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Is Omarion Hampton out for the season? When is Omarion Hampton coming back? The latest Omarion Hampton injury update and fantasy football outlook heading into Week 10 of 2025.
Los Angeles Chargers running back Omarion Hampton (ankle) was in the midst of a meteoric rise in fantasy football rankings, seemingly solidifying himself as one of the best fantasy tailbacks in all of football, before he suffered an ankle injury in Week 5.
He hasn't played in a game since then as he continues to recover. While he's been gone, running back Kimani Vidal has, at times, been a key fantasy football starter, though he's been inconsistent. Fantasy managers who invested early picks in Hampton likely have struggled this year.
Without him, the Chargers offense has still been productive, but the run game has suffered at times. When he comes back, he'll likely give them a boost -- but will it be this year?
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Is Omarion Hampton Out for the 2025 Season?
I don't think so. But if you drafted him, you might have to wait a bit longer for him to return. The latest news we have indicates that he'll return at some point after the team's Week 12 bye. We never got full clarification on what his ankle injury was, but it's likely to be a severe high-ankle sprain.
Most injuries of this nature keep NFL players out for around three to four weeks. Hampton's might have featured fractures or more serious tears to ligaments that needed more time to heal. By the time Week 13 rolls around, he'll have had seven weeks to heal.
Omarion Hampton could not be tackled 😤
LACvsNYG on CBS/Paramount+https://t.co/HkKw7uXnxV pic.twitter.com/tQLrvATbGU
— NFL (@NFL) September 28, 2025
While he will still have a lengthy recovery window, he flashed immense upside when on the field and could return to elite RB2 status when active. As shown in the highlight above, he bullied tacklers. It's pretty impressive. But we won't be seeing that for a while.
Keep in mind that after the Week 12 bye is when his practice window will be opened. It's not a guarantee that he'll return to the field. General consensus seems to think he'll come back for Week 13, but we could see one or even two more weeks missed after that. We'll just have to wait to find out.
Omarion Hampton 2025 Fantasy Football Outlook
When Hampton returns, he'll immediately become a must-start RB with top-8 potential every week. When he was active and after RB Najee Harris (Achilles) got injured, he was the undisputed workhorse of his offense. The current starter, Vidal, didn't get much work at all.
Omarion Hampton goes 54 yards for the TD!
LACvsNYG on CBS/Paramount+https://t.co/HkKw7uXnxV pic.twitter.com/G9X4Jx5KPG
— NFL (@NFL) September 28, 2025
Hampton had impressive games against the Denver Broncos, New York Giants, and was in the midst of a good one against the Washington Commanders before he got hurt. In hindsight, the Giants are one of the league's worst run defenses, so that made sense, and he had just under 3.7 yards per carry against the Broncos.
However, his usage is excellent due to the injury to Harris. He can easily have 20 or more touches per game when he's back to being fully healthy, and in an explosive offense like the Chargers, that can lead to multiple touchdowns.
He's been used quite a bit as a receiver -- in his final three games, he had 18 targets, which led to 17 receptions and 122 yards. That gives him a very nice floor in PPR leagues. There will be no reason to bench him when he's healthy again, regardless of matchup, as players with his role are coveted fantasy football assets.
If you're heading to the fantasy football playoffs or are very likely to make them, and are struggling at the running back position, it might be worthwhile to trade for Hampton if you can get a good deal for him. He would immediately give your team plenty of upside on his return.
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Who Should I Start? Who Should I Sit? Some common Week 10 fantasy football lineup decisions are regarding players like Courtland Sutton, Jordan Addison, Quentin Johnston, Tyrone Tracy Jr.. But not to worry, we are here to help make these decisions and build winning lineups in Week 10. Set your optimal fantasy football lineups for Week 10 of the 2025 NFL season. Our free Who Should I Start? tool will help make your fantasy football lineup decisions. Compare up to four NFL players, and we tell you who to start... all free! Get your winning lineups set, and make the right decisions.
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Popular Week 10 Searches. Curious to see some tough lineup decisions for Week 10 (2025)? Below you will find a list of some popular Who Should I Start? searches that RotoBaller readers are looking at this week. Click any of the links to see the result and recommendation.
Popular Week 10 Searches - Start/Sit Player Comparisons
Below are some popular Week 10 searches and comparisons from our 'Who To Start' tool for Courtland Sutton, Jordan Addison, Quentin Johnston, Tyrone Tracy Jr. compared to others:
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