September 14, 2025
Chicago Bears cornerback Jaylon Johnson (groin) is questionable to return to his team's Week 2 matchup against the Detroit Lions due to a groin injury. Johnson missed Week 1 due to a groin injury, so this could be a re-aggravation of the existing ailment. Johnson is the Bears' top cover corner, so his absence would make life considerably easier for Lions quarterback
Jared Goff and the rest of the Detroit passing game.
--Will BradySource: Chicago Bears
September 14, 2025
Pittsburgh Steelers edge rusher Alex Highsmith (ankle) is doubtful to return to his team's Week 2 matchup against the Seattle Seahawks due to an ankle injury. Highsmith is a key piece of the Steelers' pass rush, recording 28.5 sacks in 46 games since the start of 2022. If he is unable to return, the job on Sunday will get easier for Seahawks quarterback
Sam Darnold and the rest of the Seattle pass game.
--Will BradySource: Pittsburgh Post-Gazette - Ray Fittipaldo
September 14, 2025
Cincinnati Bengals quarterback
Joe Burrow (leg) was taken to the locker room on Sunday due to an apparent left leg injury. Burrow was limping heavily and required assistance from the training staff to get off the field. More will be known about the injury once the team releases an official update, but a Burrow injury would obviously be a massive blow for both fantasy managers and the Bengals' offense.
--Will BradySource: CBS - Jonathan Jones
September 14, 2025
San Francisco 49ers fullback
Kyle Juszczyk (concussion) has been ruled out for the remainder of his team's Week 2 game against the New Orleans Saints. Juszczyk is a key piece of the San Francisco offense as both a blocker and receiver. The 49ers entered the game already without quarterback
Brock Purdy (toe), tight end
George Kittle (hamstring), and wide receiver
Brandon Aiyuk (knee). Juszczyk's absence may create even more reason for San Francisco to get the ball in the hands of star running back
Christian McCaffrey.
--Will BradySource: San Francisco 49ers
September 14, 2025
The Cleveland Browns announced that wide receiver
DeAndre Carter (concussion) will not return to Sunday's game against Baltimore due to the injury. The veteran made the team out of training camp largely because of his special teams contributions. Primarily the team's kick returner, the absence will leave Cleveland without one of its key special teamers for the rest of the game.
--Nick PiotrowiczSource: Cleveland Browns
September 14, 2025
The Baltimore Ravens have ruled out running back
Rasheen Ali (concussion) from returning to Sunday's game against the Cleveland Browns. A key special teamer for the Ravens will be out of the picture for at least the rest of this week. Additionally, Baltimore did not activate running back
Keaton Mitchell ahead of the game, so the club has only its top two running backs,
Derrick Henry and
Justice Hill, available for the remainder of Sunday.
--Nick PiotrowiczSource: Brian Wacker
September 14, 2025
The Buffalo Bills can exhale after quarterback
Josh Allen (nose) has returned to the game against the New York Jets after taking a shot to the face. The superstar QB departed the game after being bloodied when he was sandwiched between two Jets defenders, a collision that popped him in the nose. Allen wasn't out for long, though, as the Bills' medical staff put gauze up one nostril and got back him on the field. Fantasy managers rostering the QB1 can forge ahead as usual.
--Nick PiotrowiczSource: Tom Pelissero
September 14, 2025
The Detroit Lions said tight end
Shane Zylstra (ankle) is questionable to return to the game Sunday against the Chicago Bears. The reserve came off the field with a bit of a limp after sustaining the injury, which could leave the Lions without a key special teamer. From a fantasy perspective, Zylstra is pretty far off the radar with starting tight end
Sam LaPorta handling the vast majority of the receiving work.
--Nick PiotrowiczSource: Detroit Lions
September 14, 2025
Baltimore Ravens running back
Rasheen Ali (concussion) is being further evaluated after taking a blow to the head on Sunday against the Cleveland Browns, the team announced. Ravens running back
Keaton Mitchell is inactive again for Baltimore, so the team is temporarily down to just
Derrick Henry and
Justice Hill at running back. Ali, also a special teamer for the Ravens, is mostly on the back burner from a fantasy perspective due to a lack of carries behind Henry and quarterback in
Lamar Jackson.
--Nick PiotrowiczSource: Baltimore Ravens
September 14, 2025
The Cleveland Browns said wide receiver
DeAndre Carter (concussion) left Sunday's game against the Baltimore Ravens to be evaluated in the locker room. The veteran does not have a target yet this season, as his primary role for Cleveland is to be a return man, so the Browns likely will have to look elsewhere if he misses any time. In any case, Carter doesn't hold much fantasy value outside of leagues of that have a designated kick returner spot.
--Nick PiotrowiczSource: Cleveland Browns
September 14, 2025
New York Jets wide receiver
Allen Lazard will make his 2025 debut in Week 2 against the division-rival Buffalo Bills on Sunday after he was a healthy scratch in the season-opening loss last Sunday to the Pittsburgh Steelers. Lazard might only be active because
Josh Reynolds is out with a hamstring injury. Although it's notable for New York's passing attack, we wouldn't recommend the 29-year-old as a streaming option this weekend, even in deep fantasy leagues.
Garrett Wilson will continue to draw the majority of aerial targets from quarterback
Justin Fields. Lazard, who has struggled with drops in his two seasons with the Jets, will be competing for targets with
Tyler Johnson mostly. Last year in New York, Lazard bounced back from a rough 2023 campaign to catch 37 passes for 530 yards and six touchdowns in 12 games (10 starts).
--Keith HernandezSource: New York Post - Brian Costello
September 14, 2025
According to CBS Sports, Cleveland Browns rookie second-round running back
Quinshon Judkins will start in his NFL debut in Week 2 against the Baltimore Ravens. Judkins may get the "start," but NFL Network's Ian Rapoport also reported on Sunday morning that the Browns plan to give Judkins backup touches -- around 10 to 15 in his first NFL game. Fantasy managers will be happy to get a look at the Ohio State product, but it would be a mistake to throw him into your starting lineup right away with the Browns easing him into their offense after he missed all of training camp, the preseason, and the Week 1 loss to the Cincinnati Bengals. Judkins should be Cleveland's RB1 by season's end, but it won't be right away, and he could also be facing a suspension of two to four games after a domestic-violence case over the summer.
--Keith HernandezSource: Brad Stainbrook
September 14, 2025
San Francisco 49ers wide receiver
Jordan Watkins (coach's decision) and running back
Jordan James (coach's decision) are both healthy scratches for Week 2 against the New Orleans Saints. Watkins and James both missed last week's season opener, and even though they're healthy for Week 2, the rookies will watch Sunday's game from the sideline.
Kendrick Bourne,
Marquez Valdes-Scantling, and
Skyy Moore will round out the wide receiver room behind
Jauan Jennings and
Ricky Pearsall. Meanwhile,
Isaac Guerendo will handle RB3 duties behind
Christian McCaffrey and
Brian Robinson Jr.--Andersen PickardSource: Matt Maiocco
September 14, 2025
The Philadelphia Eagles are "looking to get
A.J. Brown involved more and early" on Sunday against the Kansas City Chiefs, according to NFL Network's Mike Garafolo. He noted that the Eagles had several plays dialed up for Brown to get more targets last week, but they didn't work out, and the star receiver finished Week 1 with just one reception. Based on Garafolo's comments, it appears that last week should be treated as an anomaly, and Brown will be more involved in Week 2. An increased target share could come naturally for Brown as the Eagles will be without
Dallas Goedert (knee), who caught seven passes in the season opener.
--Andersen PickardSource: Mike Garafolo
September 14, 2025
Baltimore Ravens running back
Keaton Mitchell finds himself as a healthy inactive for the second straight week to open the season in Week 2 against the division-rival Cleveland Browns on Sunday. To begin the 2025 campaign, Mitchell has found himself as the team's RB4 behind
Derrick Henry,
Justice Hill, and
Rasheen Ali. The 23-year-old has intriguing power and explosiveness, but he's had trouble staying on the field early in his career, playing only 13 games (two starts) since entering the league in 2023. He has averaged a healthy 6.9 yards per carry on his 62 rushing attempts with 426 yards and two touchdowns, but right now, he's off the fantasy radar altogether in redraft leagues. Mitchell's next chance to make his 2025 debut will be in Week 3 against the Detroit Lions on Monday, Sept. 22.
--Keith HernandezSource: Baltimore Ravens
RADIO
