November 5, 2025
Buffalo Bills head coach Sean McDermott said that running back
James Cook (ankle, foot) will not practice on Wednesday due to an ankle/foot injury, according to Katherine Fitzgerald of The Buffalo News. Cook had another nice game in the team's Week 9 victory over the Kansas City Chiefs, carrying the ball 27 times for 114 yards while also catching one pass for 11 yards. However, the 26-year-old apparently came out of that game a little gimpy, and his status is now up in the air for the team's Week 10 tilt on the road against the division-rival Miami Dolphins. If Cook were to miss this weekend,
Ty Johnson and
Ray Davis would likely split backfield duties for the Bills in a great matchup. Cook has been a must-start RB1 every week in 2025, as he's currently the RB7 in fantasy in half-PPR scoring with 867 rushing yards and seven touchdowns on 153 carries.
--Keith HernandezSource: The Buffalo News - Katherine Fitzgerald
November 5, 2025
Indianapolis Colts head coach Shane Steichen said that newly acquired cornerback Sauce Gardner (concussion) is in the league's concussion protocol, but he will practice on Wednesday, according to Mike Chappell of FOX 59. The Colts gave up a lot to secure the services of the All-Pro corner at the trade deadline on Tuesday, giving up receiver
Adonai Mitchell and two first-round picks. Gardner is still in the concussion protocol despite coming off a bye last week, but the fact that he's going to practice on Wednesday means he has a chance to make his debut with the Colts this Sunday in Berlin, Germany, against the Atlanta Falcons. The Colts are 7-2 and tied for the best record in the AFC heading into Week 10, but their secondary has been a weak spot so far this year. Gardner will definitely shore up their secondary as one of the best cover corners in the NFL.
--Keith HernandezSource: FOX 59 - Mike Chappell
November 5, 2025
Cleveland Browns rookie quarterback
Shedeur Sanders (back) will return to practice on Wednesday from the back injury that sidelined him in Cleveland's most recent game against the New England Patriots. It appears Sanders is on track to be active for the Browns' Week 10 matchup against the New York Jets. If he's healthy enough to play in Week 10, Sanders would likely be the backup to fellow rookie quarterback
Dillon Gabriel. For now, Sanders is still waiting on an opportunity to make his NFL debut. Across six games (four starts), Gabriel has completed 59.9% of his pass attempts for 702 yards, five touchdowns, and two interceptions. Despite the modest production, there's been no indication out of Cleveland that the team is currently considering replacing Gabriel with Sanders any time soon.
UPDATE: Sanders was limited on Wednesday.--Will BradySource: ESPN - Daniel Oyefusi
November 5, 2025
Jaguars reporter Ryan O'Halloran of The Florida Times-Union said on a recent radio appearance that the price the team paid to acquire wide receiver
Jakobi Meyers indicates that the team views him as more than just a rental. Jacksonville traded fourth and sixth-round draft picks to the Las Vegas Raiders in exchange for Meyers on Tuesday. Meyers will provide immediate aid to a Jaguars wide receiver room that will be without
Travis Hunter (knee) for at least three more games and could be without both
Brian Thomas Jr. (ankle) and
Dyami Brown (concussion) in Week 10. Meyers recorded 33 catches for 352 yards and zero touchdowns on 49 targets across seven games for Las Vegas this season. If O'Halloran is correct and Jacksonville plans to keep Meyers beyond 2025, his presence could be a slight negative for the dynasty value of Hunter and Thomas Jr.
--Will BradySource: The Florida Times-Union - Ryan O'Halloran
November 5, 2025
Cleveland Browns rookie wide receiver
Isaiah Bond (foot) is dealing with a foot injury that is expected to keep him from practicing on Wednesday, per ESPN's Daniel Oyefusi. Bond's availability for his team's Week 10 matchup against the New York Jets appears to be in jeopardy. The 21-year-old has recorded 11 catches for 123 yards on 30 targets across eight games so far this season. However, he was held without a catch on four targets in his final two games before the Browns' Week 9 bye. If Bond is sidelined in Week 10, wide receiver
Jerry Jeudy and tight ends
David Njoku and
Harold Fannin Jr. could see a slight bump in target share. Additionally, wide receiver
Cedric Tillman (hamstring) could make his return in Week 10 from a hamstring injury that has sidelined him since Week 4. Even if Bond can play, he should likely remain off fantasy radars in Week 10 against New York.
--Will BradySource: ESPN - Daniel Oyefusi
November 5, 2025
Indianapolis Colts wide receiver
Alec Pierce has almost exclusively been known as a downfield pass-catcher throughout his career. Across his first three NFL seasons, Pierce averaged 4.3 targets per game and 17.6 yards per reception. Now in his fourth season, Pierce is still making big plays. However, there are signs that Indianapolis is viewing him as a more well-rounded wide receiver. Through his first seven games played in 2025, Pierce is averaging 6.4 targets per contest. He's been particularly involved in recent weeks with 28 targets over his last three games played. Pierce has yet to find the end zone this season, but he scored seven touchdowns across 16 games in 2024. Heading into a Week 10 matchup against the Atlanta Falcons, Pierce should be rostered in all fantasy leagues with 12 or more teams.
--Will BradySource: RotoBaller
November 5, 2025
Tampa Bay Buccaneers wide receiver
Chris Godwin (leg) is not expected to practice on Wednesday, per Rick Stroud of the Tampa Bay Times. Godwin missed the team's final three games before their Week 9 bye due to a leg injury, and it appears he may not be ready to return in Week 10 against the New England Patriots. It's beginning to look like somewhat of a lost season due to injury for Godwin, who also missed Tampa Bay's first three games of 2025 while recovering from the dislocated ankle that ended his 2024 season. In the two games he's played this season, Godwin has recorded six catches for 52 yards on 14 targets. If he remains sidelined in Week 10, Buccaneers rookie wideout
Tez Johnson could maintain a sizable role in the team's offense. Johnson has recorded 10 catches for 146 yards and two touchdowns on 18 targets over his last three games played. Veteran wideout
Sterling Shepard and tight end
Cade Otton are also candidates to be the team's number two pass-catcher behind star wide receiver
Emeka Egbuka.
--Will BradySource: Tampa Bay Times - Rick Stroud
November 5, 2025
Tampa Bay Buccaneers running back
Bucky Irving (foot, shoulder) is not expected to practice on Wednesday, according to Rick Stroud of the Tampa Bay Times. Stroud reports that Irving is "still in the rehab phase." The 23-year-old has not played since Week 4 as he battles foot and shoulder injuries. There had been hope that Irving would be ready to return for Tampa Bay's Week 10 matchup against the New England Patriots coming off the team's Week 9 bye. However, it appears that Irving's status for the game is still very much up in the air. If Irving misses a fifth consecutive game in Week 10, Buccaneers running backs
Rachaad White and
Sean Tucker would likely split backfield reps against New England. In Tampa Bay's Week 8 win over the New Orleans Saints, White saw 15 total touches compared to 12 for Tucker.
--Will BradySource: Tampa Bay Times - Rick Stroud
November 5, 2025
Cleveland Browns rookie running back
Quinshon Judkins (shoulder) is expected to return to practice on Wednesday ahead of Week 10. Judkins suffered an AC joint sprain in Week 8, but the Week 9 bye provided valuable recovery time. Through seven games, the rookie has handled 118 carries for 486 yards and five rushing touchdowns, while adding 12 receptions for 60 yards, solidifying his role as the lead back in Cleveland's offense. The Browns draw a favorable Week 10 matchup against the New York Jets, who have allowed the 11th-most fantasy points to opposing running backs this year. Judkins is on track to play and should be viewed as a strong RB2 with touchdown upside in this matchup.
--Nathan HarveySource: Tony Grossi
November 5, 2025
Seattle Seahawks wide receiver
Tory Horton has been a touchdown machine in his rookie season, scoring five touchdowns on just 13 receptions. He posted a career day in Week 9 with four catches for 48 yards and two scores while logging a season-high 73% snap share. However, Seattle's trade for
Rashid Shaheed may limit Horton's fantasy trajectory. Shaheed recorded 44 receptions in nine games with the Saints this season and is expected to slide in as the No. 2 option alongside
Jaxon Smith-Njigba. With Shaheed likely to command consistent snaps and targets, Horton becomes a far more volatile play. He should be viewed as a stash-only option in deeper leagues, not a weekly fantasy starter.
--Nathan HarveySource: Pro Football Reference
November 5, 2025
New York Jets running back
Isaiah Davis was one of the bigger losers of the trade deadline. After weeks of speculation that the team might move
Breece Hall, the Jets ultimately held onto their starter, keeping him locked in as the clear RB1. Davis was coming off the best performance of his young career before the bye, totaling 109 scrimmage yards on 12 touches, showing burst and efficiency when given opportunities. However, his path to meaningful volume remains limited with Hall still leading the backfield. The Jets also face a difficult Week 10 matchup against Cleveland, a defense allowing the second-fewest fantasy points to running backs. Davis currently profiles as a stash-and-hold handcuff rather than a startable option.
--Nathan HarveySource: Pro Football Reference
November 5, 2025
Chicago Bears wide receiver
Olamide Zaccheaus is coming off his best performance of the season, posting six receptions for 58 yards and a touchdown in Week 10 against Cincinnati. With rookie
Luther Burden III (concussion) sidelined, Zaccheaus logged his second-highest snap share of the year (66%) and delivered as the primary slot option in Ben Johnson's scheme. He's developed solid chemistry with
Caleb Williams, and now draws a favorable Week 11 matchup against the Giants, who allow the fourth-most fantasy points to opposing wideouts. If Burden remains out, Zaccheaus carries deep-league FLEX value against a struggling Giants secondary.
--Nathan HarveySource: Pro Football Reference
November 5, 2025
Chicago Bears rookie tight end
Colston Loveland broke out in a big way in Week 9, catching six of seven targets for 118 yards and two touchdowns in the Bears' 47-42 win over the Bengals. The highlight came on a 58-yard game-winning touchdown, capping off a monster performance that pushed Chicago to a 5-3 record. With
Cole Kmet exiting early due to a concussion, Loveland stepped in as the primary tight end, logging 79% of the offensive snaps. Now, with Kmet still in concussion protocol entering Week 10, Loveland could once again handle a full workload against the New York Giants, who have allowed the ninth-most passing yards in the NFL this season. If Kmet remains sidelined, Loveland is a must-start fantasy option across all formats, offering TE1 upside in Week 10.
--Nathan HarveySource: Pro Football Reference
November 5, 2025
New York Giants wide receiver
Darius Slayton emerged as one of the quiet winners of the NFL Trade Deadline. While several teams reshaped their receiving corps during the deadline, the Giants stood pat, signaling confidence in their current group and keeping Slayton locked in as a top option. Through seven games, Slayton has caught 19 of 30 targets for 254 yards without finding the end zone. Despite modest production, he's played on 85% of the team's offensive snaps, maintaining a strong role in the offense. With rookie quarterback
Jaxson Dart continuing to impress, Slayton's breakout could be right around the corner. In Week 10, Slayton draws a favorable matchup against the Chicago Bears, who have allowed the fifth-most fantasy points per game to wide receivers. Given his snap share and matchup, Slayton profiles as an intriguing deep-league FLEX flier this week.
--Nathan HarveySource: Pro Football Reference
November 5, 2025
With
Jayden Daniels (elbow) expected to miss time following a gruesome Week 9 injury,
Marcus Mariota is set to take over as the Washington Commanders' starting quarterback for the foreseeable future. In three starts this season, the veteran has completed 52 of 78 passes (66.7%) for 576 yards, throwing four touchdowns and three interceptions, while adding 102 rushing yards and a touchdown on 16 carries. Mariota draws a favorable Week 10 matchup against the Detroit Lions, who have allowed the 10th-most fantasy points per game to quarterbacks this season. With his dual-threat ability and favorable matchup, Mariota profiles as a low-end QB2 for Week 10, and potentially beyond if Daniels remains sidelined.
--Nathan HarveySource: Pro Football Reference
RADIO
