2 Start Pitchers: Fantasy Baseball Waiver Wire Pickups and Streamers for Week 25 (2025)

September 16, 2025

Pranav's 2 start pitchers streamers, fantasy baseball waiver wire pickups, sleepers, starts for Week 25 of 2025 (September 15 to September 21). His top SP matchups with two starts.

Hello, RotoBallers! Welcome back to another Two-Start Pitchers - Fantasy Baseball Waiver Wire Streamers and Starts article for Week 25 of 2025, from September 15 to September 21. We're in the thick of the fantasy baseball playoffs, where a two-start pitcher can become the difference-maker.

Every week of the 2025 fantasy baseball season, this fantasy baseball waiver wire pickups column will identify starting pitchers in line to make two starts in the upcoming week. It will look at fantasy baseball streamers ahead of the Sunday night waiver wire run for leagues with weekly transactions.

There are 35 pitchers currently scheduled for two starts in this period. We will examine the best options with roster rates under 50 percent. Pitchers with roster rates over 50 percent will also be listed. The other two-start pitchers are available, but they are not listed, as they should be avoided.

Two-Start Pitchers - Over 50% Rostered

• Carlos Rodon (@ MIN, @ BAL)
• Cam Schlittler (@ MIN, @ BAL)
• Ryan Pepiot (vs. TOR, vs. BOS)
• Jose Berrios (@ TB, @ KC)
• Kevin Gausman (@ TB, @ KC)
• Casey Mize (vs. CLE, vs. ATL)
• Logan Gilbert (@ KC, @ HOU)
• Spencer Strider (@ WAS, @ DET)
• Cade Horton (@ PIT, @ CIN)
• Andrew Abbott (@ STL, vs. CHC)
• Freddy Peralta (vs. LAA, @ STL)
• Paul Skenes (vs. CHC, vs. ATH)
• Zac Gallen (vs. SF, vs. PHI)
• Shohei Ohtani (vs. PHI, vs. SF)
• Michael King (@ NYM, @ CHW)

Best Available Two-Start Pitcher Streamers

Connelly Early (8% Rostered), Boston Red Sox

Scheduled Starts: vs. ATH, @ TB

Connelly Early had one of the season's best major-league debuts, striking out 11 batters in five shutout innings against the Athletics in hitter-friendly Sutter Health Park.

Of course, the numbers will look a bit silly after a performance like that, but a 52.4% strikeout rate, 4.8% walk rate, 55.6% ground ball rate, and .556 BABIP against an offense with a .759 OPS at home is bankable.

Early's stuff was elite against the Athletics, with his 7.1-foot extension and early 111 Location+ grade elevating a 94-mph fastball (31% usage), curveball (21% usage), 84-mph changeup (18% usage), slider 18% usage), and 93-mph sinker to a jaw-dropping 21.1% SwStr rate and 37.8% CSW rate on all pitches.

Under normal circumstances, you wouldn't stream a pitcher with just five innings in the fantasy baseball playoffs. However, Early gets the chance to dice up the Athletics again, with the following start against an ice-cold Tampa Bay offense (24th in scoring since August 1).

The southpaw isn't risk-free, but he's the only pitcher this week with a high enough ceiling to reasonably glide through his matchups.

Watch all 11 Ks from Connelly Early’s debut 🔥

🎥: @MLB pic.twitter.com/YEgPUw3W4W

— FOX Sports: MLB (@MLBONFOX) September 10, 2025

Riskier Two-Start Pitcher Streamer Picks

Jack Leiter (47% Rostered), Texas Rangers

Scheduled Starts: @ HOU, vs. MIA

Jack Leiter has had a solid second half of the season, bringing his season averages to a 3.81 ERA, 4.10 FIP, 1.31 WHIP, 23% strikeout rate, and 11.3% walk rate through 26 starts.

His 11.8% SwStr rate and 26.8% CSW rate are relatively low when compared to his strikeout rate. He's gotten a bit lucky on occasion, but his .271 BABIP, 15.1% HR/FB ratio, and 76.4% left-on-base rate are not that far off from league-average.

While the Houston Astros have the edge on Texas in the standings, Leiter should have a relatively easy time against a Houston offense ranked last in scoring since August 1. A Miami offense ranked 11th in scoring since August 1 might be a bit too intimidating for some.

If you believe enough in Leiter's 97-mph fastball, you could come out of this week with only a few scrapes. Otherwise, Leiter's high walk rate and matchup against a hot Miami offense should mean he doesn't get the nod in your fantasy lineups this week.

Kyle Bradish (41% Rostered), Baltimore Orioles

Scheduled Starts: @ CHW, vs. NYY

Kyle Bradish is now three starts deep into his comeback, brandishing a fantastic 2.65 ERA, 2.91 FIP, 0.94 WHIP, 32.3% strikeout rate, and 6.2% walk rate.

His 12.6% SwStr rate and 32.9% CSW rate are both the best marks of his career, even if it is only coming from a 17-inning sample.

His matchups this week are, unfortunately, a bit scary. He'll first get a White Sox offense ranked 13th in scoring since August 1, then he'll host a Yankees offense leading the league in scoring this season (18 more runs than the second-place Brewers).

He could very well turn in a great week, but a bad week is more of a possibility than it should be for a pitcher of Bradish's caliber.

Kyle Bradish's 2Ks in the 2nd. pic.twitter.com/2FASboAZQP

— Rob Friedman (@PitchingNinja) September 9, 2025

Eury Perez (39% Rostered), Miami Marlins

Scheduled Starts: @ COL, @ TEX

It's gotten worse for Eury Perez as of late, with the 22-year-old sporting a 4.67 ERA, 4.11 FIP, 1.11 WHIP, 23.9% strikeout rate, and 8.5% walk rate through 17 starts.

His pedigree and a 13.7% SwStr rate have kept him in the mix as a boon in the strikeout category. However, his 32.6% ground ball rate and .244 BABIP are a combination for disaster, as his 4.67 ERA should worsen if his BABIP evens out to the league average (.290).

He'll first take the trip to Coors, and then to Globe Life Field to take on a Rangers offense that ranks 14th in scoring since August 1. Perez has the talent, but he comes with great risk this week.

Zack Littell (38% Rostered), Cincinnati Reds

Scheduled Starts: @ STL, vs. CHC

Zack Littell hasn't slowed down since joining the Reds, as he goes into this week with a 3.78 ERA, 4.94 FIP, 1.12 WHIP, 17.2% strikeout rate, and 4.2% walk rate through 29 starts.

While the Cubs and Cardinals have slumped in recent months, Chicago still ranks eighth in scoring this season. Littell's low strikeout ceiling, high FIP, and poor luck indicators (.255 BABIP, 82.4% left-on-base rate) take him out of streaming consideration this week.

Jeffrey Springs (36% Rostered), Athletics

Scheduled Starts: @ BOS, @ PIT

Jeffrey Springs hasn't been able to take a step forward in Sacramento, as he's put up a 4.28 ERA, 4.72 FIP, 1.20 WHIP, 19.6% strikeout rate, and 7.3% walk rate through 162 innings.

His 12.1% SwStr rate and 28.5% CSW should keep him afloat in the strikeout category, but his .254 BABIP and 33.7% ground ball rate should worry you.

While they've lost Roman Anthony, Boston still ranks fifth in scoring this season. He should have an easier time on the road against a Pittsburgh offense ranked last in scoring this season, but it likely won't be enough.

Jose Quintana (35% Rostered), Milwaukee Brewers

Scheduled Starts: vs. LAA, @ STL

Jose Quintana has maintained his brand as an understated back-end innings-eater, with a 3.88 ERA, 4.86 FIP, 1.28 WHIP, 16.1% strikeout rate, and 8.9% walk rate through 23 starts this season.

Of course, his 7.9% SwStr rate and 25.9% CSW rate are not likely to push his strikeout rate any higher. A .258 BABIP should even out to his disadvantage, but he should keep afloat in every other category.

The Angels rank 23rd in scoring since August 1, and the Cardinals rank 29th in scoring since August 1, so his matchups shouldn't be too intimidating. Quintana likely won't get tripped up, but the low strikeout ceiling and high FIP make him much too risky to stream.

Jameson Taillon (28% Rostered), Chicago Cubs

Scheduled Starts: @ PIT, @ CIN

Jameson Taillon hasn't reprised his incredible 2024 output, with a 4.15 ERA, 4.98 FIP, 1.11 WHIP, 18.5% strikeout rate, and 5.1% walk rate through 110 2/3 innings this season.

Pittsburgh ranks last in scoring this season, but you'd rather have him not take the mound in Great American Ball Park against a Cincinnati offense ranked 14th in scoring this season.

Ian Seymour (28% Rostered), Tampa Bay Rays

Scheduled Starts: vs. TOR, vs. BOS

Ian Seymour has quietly had a fantastic MLB debut, with a 3.16 ERA, 2.74 FIP,  1.13 WHIP, 29.2% strikeout rate, and 7.9% walk rate through 42 2/3 innings as a reliever and starter.

The Blue Jays and Red Sox rank fourth and sixth, respectively, in runs scored this season. Those matchups disqualify almost every pitcher in the league -- Seymour is not an exception.

Matthew Liberatore (17% Rostered), St. Louis Cardinals

Scheduled Starts: vs. CIN, vs. MIL

After a great start to the year, Matthew Liberatore has settled into another disappointing season. Through 27 starts, he holds a 4.35 ERA, 4.14 FIP, 1.33 WHIP, 18.2% strikeout rate, and 6.3% walk rate.

It won't be enough for a Cincinnati offense ranked 14th in scoring. It certainly won't be enough for a Milwaukee offense leading the National League in scoring.

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