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DraftKings Daily Fantasy Football Picks (Week 6): NFL DFS Lineups

The top daily fantasy football lineup picks for DraftKings in Week 6. Ben Rolfe's NFL DFS analysis and sleepers for building optimal DFS rosters.

Week 5 did not really offer many surprises in terms of the overall picture of teams. We learned a few little lessons, such as the Atlanta Falcons offense is just flat-out bad on the road and we never know which Buffalo Bills team is going to show up. Entering Week 6, we, unfortunately, lose two of the most exciting offenses, in the Kansas City Chiefs and New England Patriots, from this slate. The good news is the Jacksonville Jaguars defense are playing the Dallas Cowboys and we were not really relying on Cowboys players anyway. This week the Falcons lottery falls with the Tampa Bay Buccaneers so do not be surprised to find a number of their offensive weapons below.  Below are my DraftKings DFS Lineup Picks for Week 6.

These DraftKings lineup recommendations are based on matchups, early week performances, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home field advantage, and more. There are quite a few great value plays available, so read on to find out which players are the best for Week 6.

Good luck with your DraftKings DFS lineups!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 6 Picks

Matt Ryan - ATL vs. TB (DK $6,800)

He might be the highest priced player at the position on the slate, but there is every reason to believe Ryan will be worth it. His down week against the Steelers proved that we still cannot trust him on the road even against a bad defense. This week he returns home to face yet another bad defense in the Buccaneers. In his three home games this season, Ryan is averaging 355 passing yards and 3.33 passing touchdowns per game. His current completion rate at home is 76.5% and he has a quarterback rating of 137.9. In addition, his offensive line is allowing just two sacks per game at home compared to five per game on the road. This game is likely to be a shootout with the over/under set at 57.5 in most places, the second highest line of the week. The final point is that this is a must-win game for the Falcons or they will slip to 1-5, which is virtually unrecoverable.

Jameis Winston - TB @ ATL (DK $5,800)

The Falcons defense ranks fourth against the quarterback heading into this week and actually, that number is a little misleading. The only reason they are not higher is due to their good performance against Nick Foles when they had their defense intact in Week 1. The group is completely decimated and they look a mess, unable to tackle and losing assignments. In contrast, the Buccaneers pass catchers have been on fire this year and they are coming off a bye week, giving them seven extra days to prepare to face this defense. Winston looked ugly in his first outing against the Bears, but there are extenuating circumstances. Firstly, he came in with his team chasing the game and needing to force things. Secondly, he had been away from the team three weeks and had to share practice snaps leading into Week 4. Finally, he was facing one of the best defenses in football this year, in their backyard, with the crowd right behind the team. Now he gets to face one of the worst defenses in football having had two weeks of taking starters snaps. If he doesn't perform in this game then he probably doesn't even deserve to be a starter in the NFL again.

 

DraftKings DFS Running Backs - Week 6 Picks

Todd Gurley - LAR @ DEN (DK $10,100)

I do not know how I cannot pick this guy. Yes, you are going to have to be clever with your lineup to fit him in but his production has been worth it. Through five games he has nine total touchdowns and two three-touchdown games. He is averaging 20.2 rushes and 3.8 receptions per game and a combined 129 yards per game. In addition, the Rams are going into Denver for this game, a team that currently ranks eighth-worst against running backs, with some questions marks. Brandin Cooks and Cooper Kupp left the game against Seattle with concussions and although both are expected to play Sunday I still think they might be eased back in. The other question mark is the weather in Denver this weekend. The high on Sunday is currently expected to be 28 and by game time it is likely to be slightly lower. In addition, there is a good chance this might be the first snow game of the year. That sounds like perfect conditions for a slugfest game, which features a lot of running. Exactly the type of game you pay Todd Gurley to win you.

Jordan Howard - CHI @ MIA (DK $6,500)

Howard has been disappointing this year but I think this is his bounce-back game on Sunday. The Dolphins rank fifth against running backs this season and have given up over 15 fantasy points to lead running backs each of the last two weeks. The most damming stat for me is that Joe Mixon carried the ball 22 times last week despite the Bengals trailing the entire game until the fourth quarter. Mixon's style is fairly close to Howard's and I can see the Bears utilizing Howard early in this game and then again in the second half to put the game away. This one is the pick I feel most uncertain about, because of the presence of Tarik Cohen, but the running back position is lacking depth and Howard's price here feels like a good deal to me.

Chris Carson - SEA @ OAK (DK $4,400)

Ah, the London games, where weird stuff always seems to happen. It always feels like one team does not turn up for these games and if I have to pick between Jon Gruden or Pete Carroll having his team ready then I will go Carroll all day long. The Raiders rank eighth-worst against running back, surrendering on average over 100 yards and a touchdown per game. Carson for his part has rushed for over 100-yards in each of his last two games. The only question mark is around touches, as he appears in a time-share with Mike Davis. However, at this price, it is hard to pass up a runner as dynamic as Carson facing a defense as poor as the Raiders.

 

DraftKings DFS Wide Receivers - Week 6 Picks

Mohamed Sanu - ATL vs. TB (DK $4,800)

If I am getting Gurley in my lineup, I need to save money and for that reason, I will target Sanu as the pass catcher in Atlanta to own this week. I expect Julio Jones to also have a big day, and a bounce back after last week but he is a lot more expensive. Sanu has now seen 23 targets the last three weeks, having touchdowns in two of the games and over 100-receiving yards in the other. This game is going to be another shootout, where the total likely gets into the mid-60s and the Buccaneers rank second worst against wide receivers for fantasy points this season.

DeSean Jackson - TB @ ATL (DK $5,900)

Jackson is having a monster year so far. At some point, regression is likely, given he is averaging 24.9 yards per reception and has a catch rate 12% higher than at any other time in his career, but I do not think it will be this week. The Falcons defense is ranked fifth against wide receivers this season, and I explained above why that should be higher. Jackson has been having his success against deep balls and we have seen evidence of the Falcons inexperienced safeties struggling in this regard, with John Ross' long touchdown being a prime example. Jackson may only have five receptions at a maximum this week but I think close to 100-yards and a touchdown is more than possible. Plus at this price, he is too good to pass up in a potential shootout.

Tyler Boyd - CIN vs. PIT (DK $6,000)

Boyd is coming off a down week against the Dolphins last week. To be fair the whole offense seemed to struggle against the Dolphins, who rank seventh best against wide receivers in fantasy. Last week we saw the Falcons play the Steelers and Jones was effectively eliminated by the coverage of Joe Haden. There is a good chance that we could see Haden go toe-to-toe with A.J. Green this week and if so Dalton will need to look elsewhere. When that has been the case he has gone to Boyd, who has two 100-yard receiving games and two touchdowns so far this season. As a unit the Steelers pass defense ranks fourth against receivers and the Bengals offensive line should keep Dalton clean for him to find Boyd plenty of times this week.

 

DraftKings DFS Tight Ends - Week 6 Picks

Austin Hooper - ATL vs. TB (DK $3,500)

Last week Hooper faced the second-worst defense against tight ends and this week he gets to face the worst. Hooper set season highs in targets (11), receptions (9) and yards (77) in Week 5. This week I think he can get close to those numbers again and possibly even add a touchdown as well. I expect the Falcons offense to have a lot more success this week and while Hooper might not get the same number of targets there is a good chance he sees more near or in the red zone. These two weeks may be the only time this season that it is not strictly about touchdowns for Hooper.

Antonio Gates - LAC @ CLE (DK $2,800)

Again this is thinking about how to work Gurley into a lineup. Gates is not having a great year, averaging just 21.4 yards per game and has one touchdown on the season. However, this will probably be the best pass rush the Chargers have faced and Rivers will need to get the ball out. The Browns have not been terrible against tight ends (14th worst) this season but they have not faced anyone of great reputation. The best they have faced is Jared Cook who has 110 yards and two touchdowns and Jesse James who had 60-yards on three receptions. Those numbers demonstrate that Gates can have a good day and is a player I think has a high ceiling for a bargain basement price this week.

 

DraftKings DFS Defenses - Week 5 Picks

Chicago Bears @ Miami Dolphins (DK $3,300)

The Dolphins are the third worst team against fantasy defenses in terms of average fantasy points scored by the defense. The Chicago Bears are arguably the best defense in the NFL this season. The Bengals had two defensive touchdowns last week and they are perhaps the only team the Dolphins have faced who have a comparable defensive line to the Bears. I expect Khalil Mack to have a big day in this one.

Indianapolis Colts @ New York Jets (DK $2,500)

The Jets rank 11th against fantasy defenses and despite their big week last week I think the Colts can have success. The Colts are not doing anything special but they have been having success. Before I lock this pick in on Sunday I will make sure to check the Colts inactives. If they are riddled with injuries, I might look elsewhere. However, if they have a decent unit then they are ultimately facing a rookie quarterback, and had a decent amount of success against the Patriots run game last week.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

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has Been a Top-Three Receiver During Offseason Program
Makai Lemon

Already Working With Starters in OTAs
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Might Not Return Until Midseason
Von Miller

"For Sure" Plans to Play in 2026
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Not at OTAs But Preparing for the 2026 Season
Lamar Jackson

"Absolutely" Wants to Stay With Ravens Long-Term
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NBA Upgrades Mason Plumlee's Foul to a Flagrant 1
Victor Wembanyama

Receives Warning From NBA
Atlanta Hawks

Hawks Promote Onsi Saleh to President of Basketball Operations
Jalen Williams

Listed as Questionable for Game 6
Ajay Mitchell

Ruled Out for Game 6
Michael Penix Jr.

Not Cleared for 11-on-11 Work
Jacoby Brissett

Still Absent From OTAs This Week
George Kittle

Still Hoping to be Ready for Week 1
Micah Parsons

Expected to Open Training Camp on the PUP List
Tucker Kraft

Packers Hopeful Tucker Kraft Will Participate in Training Camp
Jacory Croskey-Merritt

Held Out of OTAs on Wednesday
Jayden Daniels

Participating in Commanders OTAs
Chris Bell

No Timetable for Chris Bell's Return from Knee Surgery
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Limited in OTAs Due to Recovery From Shoulder Injury
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Participating in Packers OTAs
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Eury Perez Pulled Early on Wednesday With Hamstring Issue
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Drew Mestemaker a Top Big 12 Quarterback Right Away?
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Dynasty Stock Continues to Trend Down
Jordan Addison

Is Jordan Addison a Clear Buy-Low Candidate Ahead of 2026?
PGA

Sungjae Im Remains Boom-or-Bust at Colonial
PGA

Michael Thorbjornsen Trending in Wrong Direction Entering Colonial
De'Aaron Fox

Limited to Nine Points in Game 5 Loss
Russell Henley

a Top Option at Colonial
Harry Hall

Hoping Putter Carries Him at Colonial
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Notches 22 Points With Four Triples Tuesday
Stephon Castle

Leads Spurs in Scoring Tuesday Night
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Looks to Regain Momentum at Colonial
Victor Wembanyama

Struggles in Game 5 Loss to Thunder
Alex Caruso

a Difference-Maker Again in Game 5
Pierceson Coody

Looking to Stay Hot at Colonial
Jared McCain

Produces 20 Points in First Playoff Start
Shai Gilgeous-Alexander

Scores Game-High 32 Points in Game 5 Win
Martin Necas

Collects an Assist in Game 4 Loss to Golden Knights
Gabriel Landeskog

Scores Only Avalanche Goal in Season-Ending Loss
Carter Hart

Finishes Series-Clincher With 20 Saves
Dylan Coghlan

Continues Unlikely Success Story
Cole Smith

Scores Series-Clincher Tuesday Night
Mark Stone

Nets Another Goal as Golden Knights Finish Off Avalanche
Ludvig Aberg

Looking to Exchange Momentum for a Victory in Fort Worth
Stephan Jaeger

Trending Upward as PGA Heads to Fort Worth
Max Homa

Comes Off Awful Putting Performance at PGA Championship
Tony Finau

Faces Different Test at the Colonial
Robert MacIntyre

Seeks Better Beginning in Fort Worth
Tom Hoge

Ups and Downs Could Continue at Colonial
Brian Harman

Not Having the Best Golf Season in 2026
Austin Eckroat

Struggling Too Often Heading to Charles Schwab Challenge
Zach Bauchou

Tries to Keep Momentum Rolling at Colonial
Keegan Bradley

Looking to Rebound at Colonial
Jared McCain

Moves into Starting Five
Boston Celtics

Joe Mazzulla Wins Coach of the Year
Jalen Williams

is Ruled Out for Game 5 on Tuesday
Zion Williamson

to See More Versatile Role
Cleveland Cavaliers

Kenny Atkinson to Remain Cavaliers Head Coach Next Season
Claude Giroux

Planning to Return for 20th NHL Campaign
Carter Hart

Aiming for Sixth Consecutive Win Tuesday
Evgeni Malkin

Inks New One-Year Deal With Penguins
Mackenzie Blackwood

in Net for Game 4 Against Golden Knights
Valeri Nichushkin

a Game-Time Call Tuesday
Nathan MacKinnon

Will Suit Up Tuesday
Ben Griffin

Looking to Repeat This Week at Colonial
Rasmus Hojgaard

a Player to Avoid at Charles Schwab Challenge
Hideki Matsuyama

Needs Solid Driving Week at Charles Schwab Challenge
Justin Thomas

Trending Well Ahead of Charles Schwab Challenge
Akshay Bhatia

Lacking Driving Prowess Needed at Colonial Country Club
CFB

DJ Lagway Looking to Rebound at Baylor
CFB

Josh Hoover Tasked With Leading Indiana Back to the Playoffs
CFB

Braylon Staley the Next 1,000-Yard Tennessee Receiver?
CFB

Ahmad Hardy's Return Timeline Remains Unclear
Evan Mobley

Finishes Season-Ending Loss With 15 Points
James Harden

Wants to Stay in Cleveland
Donovan Mitchell

Remains Committed to Cavaliers
Mikal Bridges

Cools Off in Game 4 Against Cavaliers
Ivan Demidov

Contributes an Assist in Losing Effort
Lane Hutson

Records Power-Play Goal in Game 3 Loss
Frederik Andersen

Enjoys Another Easy Night at the Office in Game 3
Shayne Gostisbehere

Scores First Postseason Goal
Taylor Hall

Ends Four-Game Goal Drought
Andrei Svechnikov

Scores Game 3 Winner in Overtime
Gage Jump

Athletics to Promote Top Pitching Prospect Gage Jump to Major Leagues
Tatsuya Imai

Two Relievers Combine to No-Hit the Rangers on Monday
Valeri Nichushkin

Nathan MacKinnon, Valeri Nichushkin Uncertain for Game 4
Oliver Kapanen

Sitting as Healthy Scratch Monday
Max Domi

Out Indefinitely Due to Offseason Surgery Complications
Dylan Cease

Heading to Injured List With Hamstring Injury
Daniel Suarez

Wins at Charlotte in Rain-Shortened Coca-Cola 600
Christopher Bell

Finishes as the Runner-Up in the Coca-Cola 600 at Charlotte
Denny Hamlin

Falls Short of Winning and Places Third at Charlotte
Tyler Reddick

Places Fourth After Leading Laps at Charlotte
Kyle Larson

Strong and Consistent Day Ends in Fifth at Charlotte
Dylan Cease

Removed From Sunday's Start With Hamstring Discomfort
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Edward Cabrera

Cubs Place Edward Cabrera on the 15-Day Injured List
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
MLB

Orioles-Tigers Game Postponed on Saturday
MLB

Rays-Yankees Postponed on Saturday
Mickey Moniak

Heads to Injured List With Ankle Sprain
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
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SS
OF
SP
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