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The Indianapolis Colts defense has been an excellent unit through the first five weeks of the NFL season. The Colts have given opposing offenses fits so far, ranking third in the league with just 17.8 points allowed per game while ranking fifth with 14 sacks and fourth with six interceptions. The Cardinals have been generous to opposing D/STs this season, allowing the ninth-most fantasy points per game to the position. Add in the fact that Kyler Murray (foot) is dealing with a foot injury, and the Colts' defense is in an excellent spot in Week 6. Fantasy managers can trust them as a top-six option heading into Sunday's slate of games.--Matt Terelle
Source: NFL.com
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REAL-TIME FANTASY NEWS

Jacoby Brissett

Expected to Start on Sunday Versus Former Team
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Has a Chance to Play on Sunday, Could Miss Extended Time
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Has Been Solid at Las Vegas in Next Gen Era
AJ Allmendinger

a Sneaky Option at Las Vegas
Kyle Busch

Struggles Likely to Continue for Kyle Busch at Las Vegas
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Injures Kneecap Saturday
Pyotr Kochetkov

Out for at Least One Week
Samuel Girard

Labeled as Week-to-Week
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Available Saturday
Evgenii Dadonov

to Miss at Least Two Games
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Misses Saturday's Game
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Out Week-to-Week
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Ready for Season Debut Saturday
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Questionable for Monday Night Showdown vs. Falcons
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Week 6 Status Uncertain, Washington Will "Take it into Monday"
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Ruled Out for Week 6
Gleyber Torres

Will Undergo Surgery to Repair Sports Hernia
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Expected to be on Mariners' ALCS Roster
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Joins Team for Trip to Boston
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Remains Out Saturday
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Not Expected to Play Saturday
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Set for Season Debut Saturday
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Back at Practice
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Placed on Injured Reserve
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Suspended for Saturday's Game
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CJ Baxter to Miss Saturday's Game Against No. 6 Oklahoma
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Syracuse QB Steve Angeli Will Miss Significant Time
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Expected to Play Against Packers
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Munetaka Murakami Will be Posted This Winter
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Questionable to Suit Up in Week 6
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to Miss his Fourth Game of the Year in Week 6
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Questionable to Play in Week 6 Against Rams
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Officially Ruled Out for Week 6
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Misses Practice Again on Friday
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Ruled Out for Week 6
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Looks To Remain Undefeated
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Looks To Win Back-To-Back Fights
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Questionable to Play in Week 6 Due to Hamstring Injury
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Looks To Secure His First Octagon Win
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Looks To Get Back In The Win Column
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North Carolina's Caleb Hood Retiring from College Football
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Exits With Injury Versus Blackhawks
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Syracuse QB Steve Angeli Will Miss Remainder of 2025 Season With Torn Achilles
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Sam Leavitt Not Expected to Play for Arizona State on Saturday
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John Mateer Upgraded to Probable Ahead of Saturday's Red-River Shootout
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Shut Down for a Week
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Ryan Williams Will Be Available Against No. 14 Missouri On Saturday
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