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Break The Slate: DraftKings DFS Lineup Picks for Week 12

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 12. His top daily fantasy football recommendations to target for DraftKings DFS contests.

Hello again friends! If you've had a chance to look at this slate, then you are probably aware that it is a tough one. Bad players, bad matchups, and bad DFS pricing unfortunately seems to be the theme of Week 12. However, we are all working from the same player pool, which means can still grab an advantage over our competition by putting in the required research and work. Thanks for joining me here at RotoBaller, let's dig in and find some huge scores this week!

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are quite a few great plays available, so read on to find out which players are the best for Week 12.

Good luck with your DraftKings DFS lineups, let's Break The Slate together!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

DraftKings DFS Quarterbacks - Week 12 Picks

Matt Ryan - TB @ ATL ($6,700)

This isn't a pretty slate for the QB position (or any position really!). We've got a lot of just-plain-bad QBs and most of the elite signal callers are in less-than-desirable matchups. Matt Ryan is the exception in Week 12, and has been one of the easiest QBs to roster in DFS this year, but DraftKings finally woke up and raised his price tag this week. No matter, I'll gladly pay the freight on him in this matchup. If we throw out the game against the Rams in which he left early with an injury, Ryan has eclipsed the magic 300-yards passing mark in all but one of his starts this season. Throw in the fact that he's facing a Bucs pass defense that is 31st in the NFL in both DraftKings points and passing yards allowed to opposing QBs, and Ryan is a no-brainer on this slate.

Sam Darnold - OAK @ NYJ ($5,800)

This one feels a little gross, but this slate is going to force us to make some uncomfortable decisions. Sam Darnold and this Jets offense hasn't been good, in fact they are last in the NFL in pass offense DVOA, but this game environment should funnel both teams to the air. The Raiders have been competent at stopping the run, but stand just 27th in the NFL in yards allowed per pass this season. Darnold has struggled for the most part this season, but does still show flashes of his franchise-QB potential, with his 293 yard, four TD day against the Redskins last week being a prime example. He has attempted 30 or more passes in every game he's played this season and that volume should once again be there in Week 12 in this winnable matchup.

 

DraftKings DFS Running Backs - Week 12 Picks

Alvin Kamara - CAR @ NO ($8,200)

It's fair to call Alvin Kamara's season a disappointment. The electric Saints back has been inconsistent when on the field and has battle injuries for a good portion of the year. That being said, we're looking for 'slate breakers' in this article and Kamara still possesses the ability to post a tournament-winning score, despite his underwhelming output this season. He draws a good matchup in Week 12, as the Saints are home favorites against a Carolina team that funnels work to the RB position. The Panthers are a solid seventh in pass defense DVOA, but rank DEAD LAST in the NFL in run defense DVOA. Latavius Murray has cut into Kamara's work a bit, but we should still see somewhere from 12 to 16 carries and around 10 targets for AK in this good matchup.

Derrick Henry - JAX @ TEN ($6,900)

If you spend much time listening to DFS podcasts or reading DFS articles, at some point you have probably heard: "I love how this week sets up for Derrick Henry, but you just can't play him on DraftKings!" It's a legitimate argument, as it truly is hard to roster a back that is probably just gonna get 1-3 targets a week in the passing game on a full-PPR site like DraftKings. However, Henry has repeatedly proved that he is capable of posting smash-worthy scores on DK, even without those pesky receptions. He's in a surprisingly good spot against the Jags this week, a team that has a good defensive reputation, but ranks just 30th in run defense DVOA this season. Jacksonville is DEAD LAST in the NFL in yards per carry allowed to opposing RBs and we know that the big Titans back will be steadily fed carries in this run-heavy Tennessee offense, while also handling a huge red zone role.

 

DraftKings DFS Wide Receivers - Week 12 Picks

Odell Beckham Jr. - MIA @ CLE ($7,000)

High-profile acquisition Odell Beckham Jr. has failed to make much of an impact yet, but the Browns are finally beginning to make a concerted effort to get him involved, as OBJ has been targeted a massive 22 times over Cleveland's last two games. The matchup against the lowly Miami Dolphins presents OBJ with a true breakout opportunity. This Dolphins team is playing hard, but just has very few NFL-quality players on the roster. That is especially true on the defensive side of the ball, where Miami ranks as one of the worst defenses in the NFL by basically any metric and grade out 32nd in the league in pass defense DVOA. The Dolphins have allowed 16 TDs to opposing WRs this season on just 179 targets. This matchup, combined with Beckham's newfound usage in Cleveland's fledgling offense, presents him with a great chance to explode this week.

Calvin Ridley - TB @ ATL ($6,500)

Calvin Ridley is a volatile player (as is the nature of the WR position) and I would normally fade him coming off a huge game and getting a $1k price bump, BUT this matchup against Tampa Bay is just too hard to ignore and definitely earns Ridley a mention in this week's article. As I mentioned, Ridley is coming off a monster 8/143/1 outing against the Panthers last week, which demonstrates the type of upside that he has in Atlanta's pass-heavy offense. He's set to square off against a Bucs pass defense that is DEAD LAST in the NFL in DK points, receiving yards, and receiving TDs allowed to the WR position.

N'Keal Harry - DAL @ NE ($3,300)

With not a lot of standout values at the WR position this week, it's worth keeping an eye on the injury status of the Patriots' receiving corps. As of this writing, Phillip Dorsett is in the league's concussion protocol and Mo Sanu is nursing an ankle injury. If either is unable to suit up this week, rookie N'Keal Harry immediately becomes an intriguing GPP option. The explosive receiver's rookie season has been destroyed by injuries and he logged his first action of the season last week, playing 32 snaps against the Eagles and grabbing three of four targets for just 18 yards. This New England offense isn't as explosive as we've seen in the past, but the Patriots drafted Harry in the first round because he's capable of scoring from anywhere on the field. This one depends on the injury situations of the other Pats receivers, so keep an eye on the status of Dorsett and Sanu.

 

DraftKings DFS Tight Ends - Week 12 Picks

Zach Ertz - SEA @ PHI ($6,000)

Is Zach Ertz back? Maybe he never really left. Ertz has been targeted 86 times the year, the second-most targets for a TE, but the production just wasn't there in the first half of the season. He's stepped things up in a big way in Philly's last two, as he's been targeted a RIDICULOUS 22 TIMES and converted for 18 catches, 197 yards, and a TD. We know that the Seattle defense isn't what it once was and they've been especially susceptible to opposing TEs. The Seahawks have allowed 615 yards and four TDs to the tight end position and have allowed an average of 14 DK points per game to the position. With Ertz finally logging some production to go with his massive usage, he's the best option if you're spending up at TE this week.

Vance McDonald - PIT @ CIN ($3,500)

I'm interested in both Jacob Hollister and Ryan Griffin in the $4k range, but if you really need to save some salary at TE you can consider Pittsburgh's Vance McDonald. It's hard to trust any receiver that's relying on Mason Rudolph, but McDonald has been targeted seven times in each of the Steelers last three games. He's likely to see a bump in that already-strong usage both JuJu Smith-Schuster and Diontae Johnson is concussion protocol. We've seen splash games from McDonald in the past and he draws a good matchup against a Bengals Defense that has been middle-of-the-road against tight ends specifically, but ranks 31st in the NFL in overall pass defense DVOA.

 

DraftKings DFS Defenses - Week 12 Picks

Pittsburgh Steelers Defense - PIT @ CIN ($4,000)

It will be tough to pay up at the D/ST position this week, but if you can, go straight to the top and the Pittsburgh Steelers. This isn't a home game for the Steelers, but traveling to Cincinnati to face this winless Bengals team and rookie QB Ryan Finley isn't a matchup to worry about. Pittsburgh has amassed 34 sacks this season, the fourth-most in the NFL, and will be able to tee off on Finley and this spotty Bengals offensive line. The acquisition of Minkah Fitzpatrick has worked wonders for this Steelers unit and they trail just the Patriots for most defensive takeaways this year at 26.

Cincinnati Bengals Defense - PIT @ CIN ($2,000)

Can't afford the Steelers? On the other end of the salary spectrum you can grab the Bengals for the near-min D/ST price of $2.1k. Yes, the Bengals are a very bad football team, but they are squaring off against a Steelers offensive unit that has been inept with Mason Rudolph at the helm. Pittsburgh won't be helped by the absence of JuJu Smith-Schuster and a doubtful James Conner. This is strictly a salary-saving play, but one that has a chance to pay small dividends at the highly-volatile D/ST position.

More Weekly DFS Analysis




REAL-TIME FANTASY NEWS

Micah Parsons

Eyeing a Mid-October Return After Having Another Knee Surgery
Rome Odunze

Foot Injury Still an Issue Going into 2026 Season?
Ketel Marte

Out on Wednesday With Back, Hamstring Injuries
Mitchell Robinson

is Available for Game 1 on Wednesday
Kawhi Leonard

Unlikely to be Traded
Chicago Bulls

Bulls Host Potential Lottery Picks for Workout
Washington Wizards

Wizards Considering Trading Down in Draft
Russell Wilson

Retiring From the NFL
Corbin Burnes

has Teres Major Strain, Unlikely to Return Until September
Malik Davis

Appears to be the Front-Runner for RB2 Job in Dallas
Kayshon Boutte

to Compete for Snaps in Three-Receiver Sets
Alvin Kamara

Attends OTAs on Wednesday
Andrei Iosivas

Is it Time for Dynasty Managers to Drop Andrei Iosivas?
Tyjae Spears

Is Tyjae Spears Droppable in Dynasty Formats?
Jaylen Wright

the Dynasty Handcuff Running Back to Own in Miami?
Colby Parkinson

Facing Likely Regression After Career Year in 2025
Omarion Hampton

Remains a High-End Dynasty RB1 Despite Injury History
Rickie Fowler

Looks To Continue Resurgent Season At Memorial
Ollie Gordon II

Is Ollie Gordon II Still Worthy of a Dynasty Roster Spot?
Justin Herbert

Overhauling his Footwork This Offseason
De'Von Achane

Doing Individual Drills at Minicamp
Ashton Jeanty

Raiders Emphasizing Ashton Jeanty's Progress as Their Lead Back
Marvin Harrison Jr.

Still on the Mend From 2025 Injuries
Brandon Aiyuk

Warrant Issued for Brandon Aiyuk's Arrest in California
Blake Corum

Remains an Elite Handcuff in Dynasty Leagues
Chris Godwin Jr.

Consistency the Key for Chris Godwin Jr. in Dynasty Leagues
David Montgomery

Can Managers Look to Sell High on David Montgomery This Year?
Malik Willis

a Low-Cost Dynasty Target in Miami?
CFB

Can Eric Singleton Jr. Fully Break Out at Third School?
CFB

Katin Houser Steps into QB1 Role for Illinois
CFB

Savion Hiter an Immediate Impact Freshman for Michigan
CFB

Isaiah Horton Set to Take Over KC Concepcion's Role
CFB

UCLA Transfer Karson Gordon Signs with Austin Peay
CFB

Will Muschamp Bringing New Intensity to Texas Practices
Gary Woodland

Brings Boom-or-Bust Potential to Memorial
Jordan Spieth

Still Searching for a Breakthrough
Alex Smalley

Brings Elite Form to Memorial Tournament
Justin Rose

Looks to Recapture Memorial Tournament Success
Cameron Young

Looks to Get Back to His Contending Ways at Murifield Village
Chris Gotterup

Needs to Find Fairways at Muirfield Village
Si Woo Kim

Looks to Stay Hot at Memorial Tournament
Matt Fitzpatrick

Positioned for Success at Muirfield Village
Jalen Chatfield

Records Two Assists in Tuesday's Loss
Keegan Bradley

Looking for Another Strong Finish at Muirfield
Nikolaj Ehlers

Nets Two Goals in Game 1 Loss to Golden Knights
Shea Theodore

Notches Three Points in Game 1 Win
Brayden McNabb

Sets Up Three Goals in Game 1 Win Over Hurricanes
Justin Thomas

is an Exciting Play This Week in Ohio
Brett Howden

Starts Finals With Multi-Point Effort
Scottie Scheffler

Looks to Win Memorial Tournament for Third Consecutive Year
Tomas Hertl

Scores Game-Winner in Finals Opener
Rory McIlroy

Looking for Better Performance at Muirfield Village
Drake Baldwin

Could Return During Braves Next Homestand
Garrett Crochet

Diagnosed With Low-Grade Lat Strain
Russell Henley

Coming to Ohio on the Heels of Latest Victory
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
Isaiah Hartenstein

Hopeful to Stay with Oklahoma City
Luguentz Dort

Wants to Remain with Thunder
Mitchell Robinson

is Questionable for Game 1
Moussa Diabaté

Moussa Diabate Has Contract Guaranteed for 2026-2027 Season
Oso Ighodaro

Gets Guaranteed Contract for Next Season
NAS

Chris MacFarland Joins Predators as President and General Manager
VAN

Canucks Name Manny Malhotra as New Head Coach
Brendan Gallagher

to Leave Canadiens This Offseason
Patrik Laine

Looking Forward to Free Agency
Jeremy Lauzon

Returns to Action Tuesday
Zach Werenski

Wins 2025-26 Norris Trophy
Aaron Judge

Out on Tuesday With Rib/Shoulder Injury
Josh Hader

Set to Return from Injured List on Tuesday
CFB

SEC Coach Calls Buster Faulkner a "Home-Run Hire"
CFB

Auburn a Sleeper in the SEC Under Alex Golesh?
CFB

Noah Fifita Primed for Strong 2026 Campaign
CFB

Oregon Assistant Coach Charged with DUII, Reckless Driving
CFB

Tight End Nick Pollack Commits to Clemson
Akshay Bhatia

Needs the Driver to be True in Ohio
Aaron Rai

Primed to take on the Memorial Tournament
J.J. Spaun

Rebounded at Charles Schwab Challenge
Xander Schauffele

One to Watch This Week in Ohio
Elly De La Cruz

to Miss 2-4 Weeks of Action
Chase Burns

is Scratched Due to Illness
Deiveson Figueiredo

Suffers Second-Round Submission Loss
Song Yadong

Gets Second-Round Submission Win
Zhang Mingyang

Suffers Back-To-Back Losses
Alonzo Menifield

Gets Back In The Win Column
Tallison Teixeira

Suffers First-Round Knockout Loss
Sergei Pavlovich

Scores First-Round Knockout Win
Cameron Smotherman

Suffers Third Loss In A Row
Edwin Arroyo

Reds Promote Top Infield Prospect Edwin Arroyo, Viewed as Priority Pick Up Ahead of MLB Debut
Kai Asakura

Earns His First UFC Win
Elly De La Cruz

Placed on IL with Right Hamstring Tightness
Denny Hamlin

Earns the first Nashville Cup Series Victory of his Career on Sunday
Christopher Bell

Finishes as the Runner-Up at Nashville
Chase Briscoe

Earns First Career Podium Finish at Nashville
Ryan Blaney

Scores A Solid Top-10 Finish at Nashville
Kyle Larson

Top-10 Streak at Nashville Ends after Late Flat Tire Spin
Elly De La Cruz

Exits with Hamstring Tightness
Tyler Reddick

Is One of the Top Favorites to Win at Nashville
Kyle Larson

May Continue his Top-10 Consistency at Nashville this week
Christopher Bell

Is One of the Top Competitors for the Win at Nashville
Chase Briscoe

Is A Must Start for Nashville DFS Lineups
Chase Elliott

has Plenty of Upside for Nashville DFS Lineups
William Byron

Is William Byron A Playable DFS Option for Nashville Lineups?
Carson Hocevar

Is Likely to have Another Solid Result at Nashville
NASCAR

Should Fantasy Players Roster Bubba Wallace at Nashville?
Chris Buescher

Is A Decent All-Around DFS Option for Nashville Lineups
Daniel Suarez

is Likely to Drop Positions during the Cracker Barrel 400
Garrett Crochet

Suffers Setback, Likely to Undergo MRI for Lat Tightness
Denny Hamlin

Could Denny Hamlin Dominate at Nashville?
Ryan Blaney

Is a DFS Tournament Option at Nashville
Ty Gibbs

Don't Overlook Ty Gibbs at Nashville
Joey Logano

Could Show Life at Nashville
Ross Chastain

Needs a Good Run at Nashville
Chet Holmgren

Fails to Step Up in the Season Finale
Cason Wallace

Ends Postseason with Strong Showing
Shai Gilgeous-Alexander

Caps MVP Season with Game 7 Exit
Stephon Castle

Continues Postseason Run with 16 Points
Julian Champagnie

Shines in Series-Clinching Win
De'Aaron Fox

Provides Secondary Punch in Game 7 Triumph
Victor Wembanyama

Earns Conference Finals MVP in Spurs' Game 7 Win
NBA

Warriors Prioritize Depth Around Returning Steve Kerr
Donovan Mitchell

Remains Cleveland's Top Priority
Adou Thiero

Remains a Lakers Development Project
NBA

76ers Hire Mike Gansey as President of Basketball Operations
NBA

Chicago Bulls Explore Kevin Young as Coaching Candidate
Lane Hutson

Posts a Power-Play Assist in Game 5 Loss
Cole Caufield

Nets a Power-Play Goal in Season-Ending Loss
Seth Jarvis

Closes Out East Finals With Multi-Point Game
Logan Stankoven

Notches Three Points in Big Game 5 Win
Taylor Hall

Racks Up Three Points in Series-Clinching Win
Frederik Andersen

Remains Stellar as Hurricanes Clinch Finals Berth
Jacob Gonzalez

is Heading to the Big Leagues
Munetaka Murakami

Exits with Hamstring Tightness
Eury Pérez

Eury Perez is Placed on 15-Day Injured List
Deiveson Figueiredo

Set For UFC Macau Main Event
MMA

Yadong Song Returns At UFC Macau
Alonzo Menifield

An Underdog At UFC Macau
Zhang Mingyang

Set For UFC Macau Co-Main Event
Tallison Teixeira

Looks To Win Back-To-Back Fights
Sergei Pavlovich

A Favorite At UFC Macau
Cameron Smotherman

Looks To Bounce Back
Kai Asakura

Looks To Get Back In The Win Column
CFB

Faizon Brandon In Position to Start Week 1
CFB

Dane Weber Commits to Cal
CFB

Joey McGuire Attempts to Add Texas to Schedule
CFB

Mike Leach on 2027 College Football Hall of Fame Ballot
CFB

Maryland, Baylor Schedule Home-and-Home
CFB

Taron Dickens Decommits From North Carolina
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF