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Break The Slate: DraftKings DFS Lineup Picks for Week 12

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 12. His top daily fantasy football recommendations to target for DraftKings DFS contests.

Hello again friends! If you've had a chance to look at this slate, then you are probably aware that it is a tough one. Bad players, bad matchups, and bad DFS pricing unfortunately seems to be the theme of Week 12. However, we are all working from the same player pool, which means can still grab an advantage over our competition by putting in the required research and work. Thanks for joining me here at RotoBaller, let's dig in and find some huge scores this week!

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are quite a few great plays available, so read on to find out which players are the best for Week 12.

Good luck with your DraftKings DFS lineups, let's Break The Slate together!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 12 Picks

Matt Ryan - TB @ ATL ($6,700)

This isn't a pretty slate for the QB position (or any position really!). We've got a lot of just-plain-bad QBs and most of the elite signal callers are in less-than-desirable matchups. Matt Ryan is the exception in Week 12, and has been one of the easiest QBs to roster in DFS this year, but DraftKings finally woke up and raised his price tag this week. No matter, I'll gladly pay the freight on him in this matchup. If we throw out the game against the Rams in which he left early with an injury, Ryan has eclipsed the magic 300-yards passing mark in all but one of his starts this season. Throw in the fact that he's facing a Bucs pass defense that is 31st in the NFL in both DraftKings points and passing yards allowed to opposing QBs, and Ryan is a no-brainer on this slate.

Sam Darnold - OAK @ NYJ ($5,800)

This one feels a little gross, but this slate is going to force us to make some uncomfortable decisions. Sam Darnold and this Jets offense hasn't been good, in fact they are last in the NFL in pass offense DVOA, but this game environment should funnel both teams to the air. The Raiders have been competent at stopping the run, but stand just 27th in the NFL in yards allowed per pass this season. Darnold has struggled for the most part this season, but does still show flashes of his franchise-QB potential, with his 293 yard, four TD day against the Redskins last week being a prime example. He has attempted 30 or more passes in every game he's played this season and that volume should once again be there in Week 12 in this winnable matchup.

 

DraftKings DFS Running Backs - Week 12 Picks

Alvin Kamara - CAR @ NO ($8,200)

It's fair to call Alvin Kamara's season a disappointment. The electric Saints back has been inconsistent when on the field and has battle injuries for a good portion of the year. That being said, we're looking for 'slate breakers' in this article and Kamara still possesses the ability to post a tournament-winning score, despite his underwhelming output this season. He draws a good matchup in Week 12, as the Saints are home favorites against a Carolina team that funnels work to the RB position. The Panthers are a solid seventh in pass defense DVOA, but rank DEAD LAST in the NFL in run defense DVOA. Latavius Murray has cut into Kamara's work a bit, but we should still see somewhere from 12 to 16 carries and around 10 targets for AK in this good matchup.

Derrick Henry - JAX @ TEN ($6,900)

If you spend much time listening to DFS podcasts or reading DFS articles, at some point you have probably heard: "I love how this week sets up for Derrick Henry, but you just can't play him on DraftKings!" It's a legitimate argument, as it truly is hard to roster a back that is probably just gonna get 1-3 targets a week in the passing game on a full-PPR site like DraftKings. However, Henry has repeatedly proved that he is capable of posting smash-worthy scores on DK, even without those pesky receptions. He's in a surprisingly good spot against the Jags this week, a team that has a good defensive reputation, but ranks just 30th in run defense DVOA this season. Jacksonville is DEAD LAST in the NFL in yards per carry allowed to opposing RBs and we know that the big Titans back will be steadily fed carries in this run-heavy Tennessee offense, while also handling a huge red zone role.

 

DraftKings DFS Wide Receivers - Week 12 Picks

Odell Beckham Jr. - MIA @ CLE ($7,000)

High-profile acquisition Odell Beckham Jr. has failed to make much of an impact yet, but the Browns are finally beginning to make a concerted effort to get him involved, as OBJ has been targeted a massive 22 times over Cleveland's last two games. The matchup against the lowly Miami Dolphins presents OBJ with a true breakout opportunity. This Dolphins team is playing hard, but just has very few NFL-quality players on the roster. That is especially true on the defensive side of the ball, where Miami ranks as one of the worst defenses in the NFL by basically any metric and grade out 32nd in the league in pass defense DVOA. The Dolphins have allowed 16 TDs to opposing WRs this season on just 179 targets. This matchup, combined with Beckham's newfound usage in Cleveland's fledgling offense, presents him with a great chance to explode this week.

Calvin Ridley - TB @ ATL ($6,500)

Calvin Ridley is a volatile player (as is the nature of the WR position) and I would normally fade him coming off a huge game and getting a $1k price bump, BUT this matchup against Tampa Bay is just too hard to ignore and definitely earns Ridley a mention in this week's article. As I mentioned, Ridley is coming off a monster 8/143/1 outing against the Panthers last week, which demonstrates the type of upside that he has in Atlanta's pass-heavy offense. He's set to square off against a Bucs pass defense that is DEAD LAST in the NFL in DK points, receiving yards, and receiving TDs allowed to the WR position.

N'Keal Harry - DAL @ NE ($3,300)

With not a lot of standout values at the WR position this week, it's worth keeping an eye on the injury status of the Patriots' receiving corps. As of this writing, Phillip Dorsett is in the league's concussion protocol and Mo Sanu is nursing an ankle injury. If either is unable to suit up this week, rookie N'Keal Harry immediately becomes an intriguing GPP option. The explosive receiver's rookie season has been destroyed by injuries and he logged his first action of the season last week, playing 32 snaps against the Eagles and grabbing three of four targets for just 18 yards. This New England offense isn't as explosive as we've seen in the past, but the Patriots drafted Harry in the first round because he's capable of scoring from anywhere on the field. This one depends on the injury situations of the other Pats receivers, so keep an eye on the status of Dorsett and Sanu.

 

DraftKings DFS Tight Ends - Week 12 Picks

Zach Ertz - SEA @ PHI ($6,000)

Is Zach Ertz back? Maybe he never really left. Ertz has been targeted 86 times the year, the second-most targets for a TE, but the production just wasn't there in the first half of the season. He's stepped things up in a big way in Philly's last two, as he's been targeted a RIDICULOUS 22 TIMES and converted for 18 catches, 197 yards, and a TD. We know that the Seattle defense isn't what it once was and they've been especially susceptible to opposing TEs. The Seahawks have allowed 615 yards and four TDs to the tight end position and have allowed an average of 14 DK points per game to the position. With Ertz finally logging some production to go with his massive usage, he's the best option if you're spending up at TE this week.

Vance McDonald - PIT @ CIN ($3,500)

I'm interested in both Jacob Hollister and Ryan Griffin in the $4k range, but if you really need to save some salary at TE you can consider Pittsburgh's Vance McDonald. It's hard to trust any receiver that's relying on Mason Rudolph, but McDonald has been targeted seven times in each of the Steelers last three games. He's likely to see a bump in that already-strong usage both JuJu Smith-Schuster and Diontae Johnson is concussion protocol. We've seen splash games from McDonald in the past and he draws a good matchup against a Bengals Defense that has been middle-of-the-road against tight ends specifically, but ranks 31st in the NFL in overall pass defense DVOA.

 

DraftKings DFS Defenses - Week 12 Picks

Pittsburgh Steelers Defense - PIT @ CIN ($4,000)

It will be tough to pay up at the D/ST position this week, but if you can, go straight to the top and the Pittsburgh Steelers. This isn't a home game for the Steelers, but traveling to Cincinnati to face this winless Bengals team and rookie QB Ryan Finley isn't a matchup to worry about. Pittsburgh has amassed 34 sacks this season, the fourth-most in the NFL, and will be able to tee off on Finley and this spotty Bengals offensive line. The acquisition of Minkah Fitzpatrick has worked wonders for this Steelers unit and they trail just the Patriots for most defensive takeaways this year at 26.

Cincinnati Bengals Defense - PIT @ CIN ($2,000)

Can't afford the Steelers? On the other end of the salary spectrum you can grab the Bengals for the near-min D/ST price of $2.1k. Yes, the Bengals are a very bad football team, but they are squaring off against a Steelers offensive unit that has been inept with Mason Rudolph at the helm. Pittsburgh won't be helped by the absence of JuJu Smith-Schuster and a doubtful James Conner. This is strictly a salary-saving play, but one that has a chance to pay small dividends at the highly-volatile D/ST position.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

Radko Gudas

Unlikely to Play Thursday
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Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
EDM

Kris Knoblauch Fired as Oilers Head Coach
Micah Parsons

Expected to Miss the Early Part of the Season
Colby Parkinson

a Clear Dynasty Sell-High Candidate Entering 2026
Omarion Hampton

Poised for Year 2 Breakout in Los Angeles
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Jaxson Dart

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David Montgomery

Dynasty Stock Rising Following Move to Houston
Chris Godwin Jr.

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Malik Willis

Not Set Up for Immediate Success in Miami
Terrance Ferguson

has Promising Receiving Skills in Crowded TE Room in L.A.
Brenton Strange

Is Brenton Strange a Top-15 Dynasty Tight End?
T.J. Watt

Steelers Ready to Move on From T.J. Watt?
Jacory Croskey-Merritt

Must Make Gains as Pass-Catcher to Take the Next Step
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Kaytron Allen

Could Kaytron Allen Take on a Big Role Right Away?
Demond Claiborne

Has Long-Term Appeal in Minnesota
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Adam Randall

to Contribute as a Pass-Catcher Right Away?
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Nicholas Singleton

Could Contribute Right Away
Bryce Lance

a Perfect Fit in New Orleans?
Mike Washington Jr.

Can Mike Washington Jr. Force a Backfield Split in Vegas?
Paul Reed

Makes Big Impact Off the Bench Wednesday
Adonai Mitchell

Unlikely to be Phased Out of Jets Offense
Daniss Jenkins

Contributes 19 Points As Starter
Cade Cunningham

Tallies 39 Points in Losing Effort
Tony Pollard

an Affordable Add for Contending Dynasty Managers
Max Strus

Notches 20 Points With Six Triples
Evan Mobley

Close to Triple-Double Wednesday
Mason Taylor

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Jarrett Allen

Records Double-Double in Game 5 Win
James Harden

Leads the Way for Cavaliers in Game 5 Victory
Quinn Hughes

Finishes Postseason With 15 Points
Matt Boldy

Posts Two Assists in Season-Ending Loss
Scott Wedgewood

Perfect in Relief Effort
Martin Necas

Records Another Multi-Point Game
Brett Kulak

Sends Avalanche Into Conference Finals
Brayden McNabb

Suspended for One Game
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
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NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
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ACC, Big 12 Support 24-Team College Football Playoff
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Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
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Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
CFB

Isaac Brown Has All-American Upside in 2026
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Nyck Harbor Heading into Breakout Year?
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Notre Dame, USC in Discussions to Resume Rivalry Series
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Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

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Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

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Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
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RP

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