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DraftKings CFB DFS Picks: Daily Fantasy College Football Advice for 9/22

Week 4 college football DFS lineups, sleepers and value picks for DraftKings on September 22nd. Target these NCAA players in CFB daily fantasy tournaments and cash games.

Welcome to week four of college football daily fantasy! We're back with a 10-game slate that features some tightly (projected) contests and a lot of household teams and names. As usual, the contest begins with the noon games and features a few 3:30 eastern time matchups as well.

Before we jump into player selections and reasoning, I'd like to call out a few interesting numbers and lines from our friends in fabulous Las Vegas. For the first time in a long time, more than half of the games feature a spread of fewer than 10 points! It also features five road favorites - all favored by single digits - and a trio of games where the over/under has shot up more than five points. There are two games with big blowout potential, as Ohio State hosts Tulsa as 37 point favorites and Alabama hosts Texas A&M as 25 point favorites. The games with the highest point total projections are Tulsa at Ohio State (68.5), Boston College at Purdue (68), Georgia at Mizzou (64.5), Notre Dame at Wake Forest (61), and Texas A&M at Alabama (61). Of those, the two I find the most attractive are the Boston College at Purdue matchup because of the tight 6.5 point spread, and the Georgia at Mizzou game, because the total has been shooting up (opened at 61, currently at 68).

In this article, I will be providing you with my daily fantasy college football lineup picks for DraftKings on 9/22/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @kpLuch.

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DraftKings DFS Quarterbacks

Dwayne Haskins - QB, vs Tulsa ($10,700)

The price may look tough to stomach at first, but considering that he's averaged 31 DraftKings points this season despite the fact his team has blown out all three opponents, it's a pretty impressive point average. All of that to say, basically, is that he has been worth every penny and he has a gem of a matchup at home in The Horseshoe on Saturday which should allow him to pay off this price with ease. I'm of the opinion - and I am certainly not the only one - that thinks Ohio State is going to try to blow the doors off this game in Urban Meyer's return to the sidelines. So, while there is blowout risk, that risk is mitigated by the fact that Vegas has this game pegged at roughly a 70 point total, with the Buckeyes putting up somewhere in the range of 35-40+ points. Haskins and the offense have a super talented crop of receivers at their disposal and Haskins has logged 30+ attempts in two of three starts (with an impressive completion percentage, too) - the lone start with less than 30 coming in a 52-3 dismantling of Rutgers.

Nathan Elliott - QB, vs PITT ($6,200)

Quarterback Nathan Elliott has had a disappointing start to the season, to say the least, and his inaccuracy issues have plagued the 0-2 TarHeel squad. But where there has been disappointing performance comes decreased price tags and decreased interest - which creates an opportunity for major return on investment and leverage in tournaments, respectively. I see Elliott as a low-cost, semi-high risk to take in week four. He faces an a Pitt defense that has given up yards and points in bunches, and the fact this game has a tight spread (3.5 points) with an implied total trending up makes this a good spot to buy low on a quarterback who has attempted no less than 35 passes in a game this season.

Also Consider: Will Grier - QB, vs Kansas State ($10,500)

 

DraftKings DFS Running Backs

A.J. Dillon - RB, at Purdue ($9,000)

A.J. Dillon had an absolute beastly campaign his freshman season and he's picking up right where he left off for his sophomore season. He's an elite running back that nearly any offense is going to struggle to slow down. Last week, in a one-score contest with Wake Forest, Dillon carried the ball 33 times, racking up 185 yards and a touchdown. With that in mind, I really like his outlook for week four as this game should move at a similar pace and has a very high point total as well, with a one-score spread of just 6.5 points. Through three weeks of play, Purdue has proven they can score but have a real hard time stopping the run, which bodes well for the bellcow Dillon in West Lafayette this weekend.

Pooka Williams Jr. - RB, at Baylor ($5,700)

Never thought I'd see the day where I'd be recommending starting a Kansas football player in a big fantasy contest full of options, but here we are. Pooka Williams is legit - the freshman has been super impressive so far through three games, and Pro Football Focus has him ranked as the third-best freshman running back in the country right now. He is lightning quick and has averaged 8.8 yards a carry with a healthy workload, too. He's been responsible for three of the Jayhawks 10 touchdowns this season, and I really think he has a chance to continue the upward trend in this matchup with Baylor. The game has a healthy 54 point over/under, but what is most appealing is the low price tag and a date with the 98th ranked defense in college football according to S&P+ rankings.

Also Consider: Elijah Holyfield - RB, at Mizzou ($5,200); D'Andre Swift - RB, at Mizzou ($7,400)

 

DraftKings DFS Wide Receivers

Rondale Moore - WR, vs Boston College ($6,900)

Given the fact that this Boilermaker offense runs quickly and their defense is full of holes, it's more than likely this team is going to play in a lot of high scoring contests. That's appealing for us in the DFS community, as that combination equates to more offensive snaps, which creates higher volume for feature backs and receivers, and generally leads to desirable fantasy scoring output. Purdue head coach Jeff Brohm is pretty innovative offensively, and he's wasted little team getting his freshman phenom involved in the passing game. The wideout had an enormous coming out party last weekend against Mizzou, hauling in 11 passes for 137 yards as he found the endzone once. I'm expecting pretty big things here in week four as Brohm and his offensive staff will try to get the rock in Moore's hands early and often out in space against a team that just gave up 34 points to the Deamon Deacons.

Emmanuel Hall - WR, vs Georgia ($6,000)

Like my Nathan Elliott pick, this one is not for the faint of heart. Hall has a really tough matchup this week going up against one of the best secondaries in the NCAA. But, similar to my Elliott interest, the rationale for wanting to play him in tournaments is sound - the volume in this one is absolutely going to be there, and we are getting him with a super depressed price tag in a game that is expected to be very high scoring. Mizzou quarterback Drew Lock's game logs show a commitment to the pass - he attempted no less than 43 passes in each of the past two weeks. Hall is a really dynamic receiver and Lock's favorite target.

Also Consider: David Sills V - WR, vs Kansas State ($8,000)

More NCAA Football Analysis

REAL-TIME FANTASY NEWS

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Dynasty Value in Decline
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a Dynasty Sleeper with Room to Grow
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Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Pat Freiermuth

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Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
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Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

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Jordan Mason

a Short-Term Dynasty Depth Piece
Dontayvion Wicks

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Chuba Hubbard

Dynasty Value Back on the Rise
Juwan Johnson

an Overlooked Buy Candidate for Contending Dynasty Managers
Kimani Vidal

Easily Acquirable as a High-Value Insurance Back
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Tallies Series-High 24 Points on Saturday
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Struggles at the Line Saturday
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Nets Two Goals in Painful Loss
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Scores in Second Consecutive Game
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Won't Play Sunday
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Not on Injury Report for Game 4
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Off the Injury Report Ahead of Game 4
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Questionable for Sunday Night
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Rays-Yankees Postponed on Saturday
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Held to Four Rebounds in Game 3 Loss
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Contributes an Assist in Losing Effort
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Guides Thunder to 2-1 Series Lead
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Headlines 2025-26 All-Defensive First Team
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Attracting Interest From Senators
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Scratched for Game 2 Against Avalanche
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Won't Play Friday
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
Cale Makar

Remains Out Friday
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CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
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LSU Hires Ed Orgeron As Special Assistant
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North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Sebastian Aho

Picks Up an Assist in Series-Opening Loss
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Needs 33 Seconds to Score in Game 1 Loss
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Struggles in Game 1 Against Canadiens
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
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Lincoln Riley Believes USC is Ready for Playoff Run
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Notre Dame-Stanford Rivalry Renewed Through 2028
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Ahmad Hardy Says He's "Back to the Road to Success"
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Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
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UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
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Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
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Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
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Sungjae Im Brings Upside to TPC Craig Ranch
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Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

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Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
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is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

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Ezavier Crowell has Immediate Opportunity at Alabama
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Mark Bowman a Day 1 Impact Player for USC?
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Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
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Kemario Taylor a Breakout Candidate at Quarterback
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Rocco Becht The "Unifier" of Penn State's Roster
Jackson Holliday

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RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF