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Oct 17, 2025, 7:40 PM ET

The Indianapolis Colts defense has been a stout fantasy unit through the first six games of the regular season. They will be tested on the road in a Week 7 matchup against the Los Angeles Chargers. The Chargers are dealing with plenty of injuries on offense, but they are still allowing just the 14th-most fantasy points per game to opposing D/STs in fantasy. The Colts are set as 1.5-point road underdogs in a game with a high 48.5-point over/under. This is a difficult spot for the Colts, which puts them outside of the top-12 fantasy defenses for this weekend.--Matt Terelle
Source: NFL.com
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