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Mike's Week 10 college football betting picks against the spread for Tuesday, October 28, Wednesday, October 29, Thursday, October 30, and Friday, October 31, 2025. Free CFB betting predictions, odds analysis, and ATS picks from RotoBaller.
It wasn't as crazy as Week 8, but hey, few are. We still saw some great finishes, some ranked teams losing, and Indiana being Indiana.
We are down to 53 games this week, with nine of them taking place before Saturday. There are no FBS vs. FCS matchups, so it's a nice and proper week!
We've got some good midweek DFS slates this time around to go with the betting. Keep an eye out for those as well!
CFB Betting Picks for Week 10
I will pick every college football game every week. Not a top five. Not a top 10. All of them. Big deal, right? Lots of people make picks. Well, I do them all against the spread. I take the odds of each game and average them out at all the Vegas casinos and round to the nearest half. There will be no ties here. Ties are for the other (European) football.
I think you should know who you're listening to. I've been doing this since 2014, and I have most of my record available for viewing here. This can help you determine which teams I usually pick correctly or incorrectly, as the case may be.
UTEP at Kennesaw State (-9.5)
Betting Pick Confidence Factor: 4
Kennesaw covered this in Miami last week without a problem. UTEP is worse than FIU.
Pick: Kennesaw State -9.5
James Madison (-6.5) at Texas State
Betting Pick Confidence Factor: 2
I am on the Troy wagon lately, but I still think JMU is a more solid team. Troy covered this in San Marcos.
Pick: James Madison -6.5
Jacksonville State (-6.5) at Middle Tennessee State
Betting Pick Confidence Factor: 3
MTSU was a fluke last week. It took a Mississippi State level of boneheadedness on the part of Delaware to allow MTSU to bust the cover.
Pick: Jacksonville State -6.5
Florida International at Missouri State (-3.5)
Betting Pick Confidence Factor: 3
The Bears are even better with Jacob Clark.
Pick: Missouri State -3.5
Marshall (-5.5) at Coastal Carolina
Betting Pick Confidence Factor: 4
Is this with a mini Carlos Del Rio-Wilson or a regular Carlos Del Rio-Wilson?
Pick: Marshall -5.5
Tulane (-3.5) at UTSA
Betting Pick Confidence Factor: 2
I don't trust the Roadrunners' defense.
Pick: Tulane -3.5
(25) Memphis (-13.5) at Rice
Betting Pick Confidence Factor: 2
This is a strange one since there's almost no juice on Memphis, even in the spots where the line is up to 14.5. Vegas is begging for a Memphis bet. That makes me nervous, so I'm lowering mine.
Pick: Memphis -13.5
North Carolina at Syracuse (-2.5)
Betting Pick Confidence Factor: 4
Nope. This is where North Carolina pushes for a bowl berth.
Pick: North Carolina +2.5
Sam Houston at Louisiana Tech (-16.5)
Betting Pick Confidence Factor: 1
No chance. I'm not touching this one.
Pick: Louisiana Tech -16.5
CFB Betting Picks - Last Week's Results
I promised transparency, and you will get it, warts and all. I don't like to be wrong, but I will admit when I am. Why listen to someone if they won't admit the good or the bad? I know this week was better than last week, but I also know that I was burned by a lot of close games just in the ones I've watched so far. I'm just trying to break even at this point.
You can track my wins and losses on this sheet. I have everything updated from 2014-18 and 2023-present. I'm still looking for missing articles from 2019 and 2020 to get a running total of all of my picks. Winners against the spread will be in bold. My result will follow.
Kennesaw State (-3.5) at Florida International: MISS!
Betting Pick Confidence Factor: 2
FIU is still winless on Vice Night. Maybe they should try something different...
Western Kentucky at Louisiana Tech (-3.5): HIT!
Betting Pick Confidence Factor: 2
Rodney Tisdale Jr. got the start for Western Kentucky. His deep arm isn't as good as McIvor's, but he's got some wheels!
Middle Tennessee State at Delaware (-8.5): MISS!
Betting Pick Confidence Factor: 2
This was a bad beat. Delaware needed one first down. Why in the hell were they throwing on first and second down?
Missouri State (-1.5) at New Mexico State: MISS!
Betting Pick Confidence Factor: 2
The Bears may have a QB controversy going on down there in Springfield.
South Alabama (-6.5) at Georgia State: MISS!
Betting Pick Confidence Factor: 2
USA finally got the cover on one of these. The Georgia State defense had no answer for Bishop Davenport or Kentrel Bullock.
North Texas (-26.5) at Charlotte: HIT!
Betting Pick Confidence Factor: 4
Charlotte played maybe its best first half of the year, but lost control in the second half. I hope that Drew Mestemaker stays at North Texas, but I have a feeling he'll get more than one offer that he can't refuse.
Drew Mestemaker tonight 🔥🔥🔥
37/49 - 608 yards - 4 TD
No other player has thrown for more than 500 yards in a single game this season. The next highest is San Jose State’s Walker Eget with 473 yards vs Stanford pic.twitter.com/4opt4sCjHY
— College Football Zone (@CollegeFBonX) October 25, 2025
Not bad for a guy who never started a game in high school.
California at Virginia Tech (-4.5): HIT!
Betting Pick Confidence Factor: 3
The real Virginia Tech is somewhere between the team that got blown out by Old Dominion and the one on Friday night. Kyron Drones deserved better this year.
Boise State (-21.5) at Nevada: MISS!
Betting Pick Confidence Factor: 2
I knew that I hated that hook...
(8) Mississippi at (13) Oklahoma (-5.5): MISS!
Betting Pick Confidence Factor: 2
You can't make the mistakes that Oklahoma did and expect to win the game against a team that is evenly matched with your own. The roughing the passer penalty was bogus, but that was far from the only bailout that Mississippi got from dumb Oklahoma penalties.
The fumbled punt by Isaiah Sategna III hurt because of the long return and because Oklahoma finally had momentum. The fact is that Oklahoma got outplayed. The defense did a good job at making Trinidad Chambliss uncomfortable, but we couldn't handle him once he took off.
John Mateer overthrew or missed the read on at least three long gains, probably touchdowns, in the second half. Everything was on the table for Oklahoma, but Mississippi took advantage of its opportunities. We did not.
As far as Lane Kiffin jawing with a player after the game, I have no issue with it, and neither did Stone. He was dishing it out all game. That's to be expected if you can't back it up.
It's easier to accept a loss if the other team just shows up and beats you. Oklahoma had the chances but left a lot on the table. Mississippi executed, and the Sooners did not. Sometimes it really is that easy.
UCLA at (2) Indiana (-25.5): MISS!
Betting Pick Confidence Factor: 3
This doesn't make UCLA any less of a good story. It's time for many to admit that Indiana might just be that good. I did a while ago.
Syracuse at (7) Georgia Tech (-17.5): HIT
Betting Pick Confidence Factor: 2
It's almost like Brent Key realized that most voters on anything don't actually watch the games. They look at stat sheets, and if' we're lucky, they look at who won. Key let Haynes King cook finally. He only had four passing touchdowns coming into the game.
Haynes King today in Georgia Tech’s blowout victory over Syracuse:
25/31 passing (80.6%)
395 total yards
5 total touchdowns
0 interceptionsHEISMAN 🐝 pic.twitter.com/v26S8Ef3Jt
— CFB Kings (@CFBKings) October 25, 2025
(16) Virginia (-10.5) at North Carolina: HIT!
Betting Pick Confidence Factor: 2
The cardiac Cavs are at it again. In the last four games, Virginia has won in double overtime once, overtime twice, and a third time on a safety inside of two minutes left in the game. In this overtime game, the Hoos won on a failed two-point conversion by North Carolina. What next?
(18) South Florida (-5.5) at Memphis: MISS!
Betting Pick Confidence Factor: 4
Once again, Byrum Brown had a huge game in Memphis, but didn't come out with a win. USF was in control of this game until Memphis took over in the fourth quarter.
Northwestern at Nebraska (-7.5): HIT!
Betting Pick Confidence Factor: 5
It's a good thing Nebraska got sloppy, but the Cornhuskers won another one-score game. Healing is a process.
Rutgers (-1.5) at Purdue: HIT!
Betting Pick Confidence Factor: 2
KJ Duff wasn't supposed to be the big-play receiver on this team, but here we are.
SMU (-2.5) at Wake Forest: HIT!
Betting Pick Confidence Factor: 2
This was a slow mesh clinic by the Wake offense. The defense wasn't too shabby either.
Kansas State at Kansas (-3.5): MISS!
Betting Pick Confidence Factor: 3
The 17th straight victory for K-State over KU in the Sunflower Showdown was a lopsided one.
MORE >>> https://t.co/LOVRejJKvE pic.twitter.com/oVukbGRngB
— KCTV5 News (@KCTV5) October 25, 2025
I could have been worse since I don't think the first Jalon Daniels touchdown was a touchdown. He fumbled before he crossed the goal line. It has to be mental at this point, right?
Appalachian State at Old Dominion (-14.5): MISS!
Betting Pick Confidence Factor: 2
The Monarchs may still go bowling, but Colton Joseph Hero Ball isn't working the way it did a month ago.
Bowling Green (-7.5) at Kent State: MISS!
Betting Pick Confidence Factor: 3
Kent State has two conference wins this year after finishing 0-16 in the MAC in the last two years.
Ohio (-11.5) at Eastern Michigan: MISS!
Betting Pick Confidence Factor: 3
Ohio, the best rushing team in the MAC, only had 172 rushing yards on the worst rush defense in FBS.
Auburn at Arkansas (-2.5): HIT!
Betting Pick Confidence Factor: 2
I know that the Auburn offense wasn't light-years better with Ashton Daniels, but the Tigers were able to sustain drives. Jackson Arnold should not be the starter this week.
Akron at Buffalo (-10.5): HIT!
Betting Pick Confidence Factor: 1
I didn't expect an outright win for the Zips, but I can't say that I'm surprised since Buffalo should have lost to UMass.
Connecticut (-10.5) at Rice: MISS!
Betting Pick Confidence Factor: 1
There's a reason that I didn't bet on this. The Rice football team is schizophrenic.
Utah State at New Mexico (-2.5): MISS!
Betting Pick Confidence Factor: 3
New Mexico is a good team when they don't turn the ball over.
(4) Alabama (-11.5) at South Carolina: MISS!
Betting Pick Confidence Factor: 4
This one has to hurt for South Carolina. The Alabama defense came up big at the end of this game. South Carolina was right in letting Germie Bernard score. They had no other choice.
(15) Missouri at (10) Vanderbilt (-2.5): HIT!
Betting Pick Confidence Factor: 3
This was a defensive battle just like we all expected, right? I don't know if this would have ended differently with Beau Pribula in for Missouri, but you can't say that Matt Zollers didn't play well enough. Missouri was this close.
VANDERBILT HOLDS ON BY LITERAL INCHES AS MISSOURI CATCHES A PASS AS TIME EXPIRES BUT WAS JUST SHORT OF THE GOAL LINE pic.twitter.com/jYbEuwcTXD
— CFB Kings (@CFBKings) October 25, 2025
(11) BYU at Iowa State (-2.5): HIT!
Betting Pick Confidence Factor: 4
We all should be making money on BYU by now. Take the money while Vegas keeps giving it to us!
(23) Illinois at Washington (-4.5): MISS!
Betting Pick Confidence Factor: 1
Even the sharps are wrong from time to time.
Minnesota at Iowa (-9.5): MISS!
Betting Pick Confidence Factor: 5
Floyd stays home! Best photos from Iowa football's 41-3 trouncing of Minnesota https://t.co/GOz3xlyDaQ pic.twitter.com/jg7LEzi4Tn
— Hawkeyes Wire (@HawkeyesWire) October 26, 2025
There really is no way your rival should smoke you like this in a rivalry game, especially when the teams feel equal.
Toledo (-1.5) at Washington State: HIT!
Betting Pick Confidence Factor: 3
Washington State may not be a very good team, but at least we know what to expect. I can't say the same for Toledo.
North Carolina State at Pittsburgh (-6.5): MISS!
Betting Pick Confidence Factor: 2
Week 9 CFB Freshman of the Week: Pitt QB Mason Heintschel
🎯 423 passing yards
🎯 3 TDs
🎯 +0.45 EPA per dropback
🎯 84.2 PFSN College QB Impact grade@Pitt_FB | @mason_heinch06 pic.twitter.com/bvV94au6Ed— PFSN College (@PFSNcollege) October 27, 2025
Those 423 passing yards are a Pitt freshman record. Not bad, considering some guy named Dan Marino played here.
San Diego State (-2.5) at Fresno State: HIT!
Betting Pick Confidence Factor: 5
San Diego State has outscored opponents 152-37 since a Week 2 loss to Washington State.
Louisiana-Monroe at Southern Mississippi (-12.5): HIT!
Betting Pick Confidence Factor: 2
Charles Huff is going to be the next star coach for the AD who is willing to take a chance on a lesser-known Group of 5 coach. We all remember how bad Southern Miss was last year, right? I sure do.
Florida Atlantic at Navy (-14.5): HIT!
Betting Pick Confidence Factor: 1
I'm convinced that North Texas might score 100 on Navy if it weren't for the stupid running clock.
Temple (-5.5) at Tulsa: MISS!
Betting Pick Confidence Factor: 3
If it feels like a lot of teams go for two and the win in overtime only to miss, it's because it's true. It's also true that the coaches of those teams feel overmatched just running single plays at each other until eternity. This is a byproduct of the new overtime rules.
Ball State at Northern Illinois (-6.5): MISS!
Betting Pick Confidence Factor: 2
The Bronze Stalk will go to the Mountain West with NIU.
Massachusetts at Central Michigan (-16.5): HIT!
Betting Pick Confidence Factor: 2
Hey, UMass scoring 13 points is kind of a big deal. It has only happened twice against FBS teams this year...both in the last two weeks.
Western Michigan at Miami (OH) (-1.5): MISS!
Betting Pick Confidence Factor: 2
And just like that, the Redhawks are the favorites to win the MAC again. MACtion is going to be lit this year!
Oklahoma State at (14) Texas Tech (-36.5): HIT!
Betting Pick Confidence Factor: 3
In all fairness, Texas Tech probably didn't need a quarterback in this one. However, if Behren Morton can't go this week, Mitch Griffiss better be ready. Will Hammond is done for the season.
Baylor at (21) Cincinnati (-3.5): HIT!
Betting Pick Confidence Factor: 4
Cincinnati QB Brendan Sorsby is having a Heisman worthy season, but he doesn't play in the big 10 or SEC so we'll never hear about it on ESPN.
P4 Team 7-1 Overall
20 TDs - 1 INT
425 Rushing Yards - 7 TDsHe's doing what you guys think Diego Pavia is doing. pic.twitter.com/WoYtQKk56e
— Rico Rico (@Ricoknowstiktok) October 27, 2025
If you have been reading my top 25 QB rankings this year, you know what I think of Sorsby. He's the best quarterback in the conference (sorry, Bear) and one of the best in the country.
(22) Texas (-7.5) at Mississippi State: HIT
Betting Pick Confidence Factor: 3
TEXAS PUNT RETURN FOR A TOUCHDOWN TO TIE IT AT 38 🏡🏡🏡#HookEm #SECFB pic.twitter.com/6xPMitIGtd
— Vendetta Media (@VendettaVSM) October 25, 2025
DON'T KICK TO RYAN NIBLETT! Seriously? How don't people know this by now? It was a hell of a comeback by Texas, but we can't say that without the epic meltdown in every facet by Mississippi State.
TCU (-16.5) at West Virginia: MISS!
Betting Pick Confidence Factor: 2
Only beating this West Virginia team by six should count as a loss.
Wisconsin at (6) Oregon (-31.5): MISS!
Betting Pick Confidence Factor: 5
I should have backed off on this in a deluge, but how in the world did Wisconsin score? Wisconsin's run defense is one of the best in the country, and Oregon couldn't throw with or without Dante Moore.
Stanford at (9) Miami (FL) (-29.5): MISS!
Betting Pick Confidence Factor: 1
Damn you, Stanford... At least they gave me hope for one half.
Georgia Southern at Arkansas State (-1.5): MISS!
Betting Pick Confidence Factor: 3
The storm held off, which was bad for my bet.
Louisiana at Troy (-9.5): HIT!
Betting Pick Confidence Factor: 3
Troy is easy money right now!
(3) Texas A&M (-2-5) at (20) LSU: HIT!
Betting Pick Confidence Factor: 4
It's not just that LSU lost this game. It's how they lost the game. The Tigers were ahead by four points at the half, then got blown off the field in the second half. The offense never got better. LSU has two good backs and doesn't like to use them.
This is a change that needed to be made. I'm curious to see what LSU will look like against Alabama in two weeks.
Boston College at (19) Louisville (-25.5): MISS!
Betting Pick Confidence Factor: 1
Isaac Brown was the only bright spot for either team...
(25) Michigan (-14.5) at Michigan State: HIT!
Betting Pick Confidence Factor: 1
Michigan couldn't care less about covering a spread. They'd rather bully you into submission.
Colorado State at Wyoming (-4.5): HIT!
Betting Pick Confidence Factor: 2
Colorado State has nothing left, but anyone who follows the Mountain West at all knew that already.
(17) Tennessee (-8.5) at Kentucky: HIT
Betting Pick Confidence Factor: 3
Think of how great the end of this game would have been with a smiling Joey Aguilar picking up the beer barrel? See what the schools are robbing us of?
Houston at (24) Arizona State (-7.5): HIT!
Betting Pick Confidence Factor: 4
Jordyn Tyson is a big part of the Arizona State offense, but the Sun Devils may have still had a chance with a healthy Sam Leavitt.
Colorado at Utah (-13.5): MISS!
Betting Pick Confidence Factor: 2
Utah covered this without Devin Dampier. Freshman Byrd Ficklin went nuts on the Ralphies.
College Football Betting Season Results
I had another bad start with Weekday CUSA, but still ended up a respectable 26-27. That puts me at 230-234 on the season. I'm going the wrong way, but I think I did okay with points this week.
The weekly totals follow the bet. Season totals are in parentheses.
1. 3-4 (32-24) = 8
2. 9-12 (75-94) = -38
3. 7-7 (76-69) = 21
4. 5-2 (31-35) = -16
5. 2-2 (16-12) = 20
I gained five points on the week, which cut my season deficit in half. We're getting back to the middle. Profits are in the near future!
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