NFL Week 13 Predictions: Picks and Analysis for Every Football Game

November 29, 2025

Free NFL betting picks for every Week 13 matchup in 2025. Expert analysis and predictions for NFL Week 13. Who should you bet in Week 13? Analysis for every game on the slate.

The football gods blessed us with a cornucopia of great matchups on Turkey Day this year, and we have some fun games to look forward to on the Week 13 Sunday slate.

With the postseason drawing closer, several NFL teams remain "in the hunt". The outcome of every game is magnified with the playoffs just around the corner.

Through the good, bad, and ugly, we'll dive into all the juicy spots on this slate, as we go through every Week 13 game in this article, offering picks, predictions, and analysis for each and every one. We appreciate you joining us here at RotoBaller; let's dive in!

Jacksonville Jaguars 21, Tennessee Titans 17

The 1-10 Titans showed some moxie with 21 second-half points against the Seattle Seahawks last week, though this abysmal Tennessee franchise still dropped its sixth-straight game in Week 12. They'll take whatever small positive momentum into a Week 13 divisional matchup against the Jaguars - a team that seems to be involved in nailbiters on an almost weekly basis.

Jacksonville escaped Arizona with an overtime win last week for its third victory in its last four games. Despite that success, quarterback Trevor Lawrence has remained inconsistent at best. However, the Jaguars' rushing attack has looked increasingly good as the season has progressed, with their average of 128.1 rushing yards per game ranking eighth in the NFL. That ability to run the ball, as well as the fact that they're playing, yanno, the Titans, should be enough this week.

Atlanta Falcons 21, New York Jets 13

The Falcons entered Week 12 on a five-game losing streak and without quarterback Michael Penix Jr. and star wide receiver Drake London. They left New Orleans with a 24-10 win over the Saints thanks to a pair of touchdown passes from Kirk Cousins and a pass rush that applied pressure all day.

That should remain the recipe for the Falcons in their Week 13 meeting with the New York Jets - a team that shares plenty of traits with the Saints. New York turned to Tyrod Taylor at QB last week, getting similar results as they've had with Justin Fields in a 23-10 loss at Baltimore. If any team can lose to the Jets, it's this unpredictable Falcons squad, but we have to give the edge to Atlanta here.

Los Angeles Rams 24, Carolina Panthers 14

Fresh off a Sunday night beatdown of the Tampa Bay Bucs, the Rams will travel cross-country for a 1:00 ET kickoff against the Panthers. Carolina was drubbed by another NFC West squad - the San Francisco 49ers - on Monday night and has now lost two of their last three.

Despite the home-field advantage, Bryce Young and company will have a tough time overcoming a surging Rams squad that's won six in a row. Matthew Stafford has earned serious MVP buzz while piloting an L.A. offense that's fifth in the NFL in passing yards per game and has been one of the league's most efficient units.

Miami Dolphins 21, New Orleans Saints 13

While Miami has certainly failed to live up to preseason expectations this year, it has quietly played better football over the past month, winning three of its last four. Well rested off their Week 12 bye, the 'Fins have a great chance to continue their late-season surge with the lowly Saints coming to South Beach.

A surprising Week 10 win in Carolina looked to be nothing more than a fluke for the Saints last week, as Kellen Moore's bunch was thoroughly dominated by the visiting Falcons. While the Dolphins aren't an impossible hill to climb, Hard Rock Stadium isn't an easy environment to play in - especially for a Saints team that's 31st in the NFL in points per game and is likely to be without Alvin Kamara.

Tampa Bay Bucs 28, Arizona Cardinals 24

The Bucs head to the desert looking to halt a three-game slide. Tampa's most recent loss was an ugly Sunday night beatdown at the hands of the Rams - a game in which franchise QB Baker Mayfield was forced to sit out the second half due to a shoulder injury to his non-throwing arm.

Baker Mayfield was at Wednesday's walkthrough practice. Teddy Bridgewater was taking more reps, just in case Mayfield can't go. #GoBucs pic.twitter.com/ljKtOKAdPH

— Kyle Burger (@kyle_burger) November 26, 2025

Obviously, Mayfield's availability looms large in this Week 13 matchup against a Cardinals team that's lost three straight themselves. The murmurs out of Tampa Bay are that Mayfield will try to suit up in this one, and as long as he does, expect the Bucs to rebound against an Arizona defense that's allowed opponents to score 27 or more points in five of their last six.

San Francisco 49ers 21, Cleveland Browns 13

Shedeur Sanders' first NFL start wasn't always pretty, but the much-talked-about rookie did help the Browns pick up their first road win of the season against the Raiders last week. It was a ferocious Cleveland defense that was the true star of the show in Week 12, as Myles Garrett and company recorded an eye-popping 10 sacks against Las Vegas.

The Browns will look to slow down Christian McCaffrey and the 49ers in Week 13, and while they could find some success against San Fran's Brock Purdy-led attack, I'm siding with the Niners defense over the inexperienced Sanders in this one.

Houston Texans 21, Indianapolis Colts 20

The red-hot Texans will look to get themselves squarely back into the AFC South race in Week 13, as they travel to Indy to face a Colts squad that's lost two of their last three after getting off to a 7-1 start this season. Conversely, Houston has won three straight - and four of their last five - behind an elite defense that's allowing the NFL's fewest total yards (287.9) per game.

Indy running back Jonathan Taylor is having an MVP-caliber season, but could struggle to find much running room against a Texans front that's allowing just 92.2 rushing yards to enemy backs this season. C.J. Stroud's availability is still unclear as of this writing, but Davis Mills has been a competent stand-in who is capable of helping Houston spring the upset here.

Seattle Seahawks 24, Minnesota Vikings 13

It's a #RevengeGame for Sam Darnold, as Seattle hosts a Vikings organization that Darnold led to a 14-3 record in 2024. Minnesota's decision to replace Darnold with second-year QB J.J. McCarthy looks horrendous at the moment, as McCarthy has been abysmal in his first pro campaign, most recently throwing for 87 yards with two picks in the team's Week 12 loss to the Packers.

Mike Macdonald's Seahawks defense is one of the most talented young groups in the league, and I expect them to harass the struggling McCarthy accordingly. Darnold has formed a record-breaking connection with Jaxon Smith-Njigba this season, but look for Seattle to lean on the run game to successfully combat Minnesota's blitz-happy scheme.

Buffalo Bills 24, Pittsburgh Steelers 23

Since a huge win over the Chiefs in Week 9, the Bills have looked vulnerable while losing two of their last three. They will look to rebound from a Week 12 Thursday night loss to the Texans against a Steelers squad that's lost four of their last six games following a fast start to the season.

Only six teams are averaging fewer carries per game than the #Steelers.

Will they actually commit to the run game against the #Bills, who are 3rd worst in the #NFL vs. the run?@MarkKaboly @THEChrisMack #HereWeGo #BillsMafia pic.twitter.com/KWmyDZs13i

— Kaboly+Mack (@KabolyAndMack) November 26, 2025

Pittsburgh quarterback Aaron Rodgers' availability is unclear as of this writing, but we can expect the Steelers to pound the rock on the ground no matter who is under center in Week 13. Buffalo ranks just 30th in the NFL in rushing yards (148.9) allowed per game this season - a weakness that the Steelers will look to exploit. Despite the noticeable chinks in Buffalo's armor, they do still have Josh Allen, a player who's capable of carrying the team on his back in a matchup that I expect to be tight.

Los Angeles Chargers 27, Las Vegas Raiders 13

Perhaps the only offensive line in the NFL that's struggling worse than the Chargers' injury-ravaged unit is that of the Raiders. Las Vegas allowed a mind-blowing 10 sacks to the Browns last week, an outing that led to this week's firing of offensive coordinator Chip Kelly.

The Chargers held the Silver & Black to just nine points when the teams met earlier this season, and we can expect more of the same in Week 13. Geno Smith has been a disaster behind the swinging-gate protection of the Raiders, as the offense is managing just 15.0 points per game in 2025. While the Bolts have been a bit erratic this season, look for Jim Harbaugh's well-rested squad to take care of business within the division this week.

Denver Broncos 23, Washington Commanders 13 (Sunday Night)

This probably wasn't what the NFL decision-makers had in mind when scheduling this primetime matchup, as the injury-plagued Commanders have stumbled to a 3-8 record in 2025 following last year's magical run to the NFC Conference Championship game. Washington will take on one of the NFL's best defensive units without the services of Jayden Daniels or Terry McLaurin.

Year two of Bo Nix's pro career hasn't exactly been smooth sailing, but the Denver signal caller has played well enough to help the Broncos to a 9-2 record. The real star of the show has been Denver's elite defense - a group that's at or near the top of the league in nearly every statistical category. They shouldn't have much trouble slowing down a Marcus Mariota-led Commanders attack.

New England Patriots 21, New York Giants 20 (Monday Night)

The 10-2 Patriots enter Week 13 as one of the league's biggest surprises. They will look to keep their march to the NFL Playoffs going against the Giants in a Monday night clash in Gillette Stadium that's expected to have some winter weather.

Second-year New England quarterback Drake Maye has been everything the Pats organization could've dreamed of this season, but with multiple offensive linemen potentially out for this game, look for New England to attack a New York rush defense that's allowing a league-worst 157.2 rushing yards per game.

As first reported by @art_stapleton, the Giants are firing defensive coordinator Shane Bowen.

The Giants' defense ranks 30th in the NFL in both yards allowed per game and points allowed per game this season. pic.twitter.com/mNEB2RnPQw

— Giants Videos (@SNYGiants) November 24, 2025

The G-Men have spent the entirety of 2025 blowing leads on the road, and that was again the case last week in Detroit, as New York squandered a legendary Jameis Winston performance against the Lions. I expect them to follow a similar script this week, i.e., keep this one interesting but ultimately take yet another loss.

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