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DraftKings CFB DFS Picks: Daily Fantasy College Football Advice for 9/22

Week 4 college football DFS lineups, sleepers and value picks for DraftKings on September 22nd. Target these NCAA players in CFB daily fantasy tournaments and cash games.

Welcome to week four of college football daily fantasy! We're back with a 10-game slate that features some tightly (projected) contests and a lot of household teams and names. As usual, the contest begins with the noon games and features a few 3:30 eastern time matchups as well.

Before we jump into player selections and reasoning, I'd like to call out a few interesting numbers and lines from our friends in fabulous Las Vegas. For the first time in a long time, more than half of the games feature a spread of fewer than 10 points! It also features five road favorites - all favored by single digits - and a trio of games where the over/under has shot up more than five points. There are two games with big blowout potential, as Ohio State hosts Tulsa as 37 point favorites and Alabama hosts Texas A&M as 25 point favorites. The games with the highest point total projections are Tulsa at Ohio State (68.5), Boston College at Purdue (68), Georgia at Mizzou (64.5), Notre Dame at Wake Forest (61), and Texas A&M at Alabama (61). Of those, the two I find the most attractive are the Boston College at Purdue matchup because of the tight 6.5 point spread, and the Georgia at Mizzou game, because the total has been shooting up (opened at 61, currently at 68).

In this article, I will be providing you with my daily fantasy college football lineup picks for DraftKings on 9/22/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @kpLuch.

 

DraftKings DFS Quarterbacks

Dwayne Haskins - QB, vs Tulsa ($10,700)

The price may look tough to stomach at first, but considering that he's averaged 31 DraftKings points this season despite the fact his team has blown out all three opponents, it's a pretty impressive point average. All of that to say, basically, is that he has been worth every penny and he has a gem of a matchup at home in The Horseshoe on Saturday which should allow him to pay off this price with ease. I'm of the opinion - and I am certainly not the only one - that thinks Ohio State is going to try to blow the doors off this game in Urban Meyer's return to the sidelines. So, while there is blowout risk, that risk is mitigated by the fact that Vegas has this game pegged at roughly a 70 point total, with the Buckeyes putting up somewhere in the range of 35-40+ points. Haskins and the offense have a super talented crop of receivers at their disposal and Haskins has logged 30+ attempts in two of three starts (with an impressive completion percentage, too) - the lone start with less than 30 coming in a 52-3 dismantling of Rutgers.

Nathan Elliott - QB, vs PITT ($6,200)

Quarterback Nathan Elliott has had a disappointing start to the season, to say the least, and his inaccuracy issues have plagued the 0-2 TarHeel squad. But where there has been disappointing performance comes decreased price tags and decreased interest - which creates an opportunity for major return on investment and leverage in tournaments, respectively. I see Elliott as a low-cost, semi-high risk to take in week four. He faces an a Pitt defense that has given up yards and points in bunches, and the fact this game has a tight spread (3.5 points) with an implied total trending up makes this a good spot to buy low on a quarterback who has attempted no less than 35 passes in a game this season.

Also Consider: Will Grier - QB, vs Kansas State ($10,500)

 

DraftKings DFS Running Backs

A.J. Dillon - RB, at Purdue ($9,000)

A.J. Dillon had an absolute beastly campaign his freshman season and he's picking up right where he left off for his sophomore season. He's an elite running back that nearly any offense is going to struggle to slow down. Last week, in a one-score contest with Wake Forest, Dillon carried the ball 33 times, racking up 185 yards and a touchdown. With that in mind, I really like his outlook for week four as this game should move at a similar pace and has a very high point total as well, with a one-score spread of just 6.5 points. Through three weeks of play, Purdue has proven they can score but have a real hard time stopping the run, which bodes well for the bellcow Dillon in West Lafayette this weekend.

Pooka Williams Jr. - RB, at Baylor ($5,700)

Never thought I'd see the day where I'd be recommending starting a Kansas football player in a big fantasy contest full of options, but here we are. Pooka Williams is legit - the freshman has been super impressive so far through three games, and Pro Football Focus has him ranked as the third-best freshman running back in the country right now. He is lightning quick and has averaged 8.8 yards a carry with a healthy workload, too. He's been responsible for three of the Jayhawks 10 touchdowns this season, and I really think he has a chance to continue the upward trend in this matchup with Baylor. The game has a healthy 54 point over/under, but what is most appealing is the low price tag and a date with the 98th ranked defense in college football according to S&P+ rankings.

Also Consider: Elijah Holyfield - RB, at Mizzou ($5,200); D'Andre Swift - RB, at Mizzou ($7,400)

 

DraftKings DFS Wide Receivers

Rondale Moore - WR, vs Boston College ($6,900)

Given the fact that this Boilermaker offense runs quickly and their defense is full of holes, it's more than likely this team is going to play in a lot of high scoring contests. That's appealing for us in the DFS community, as that combination equates to more offensive snaps, which creates higher volume for feature backs and receivers, and generally leads to desirable fantasy scoring output. Purdue head coach Jeff Brohm is pretty innovative offensively, and he's wasted little team getting his freshman phenom involved in the passing game. The wideout had an enormous coming out party last weekend against Mizzou, hauling in 11 passes for 137 yards as he found the endzone once. I'm expecting pretty big things here in week four as Brohm and his offensive staff will try to get the rock in Moore's hands early and often out in space against a team that just gave up 34 points to the Deamon Deacons.

Emmanuel Hall - WR, vs Georgia ($6,000)

Like my Nathan Elliott pick, this one is not for the faint of heart. Hall has a really tough matchup this week going up against one of the best secondaries in the NCAA. But, similar to my Elliott interest, the rationale for wanting to play him in tournaments is sound - the volume in this one is absolutely going to be there, and we are getting him with a super depressed price tag in a game that is expected to be very high scoring. Mizzou quarterback Drew Lock's game logs show a commitment to the pass - he attempted no less than 43 passes in each of the past two weeks. Hall is a really dynamic receiver and Lock's favorite target.

Also Consider: David Sills V - WR, vs Kansas State ($8,000)

More NCAA Football Analysis

REAL-TIME FANTASY NEWS

NBA

Hawks Promote Onsi Saleh to President of Basketball Operations
Jalen Williams

Listed as Questionable for Game 6
Ajay Mitchell

Ruled Out for Game 6
Michael Penix Jr.

Not Cleared for 11-on-11 Work
Jacoby Brissett

Still Absent From OTAs This Week
George Kittle

Still Hoping to be Ready for Week 1
Micah Parsons

Expected to Open Training Camp on the PUP List
Tucker Kraft

Packers Hopeful Tucker Kraft Will Participate in Training Camp
Jacory Croskey-Merritt

Held Out of OTAs on Wednesday
Jayden Daniels

Participating in Commanders OTAs
Chris Bell

No Timetable for Chris Bell's Return from Knee Surgery
De'Von Achane

Limited in OTAs Due to Recovery From Shoulder Injury
MarShawn Lloyd

Participating in Packers OTAs
Josh Jacobs

No Criminal Charges Filed Against Josh Jacobs
Eury Pérez

Eury Perez Pulled Early on Wednesday With Hamstring Issue
Daniel Jones

Present at OTA Practice on Wednesday
CFB

Drew Mestemaker a Top Big 12 Quarterback Right Away?
T.J. Hockenson

Dynasty Stock Continues to Trend Down
Jordan Addison

Is Jordan Addison a Clear Buy-Low Candidate Ahead of 2026?
Cade Otton

Continues to Offer Depth in Dynasty Leagues
PGA

Sungjae Im Remains Boom-or-Bust at Colonial
Jared Goff

Continues to Have Dynasty Appeal at 31 Years Old
Tez Johnson

No Clear Path to Fantasy Relevance for Tez Johnson in Tampa Bay?
PGA

Michael Thorbjornsen Trending in Wrong Direction Entering Colonial
Zach Ertz

Could Still Contribute in Dynasty Leagues
De'Aaron Fox

Limited to Nine Points in Game 5 Loss
Russell Henley

a Top Option at Colonial
Dyami Brown

Holds Little Dynasty Value in His Return to Washington
Harry Hall

Hoping Putter Carries Him at Colonial
Julian Champagnie

Notches 22 Points With Four Triples Tuesday
Trevor Etienne

Could Still Find Dynasty Relevance After Quiet Rookie Season
Stephon Castle

Leads Spurs in Scoring Tuesday Night
Rickie Fowler

Looks to Regain Momentum at Colonial
Victor Wembanyama

Struggles in Game 5 Loss to Thunder
Bam Knight

Dynasty Value Has Run Dry in Crowded Running Back Room
Alex Caruso

a Difference-Maker Again in Game 5
Pierceson Coody

Looking to Stay Hot at Colonial
Jared McCain

Produces 20 Points in First Playoff Start
Shai Gilgeous-Alexander

Scores Game-High 32 Points in Game 5 Win
Martin Necas

Collects an Assist in Game 4 Loss to Golden Knights
Gabriel Landeskog

Scores Only Avalanche Goal in Season-Ending Loss
Carter Hart

Finishes Series-Clincher With 20 Saves
Dylan Coghlan

Continues Unlikely Success Story
Cole Smith

Scores Series-Clincher Tuesday Night
Mark Stone

Nets Another Goal as Golden Knights Finish Off Avalanche
Ludvig Aberg

Looking to Exchange Momentum for a Victory in Fort Worth
Stephan Jaeger

Trending Upward as PGA Heads to Fort Worth
Max Homa

Comes Off Awful Putting Performance at PGA Championship
Tony Finau

Faces Different Test at the Colonial
Robert MacIntyre

Seeks Better Beginning in Fort Worth
Tom Hoge

Ups and Downs Could Continue at Colonial
Brian Harman

Not Having the Best Golf Season in 2026
Austin Eckroat

Struggling Too Often Heading to Charles Schwab Challenge
Zach Bauchou

Tries to Keep Momentum Rolling at Colonial
Keegan Bradley

Looking to Rebound at Colonial
Jared McCain

Moves into Starting Five
Boston Celtics

Joe Mazzulla Wins Coach of the Year
Jalen Williams

is Ruled Out for Game 5 on Tuesday
Zion Williamson

to See More Versatile Role
Cleveland Cavaliers

Kenny Atkinson to Remain Cavaliers Head Coach Next Season
Claude Giroux

Planning to Return for 20th NHL Campaign
Carter Hart

Aiming for Sixth Consecutive Win Tuesday
Evgeni Malkin

Inks New One-Year Deal With Penguins
Mackenzie Blackwood

in Net for Game 4 Against Golden Knights
Valeri Nichushkin

a Game-Time Call Tuesday
Nathan MacKinnon

Will Suit Up Tuesday
Ben Griffin

Looking to Repeat This Week at Colonial
Rasmus Hojgaard

a Player to Avoid at Charles Schwab Challenge
Hideki Matsuyama

Needs Solid Driving Week at Charles Schwab Challenge
Justin Thomas

Trending Well Ahead of Charles Schwab Challenge
Akshay Bhatia

Lacking Driving Prowess Needed at Colonial Country Club
CFB

DJ Lagway Looking to Rebound at Baylor
CFB

Josh Hoover Tasked With Leading Indiana Back to the Playoffs
CFB

Braylon Staley the Next 1,000-Yard Tennessee Receiver?
CFB

Ahmad Hardy's Return Timeline Remains Unclear
Evan Mobley

Finishes Season-Ending Loss With 15 Points
James Harden

Wants to Stay in Cleveland
Donovan Mitchell

Remains Committed to Cavaliers
Mikal Bridges

Cools Off in Game 4 Against Cavaliers
OG Anunoby

Active on Both Ends in Blowout Win
Karl-Anthony Towns

Leads Knicks in Scoring During Series-Clincher
Ivan Demidov

Contributes an Assist in Losing Effort
Lane Hutson

Records Power-Play Goal in Game 3 Loss
Frederik Andersen

Enjoys Another Easy Night at the Office in Game 3
Shayne Gostisbehere

Scores First Postseason Goal
Taylor Hall

Ends Four-Game Goal Drought
Andrei Svechnikov

Scores Game 3 Winner in Overtime
Gage Jump

Athletics to Promote Top Pitching Prospect Gage Jump to Major Leagues
Tatsuya Imai

Two Relievers Combine to No-Hit the Rangers on Monday
Valeri Nichushkin

Nathan MacKinnon, Valeri Nichushkin Uncertain for Game 4
Oliver Kapanen

Sitting as Healthy Scratch Monday
Max Domi

Out Indefinitely Due to Offseason Surgery Complications
Dylan Cease

Heading to Injured List With Hamstring Injury
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
MLB

Orioles-Tigers Game Postponed on Saturday
MLB

Rays-Yankees Postponed on Saturday
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF