Against Nets
Chris Kreider

Returns From Two-Game Absence Monday
Corey Perry

Back With Kings
Paul George

Sidelined on Monday
Bobby Brink

Available Monday Night
William Nylander

Misses Second Straight Game Monday
Draymond Green

Downgraded to Questionable on Monday
Kiefer Sherwood

Sharks Pick Up Kiefer Sherwood From Canucks
Matthew Tkachuk

Set for Season Debut Monday
Sepp Straka

Eyes Repeat At The American Express
Si Woo Kim

Poised To Contend At The American Express
Zach Charbonnet

has Torn ACL
Zach Charbonnet

Needs Knee Surgery, Out for Rest of Playoffs
Tennessee Titans

Mike McCarthy a Finalist for Titans Head-Coaching Job?
Colston Loveland

Suffers Concussion in Divisional Round Loss
Kyren Williams

Scores Two Touchdowns in Divisional Round Win
Buffalo Bills

Bills Fire Head Coach Sean McDermott
De'Anthony Melton

Out for Front End of Back-to-Back
Tom Wilson

May Return Monday
Zaccharie Risacher

to Miss Another Game vs. Bucks
Henri Jokiharju

Moved to Non-Roster List
Daniel Gafford

Remains Out Monday Against New York
Frank Nazar

Returns to Practice
Oskar Sundqvist

Suffers Skate Cut Sunday
Kasperi Kapanen

Considered Day-to-Day
Zach Whitecloud

Joins Flames
Rasmus Andersson

Moves to Vegas
Carson Soucy

Expected Back on Monday
Teuvo Teravainen

to Remain Out Monday
Matthew Tkachuk

"Close" to Season Debut
Rodrigo Abols

Flyers Place Rodrigo Abols on Injured Reserve
Alex Lyon

Practices on Sunday
Rhamondre Stevenson

Returns in Sunday's AFC Divisional Round Game
Josh Norris

Out Week-to-Week
Dylan Holloway

Set to Return Sunday
Ha-Seong Kim

has Finger Surgery, Out 4-5 Months
Rhamondre Stevenson

Questionable to Return on Sunday With Eye Injury
Woody Marks

Returns Following Brief Exit on Sunday
Dalton Schultz

Won't Return in Sunday's AFC Divisional Round Game
Aaron Rodgers

Steelers Open to Aaron Rodgers Returning in 2026?
Jarrett Stidham

to Start AFC Championship Game
Zach Charbonnet

Questionable to Return Against 49ers
Atlanta Falcons

Falcons Hiring Kevin Stefanski as Head Coach
Bo Nix

Suffers Broken Bone in Ankle, Done for Playoffs
Green Bay Packers

Packers Sign Head Coach Matt LaFleur to Multi-Year Extension
Ricky Pearsall

Active for Divisional Round
Sam Darnold

Officially Active for Saturday's Divisional Round Game vs. 49ers
Pat Bryant

Won't Return on Saturday, Ruled Out with a Concussion
CFB

Darian Mensah Entering Transfer Portal
J.T. Realmuto

Signs Three-Year Deal to Return to Phillies
Bo Bichette

Agrees to Three-Year Contract With Mets
CFB

Weber State Signs former Ohio State, Cal Quarterback Devin Brown
Bo Bichette

Phillies the "Overwhelming" Favorite to Sign Bo Bichette
Josh Lowe

Angels Acquire Josh Lowe in Three-Team Trade
Kyle Tucker

Signs Four-Year Contract With Dodgers
Clayton Kershaw

to Pitch for Team USA in World Baseball Classic
CFB

Auburn, Ohio State the Lead Suitors for Kyle Parker
CFB

Oregon QB Transfer Bryson Beaver Linked to Georgia, Kentucky
CFB

Jake Merklinger Commits to UConn
Ben Griffin

Looks To Stay Hot In 2026
Ranger Suárez

Ranger Suarez Agrees to Five-Year Deal With Red Sox
CFB

Dante Moore Not Entering 2026 NFL Draft, Will Return to Oregon
CFB

FBS Coaches Unanimously Vote to Expand Redshirt Eligibility to Nine Games

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