October 22, 2025
Boston Celtics forward
Jaylen Brown (hamstring) will play on Wednesday versus the Philadelphia 76ers. The 28-year-old was listed as questionable because of a hamstring injury. However, it won't be enough to keep him off the floor for the opener. Brown averaged 22.2 points, 5.8 rebounds, 4.5 assists, and 1.2 steals last season. With
Jayson Tatum (Achilles) out for the foreseeable future, he could see an increase in all statistical areas. Brown's availability will presumably mean fewer scoring opportunities for
Anfernee Simons,
Derrick White, and
Payton Pritchard.
--Dennis ClausenSource: Boston Celtics
October 22, 2025
New York Knicks forward
OG Anunoby (ankle) is available to play in Wednesday's season opener against the Cleveland Cavaliers. As expected, Anunoby is cleared to play after coming into this game as probable with an ankle injury. The expectation was that he'd play unless something happened pre-game. He'll slide right into the starting five and should be started in basically all fantasy formats. Last season, Anunoby finished with top-40 value and should be able to offer similar value again.
--Andy WebbSource: James L. Edwards
October 22, 2025
On Wednesday, Rylan Stiles of SI.com reports that Oklahoma City Thunder guard
Alex Caruso has been placed in concussion protocol. Caruso sustained a concussion during the season-opening 125-124 win over the Houston Rockets on Tuesday. He registered eight points, two rebounds, three assists, two steals, and one block across 30 minutes in a double-overtime thriller. While the 30-year-old is out of action,
Aaron Wiggins and
Cason Wallace will likely see a boost in fantasy production with the added minutes on the floor.
--Andrew LennoxSource: Rylan Stiles
October 22, 2025
Philadelphia 76ers center
Joel Embiid (knee) is available for Wednesday's matchup versus the Boston Celtics. The 31-year-old spent all offseason working his way back from knee surgery. While he's received the green light to get on the floor, head coach Nick Nurse indicated Embiid would be on a minutes cap. It's unknown how much action he'll see. However, Embiid is still a must-start in all fantasy formats. On the other hand, he may not be the safest option for DFS managers.
Adem Bona and
Andre Drummond may also get some extra work, although not enough to warrant serious consideration for fantasy lineups.
--Dennis ClausenSource: Bobby Krivitsky
October 22, 2025
Miami Heat center
Kel'el Ware (ankle) is available to play ahead of Wednesday's season opener against the Orlando Magic. Ware was questionable coming into this game due to an ankle issue. Despite that, Ware is good to go and doesn't appear to have any minutes limit for this contest. It's unclear if he'll be in the starting five, but regardless Ware should be rostered in most standard leagues. Last season, Ware averaged 9.3 points and 7.4 rebounds in 22.2 minutes per game with the Heat. He figures to have a similar role or increased responsibilities this season.
--Andy WebbSource: Tim Reynolds
October 22, 2025
Cleveland Cavaliers forward
De'Andre Hunter (knee) is headed to the bench ahead of Wednesday's season opener against the New York Knicks. Hunter was listed as questionable coming into this game due to a knee contusion. He suffered the injury in a preseason game roughly a week ago and is still dealing with the issue.
Dean Wade and
Jaylon Tyson figure to see increased roles with Hunter sidelined. Between the two, Tyson has the higher ceiling in terms of streaming value for Wednesday's slate. It's unclear when Hunter will return, so fantasy managers will need to stay tuned for more updates.
--Andy WebbSource: Chris Fedor
October 22, 2025
New York Knicks forward/center
Karl-Anthony Towns (quad) has been cleared to suit up for Wednesday's season opener against the Cleveland Cavaliers. His status has changed throughout the day, but it sounds like Towns will play, barring any setbacks. It doesn't sound like Towns is going to be limited at all. However, it's the season opener, so the Knicks might be cautious given Towns probably isn't 100 percent healthy. He figures to play a bigger role than normal with
Mitchell Robinson (ankle) sidelined. Fantasy managers can feel safe plugging Towns into their lineups right now.
--Andy WebbSource: Ian Begley
October 22, 2025
NBA reporter Chris Haynes reports that Minnesota Timberwolves point guard
Mike Conley will begin the new season coming off the bench. Dante DiVincenzo will be the starting floor general for Wednesday's matchup with the Portland Trail Blazers and beyond. Last season across 71 games, Conley averaged 8.2 points, 4.5 assists, 2.6 rebounds and 1.1 steals in 24.7 minutes per contest. Now in a reserve role, the 38-year-old's fantasy value is expected to keep trending downward.
--Andrew LennoxSource: Chris Haynes
October 22, 2025
According to NBA reporter Chris Haynes, guard
Donte DiVincenzo has been named to the starting five for the Minnesota Timberwolves to open the 2025-26 season on Wednesday. DiVincenzo replaces 38-year-old
Mike Conley as the team's starting point guard. Conley will remain a crucial component for Minnesota, but will now come off the bench. Across 62 games last season, DiVincenzo averaged 11.7 points, 3.7 rebounds, 3.6 assists and 1.2 steals in 25.9 minutes per contest. With an increase in playing time, the 28-year-old's fantasy value should see a notable boost this season.
--Andrew LennoxSource: Chris Haynes
October 22, 2025
Milwaukee Bucks forward/center
Giannis Antetokounmpo has been added to the injury report and is listed as probable for Wednesday's matchup with the Washington Wizards due to lower back soreness. Fantasy managers shouldn't be overly concerned about the star forward's status, as he is still expected to take the floor this evening. The 30-year-old averaged 30.4 points, 11.9 rebounds, 6.5 assists, and 1.2 blocks in 34.2 minutes per contest across 67 outings. Heading into the new campaign, Antetokounmpo remains an elite fantasy option across all formats.
--Andrew LennoxSource: NBA Injury Report
October 22, 2025
According to Shams Charania of ESPN, New York Knicks center/forward
Karl-Anthony Towns (quadriceps) has been upgraded to questionable heading into Wednesday's game against the Cleveland Cavaliers. His status for the team's season opener has now changed repeatedly, shifting from questionable to doubtful and back again. Fantasy managers have to hope that the 29-year-old isn't dealing with anything injury-wise that sidelines him throughout the season. If Towns is unable to suit up, he'll join
Mitchell Robinson (ankle) on the sidelines, which would likely open the door for
Guerschon Yabusele to start this evening. Yabusele agreed to a two-year, $11.7 million contract with the Knicks in July and could make an immediate impact in the frontcourt if given extended minutes.
--Andrew LennoxSource: Shams Charania
October 22, 2025
Orlando Magic guard
Jalen Suggs (knee) will play in Wednesday's matchup with the Miami Heat, according to head coach Jamahl Mosley. There was some doubt about his availability for the opener after he underwent knee surgery back in March. However, the 24-year-old will be out there when the Magic begin the 2025 campaign. Suggs averaged 16.2 points, 4.0 boards, and 1.5 steals last season. Unfortunately, he was limited to only 35 appearances. With that said, Suggs is worthy of a place in any fantasy lineup, although he may see fewer than the 28.6 minutes he averaged last season. Still, his presence will presumably mean fewer minutes for
Tyus Jones, who would have been the favorite to enter the starting lineup.
--Dennis ClausenSource: Jason Beede
October 22, 2025
New York Knicks center/forward
Karl-Anthony Towns (quadriceps) is now listed as doubtful heading into Wednesday's game against the Cleveland Cavaliers. He was deemed questionable as of Tuesday evening. Unfortunately, it appears KAT is heading in the wrong direction, putting his availability for the opener in doubt. At this point, fantasy managers are certainly hoping Towns isn't dealing with anything that will keep him out beyond Wednesday's contest, specifically, for upcoming matchups versus the Celtics and Heat. However,
Mitchell Robinson (ankle) has already been ruled out, meaning
Guerschon Yabusele will presumably roll with the first five. Yabusele, who signed a two-year, $11.7 million contact with the Knicks in July, averaged 11.3 points and 6.2 rebounds in 43 starts with the Sixers throughout the 2024 campaign, giving him plenty of upside for those in need of a streaming option.
--Dennis ClausenSource: Shams Charania
October 22, 2025
Charlotte Hornets forward
Grant Williams (knee) has been ruled out for the team's season opener on Wednesday against the Brooklyn Nets. Williams is still recovering from knee surgery, and there isn't a specific date set for his return. However, considering it's been 11 months since Williams injured his right knee, his comeback could be close.
Josh Green (shoulder) also won't be available for the start of the season, which may give rookie
Kon Knueppel a large workload right off the bat. The injuries could also open up additional minutes for
Tidjane Salaun and
Tre Mann.
--Taavi PailkSource: NBA Injury Report
October 22, 2025
Dallas Mavericks guard
Dante Exum (knee) won't suit up for Wednesday's contest against the San Antonio Spurs. This isn't surprising, as Exum has been dealing with a right knee problem throughout the preseason. Health issues also sidelined him for nearly the entire 2024-25 campaign, as Exum participated in only 20 games. He averaged 8.7 points and 2.8 assists.
Brandon Williams and
Max Christie are expected to handle the backup guard minutes in Wednesday's game. Although Williams has a higher fantasy ceiling, there may not be enough minutes available for either player to make a significant impact.
--Taavi PailkSource: NBA Injury Report
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