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Top MLB Betting Picks for Today's Slate (5/21/19)

Nate Duffett's MLB betting picks for 5/21/19. He analyzes Vegas lines and recommends the top expert bets for today's MLB slate including moneylines and over/unders.

Welcome back RotoBallers! On Tuesday, May 21st, we see a huge 15 game MLB slate. The day starts with a 6:10 PM game between the Oakland Athletics and Cleveland Indians, and ends with a 10:10 PM game between the Arizona Diamondbacks and San Diego Padres.

In this article, we will dive into the numbers and pick out my top recommended betting picks for today's slate. Feel free to hit me up on Twitter @Roto_Nate if you have any questions.

So without any further delay, below are my picks for Tuesday, May 21st. Good luck!

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Boston Red Sox (-150) @ Toronto Blue Jays | O/U: 9

We see a considerable change in the odds from yesterday's game, as the Red Sox drop to only -150 favorites against the Blue Jays. This is due in part to Marcus Stroman's 2.95 ERA and Ace status in the Blue Jays rotation. I will look to the numbers to see that this could be a bit of mispricing, as the Blue Jays have been 2-8 straight up when Stroman starts the game.

These results make Stroman the fifth-least profitable pitcher in the Majors. When it comes to recent form, the Blue Jays have only managed four wins over their last 10 games, while the Red Sox have been hot with seven wins in their last 10. Oddly enough, the Blue Jays have also struggled at the Rogers Centre this season, coming in with an abysmal 6-15 record.

My Picks: Red Sox (-150)

 

Cincinnati Reds @ Milwaukee Brewers (-135) | O/U: 8.5

We have another mispricing here in this game with the Brewers coming in at -135 favorites against the Cincinnati Reds. For starters, the Brewers have Gio Gonzalez taking the mound with his 2-0 record and 1.69 ERA, while the Reds counter with Sonny Gray and his 0-4 record and 4.30 ERA.

The Brewers have played their best baseball at home, boasting a 16-7 record, while the Reds have struggled outside of Cincinnati, putting up a 9-15 record. There isn't much else to say here except lock in the Brewers while these odds still exist.

My Picks: Brewers (-135), Brewers -1.5 

 

Colorado Rockies (-116) @ Pittsburgh Pirates | O/U: 7.5

This number seems too good to be true in this matchup. German Marquez has struggled in his last two starts on the road, allowing nine runs over 13 innings. Chris Archer has been a shell of his former self, allowing six earned runs in each of his last two starts, and failing to make it past the fourth inning in either outing.

Rockies games have gone over in seven of the last ten games, while the Pirates have gone over in four of their last five. This total number could hit before the starters even come out of the game, so I will be locking in the Over. Both teams have team totals of 3.5, so I would be interested in sprinkling a bit of cash on both of these numbers as well considering the struggles that each starting pitcher have had in the past month.

My Picks:  Over 7.5, Rockies Team Total O3.5, Pirates Team Total O3.5

 

Miami Marlins @ Detroit Tigers (-107) | O/U: 7.5

There's nothing I hate more than betting the under and rooting for a pitching duel, so if you see me picking an under, you should know that the numbers are there to back it up. Betting the under on a 7.5 total is one of the worst feelings ever, but you have to consider it when two of the worst offences in baseball face off. Spencer Turnbull has had some outstanding outings against teams that are a lot better than the Marlins, so I can't see them getting much off of him in this matchup.

The Marlins will send their best starter, Caleb Smith, who hasn't given up more than 2 earned runs since early April. The Tigers have scored 11 runs in their last five games, while the Marlins have only managed 13 in their last five, with eight of those runs coming in one outlier of a game against the Mets. This could be a snoozefest of a game unless you like watching hitters fail, so my suggestion is to lock in this bet and check the score when it's over.

My Pick: Under 7.5

 

Arizona Diamondbacks @ San Diego Padres (-107) | O/U: 7

The oddsmakers have this game billed as a toss-up which is understandable since both of these teams have been struggling with identical 3-7 records in their last 10 games. The thing that stands out to me is that the Diamondbacks 14-10 away from home while the Padres are 11-14 at Petco Park.

Zack Greinke takes the hill for the Diamondbacks, and he has been dealing in his past six starts, allowing one or fewer runs in all except for a three-run game at Coors Field. Meanwhile, Matt Strahm has been doing good as well allowing two runs in each of his last four starts, but I will take the more experienced Greinke here who will be determined to get his team back on the winning track.

My Pick: Diamondbacks (-101)

More Fantasy Baseball Analysis




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REAL-TIME FANTASY NEWS

Luis Arraez

Signs One-Year Deal with Giants
Troy Terry

Ready to Return Sunday
Victor Hedman

Set to Return Sunday
Connor McMichael

Out Week-to-Week
Kris Letang

Out for Four Weeks
Nico Hischier

a Game-Time Call Saturday
Jack Hughes

Won't Play Saturday
Linus Ullmark

Returns to Action Saturday
Blake Snell

Dodgers Plan to Have Blake Snell Ready for Opening Day
Paul George

Suspended for 25 Games
Shohei Ohtani

Will be Ready to Pitch to Start the 2026 Season
Francisco Lindor

Won't Play in WBC After Elbow Surgery
Nikola Vučević

Nikola Vucevic Unlikely to Play Against Miami
Tre Jones

Still Sidelined as Bulls Face Miami
Tyler Herro

Remains Sidelined Saturday vs. Bulls
Norman Powell

Ruled Out vs. Bulls
Jeremy Sochan

Still Sidelined as Spurs Visit Charlotte
Keyonte George

Injures Ankle Late in Loss to Nets
Stephen Curry

Exits Early Against Pistons with Knee Issue
Charlie Coyle

Pots Second Career Hat Trick
Filip Hronek

Expected to Play Saturday
Pavel Zacha

Not Traveling With Bruins
Elias Lindholm

to Miss at Least Two More Games
William Nylander

on Track to Return Saturday
Kris Letang

Misses Practice, Uncertain for Saturday
Evgeni Malkin

Iffy for Saturday
Cade Cunningham

Ready to Rock Friday
Gui Santos

Available Against Pistons
Caris LeVert

Remains Sidelined Friday
Craig Porter Jr.

Out Against Suns
Jonas Valančiūnas

Jonas Valanciunas Active Friday
Jamal Murray

Upgraded to Available Friday
Nikola Jokić

Nikola Jokic Officially Available Friday
Vinnie Pasquantino

Royals Agree on Two-Year Contract
Neemias Queta

Back in Action Friday
Miles McBride

Misses Friday's Game
Josh Hart

Active Against Trail Blazers
Tre Johnson

Out Against Lakers
Khris Middleton

Sits Out Meeting With Lakers
Austin Reaves

Remains Out Friday
Jacob Wilson

Signs Seven-Year Extension
Diego Lopes

An Underdog At UFC 325
Alexander Volkanovski

Set For UFC 325 Main Event
Benoît Saint Denis

Benoit Saint Denis Looks To Extend His Win Streak
Dan Hooker

Set For UFC 325 Co-Main Event
Mauricio Ruffy

Looks To Get Back In The Win Column
Rafael Fiziev

Returns At UFC 325
CFB

Texas Lands Wake Forest Transfer Sterling Berkhalter
Samuel Ersson

Sustains Lower-Body Injury Thursday
Pavel Zacha

Exits Early Thursday
Charlie Lindgren

Hurt Versus Red Wings
Jack Hughes

Exits With Lower-Body Injury Thursday
Brad Marchand

Suffers New Injury Blow
Patrick Kane

Becomes NHL's Highest-Scoring U.S-Born Player
Ukko-Pekka Luukkonen

Expected to Miss a Week
Tommy Edman

Will Have Delayed Start to Spring Training, Could Miss Opening Day
Kirk Cousins

Falcons Expected to Release Kirk Cousins
Chase Brown

Working on Extension With Bengals
Michael Penix Jr.

Hopes to be Ready for Week 1
Isaac Paredes

Not a Lock for Opening Day Lineup?
Dalton Kincaid

Doesn't Need Offseason Surgery
Josh Allen

Undergoes Foot Surgery
Josh Allen

on Crutches, Wearing Walking Boot
Corbin Carroll

a Top Fantasy Outfielder After Joining 30-30 Club
Jonah Tong

Won't Pitch in the World Baseball Classic
CFB

Michigan RB Bryson Kuzdzal Withdrawing from Transfer Portal
Aaron Judge

Appears to be Past his Elbow Issues
Bo Nix

Expected to Resume Training in 4-6 Weeks
Michael Penix Jr.

Thinks he'll be Ready by April
Evan Carter

Establishes a Goal to Steal 30 Bases
Edouard Julien

Traded to the Rockies
Cleveland Browns

Browns Hiring Todd Monken as Next Head Coach
Sahith Theegala

Off to Much Better 2026 Start
Gary Woodland

an Intriguing Option at Torrey Pines This Week
CJ Abrams

Giants Offer "Aggressive Pitch" for CJ Abrams
Andrew Putnam

Hopes to Keep Momentum Rolling This Week
Matthieu Pavon

Seeks to Return to 2024 Form at Torrey Pines
Luke List

Still Looking For Birdies at Torrey Pines
Jake Knapp

Faces Stiff Challenge at Farmers Insurance Open
Rasmus Hojgaard

Needs to Play Better at Torrey Pines
Christiaan Bezuidenhout

Could Struggle at Farmers Insurance Open
J.J. Spaun

A Steady Option At Farmers Insurance Open
Andrew Novak

Looking For More Success At Torrey Pines
Denny McCarthy

A Wild Card At Farmers Insurance Open
Max Homa

Looks To Keep Resurgence Going At Torrey Pines
Joe Highsmith

Struggling Heading Into Torrey Pines
Wyndham Clark

Looks To Carry Momentum Into Farmers Insurance Open
Tony Finau

Aims To Turn Things Around At Torrey Pines
Akshay Bhatia

Looks to Bounce Back at Torrey Pines
Paul Goldschmidt

Yankees Expressing Interest in Re-Signing Paul Goldschmidt
Bo Bichette

Won't Play in World Baseball Classic
NFL

Bill Belichick Won't be First-Ballot Hall of Famer
Carlos Correa

Won't Play for Puerto Rico in World Baseball Classic
Si Woo Kim

Looks to Continue Incredible Run at Torrey Pines
Jason Day

has a Good Chance to Keep Momentum This Weekend
Keegan Bradley

has Good Course History at Torrey Pines
Billy Horschel

Isn't a Great DFS Option at Torrey Pines
Aaron Rodgers

Mike McCarthy Says he Wants Aaron Rodgers to Return
Will Zalatoris

Has a Shot to Challenge at the Farmers Insurance Open
Drake Maye

Expected to be Fine for Super Bowl
Tennessee Titans

Titans Set to Hire Brian Daboll as New Offensive Coordinator
Buffalo Bills

Bills Promote Joe Brady to Head Coach
CFB

Quarterback Brayden Fowler-Nicolosi Signs with Michigan
CFB

Darian Mensah Reaches Settlement with Duke, Expected to Land at Miami
Eugenio Suárez

Eugenio Suarez Not Drawing Interest on Open Market?
Shedeur Sanders

Named as Pro Bowl Replacement
Framber Valdez

Among Many High-End Pitchers on Free-Agent Market
Jose Altuve

Won't Participate in World Baseball Classic
Harrison Bader

Agrees With Giants on Two-Year Deal
Paddy Pimblett

Drops Decision
Justin Gaethje

Becomes the New Interim-Lightweight Champion
Song Yadong

Suffers Unanimous Decision Loss
MMA

Sean O'Malley Gets Back In The Win Column
Waldo Cortes-Acosta

Extends His Win Streak
Derrick Lewis

Suffers Second-Round TKO Loss
Los Angeles Chargers

Chargers Officially Hire Mike McDaniel as Offensive Coordinator
Jaxon Smith-Njigba

Dominates in NFC Championship Game Win

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K
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