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Top MLB Betting Picks for Today's Slate (5/21/19)

Nate Duffett's MLB betting picks for 5/21/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Tuesday, May 21st, we see a huge 15 game MLB slate. The day starts with a 6:10 PM game between the Oakland Athletics and Cleveland Indians, and ends with a 10:10 PM game between the Arizona Diamondbacks and San Diego Padres.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Tuesday, May 21st. Good luck!

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Boston Red Sox (-150) @ Toronto Blue Jays | O/U: 9

We see a considerable change in the odds from yesterday's game, as the Red Sox drop to only -150 favorites against the Blue Jays. This is due in part to Marcus Stroman's 2.95 ERA and Ace status in the Blue Jays rotation. I will look to the numbers to see that this could be a bit of mispricing, as the Blue Jays have been 2-8 straight up when Stroman starts the game.

These results make Stroman the fifth-least profitable pitcher in the Majors. When it comes to recent form, the Blue Jays have only managed four wins over their last 10 games, while the Red Sox have been hot with seven wins in their last 10. Oddly enough, the Blue Jays have also struggled at the Rogers Centre this season, coming in with an abysmal 6-15 record.

My Picks: Red Sox (-150)

 

Cincinnati Reds @ Milwaukee Brewers (-135) | O/U: 8.5

We have another mispricing here in this game with the Brewers coming in at -135 favorites against the Cincinnati Reds. For starters, the Brewers have Gio Gonzalez taking the mound with his 2-0 record and 1.69 ERA, while the Reds counter with Sonny Gray and his 0-4 record and 4.30 ERA.

The Brewers have played their best baseball at home, boasting a 16-7 record, while the Reds have struggled outside of Cincinnati, putting up a 9-15 record. There isn't much else to say here except lock in the Brewers while these odds still exist.

My Picks: Brewers (-135), Brewers -1.5 

 

Colorado Rockies (-116) @ Pittsburgh Pirates | O/U: 7.5

This number seems too good to be true in this matchup. German Marquez has struggled in his last two starts on the road, allowing nine runs over 13 innings. Chris Archer has been a shell of his former self, allowing six earned runs in each of his last two starts, and failing to make it past the fourth inning in either outing.

Rockies games have gone over in seven of the last ten games, while the Pirates have gone over in four of their last five. This total number could hit before the starters even come out of the game, so I will be locking in the Over. Both teams have team totals of 3.5, so I would be interested in sprinkling a bit of cash on both of these numbers as well considering the struggles that each starting pitcher have had in the past month.

My Picks:  Over 7.5, Rockies Team Total O3.5, Pirates Team Total O3.5

 

Miami Marlins @ Detroit Tigers (-107) | O/U: 7.5

There's nothing I hate more than betting the under and rooting for a pitching duel, so if you see me picking an under, you should know that the numbers are there to back it up. Betting the under on a 7.5 total is one of the worst feelings ever, but you have to consider it when two of the worst offences in baseball face off. Spencer Turnbull has had some outstanding outings against teams that are a lot better than the Marlins, so I can't see them getting much off of him in this matchup.

The Marlins will send their best starter, Caleb Smith, who hasn't given up more than 2 earned runs since early April. The Tigers have scored 11 runs in their last five games, while the Marlins have only managed 13 in their last five, with eight of those runs coming in one outlier of a game against the Mets. This could be a snoozefest of a game unless you like watching hitters fail, so my suggestion is to lock in this bet and check the score when it's over.

My Pick: Under 7.5

 

Arizona Diamondbacks @ San Diego Padres (-107) | O/U: 7

The oddsmakers have this game billed as a toss-up which is understandable since both of these teams have been struggling with identical 3-7 records in their last 10 games. The thing that stands out to me is that the Diamondbacks 14-10 away from home while the Padres are 11-14 at Petco Park.

Zack Greinke takes the hill for the Diamondbacks, and he has been dealing in his past six starts, allowing one or fewer runs in all except for a three-run game at Coors Field. Meanwhile, Matt Strahm has been doing good as well allowing two runs in each of his last four starts, but I will take the more experienced Greinke here who will be determined to get his team back on the winning track.

My Pick: Diamondbacks (-101)

More Fantasy Baseball Analysis




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REAL-TIME FANTASY NEWS

Cameron Johnson

to Miss Time With Bone Bruise in Right Knee
Jaxson Hayes

Considered Questionable for Christmas Matchup
Rui Hachimura

Likely to Return Thursday
Dorian Finney-Smith

Could Make Season Debut on Christmas Day
Alperen Sengün

Alperen Sengun Uncertain for Christmas Day
Luka Dončić

Luka Doncic Listed as Questionable for Christmas Game
Al Horford

on Track to Return Thursday
Jaden McDaniels

Iffy for Christmas Day
Brandon Williams

Expected to Play on Christmas Day
P.J. Washington

at Risk of Missing Second Straight Game
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Likely to Play on Christmas Day
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Probable for Christmas Day
Ajay Mitchell

Out on Christmas Day
Chet Holmgren

Available on Christmas Day
Lonzo Ball

Available Against Knicks
Evan Mobley

Listed as Questionable for Christmas Tilt
OG Anunoby

Returns to Action Thursday
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Available on Christmas Day
David Montgomery

Questionable to Play With Illness
Amon-Ra St. Brown

Questionable, Expected to Play on Thursday
Rashee Rice

Chiefs Place Rashee Rice on Injured Reserve
T.J. Hockenson

Ruled Out for Week 17
Pete Fairbanks

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to Start at QB on Thursday Against Dallas
Brooks Koepka

Leaving LIV Golf
Davante Adams

Could Sit Out Final Two Regular-Season Games
Brock Bowers

Placed on Injured Reserve Due to Lingering Knee Injury
Amon-Ra St. Brown

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Connor McDavid

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Karel Vejmelka

Battling Upper-Body Injury
Alexandre Texier

Suffers Upper-Body Injury Against Bruins
Alexander Nikishin

Dealing With Apparent Ankle Injury
Denver Barkey

Exits Early Tuesday
Travis Sanheim

Pulled by Concussion Spotter Tuesday
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Out Indefinitely With Deep Vein Thrombosis
Corey Kispert

Lasts for 13 Minutes in Comeback Game
Jaxson Hayes

Makes Early Exit Versus Suns
Ryan O'Hearn

Pirates Agree on Two-Year Deal
DK Metcalf

has Two-Game Suspension Upheld
Philip Rivers

to Remain the Starter in Week 17
George Kittle

Dealing With Mid-to-Low Ankle Sprain
Viktor Arvidsson

a Game-Time Decision Tuesday
Ryan Leonard

Available Tuesday
Tom Wilson

in Danger of Missing First Game of the Season
Phillip Danault

Makes Second Canadiens Debut Tuesday
Collin Graf

Available Against Golden Knights
Jack Eichel

Misses Fourth Straight Game
Vince Dunn

Won't Play Tuesday
Deshaun Watson

Will Not be Activated Off PUP List, 2025 Season is Over
J.J. McCarthy

Ruled Out for Week 17
Rome Odunze

Expected to Return This Season
Christian McCaffrey

Another Monster Game for Christian McCaffrey in Week 16
Brock Purdy

Throws for Five Touchdowns in Week 16
TreVeyon Henderson

in Concussion Protocol, Week 17 Status Unclear
George Kittle

Week 17 Availability in Question?
CFB

Jeff Brohm, Eli Drinkwitz "Names of Interest" for Michigan Head Coach
Timothy Liljegren

to Miss Second Straight Game Tuesday
Will Smith

Out Week-to-Week
Jaccob Slavin

Placed on Injured Reserve, Out Week-to-Week
Seth Jarvis

Considered Week-to-Week
Darren Raddysh

Totals Three Points in Monday's Win
Mason Marchment

Scores Twice Monday
Vince Dunn

Injured in Monday's Win
Rashee Rice

Still in Concussion Protocol, Estimated as Non-Participant on Monday
J.J. McCarthy

Listed as DNP on Monday Ahead of Week 17
Ilya Sorokin

to Miss Tuesday's Game
DK Metcalf

Suspended for Two Games Following Confrontation with Fan
CFB

Byrum Brown Entering Transfer Portal
CFB

Bobby Petrino Joining Bill Belichick as North Carolina's Offensive Coordinator
Willson Contreras

Shipped to the Red Sox
Brandon Lowe

Pirates Acquire Brandon Lowe in Three-Team Trade
Shane Baz

Orioles Acquire Shane Baz From the Rays
CFB

Darian Mensah Returning to Duke Next Season
CFB

Josh Hoover Linked to Indiana in Transfer Portal
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Arch Manning Agrees to Reduced Compensation for 2026 Season

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