MLB DFS Picks Today: Daily Fantasy Baseball Strategy and Tips For FanDuel, DraftKings (5/21/25)

CeeGee's top DraftKings and FanDuel MLB DFS picks for today, Wednesday, 5/21/25. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.

Happy Wednesday, RotoBallers! We’ve got a seven-game main slate kicking off at 6:45 p.m. EDT, featuring a mix of high-upside pitchers, Coors Field bats, and some sneaky value plays to help you build those winning lineups on DraftKings and FanDuel.

The weather looks dicey in a few spots. New York, Washington, and Boston have risks, so keep an eye on lineup changes and potential delays. I will dive into the best pitching options, hitters, and stacks to target for cash games and GPPs. Let’s get to it!

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 5/21/2025, with the slate starting at 6:45 p.m. EDT. The lineup picks will showcase elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Garrett Crochet - BOS - P ($10,500 DK; $10,800 FD)

Crochet is the slate’s premier arm, and for good reason. Facing the Mets at Fenway, he’s been a strikeout machine with a 39.7% K% against lefties and 32.1% against righties this season. His last six starts show consistency, averaging a 29.6% K% with a 19.8% FB% against right-handed bats, which dominate the Mets lineup.

New York’s 20.7% K% against left-handed pitching and middling .357 xwOBA make this a juicy matchup. Crochet’s 15.59 DK points projection (6.2 Ks) is tops on the slate, and his ability to rack up strikeouts gives him GPP-winning upside. His high price is justified for cash games due to his floor and ceiling.

Jacob deGrom - TEX - P ($10,000 DK; $10,200 FD)

Texas' deGrom is back to his elite self, and the Yankees at home are a favorable matchup despite their power potential. He’s posted a 28.6% K% against lefties and 26.6% against righties, with a sparkling .216 wOBA allowed to right-handed bats. His last six starts show a 29.4% K% and just a 3.7% BB%, with three starts exceeding 25 DK points.

The Yankees’ 22.7% K% against right-handed pitching and .342 xwOBA are solid but not too daunting. deGrom’s 18.64 DK points projection makes him a strong cash and GPP play tonight.

Corbin Burnes - ARI - P ($9,300 DK; $9,400 FD)

Burnes is a great pivot for those looking to save a bit of salary while still getting elite production. Facing the Dodgers at Dodger Stadium, he’s been steady with a 21.8% K% against lefties and 24.1% against righties, allowing a .266 wOBA to left-handed bats. His last start against the Rockies was a 10-K gem, and he’s averaged 20.1 DK points over his previous six outings.

The Dodgers’ 21.5% K% and .351 xwOBA against RHP are respectable, but Dodger Stadium’s pitcher-friendly environment will help Burnes keep runs in check. He’s a solid cash game option on both sites and a GPP option with strikeout upside.

Also Consider:

Kevin Gausman - TOR - P ($8,800 DK; $8,500 FD): Facing the Padres at Rogers Centre, Gausman’s 23.0% K% against righties and 20.6% against lefties give him a nice floor. San Diego’s 17.7% K% and .347 xwOBA against RHP make this a decent matchup, and his recent inconsistency makes him a GPP-only play.

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DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Bryce Harper - PHI - 1B ($6,400 DK; $4,300 FD)

Harper is a Coors Field must-play, especially against the unproven Carson Palmquist, who’s struggled with a .763 wOBA against lefties in limited action. Harper’s .385 xwOBA and .214 ISO against LHP are elite, and his 12.73 DK points projection reflects his massive ceiling in this hitter’s paradise. On FanDuel, his price is a steal for cash games, and his power makes him a GPP staple. Coors Field's thin air amplifies his home run potential; lock him in.

Trea Turner - PHI - SS ($6,200 DK; $4,000 FD)

Turner is another Phillies bat to lock in at Coors. His .331 xwOBA and .186 ISO against LHP pair well with Palmquist’s inexperience, and Turner’s speed adds stolen base upside on DraftKings, where his 11.27 DK points projection is enticing. On FanDuel, his price makes him a cash game priority, and his ability to pile up hits and runs in Coors gives him GPP appeal. Stack him with Harper for max exposure to Philly’s top order.

Vladimir Guerrero Jr. - TOR - 1B ($4,700 DK; $3,300 FD)

Guerrero is a value gem against Randy Vasquez, who’s struggled with an 18.7% K% and .135 ISO against righties. Guerrero’s .407 xwOBA and .196 ISO against RHP are stellar, and his 10.27 DK points projection makes him a great mid-tier option. Rogers Centre’s hitter-friendly dimensions boost his power upside, and his price on both sites fits cash and GPP builds. Vasquez has struggled vs. lefties, allowing a .228 ISO and .398 wOBA over his last six games, so pair Vlad with a few lefty Blue Jays bats like Anthony Santander or Daulton Varsho.

Also Consider:
Francisco Lindor - NYM - SS ($5,300 DK; $3,700 FD), Pete Alonso - NYM - 1B ($5,500 DK; $3,800 FD), Rafael Devers - BOS - 3B ($5,000 DK; $3,700 FD): These power bats at Fenway face tough pitchers (Crochet, Megill), but their high xHR projections and favorable park factors make them GPP dart throws for home run upside.

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Kyle Schwarber - PHI - OF ($6,500 DK; $4,500 FD)

Schwarber is the top outfield play at Coors, where his .400 xwOBA and .246 ISO against LHP could lead to a monster night against Palmquist. His 12.73 DK points projection is among the slate’s highest, and Coors’ hitter-friendly environment maximizes his home run potential. On FanDuel, he’s a cash game lock, and his power makes him a GPP tournament winner. Pair him with Harper and Turner for an expensive Phillies stack.

Shohei Ohtani - LAD - 1B/OF ($6,300 DK; $4,800 FD)

Ohtani is always a premium play even in a tough matchup against Burnes. Ohtani’s .480 xwOBA and .396 ISO against RHP are absurd, and his 15.41 DK points projection reflects his ability to go yard or steal a base on any night. Dodger Stadium isn’t Coors, but Ohtani’s raw talent makes him a GPP differentiator. His price is steep, but worth it for his ceiling.

Fernando Tatis Jr. - SD - OF ($5,700 DK; $4,100 FD)

Tatis is a great mid-range option against Gausman, who’s been inconsistent lately (6.8 FD points in his last start). Tatis’ .416 xwOBA and .270 ISO against RHP are elite, and his 12.09 DK points projection makes him a strong play at Rogers Centre. On DraftKings, his price is a bit high for cash, but he’s a GPP stud. On FanDuel, he’s a cash game fit due to his power-speed combo.

Also Consider:
Jordan Beck - COL - OF ($4,800 DK; $3,500 FD), Hunter Goodman - COL - C/OF/1B ($4,400 DK; $3,400 FD): These Rockies bats are Coors Field value plays against Taijuan Walker, who’s allowed a .347 xwOBA to lefties and .406 to righties. Their high xHR projections make them GPP targets.

DraftKings, FanDuel MLB DFS Stacks

Philadelphia Phillies (vs. Carson Palmquist - COL)

Coors Field is the place to stack, and the Phillies’ top order is primed to feast on Palmquist’s inexperience. Harper, Turner, Schwarber, and Nick Castellanos are the core pieces, with Harper and Schwarber offering massive power and Turner adding speed. Castellanos’ .355 xwOBA and .285 xHR projection make him a nice addition. Due to Coors' run-scoring environment and Palmquist's struggles, this stack is a cash and GPP priority on both sites.

Toronto Blue Jays (vs. Randy Vasquez - SD)

The Blue Jays offer a mid-range stack with huge upside against Vasquez’s poor metrics. The top targets are Guerrero, George Springer, Varsho, and Bo Bichette. Guerrero’s power and Springer’s leadoff role maximize run production, while Varsho and Bichette add pop at reasonable prices. Rogers Centre’s hitter-friendly park factors boost this stack’s appeal for GPPs on both platforms.

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