RADIO
We have a lot of good offenses on the main slate this week, with the Saints, Chiefs, Rams, Falcons, Patriots and Chargers all suiting up Sunday. The only offenses really missing are the Steelers and Panthers who met last night. In addition, a couple of the stingier defenses are out of the slate, with the Cowboys and Eagles facing off on Sunday Night Football. That should make for an entertaining week full of big plays. However, the only downside is that a couple of those high flying teams are facing decent defenses, Seahawks, Titans and Cardinals, and some are facing teams so poor that the game could be out of site by the end of the third quarter, Cardinals and Raiders. That could lead to a frustrating last quarter for some owners. However, the real bright spot on the slate is the Saints matching up with the Bengals. The Saints are not great on the road but they are facing a bad pass defense so a few of their players are nice options this week. Overall, this is a week full of high flying offenses games and some questionable defenses for you to select your DFS options from or against. Below are my DraftKings DFS Lineup Picks for Week 10.
These DraftKings lineup recommendations are based on matchups, performances so far, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home field advantage, and more. There are quite a few great value plays available, so read on to find out which players are the best for Week 10.
Good luck with your DraftKings DFS lineups!
Be sure to check all of our fantasy football rankings for 2025:- 2025 fantasy football rankings
- Running back (RB) fantasy football rankings
- Wide receiver (WR) fantasy football rankings
- Tight end (TE) fantasy football rankings
- Quarterback (QB) fantasy football rankings
- FLEX fantasy football rankings
- Defense (D/ST) fantasy football rankings
- Kicker (K) fantasy football rankings
- Dynasty fantasy football rankings
DraftKings DFS Quarterbacks - Week 10 Picks
Philip Rivers - LAC @ OAK (DK $6,000)
Rivers fantasy production has been somewhat up and down this season but the most recent down weeks have been on the road against solid defenses. This week he does not have to go up against a strong defense playing the Oakland Raiders. The Raiders defense was pulled apart by Nick Mullens and the 49ers offense so Rivers should be able to have a good day against them. Last time he faced the Raiders Rivers scored 24 fantasy points, throwing for 339 yards and two touchdowns. My only concern here is that the Chargers are coming off three physical games and a lot of traveling, which could mean that once they get up they back off slightly on offense. However, I think before that happens Rivers will have both yards and touchdowns and chances are it will be the likes of Melvin Gordon who rest not Rivers.
Baker Mayfield - CLE vs. ATL (DK $5,400)
The issue with picking Mayfield is that he has only put up 20 fantasy points on DraftKings twice this season. However, the Falcons defense is not as good as they looked last week. The Browns have the weapons in Chubb and Duke Johnson to attack this Falcons defense and Mayfield should be able to pick up plenty of yards throwing to those two. In addition, the Falcons have had their issues against the tight end and David Njoku should be set for a decent game.
DraftKings DFS Running Backs - Week 10 Picks
David Johnson - ARI @ KC (DK $6,800)
As bad as it has felt like Johnson has been he has managed to have double-digit fantasy points each of the last six weeks and in seven of his eight games so far. Early in the game, the Cardinals need to control the pace of the game on offense and they should lean on Johnson to do that. As the game progresses they may need to open it up and then Johnson should still be a big part of the offense. The Chiefs are allowing an average of 108.3 rushing yards, 0.9 rushing touchdowns, 7.3 receptions, 70.4 receiving yards and 0.6 receiving touchdowns per game to running backs. There is no real competition for those touches in this backfield and Johnson should be able to have a very successful day.
Aaron Jones - GB vs. MIA (DK $5,000)
Jones might have found himself in the doghouse early this week after his fumble against the Patriots. However, he is the most talented runner on the Packers roster so I cannot see his punishment lasting too long. This week he faces a Miami Dolphins defense that is allowing an average of 120 rushing yards and 53.8 receiving yards to running backs per game. Unlike last week I do not think the Packers will need to open the taps on their offense and they should be able to have success running the ball at home.
Duke Johnson Jr. - CLE vs. ATL (DK $4,700)
Johnson had his 2018 breakout game last week against the Chiefs. The Browns appeared to make a concerted effort to get him the ball more and he rewarded them with two touchdowns. Last week he faced one of the worst defenses in terms of allowing receiving yards to running backs and this week he gets another defense in the top-5 in that category. The Falcons allow an average of 64.4 receiving yards to running backs and a league-high 10.4 targets and 8.5 receptions to the position. With Deion Jones still out these underneath passes are a great way to attack the Falcons defense and Johnson should see somewhere in the region of 5-10 targets in this game.
DraftKings DFS Wide Receivers - Week 10 Picks
Michael Thomas - NO @ CIN (DK $8,100)
I want to set my team up this week to have one of the two main receivers on the slate. Whether that is Thomas or Julio Jones @ $8,300 I am not worried. My preference is ever so slightly to Thomas because I just like the spot a fraction more. Both of these guys are absolute monsters but Thomas is facing the fourth worst defense in terms of fantasy points allowed to wide receivers. In addition, the Saints game has the highest over/under of the week at 55 in some places. Everyone is expecting a shootout in this game and that should play nicely into the hands of Thomas who has had over 20 fantasy points against every bad defense he has faced this year.
Josh Doctson - WAS @ TB (DK $4,300)
The Washington offense is in somewhat of a mess right now. They lost more offensive linemen last week and that leaves their offense potentially having to reshape itself. Doctson has been a fairly consistent part of this offense with at least five targets in five of the seven games he has been healthy. His yardage returns have not always been great but he did manage to find the end zone last week against one of the worst pass defenses in the league this season. This week he faces a team who have a worse pass defense! The Tampa Bay Buccaneers allow an average of 38.35 points to opposing wide receivers. Part of the reason is that they give up the second most touchdowns on average to the position with 1.8 per game. With Paul Richardson on the injured reserve, Doctson is the best outside receiver left on the team and has a shot to find the end zone this week.
Devante Parker - MIA @ GB (DK $4,200)
Last week was such a major let down for Parker. Coming off a nine target, 134 yard game against the Texans he had just two targets, with one reception for eight yards against the Jets. However, that game was played on one of the worst fields I have seen in a while. The field looked a mess in the college football game Saturday and it had not recovered by Sunday. Therefore, this game was played in a controlled manner with both teams looking to avoid mistakes. I think that is different this week in Green Bay. The Packers offense will put up points and the Dolphins will have to hang with them. The Packers defense ranks sixth worst against wide receivers with 34.27 fantasy points allowed per game. Parker is a monster weapon who is extremely hard to cover and with Kenny Stills still struggling with a groin injury he should be one of the main two targets. I am expecting a big day from Parker in a game that should have much more than the 20 points in last weeks game.
DraftKings DFS Tight Ends - Week 10 Picks
Benjamin Watson - NO @ CIN (DK $3,400)
I do have some concern about the effect of the Dez Bryant signing on Watson long-term. However, short-term I do not think Bryant will have had enough time in the offense to make a big impact. Watson comes into this game with 10 targets, nine receptions, 105 yards and two touchdowns in his last three games. In one of those games, he was not targeted once in a strange game for the Saints offense in Minnesota. I mentioned above that this game should be a shootout and I think Watson sees enough targets, especially around the red zone for him to have success for fantasy owners. There are higher priced tight end options who are safer but if you need to save some money then Watson is a good upside bet this week.
Jonnu Smith - TEN vs. NE (DK $2,500)
I pick against the Patriots a lot when it comes to tight ends. The Patriots very much fit their scheme around an opponent's best weapons and I do not think Smith will register much this week. They know the threat of Dion Lewis out of the backfield and therefore I think they use their Swiss army knife cover guy, Patrick Chung, to provide protection against Lewis. That likely leaves Smith with either Duron Harmon or a linebacker covering him. I believe Smith can have success against either of those guys and he is a sneaky bet to have a nice game at a really low price this week. It is an extremely risk/reward play but if you want to squeeze an extra high priced guy into your lineup then it may be worth the risk.
DraftKings DFS Defenses - Week 10 Picks
Chicago Bears vs. Detroit Lions (DK $3,600)
The Minnesota Vikings managed 10 sacks of Matthew Stafford last week in the game in Minnesota. I would make the case that the Bears defensive line is better than the Vikings and playing in Chicago they could get close to that. The Lions traded away their hardest-to-cover wide receiver in Golden Tate, which should also play into the hands of the Bears. Tate is a quick twitch type receiver who helped Stafford out a lot on short routes. Kenny Golladay and Marvin Jones are bigger play receivers who see a lot of targets down the field. Without Tate, Stafford will have to hold onto the ball longer and that will open up opportunities for the Bears defense to get to him.
New York Jets vs. Buffalo Bills (DK $3,400)
At this stage, I am not sure it matters who plays quarterback for the Bills. At home, they struggle enough so on the road I cannot imagine they are going to be better. The Patriots defense is not great and even they managed to completely shut down the Bills offense a couple of weeks ago. The Jets are not as good as the Bears so do not expect numbers like we saw last week. However, I still expect a solid return from the Jets defense for a slightly lower price than the Bears defense is currently at.
