2025 Fantasy Football QB Rankings - Week 5 Start, Sit Quarterbacks

October 2, 2025

2025 fantasy football QB rankings - Week 5 start, sit quarterback rankings. Win more with our updated QB fantasy football rankings and tiers for Week 5.

A spike week from a quarterback can carry a middling fantasy team to a win, so finding the top available option is key if you don't have a must-start stud. To assist with your start-sit calls, we're back with our Week 5 fantasy football quarterback rankings for 2025. Below, check out where Matthew Stafford, Daniel Jones, Justin Fields, Bo Nix, Drake Maye, Jaxson Dart, and more stand among all QB options.

Our QB fantasy football rankings for Week 5 are put together by Nick Mariano. Below the rankings, you will also find a summary of the important fantasy football news for this week. There are always key injuries and developments to keep track of, so check back throughout the week for updates.

Be sure to bookmark our fantasy football rankings portal and check back regularly for updates. Most importantly, our free mobile app is a must-have - download it and configure your push notifications. We deliver all the top NFL news, injuries, and fantasy analysis 24x7 with our free push notification alerts... all for free!

Week 5 Fantasy Football Quarterback Rankings

Bookmark our PPR rankings, Half-PPR rankings, and standard (non-PPR) rankings 

Week 5 Fantasy Football Quarterback Outlooks

Mac Jones, San Francisco 49ers

San Francisco 49ers quarterback Mac Jones will draw another start when the team kicks off Week 5 on Thursday against the Rams. Starter Brock Purdy is still dealing with soreness related to the turf toe that kept him out of Weeks 2 and 3. In those two games, Jones completed 66.3% of his passes for 563 yards and four touchdowns.

Jones was serviceable in those spot starts, but this time around will be without the services of both Ricky Pearsall (knee) and Jauan Jennings (ankle/ribs), who have been ruled out due to injuries of their own. Missing his top wide receivers and facing a stifling Rams defense, it would be unwise to turn to Jones in the first game of Week 5.

Matthew Stafford, Los Angeles Rams

Los Angeles Rams quarterback Matthew Stafford has plenty of momentum heading into a Week 5 clash against the San Francisco 49ers. He ranks as the overall QB12 in fantasy football this season and is coming off a spectacular outing that saw him rack up 375 yards, three touchdowns, and zero interceptions.

He fared quite well in Week 4, but he did so against the Indianapolis Colts, whose defense is nothing more than average this season. He'll face a tougher test Thursday night in the form of the 49ers, who have allowed the fifth-fewest passing yards and fantasy points to opposing quarterbacks in 2025. Stafford's top-12 upside is undeniable, but he'll rank as a mid-to-high QB2 this week.

Jayden Daniels, Washington Commanders

Washington Commanders quarterback Jayden Daniels (knee) expects to be back in action on Sunday when the Commanders travel to Los Angeles to face the Chargers. When asked about his recovery, the reigning Offensive Rookie of the Year said, "I plan on going out there Sunday." Daniels has missed the last two contests due to a knee sprain. In his absence, veteran Marcus Mariota has taken over QB1 duties in D.C. While he led the Commanders to victory in Week 3, he fell short against the Atlanta Falcons in Week 4.

During this two-game stretch, Mariota has tossed three passing scores and added one with his legs. If Daniels can return to action, fantasy managers should view him as a high-end QB1 in all leagues, despite potentially beginning without his top wideout, Terry McLaurin, who is sidelined with a quadriceps injury.

Carson Wentz, Minnesota Vikings

Minnesota Vikings head coach Kevin O'Connell said this week that his team must cut down on penalties to help backup quarterback Carson Wentz and the offense stay in favorable down-and-distance situations against the Cleveland Browns in London. Wentz threw for 350 yards last week against Pittsburgh, but in part because Minnesota committed several costly offensive penalties, fell behind in the game, and attempted 46 passes.

The Vikings will be without starting left guard Donovan Jackson (wrist), starting center Ryan Kelly (concussion), and starting right tackle Brian O'Neill (knee), and are likely to feature another game plan that includes more quick, high-percentage throws to stay away from the Cleveland pass rush. It's not an ideal situation for Wentz, though he still carries some Superflex value as long as starter J.J. McCarthy (ankle) is out.

Baker Mayfield, Tampa Bay Buccaneers

Tampa Bay Buccaneers quarterback Baker Mayfield (knee, biceps) was unable to take the practice field on Wednesday. Mayfield was limited all last week due to a right biceps injury. Now, it appears Mayfield has picked up a knee injury during last week's game against the Philadelphia Eagles.

That being said, the Bucs have decided to hold Mayfield out on Wednesday. This is a bit concerning for fantasy managers, but it's probably just the Bucs being cautious with their banged-up quarterback. These seem like minor issues that shouldn't cause Mayfield to miss Week 5. However, fantasy managers should check back on Thursday for another update on his status. The absence of Mayfield would likely mean Teddy Bridgewater would start against the Seattle Seahawks in Week 5.

Brock Purdy, San Francisco 49ers

San Francisco 49ers quarterback Brock Purdy (toe) has already been ruled out for the upcoming Week 5 matchup against the Los Angeles Rams. Purdy made his return to the field last Sunday and looked decent under center. Afterwards, head coach Kyle Shanahan revealed that Purdy is dealing with toe soreness, which is likely related to his turf toe injury.

Regardless, there wasn't enough time for Purdy to get ready to play during this Thursday night matchup. The 25-year-old isn't even healthy enough to serve as the emergency backup. The 49ers are fearful that this toe injury could be something that lingers all season long. Fantasy managers better get a viable backup with Purdy already missing three of the first five games of the season. Mac Jones will start under center on Thursday night. Jones has looked solid under center and has some streaming value for this one.

Jaxson Dart, New York Giants

New York Giants quarterback Jaxson Dart (hamstring) was listed as a full participant in Wednesday's practice, according to Jordan Raanan of ESPN. Dart reportedly hurt his hamstring at some point during his first career win over the undefeated Chargers. However, it doesn't appear to be anything serious, as he finished out the game.

It's still important to be aware of, as his legs were a huge part of his performance and drove most of the value generated. If the hamstring injury impacts his willingness to run or effectiveness as a runner, he'll be less appealing as a fantasy starter. And of course, he will also be without his superstar wide receiver Malik Nabers. Dart is right on the QB1/QB2 line for Week 6 in a soft matchup against New Orleans.

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