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Oct 11, 2025, 7:17 PM ET

The Indianapolis Colts defense has been an excellent unit through the first five weeks of the NFL season. The Colts have given opposing offenses fits so far, ranking third in the league with just 17.8 points allowed per game while ranking fifth with 14 sacks and fourth with six interceptions. The Cardinals have been generous to opposing D/STs this season, allowing the ninth-most fantasy points per game to the position. Add in the fact that Kyler Murray (foot) is dealing with a foot injury, and the Colts' defense is in an excellent spot in Week 6. Fantasy managers can trust them as a top-six option heading into Sunday's slate of games.--Matt Terelle
Source: NFL.com
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