Start/Sit Chart - Week 6 Fantasy Football Matchups for Monday Night Football

Fantasy football starts/sits for MNF, expert advice for all Bills vs. Falcons and Bears vs. Commanders Week 6 NFL matchups on Monday Night Football. Our start em, sit em picks for Khalil Shakir, Kyle Pitts, DJ Moore, D'Andre Swift, more.

Welcome to our Monday Night Football start/sit chart for Week 6 of the 2025 NFL season. Below you will find our start/sit matchups charts for all players in the MNF games between the Buffalo Bills vs. Atlanta Falcons, and Chicago Bears vs. Washington Commanders. This week brings yet another Monday Night Football double-header, meaning tons of fantasy matchups will go down to the wire and be decided on the final day of the slate

In addition to our start/sit recommendation and matchup ratings for each player, you can also read the fantasy football outlooks for key players like Khalil Shakir, Keon Coleman, Dalton Kincaid, Joshua Palmer, Kyle Pitts, Drake London, DJ Moore, D'Andre Swift, Luther Burden, Deebo Samuel, Jacory Croskey-Merritt, Zach Ertz. Which Bills, Falcons, Bears and Commanders players should you start or sit in Week 6?

We are here to help you set those winning lineups for Week 6, whether you're playing in season-long leagues or DFS contests. We will have our fantasy football start/sit matchup charts available all season long -- focusing on who to start, who is on the fence, and who should find the bench -- so be sure to check back. Good luck in Week 6, RotoBallers!

• 2025 fantasy football rankings
• Running back (RB) rankings
• Wide receiver (WR) rankings
• Quarterback (QB) rankings
• Tight end (TE) rankings
• Defense (D/ST) rankings
• Kicker (K) rankings
• FLEX rankings
• Dynasty rankings

Buffalo Bills Start/Sit Matchups

See the full stats in our Fantasy Football Matchup Ratings Projections

Khalil Shakir, WR, Bills

Buffalo Bills wide receiver Khalil Shakir has been the definition of a boom-or-bust fantasy option through the first four weeks of the season, posting point totals of 9.4, 1.7, 12.5, and 15.4.

His limited usage in the offense--typically fewer than six targets per game--makes him heavily touchdown dependent, which creates weekly volatility for fantasy managers. While Shakir's big-play ability gives him upside, it's difficult to predict when those breakout games will come, making him far more valuable in best ball formats than in standard redraft leagues.

Heading into Week 5, Shakir should be treated as a mid-level flex option, ranking behind more reliable volume-based receivers such as Wan'Dale Robinson and Ladd McConkey. Managers seeking a safe floor may want to look elsewhere, but those chasing upside can still take the gamble.

Keon Coleman, WR, Bills

Buffalo Bills wide receiver Keon Coleman will look to bounce back in Week 6 after cooling off since his explosive eight-catch, 112-yard debut. Over his last four games, Coleman has averaged just 3.3 receptions for 28.5 yards while posting a modest 10.8 yards per catch--a steep drop from his 19.2 average as a rookie.

The 22-year-old could see a slight boost in usage if tight end Dalton Kincaid (oblique) is sidelined, but he'll face a tough test against the Falcons' top-ranked pass defense. Atlanta has stifled opposing wideouts all season, and Coleman's fantasy value will likely hinge on volume and red zone looks. He remains a risky, touchdown-dependent WR4 heading into Monday night's matchup.

Atlanta Falcons Start/Sit Matchups

See the full stats in our Fantasy Football Matchup Ratings Projections

Kyle Pitts, TE, Falcons

Atlanta Falcons tight end Kyle Pitts Sr. has been a steady performer so far this year, logging at least five targets and at least four receptions in each of the team's first four games, even logging a season-high 70 yards receiving and catching his first touchdown pass of the season in Week 4.

Week 6 brings a difficult matchup against the Bills, a defense that has limited opposing offenses to the second-fewest yards per game through the air, and it's a unit that has yielded the second-fewest fantasy points to tight ends so far this season.

However, with the Bills' LB Matt Milano (pec) ruled out, intermediate targets could open a bit more, and with the Falcons' WR Darnell Mooney (hamstring) also ruled out, a few more targets could be headed Pitts' way. The 6-foot-6 tight end saw a season-high eight targets in Week 1 without Mooney on the field, and is looking like a low-end TE1 for Monday's matchup in Atlanta.

Drake London, WR, Falcons

Atlanta Falcons wide receiver Drake London had his best game of the season by far his last time out, putting up 110 yards and a touchdown on 10 targets and eight catches. The 24-year-old is averaging over nine targets per contest and has had at least five catches in three of his four games, however, Week 6 brings a matchup with Buffalo.

The Bills have held receivers to the eighth-fewest half-point PPR points and are allowing only 154 yards per game through the air, the second fewest in the league. On the other hand, Darnell Mooney (hamstring) has been ruled out for Monday's contest, and that could mean a couple of extra looks for London, who already owns a team-best 28.5 percent target share and has the most red zone targets of any of the team's wide receivers.

The Falcons could be playing from behind for much of the game as well, so expect London to be the focal point of the receiving corps once again. It may not be a big yardage day for the 6-foot-4 wideout, but his heavy usage in the passing game makes him a mid-range WR1 most weeks, including Week 6.

Chicago Bears Start/Sit Matchups

See the full stats in our Fantasy Football Matchup Ratings Projections

DJ Moore, WR, Bears

Chicago Bears wide receiver D.J. Moore has gotten off to a sluggish start this season, recording just 16 catches on 21 targets for 173 yards and one touchdown through four games. The veteran wideout appears to have ceded the WR1 role to emerging second-year star Rome Odunze, who has quickly become Caleb Williams' favorite target.

Before the bye week, Williams mentioned that Moore could serve as the "Deebo Samuel" of the Bears' offense, which has fantasy managers feeling uneasy. Fortunately, the Week 6 matchup against the Washington Commanders offers some hope.

Washington has surrendered the eighth-most fantasy points to opposing wide receivers this season, providing Moore with a chance to bounce back. Still, Moore profiles as a low-end WR3 for Week 6, as his fantasy production will likely hinge on whether he finds the end zone.

D'Andre Swift, RB, Bears

Chicago Bears running back D'Andre Swift will look to bounce back after a sluggish start to the 2025 season. Through four games, Swift has logged 56 carries for 187 yards and two touchdowns, adding 13 receptions for 85 yards through the air.

It's been an inefficient stretch for the former second-round pick, averaging just 3.3 yards per carry, with only one broken tackle so far. Rookie Kyle Monangai has impressed early, which could start to pressure Swift's workload if his struggles continue.

The matchup against the Commanders isn't ideal either, as they've allowed the 10th-fewest fantasy points to running backs this season. However, Swift torched Washington last year for 129 yards and a touchdown on 18 carries, showing he's capable of breaking out in this spot. Swift projects as a low-end RB2, as he hopes to rebound off a slow start.

Washington Commanders Start/Sit Matchups

See the full stats in our Fantasy Football Matchup Ratings Projections

Jacory Croskey-Merritt, RB, Commanders

Washington Commanders running back Jacory Croskey-Merritt broke out with his best game of the season in Week 5 against the Chargers, totaling 150 yards and two touchdowns on 16 touches. The Croskey-Merritt takeover finally happened in Week 5, posting a season-high 50.9% snap share, handling 50% of the team's rush attempts, and running 31.3% of the team's routes.

All marks were the highest of any Washington back in Week 5, and he delivered with a remarkable performance. For the season, he's rushed 283 yards and four touchdowns on 43 carries, averaging a league-best 6.6 yards per carry. Offensive coordinator Kliff Kingsbury provided some reason to keep the optimism in check, saying that the rookie still has "ways to go" in terms of playing without the ball in his hands. His work in pass protection has improved, but that is still an area where veteran Jeremy McNichols is most trusted.

Third-year back Chris Rodriguez Jr. saw his lowest snap count and fewest carries in a game since becoming active in Week 5, suggesting he may be slipping back into a depth role. Croskey-Merritt should be expected to handle the bulk of the touches again in Week 6 against a Bears defense that is allowing an absurd 6.1 yards per carry and the fourth-most PPR points per game to opposing running backs. He should be fired up as a high-upside RB2 on Monday night.

Zach Ertz, TE, Commanders

Washington Commanders tight end Zach Ertz was held catchless in a game in Week 5 against the Chargers for the first time since Week 13 of the 2014 season, crazy enough. Ertz has been a reliable target over the middle for quarterback Jayden Daniels, but the two did not connect on just one target in Week 5.

He'll look to get back on track Monday night against a Bears defense that has allowed nearly 30 points per game through four weeks. And Ertz could see an increase in targets if star receiver Deebo Samuel Sr. (heel) is unable to play. Ertz remains a low-end TE1 for Monday night.

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Who Should I Start? Who Should I Sit? Some common Week 6 fantasy football lineup decisions are regarding players like Khalil Shakir, Keon Coleman, Dalton Kincaid, Joshua Palmer, Kyle Pitts, Drake London, DJ Moore, D'Andre Swift, Luther Burden, Deebo Samuel, Jacory Croskey-Merritt, Zach Ertz. But not to worry, we are here to help make these decisions and build winning lineups in Week 6.

Week 6 Player Decisions. Set your optimal fantasy football lineups for Week 6 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.

Using The Tool. This is a simple tool but very powerful. The first step is to enter the player names that you want to compare. In the first box, search for the first player's name. In the second box, search for the second player's name. Compare up to four NFL players at once, and then click the Who To Start? button to see who the recommended starts are based on weekly fantasy football matchups.

Improvements For Who Should I Start? You may have noticed, we've added lots of great features for you to give you as much information as possible to win your fantasy football matchups each week. You'll see NFL player tiles with headshots and bye weeks, enhanced search results with data to compare, and a slick new interface. We hope you enjoy!

How It Works. Each week, our RotoBaller staff puts together their weekly fantasy football rankings and projections based on their research. That information is the core data that is powering the decision-making in this tool. When you search for player names, you will only see those players who are ranked. If someone is out for the week, they will not appear in the search results.

Scoring Formats. Fantasy football managers play in various types of leagues, and this tool allows you to choose whether it's PPR scoring, Half-PPR scoring, or Standard (Non-PPR) scoring. The second thing you want to do is to select the scoring format. There are three small radio buttons (small circles), so click on the scoring format you prefer. The results may vary based on the scoring format you select.

Popular Week 6 Searches. Curious to see some tough lineup decisions for Week 6 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.

Popular Week 6 Searches - Start/Sit Player Comparisons

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