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Top MLB Betting Picks for Today's Slate (5/21/19)

Nate Duffett's MLB betting picks for 5/21/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Tuesday, May 21st, we see a huge 15 game MLB slate. The day starts with a 6:10 PM game between the Oakland Athletics and Cleveland Indians, and ends with a 10:10 PM game between the Arizona Diamondbacks and San Diego Padres.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Tuesday, May 21st. Good luck!

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Boston Red Sox (-150) @ Toronto Blue Jays | O/U: 9

We see a considerable change in the odds from yesterday's game, as the Red Sox drop to only -150 favorites against the Blue Jays. This is due in part to Marcus Stroman's 2.95 ERA and Ace status in the Blue Jays rotation. I will look to the numbers to see that this could be a bit of mispricing, as the Blue Jays have been 2-8 straight up when Stroman starts the game.

These results make Stroman the fifth-least profitable pitcher in the Majors. When it comes to recent form, the Blue Jays have only managed four wins over their last 10 games, while the Red Sox have been hot with seven wins in their last 10. Oddly enough, the Blue Jays have also struggled at the Rogers Centre this season, coming in with an abysmal 6-15 record.

My Picks: Red Sox (-150)

 

Cincinnati Reds @ Milwaukee Brewers (-135) | O/U: 8.5

We have another mispricing here in this game with the Brewers coming in at -135 favorites against the Cincinnati Reds. For starters, the Brewers have Gio Gonzalez taking the mound with his 2-0 record and 1.69 ERA, while the Reds counter with Sonny Gray and his 0-4 record and 4.30 ERA.

The Brewers have played their best baseball at home, boasting a 16-7 record, while the Reds have struggled outside of Cincinnati, putting up a 9-15 record. There isn't much else to say here except lock in the Brewers while these odds still exist.

My Picks: Brewers (-135), Brewers -1.5 

 

Colorado Rockies (-116) @ Pittsburgh Pirates | O/U: 7.5

This number seems too good to be true in this matchup. German Marquez has struggled in his last two starts on the road, allowing nine runs over 13 innings. Chris Archer has been a shell of his former self, allowing six earned runs in each of his last two starts, and failing to make it past the fourth inning in either outing.

Rockies games have gone over in seven of the last ten games, while the Pirates have gone over in four of their last five. This total number could hit before the starters even come out of the game, so I will be locking in the Over. Both teams have team totals of 3.5, so I would be interested in sprinkling a bit of cash on both of these numbers as well considering the struggles that each starting pitcher have had in the past month.

My Picks:  Over 7.5, Rockies Team Total O3.5, Pirates Team Total O3.5

 

Miami Marlins @ Detroit Tigers (-107) | O/U: 7.5

There's nothing I hate more than betting the under and rooting for a pitching duel, so if you see me picking an under, you should know that the numbers are there to back it up. Betting the under on a 7.5 total is one of the worst feelings ever, but you have to consider it when two of the worst offences in baseball face off. Spencer Turnbull has had some outstanding outings against teams that are a lot better than the Marlins, so I can't see them getting much off of him in this matchup.

The Marlins will send their best starter, Caleb Smith, who hasn't given up more than 2 earned runs since early April. The Tigers have scored 11 runs in their last five games, while the Marlins have only managed 13 in their last five, with eight of those runs coming in one outlier of a game against the Mets. This could be a snoozefest of a game unless you like watching hitters fail, so my suggestion is to lock in this bet and check the score when it's over.

My Pick: Under 7.5

 

Arizona Diamondbacks @ San Diego Padres (-107) | O/U: 7

The oddsmakers have this game billed as a toss-up which is understandable since both of these teams have been struggling with identical 3-7 records in their last 10 games. The thing that stands out to me is that the Diamondbacks 14-10 away from home while the Padres are 11-14 at Petco Park.

Zack Greinke takes the hill for the Diamondbacks, and he has been dealing in his past six starts, allowing one or fewer runs in all except for a three-run game at Coors Field. Meanwhile, Matt Strahm has been doing good as well allowing two runs in each of his last four starts, but I will take the more experienced Greinke here who will be determined to get his team back on the winning track.

My Pick: Diamondbacks (-101)

More Fantasy Baseball Analysis




REAL-TIME FANTASY NEWS

Adam Randall

to Contribute as a Pass-Catcher Right Away?
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Nicholas Singleton

Could Contribute Right Away
Bryce Lance

a Perfect Fit in New Orleans?
Mike Washington Jr.

Can Mike Washington Jr. Force a Backfield Split in Vegas?
Paul Reed

Makes Big Impact Off the Bench Wednesday
Adonai Mitchell

Unlikely to be Phased Out of Jets Offense
Daniss Jenkins

Contributes 19 Points As Starter
Cade Cunningham

Tallies 39 Points in Losing Effort
Tony Pollard

an Affordable Add for Contending Dynasty Managers
Max Strus

Notches 20 Points With Six Triples
Evan Mobley

Close to Triple-Double Wednesday
Mason Taylor

How Much Dynasty Value Will Mason Taylor Hold After Offensive-Heavy Draft?
Jarrett Allen

Records Double-Double in Game 5 Win
De'Von Achane

a Dynasty Cornerstone
James Harden

Leads the Way for Cavaliers in Game 5 Victory
Quinn Hughes

Finishes Postseason With 15 Points
Matt Boldy

Posts Two Assists in Season-Ending Loss
Scott Wedgewood

Perfect in Relief Effort
Martin Necas

Records Another Multi-Point Game
Brett Kulak

Sends Avalanche Into Conference Finals
Brayden McNabb

Suspended for One Game
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Tim Patrick

Jets Agree to Terms With Veteran Receiver Tim Patrick
Malik Nabers

Undergoes Second Knee Surgery
De'Von Achane

Dolphins, De'Von Achane Agree to Four-Year Contract Extension
Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
De'Zhaun Stribling

to be 49ers' New "F" Receiver?
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
Drew Allar

Steelers "Uninstalling" Everything Drew Allar Learned in College
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

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RB
WR
TE
K
DEF