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Top MLB Betting Picks for Today's Slate (5/21/19)

Nate Duffett's MLB betting picks for 5/21/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Tuesday, May 21st, we see a huge 15 game MLB slate. The day starts with a 6:10 PM game between the Oakland Athletics and Cleveland Indians, and ends with a 10:10 PM game between the Arizona Diamondbacks and San Diego Padres.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Tuesday, May 21st. Good luck!

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Boston Red Sox (-150) @ Toronto Blue Jays | O/U: 9

We see a considerable change in the odds from yesterday's game, as the Red Sox drop to only -150 favorites against the Blue Jays. This is due in part to Marcus Stroman's 2.95 ERA and Ace status in the Blue Jays rotation. I will look to the numbers to see that this could be a bit of mispricing, as the Blue Jays have been 2-8 straight up when Stroman starts the game.

These results make Stroman the fifth-least profitable pitcher in the Majors. When it comes to recent form, the Blue Jays have only managed four wins over their last 10 games, while the Red Sox have been hot with seven wins in their last 10. Oddly enough, the Blue Jays have also struggled at the Rogers Centre this season, coming in with an abysmal 6-15 record.

My Picks: Red Sox (-150)

 

Cincinnati Reds @ Milwaukee Brewers (-135) | O/U: 8.5

We have another mispricing here in this game with the Brewers coming in at -135 favorites against the Cincinnati Reds. For starters, the Brewers have Gio Gonzalez taking the mound with his 2-0 record and 1.69 ERA, while the Reds counter with Sonny Gray and his 0-4 record and 4.30 ERA.

The Brewers have played their best baseball at home, boasting a 16-7 record, while the Reds have struggled outside of Cincinnati, putting up a 9-15 record. There isn't much else to say here except lock in the Brewers while these odds still exist.

My Picks: Brewers (-135), Brewers -1.5 

 

Colorado Rockies (-116) @ Pittsburgh Pirates | O/U: 7.5

This number seems too good to be true in this matchup. German Marquez has struggled in his last two starts on the road, allowing nine runs over 13 innings. Chris Archer has been a shell of his former self, allowing six earned runs in each of his last two starts, and failing to make it past the fourth inning in either outing.

Rockies games have gone over in seven of the last ten games, while the Pirates have gone over in four of their last five. This total number could hit before the starters even come out of the game, so I will be locking in the Over. Both teams have team totals of 3.5, so I would be interested in sprinkling a bit of cash on both of these numbers as well considering the struggles that each starting pitcher have had in the past month.

My Picks:  Over 7.5, Rockies Team Total O3.5, Pirates Team Total O3.5

 

Miami Marlins @ Detroit Tigers (-107) | O/U: 7.5

There's nothing I hate more than betting the under and rooting for a pitching duel, so if you see me picking an under, you should know that the numbers are there to back it up. Betting the under on a 7.5 total is one of the worst feelings ever, but you have to consider it when two of the worst offences in baseball face off. Spencer Turnbull has had some outstanding outings against teams that are a lot better than the Marlins, so I can't see them getting much off of him in this matchup.

The Marlins will send their best starter, Caleb Smith, who hasn't given up more than 2 earned runs since early April. The Tigers have scored 11 runs in their last five games, while the Marlins have only managed 13 in their last five, with eight of those runs coming in one outlier of a game against the Mets. This could be a snoozefest of a game unless you like watching hitters fail, so my suggestion is to lock in this bet and check the score when it's over.

My Pick: Under 7.5

 

Arizona Diamondbacks @ San Diego Padres (-107) | O/U: 7

The oddsmakers have this game billed as a toss-up which is understandable since both of these teams have been struggling with identical 3-7 records in their last 10 games. The thing that stands out to me is that the Diamondbacks 14-10 away from home while the Padres are 11-14 at Petco Park.

Zack Greinke takes the hill for the Diamondbacks, and he has been dealing in his past six starts, allowing one or fewer runs in all except for a three-run game at Coors Field. Meanwhile, Matt Strahm has been doing good as well allowing two runs in each of his last four starts, but I will take the more experienced Greinke here who will be determined to get his team back on the winning track.

My Pick: Diamondbacks (-101)

More Fantasy Baseball Analysis




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REAL-TIME FANTASY NEWS

Ja Morant

Remains Out on Wednesday
Shai Gilgeous-Alexander

Will Suit Up Versus Utah
Jaren Jackson Jr.

Good to Go Against Phoenix
Santi Aldama

Cleared to Play on Wednesday
Sam LaPorta

Plans to be Back for Training Camp
Brandon Miller

Unavailable Versus Raptors
Owen Caissie

Shipped to Miami as Centerpiece of Trade
Edward Cabrera

Cubs Officially Acquire Edward Cabrera From Marlins
Onyeka Okongwu

Sidelined Wednesday
Nathan Walker

Ready to End 16-Game Absence
Rutger McGroarty

Out Indefinitely With Concussion
Jaren Jackson Jr.

Downgraded to Questionable For Wednesday
Kevin Stenlund

a Game-Time Call Wednesday
Ty Dellandrea

Ruled Out Wednesday
Matas Buzelis

Set to Suit Up Wednesday
Adam Erne

Misses Wednesday's Action
Tom Wilson

Aliaksei Protas Won't Play Wednesday
Coby White

Sidelined Versus Pistons
Anze Kopitar

Out Wednesday
Draymond Green

Upgraded to Probable on Wednesday
Rome Odunze

Plans to Play on Saturday
LeBron James

Considered Questionable For Wednesday
Edward Cabrera

Cubs Finalizing Deal to Acquire Edward Cabrera From Marlins
New York Giants

Giants "All-In" on Hiring John Harbaugh
CFB

Jackson Arnold Signs with UNLV
CFB

Sam Leavitt Scheduled to Visit Tennessee
Devon Toews

to Miss at Least Two Weeks
Gabriel Landeskog

Out for Several Weeks
Jamie Drysdale

Makes Early Exit Tuesday
Bobby Brink

Injured in Tuesday's Win
Adam Henrique

Expected to Miss Time
Brad Marchand

Dealing With Lingering Health Issue
Haydn Fleury

Hospitalized Tuesday
Moussa Diabaté

Ryan Kalkbrenner Out, Moussa Diabate Probable Wednesday
Brandon Miller

Listed as Probable Wednesday
Alex Caruso

Absent for Second Consecutive Game
Nicolas Claxton

Available Wednesday
Moritz Wagner

Still Out Wednesday
Franz Wagner

Not Ready to Return Wednesday
Jalen Suggs

Remains Out Wednesday
Draymond Green

Questionable to Suit Up Wednesday
Jalen Smith

Ruled Out for Second Straight Game
Matas Buzelis

Could Miss First Game of the Season Wednesday
New York Giants

John Harbaugh Expected to be Favorite to Become New Giants Head Coach
Mason Marchment

Out Tuesday
Sean Monahan

Available Tuesday
Jason Zucker

Set to Return From 11-Game Absence
Matvei Michkov

a Game-Time Call Tuesday
Matthew Schaefer

Cleared for Action Tuesday
Baltimore Ravens

John Harbaugh Won't Return as Ravens Head Coach
Adam Fox

Landing Back on Long-Term Injured Reserve
Seth Jarvis

Back for Hurricanes Tuesday
Bo Bichette

Unlikely to Return to Toronto?
Jordan Love

Ready to Start in Wild-Card Game Against Bears
CFB

Jadan Baugh Staying with Florida for Junior Season
Washington Commanders

Commanders "Mutually" Parting Ways With OC Kliff Kingsbury
CFB

Byrum Brown Officially Commits to Auburn
CFB

Austin Simmons Signing with Missouri
CFB

Ty Simpson Undecided on 2026 Plans
CFB

Quarterback AJ Hill Following Ryan Silverfield to Arkansas
Atlanta Falcons

Falcons Have Requested an Interview With Klint Kubiak
Deshaun Watson

Browns Expect Deshaun Watson to be on the Team Next Year
Wan'Dale Robinson

Dealing With Fractured Ribs
Cam Skattebo

Hopes to be Back by Training Camp
Cameron Ward

Won't Need Surgery on his Shoulder
Davante Adams

Rams Expect Davante Adams to Return in Wild-Card Round
Arizona Cardinals

Cardinals Fire Head Coach Jonathan Gannon
Las Vegas Raiders

Raiders Fire Head Coach Pete Carroll
Malik Nabers

Unsure if He Will Be Ready for Week 1 of 2026 Season
CFB

Trinidad Chambliss Will Return to Ole Miss If Granted Sixth Year of Eligibility
Cincinnati Bengals

Zac Taylor Will Return as Bengals Head Coach in 2026
New York Giants

Giants Expected to Show Interest in Former Browns Head Coach Kevin Stefanski
Daniel Jones

Colts, Daniel Jones Appear to Have "Mutual Interest" in a 2026 Reunion
Cleveland Browns

Browns Fire Kevin Stefanski After Another Losing Season
Zay Flowers

Goes Off for 138 Yards, Two Touchdowns in Loss
Bo Bichette

Phillies Have Interest in Bo Bichette
Kansas City Royals

Matt Quatraro Signs Three-Year Extension With Royals
CFB

Transfer QB Billy Edwards Commits to North Carolina
CFB

Sam Leavitt Visiting Texas Tech on Saturday
CFB

DJ Lagway Expected To Visit Florida State
Kyle Tucker

Blue Jays "Remain the Favorite" to Sign Kyle Tucker
CFB

Joey Aguilar Undergoes Surgery to Remove Tumor on Friday
CFB

Texas the "Team to Beat" for Transfer Running Back Isaac Brown
CFB

Rocco Becht to Follow Matt Campbell to Penn State?
CFB

Texas Targeting Cam Coleman in Transfer Portal
CFB

Former Texas Running Back CJ Baxter Visiting Kentucky
CFB

Beau Pribula Visiting Virginia Tech, Georgia Tech

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