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Top MLB Betting Picks for Today's Slate (5/21/19)

Nate Duffett's MLB betting picks for 5/21/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Tuesday, May 21st, we see a huge 15 game MLB slate. The day starts with a 6:10 PM game between the Oakland Athletics and Cleveland Indians, and ends with a 10:10 PM game between the Arizona Diamondbacks and San Diego Padres.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Tuesday, May 21st. Good luck!

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Boston Red Sox (-150) @ Toronto Blue Jays | O/U: 9

We see a considerable change in the odds from yesterday's game, as the Red Sox drop to only -150 favorites against the Blue Jays. This is due in part to Marcus Stroman's 2.95 ERA and Ace status in the Blue Jays rotation. I will look to the numbers to see that this could be a bit of mispricing, as the Blue Jays have been 2-8 straight up when Stroman starts the game.

These results make Stroman the fifth-least profitable pitcher in the Majors. When it comes to recent form, the Blue Jays have only managed four wins over their last 10 games, while the Red Sox have been hot with seven wins in their last 10. Oddly enough, the Blue Jays have also struggled at the Rogers Centre this season, coming in with an abysmal 6-15 record.

My Picks: Red Sox (-150)

 

Cincinnati Reds @ Milwaukee Brewers (-135) | O/U: 8.5

We have another mispricing here in this game with the Brewers coming in at -135 favorites against the Cincinnati Reds. For starters, the Brewers have Gio Gonzalez taking the mound with his 2-0 record and 1.69 ERA, while the Reds counter with Sonny Gray and his 0-4 record and 4.30 ERA.

The Brewers have played their best baseball at home, boasting a 16-7 record, while the Reds have struggled outside of Cincinnati, putting up a 9-15 record. There isn't much else to say here except lock in the Brewers while these odds still exist.

My Picks: Brewers (-135), Brewers -1.5 

 

Colorado Rockies (-116) @ Pittsburgh Pirates | O/U: 7.5

This number seems too good to be true in this matchup. German Marquez has struggled in his last two starts on the road, allowing nine runs over 13 innings. Chris Archer has been a shell of his former self, allowing six earned runs in each of his last two starts, and failing to make it past the fourth inning in either outing.

Rockies games have gone over in seven of the last ten games, while the Pirates have gone over in four of their last five. This total number could hit before the starters even come out of the game, so I will be locking in the Over. Both teams have team totals of 3.5, so I would be interested in sprinkling a bit of cash on both of these numbers as well considering the struggles that each starting pitcher have had in the past month.

My Picks:  Over 7.5, Rockies Team Total O3.5, Pirates Team Total O3.5

 

Miami Marlins @ Detroit Tigers (-107) | O/U: 7.5

There's nothing I hate more than betting the under and rooting for a pitching duel, so if you see me picking an under, you should know that the numbers are there to back it up. Betting the under on a 7.5 total is one of the worst feelings ever, but you have to consider it when two of the worst offences in baseball face off. Spencer Turnbull has had some outstanding outings against teams that are a lot better than the Marlins, so I can't see them getting much off of him in this matchup.

The Marlins will send their best starter, Caleb Smith, who hasn't given up more than 2 earned runs since early April. The Tigers have scored 11 runs in their last five games, while the Marlins have only managed 13 in their last five, with eight of those runs coming in one outlier of a game against the Mets. This could be a snoozefest of a game unless you like watching hitters fail, so my suggestion is to lock in this bet and check the score when it's over.

My Pick: Under 7.5

 

Arizona Diamondbacks @ San Diego Padres (-107) | O/U: 7

The oddsmakers have this game billed as a toss-up which is understandable since both of these teams have been struggling with identical 3-7 records in their last 10 games. The thing that stands out to me is that the Diamondbacks 14-10 away from home while the Padres are 11-14 at Petco Park.

Zack Greinke takes the hill for the Diamondbacks, and he has been dealing in his past six starts, allowing one or fewer runs in all except for a three-run game at Coors Field. Meanwhile, Matt Strahm has been doing good as well allowing two runs in each of his last four starts, but I will take the more experienced Greinke here who will be determined to get his team back on the winning track.

My Pick: Diamondbacks (-101)

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REAL-TIME FANTASY NEWS

CFB

Quarterback Brayden Fowler-Nicolosi Signs with Michigan
Teuvo Teravainen

Set to Return Tuesday
CFB

Darian Mensah Reaches Settlement with Duke, Expected to Land at Miami
Simon Edvinsson

Out Until Olympics
Josh Norris

Won't Play This Week
Zeev Buium

Lands on Injured Reserve
Brock Boeser

Canucks Place Brock Boeser on Injured Reserve
Sean Durzi

Hurt on Monday Night
Lauri Markkanen

Expected to Return Tuesday
Keyonte George

Resting Tuesday
Malik Monk

Tagged as Questionable for Tuesday
Zach LaVine

Iffy for Tuesday's Action
Kawhi Leonard

Questionable Tuesday
Giannis Antetokounmpo

Without Timetable for Return
Devin Booker

Unavailable This Week
Anthony Edwards

Won't Play on Monday Night
Jusuf Nurkić

Jusuf Nurkic Not Expected to Play on Tuesday Night
Jalen Green

Questionable to Suit Up on Tuesday
Santi Aldama

Back in Action on Monday
Eugenio Suárez

Eugenio Suarez Not Drawing Interest on Open Market?
Tre Jones

Sidelined Versus Lakers
Jonas Brodin

to Miss 6-8 Weeks
Sam Merrill

Won't Play Monday
Kasperi Kapanen

Returns From Three-Game Absence Monday
Lawson Crouse

Available Against Lightning
Draymond Green

Considered Questionable for Monday
Carson Soucy

Won't Play Monday
Rasmus Ristolainen

Returns to Flyers Lineup
Al Horford

Ruled Out for Monday's Matchup with Minnesota
Ryan Pulock

Misses Second Consecutive Game
Shedeur Sanders

Named as Pro Bowl Replacement
Stephen Curry

Questionable on Monday
Simon Holmstrom

a Game-Time Call Monday
Framber Valdez

Among Many High-End Pitchers on Free-Agent Market
Jose Altuve

Won't Participate in World Baseball Classic
Harrison Bader

Agrees With Giants on Two-Year Deal
Paddy Pimblett

Drops Decision
Justin Gaethje

Becomes the New Interim-Lightweight Champion
Song Yadong

Suffers Unanimous Decision Loss
MMA

Sean O'Malley Gets Back In The Win Column
Waldo Cortes-Acosta

Extends His Win Streak
Derrick Lewis

Suffers Second-Round TKO Loss
Los Angeles Chargers

Chargers Officially Hire Mike McDaniel as Offensive Coordinator
Nathan Eovaldi

Doesn't Expect Any Limitations in Spring Training
Jaxon Smith-Njigba

Dominates in NFC Championship Game Win
Scott Wedgewood

Activated From Non-Roster List
Nikita Zadorov

Questionable for Monday
Stephen Halliday

Injured Sunday
Jack St. Ivany

Exits With Upper-Body Injury Sunday
Brock Boeser

Takes Hit to the Head
Evgeni Malkin

Suffers Apparent Injury in Sunday's Win
Sam Merrill

Still Uncertain to Play Monday
Deni Avdija

Could Miss Second Straight Game Monday
Zaccharie Risacher

Misses Ninth Straight Game Monday
Kristaps Porzingis

Still Out Monday Against Pacers
Austin Reaves

Not Ready to Return Monday
Philipp Kurashev

Joins Sharks for Road Trip
Charle-Edouard D'Astous

Placed on Injured Reserve
Matthew Stafford

Plans to Return in 2026
CFB

Arthur Smith to Become Ohio State's Offensive Coordinator
Bo Nix

Sidelined for 12 Weeks With Broken Ankle
Jose Altuve

to Mainly Play Second Base
Yu Darvish

Considering Retirement
Pittsburgh Steelers

Steelers Finalizing Deal to Make Mike McCarthy Their Head Coach
José Ramírez

Jose Ramirez Signs Seven-Year Extension With Guardians
Gunnar Henderson

is Fully Healthy Heading into Spring Training
Tyreek Hill

Dolphins Expected to Release Tyreek Hill
Paddy Pimblett

Set For Interim Lightweight Title Fight
Justin Gaethje

An Underdog At UFC 324
Song Yadong

Looks To Win Back-To-Back Fights
MMA

Sean O'Malley Looks To Get Back In The Win Column
Derrick Lewis

Returns At UFC 324
Waldo Cortes-Acosta

Looks For His Third Consecutive Win
Philip Rivers

Interviewing for Bills Head-Coaching Job
NFL

Fernando Mendoza Officially Declares for NFL Draft
CFB

Arch Manning Undergoes Foot Surgery
Dalton Kincaid

Played Through Torn PCL
CFB

College Football Playoff Expected to Remain a 12-Team Field in 2026
Baltimore Ravens

Ravens Hire Jesse Minter as Their Head Coach
Indianapolis Colts

FBI Investigating the Death of Colts Owner Jim Irsay
MacKenzie Gore

Rangers Acquire MacKenzie Gore From the Nationals
Brandon Sproat

Dealt to Brewers in Four-Player Trade
Jett Williams

Brewers Acquire Jett Williams From Mets
Freddy Peralta

Mets Acquire Freddy Peralta From Brewers
Kyle Tucker

Expected to Bat Second or Third in Dodgers' Lineup
Brandon Aiyuk

has "Played his Last Snap as a Niner"
Cody Bellinger

Signs Five-Year, $162.5 Million Contract With Yankees
Adam Scott

Looks to Overcome Putting Woes at American Express
Billy Horschel

Looking to Rebound at The American Express
Josh Allen

Might Need Foot Surgery
Russell Henley

Looks to Build on Strong Start at The American Express
Jason Day

Looking to Start 2026 Strong at The American Express
Wyndham Clark

Looking to Regain Form at The American Express
Sam Burns

Looks to Continue Success at The American Express
Akshay Bhatia

Looking to Flip the Script at The American Express
Christiaan Bezuidenhout

Looking to Build on Strong Fall in Season Debut
Kurt Kitayama

Hopes To Continue Strong Start to 2026 Season at American Express
CFB

Princewill Umanmielen Expected to Sign with LSU
Scottie Scheffler

Returns To American Express After Missing Last Year's Edition

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