MLB DFS Picks Today: Daily Fantasy Baseball Strategy and Tips For FanDuel, DraftKings (9/16/25)

Koby's top DraftKings and FanDuel MLB DFS picks for today, Tuesday, 9/16/25. His favorite daily fantasy baseball lineup sleepers and value picks for DFS on DraftKings and FanDuel.

Welcome Back, RotoBallers! No football today, so we can fully focus on this big 11-game MLB slate ahead of us. We are getting down to the nitty-gritty with only about 12 or so games left in the season. There are quite a bit of playoff spots up for the taking and a bunch of matchups that could take a team one step closer to getting there.

The weather is looking good across the slate. Keep an eye on the Mariners/Royals game, as that could have a potential weather delay. If you wanna stay up-to-date, we have a bunch of great minds in the RotoBaller Discord who are around to help with lineups and any last-minute updates!

This article will provide my daily fantasy baseball lineup picks for DraftKings and FanDuel on 9/16/2025, with the slate starting at 7:10 PM EST. Keep in mind the FanDuel slate has chopped off the late afternoon games from their main slate. The lineup picks will showcase elite players, mid-priced options, and value plays. You can also read more DFS advice and lineup picks for other sports here. Monitoring injury news and today's MLB starting lineups is always essential.

DraftKings, FanDuel Pitchers - MLB DFS Lineup Picks

Logan Gilbert, SP - SEA ($10K DK/$10.3K FD)

I almost went with Freddy Peralta in this spot, and I think he is still a good play, but with Milwaukee locking up a playoff spot. I almost think they may start to limit start innings, to give them a bit more rest before the playoffs. Logan Gilbert and the Mariners are fighting for the coveted AL West title still. They come into Kansas City on a nine-game win streak.

Logan has had four straight solid starts, finishing with 30+ fantasy points in all four games. He has struck out six or more in all four games, and even with the Royals only having a 17.5% K%, Gilbert's 34% K% should trump all of that.

There are only four starters with a whiff rate above 50% on a pitch this season (min 200 thrown)...

Zack Wheeler (Curveball): 54.7% Whiff
Logan Gilbert (Splitter): 51% Whiff
Joey Cantillo (Changeup): 51% Whiff 🎥
Freddy Peralta (Slider): 50.4% Whiffpic.twitter.com/AY5z4T2DY4

— Eric Cross (@EricCrossMLB) September 12, 2025

The Royals have been below average across the last two weeks with 91 wRC+ and a weak .301 wOBA. This is the time for the Mariners to continue their hot streak, and it all starts with the elite pitching on the mound. The only thing we have to worry about here is the possibility of rain. If it looks like we may see a delay, I would highly recommend pivoting, but if it clears up, then start Gilbert up.

Andrew Abbott, SP - CIN ($8.5K DK/$9.2K FD)

Andrew Abbott might be in one of the best spots for a pitcher on this slate. The Cardinals this month have been terrible against lefties. They have put out the second-worst wRC+ in the league at a mere 54. They have also put together a league-low wOBA of .237 and SLG of .232. Abbott is also getting the benefit of not playing in Cincinnati, which is a very favorable park for hitters.

In Abbott's last outing, he finished with 49 fantasy points. He put it on the Padres as he went eight innings while striking out six. We have seen how deep Abbott can go in games, and this could be another opportunity for the third-year pitcher. He has put out a 22% K% and has a low 6.8% BB% to go with it. If the Cardinals' struggles continue against lefties, then Abbott is about to have a career game here against them.

Others To Consider (Cash/GPP):

• Freddy Peralta, SP - MIL ($10.5K DK/$10K FD)
• Shane Smith, SP - CWS ($7K DK/$8.3K FD)
• Tyler Wells, SP - BAL ($9K DK/$8.6K FD)

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DraftKings, FanDuel Infielders - MLB DFS Lineup Picks

Geraldo Perdomo, SS  - ARI ($4.9K DK/$3.9K FD)

It is for good reason that Perdomo has seen his price increase dramatically. He has ten hits and seven walks, including two home runs in his last six games. He is on an absolute tear right now, and now he is going to be going against Carson Seymour, whom he just hammered a home run off of less than a week ago.

Geraldo Perdomo tonight:

3-for-3
2B
3B
2 RBI
2 BB
1 R

He’s now at 19 HR, 97 RBI and 26 SB.

No player in #DBacks history has ever had a 20 HR, 100 RBI, 25 SB season 👀 pic.twitter.com/GWdloXf2Jy

— Logan🌵 (@phxlogan) September 16, 2025

Perdomo isn't hitting for a lot of power against RHP, but he still has a wOBA of .360, a .450 SLG, and an .185 ISO. He is also leading his team with a low of 15.9% K% against righties. This is an elite spot for the lead-off shortstop.

Yandy Diaz, 1B - TBR ($4.8K DK/$3.1K FD)

I don't usually like going against Jose Berrios because, for some reason, I have no luck when it comes to this guy. If I bet on him, he fails; if I bet against him, he thrives. This spot is just too juicy for Yandy Diaz. Jose Berrios has struggled against RHH this season. He has given up 17 of his 24 home runs to righties and has a .498 SLG and a .242 ISO that are both concerning. The hitters should also benefit from the minor league stadium at George M. Steinbrenner Field.

Yandy Diaz has been crushing righties, though this season, he has a .350 wOBA to go with a .462 SLG. He has been very efficient at home this season and gets a great matchup to take advantage of. I don't love Tampa Bay as a full stack, but as a one-off or small stack, this should be a great spot for the righties.

Sal Stewart, 3B - CIN ($2.8K DK/$2.3K FD)

Sal Stewart is off to a hot start in his young career. He has been on an absolute heater across his last eight games, which includes four home runs and two multi-hit games. We are still getting him for near min-priced, which makes him an elite one-off spot in your lineups. Most of the pitching on this slate is pretty expensive. This is a good spot to relieve some of that salary.

Sal Stewart is hitting righties really well to the tune of a .351 wOBA, with a .594 SLG, and a .281 ISO. He also has a 25% Barrel%. The stats are fairly limited on him so far, as he hasn't even hit the 50 AB mark, but all the signs are encouraging for Stewart.

Others To Consider (Cash/GPP):

• Ketel Marte, 2B - ARI ($5.4K DK/$3.7K FD)
• William Contreras, C - MIL ($4.6K DK/$3.1K FD)
• Jazz Chisholm Jr., 2B/3Bja(FD) - NYY ($5.5K DK/$3.8K FD)

DraftKings, FanDuel Outfielders - MLB DFS Lineup Picks

Jackson Chourio, OF - MIL ($4.9K DK/$3.5K FD)

After missing most of August, Chourio has been back with his team and has started to find his footing across the last few games, and now he gets an elite spot that I can't overlook. Caden Dana has been terrible against RHH this season. He has faced 28 RHH so far this season, and in that time, they have a .489 wOBA, a .750 SLG, and a .417 ISO! Milwaukee has a pretty lefty-heavy lineup, but that's what makes Chourio such an elite play here.

Jackson Chourio covers an unbelievable amount of ground to make a wild diving grab 💪 pic.twitter.com/psHvbcuqds

— MLB (@MLB) September 14, 2025

Chourio has had 10 hits and three walks in his last seven games, including two dingers. Chourio and William Contreras are in a great smash spot here against Dana. Let's just hope they can take advantage of it.

Julio Rodriguez, SEA ($5.2K DK/$3.9K FD)

Keep an eye on the weather, but if we get cleared to play, this is a great spot for Julio. All eyes have been on Cal Raleigh this season for the Mariners, but 2nd-half Julio has been the real hero for this Mariners team that leads the AL West by half a game now.

In the second half of the season, he has worked his wOBA up 70 points to .388, and his SLG is up 170 points to .586. He is on the verge of another 30/30 season with only three stolen bases to go. Against RHP this season, he has a .343 wOBA with a .469 SLG. Michael Wacha is coming off of concussion protocol to throw this one, and he has been good against lefties, but the righties have caused him issues this season.

Wacha has given up 10 home runs to RHH with a SLG of .411 and a .310 wOBA. This is a tougher matchup than I would have liked, but him coming off a concussion may be a good spot for us, and if we get a rain delay, Wacha may be out of the game early.

Heriberto Hernandez, MIA ($4K DK/$3.1K FD)

Heriberto Hernandez finds himself at Coors Field against Kyle Freeland, whom he already has experience against this season. He has two hits in three ABs from a matchup earlier this season in Miami. He hasn't gone up against many lefties, but has been solid in limited time. He has .321 wOBA and .400 SLG. But the thing that sticks out to me the most is his Barrel%, which sits at 17.2% against LHP.

That on top of Coors Field could make us some serious dough. Even with the Coors bump in price, he is still very affordable with solid potential. Freeland has been hit hard by RHP this season, especially at home, where he holds a .389 wOBA with a .515 SLG.

Others To Consider (CASH/GPP): 

• George Springer, OF - TOR ($5.8K DK/$3.7K FD)
• Ramon Laureano, OF - SDP ($4.4K DK/$3K FD)
• Trent Grisham, OF - NYY ($4.4K DK/$3.1K FD)

DraftKings, FanDuel MLB DFS Stacks

1. Arizona Diamondbacks (Implied Run Total - TBD) vs Carson Seymour

Even with Coors on the slate, I like Arizona as a stack a bit more against Carson Seymour, who has been terrible in his last few outings. It looks like Matt Gage might open up the game, but Seymour is projected to carry the bulk of the innings. He has given up 10 runs in his last 10.1 innings pitched, including four runs against this very Diamondbacks squad in just 1 and 1/3 innings less than a week ago. Run it back up with this Diamondbacks squad.

Favorite Combo: Perdomo, Marte, Carroll, Thomas

2. Milwaukee Brewers (Implied Run Total - 5.1) vs Caden Dana

The Brewers continue their dominance across the league; they have only been swept twice this whole season! They are ranked the sixth best via wRC+ against RHP this month, with a 119. As a team, they have a wOBA of .340 and a .474 SLG. Caden Dana has had four starts this season and has given up 10 runs in that time. He gave up five runs in his last outing against the Twins. The Brewers could light him up and continue to increase that already high 6.32 ERA.

Favorite Combo: Chourio, Contreras, Turang, Yelich

3. Miami Marlins (Implied Run Total - 5.6) vs Kyle Freeland

I wouldn't say the Marlins are a lock to play just because they are playing in Coors Field. I do love that they are going against the always liable Kyle Freeland. Especially the righties for this Marlins offense should be able to eat against him at home, where he has a 5.82 ERA and is pushing a near .500 SLG. It'll be chalky, but in the right spots, the Marlins are worth a small stack.

Favorite Combo: Hernandez, Marsee, Wagaman, Ramirez

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