Wide Receiver Matchups to Target in Week 11 (2025) - Jaxon Smith-Njigba, Justin Jefferson, Nico Collins, Rashee Rice, Michael Wilson

November 16, 2025

Kyle's favorite WR vs. CB matchups to exploit for Week 11 of 2025 - DFS wide receivers to target on DraftKings and FanDuel. These WR/CB matchups are GPP and cash game opportunities.

Welcome to the Wide Receiver Matchups to Target column for Week 11 of the 2025 NFL season. We now have 10 games to work with, so we'll use individual performance, matchup grades, pace of play, and implied totals to pinpoint the best WRs to target in daily fantasy lineups. Week 10 wasn't the best, as Justin Jefferson and Jaylen Waddle disappointed, while Davante Adams, Zay Flowers, and Wan'Dale Robinson came close but didn't reach 3x their salaries.

This week, we'll break down the top five WR/CB matchups using Pro Football Focus (PFF) grades, along with key usage metrics that indicate which players can realistically hit three times their DraftKings salary. This is meant to serve as a guide for both cash games and GPPs -- these guys are in position to smash regardless of the contest type you're playing in.

Be sure to jump into our RotoBaller Discord! We have so many different channels devoted to whatever you're playing in fantasy football. We also have lots of great NFL DFS articles and NFL DFS tools to help you win MORE this season! Below are my top five WR vs. CB matchups for this week’s DFS main slate. Use these insights to fine-tune season-long lineups, player props, and DFS builds. Let’s get to it!

Jaxon Smith-Njigba, Seattle Seahawks

• $8.9K on DraftKings, $9.7K on FanDuel
• Vs. Cobie Durant (Los Angeles Rams)

Smith-Njigba has parlayed his furious finish in 2024 into becoming arguably the most dangerous receiver in the NFL in 2025. He ranks first in PFF's grading, yards per route run, and fantasy points per route run, and second in fantasy points per game, expected fantasy points per game, yards per target, and EPA. He ranks second in DK PPG (24) among all skill players on the Week 11 slate, and he has only posted one "down" game all season (13 DK points in Week 4).

JAXON SMITH-NJIGBA 43-YARD TD!

AZvsSEA on CBS/Paramount+https://t.co/HkKw7uXVnt pic.twitter.com/VVdagHvINa

— NFL (@NFL) November 9, 2025

While his matchup against the Rams on Sunday may seem a bit daunting, it's actually much more favorable than it appears. They're allowing the 18th-most fantasy points per game to WRs and rank eighth in pass DVOA, but they rank just 27th in DVOA vs. WR1s this season. They run zone on 82% of snaps, and JSN holds the highest yards per route run vs. zone (5.37) on the slate by a wide margin.

He'll spend a lot of time matched up against Cobie Durant (50th of 112 CBs), who has allowed 298 receiving yards (12.4 yards per reception) and a high 13.3 ADOT (average depth of target) in his coverage this season.

This game is shaping up to be a shootout as it holds a high 48.5-point implied total - getting over the field on the highest-priced WR on the slate feels like the right move in this spot.

Justin Jefferson, Minnesota Vikings

• $7.5K on DraftKings, $8.6K on FanDuel
• Vs. Tyrique Stevenson, Nahshon Wright (Chicago Bears)

Jefferson is now officially underpriced following a subpar Week 10 (7.7 DK points) and having produced just two 20+ DK point games this season. There have been signs of frustration from Jefferson and the Vikings fanbase as rookie QB J.J. McCarthy has struggled with accuracy and feeding his All-Pro receiver. However, this week's clash against the division rival Bears at home is a glorious spot for him to bounce back and remind everyone how special he is.

Chicago has allowed the fourth-most fantasy points per game to WRs this season, trailing only the Cowboys, Steelers, and Commanders. They rank 26th in pass DVOA, 26th in passing yards per game, and have allowed 13 touchdowns to WRs over their nine games this season. They're struggling even more recently, as their 296.3 passing yards per game allowed over their last three contests trails only the Commanders.

Tyrique Stevenson (90th of 112 CBs), Nahshon Wright (78th of 112 CBs), and C.J. Gardner-Johnson (75th of 91 Ss) aren't equipped to stop him, so it's all going to depend on whether McCarthy can get his act together and show off the accuracy he was known for in college at Michigan.

#Vikings WR Justin Jefferson says the way defenses play him takes away “a little bit of the joy” that he once had playing football. Despite that, he still loves playing football:

“I love this job, and I love being here with these guys, being here with this organization.” pic.twitter.com/E8L5KzeJAh

— VikingzFanPage (@vikingzfanpage) November 14, 2025

This matchup could be a shootout, too, as Vegas has it pegged for a high 48.5-point implied total. It's a pace-up game for the Vikings with the Bears ranking ninth in plays per game, which means both teams should get an extra possession or two to accumulate fantasy points. He'll be among the most popular plays at the position, but that's a gamble worth taking as this is a ceiling game waiting to happen.

Nico Collins, Houston Texans

• $6.7K on DraftKings, $8.3K on FanDuel
• Vs. Jalyn Armour-Davis, Darrell Baker Jr. (Tennessee Titans)

Some may be scared off of Collins with backup quarterback Davis Mills drawing another start, but we should continue to roll with him in Week 11. He produced his second-best outing of the year with Mills at the helm last week, finishing with 25.6 DK points thanks to seven receptions for 136 yards in a comeback win over the Jaguars. This week's matchup against the Titans doesn't look great on paper, as the game has the lowest implied total on the slate at 37.5 points, but the matchup against this leaky Titans' secondary is too good to ignore.

Tennessee has allowed the 10th most fantasy points per game to WRs, ranks 22nd in pass DVOA, and ranks 30th in DVOA vs. WR1s. They'll use Jalyn Armour-Davis (109th of 112 CBs) and Darrell Baker Jr. (52nd of 112 CBs) in rotation to cover him, with the former being among the worst cover corners in the league (44.7 coverage rating, 74% catch rate, 16.5 yards per reception allowed).

Both corners allow the highest yards per target on the slate, and with Collins averaging 12 targets per game over his last three contests, he'll have plenty of chances to exploit them in Week 11.

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Rashee Rice, Kansas City Chiefs

• $7.9K on DraftKings, $8.2K on FanDuel
• Vs. Riley Moss, Ja'Quan McMillian (Denver Broncos)

What can we really say about Rashee Rice at this point? He has stepped into the exact role we all thought he would and delivered the WR1-level production expected from a player of his caliber.

He's averaging an absurd 22.4 DK PPG through three weeks. He holds several small-sample metrics that stand out: 27.4% target share (11th among qualified WRs), 32.5% target rate (third), 37.5% red zone target share (third), 2.69 yards per route run (fourth), 0.84 fantasy points per route run (second), 2.59 fantasy points per target (third), and 0.89 fantasy points per route run vs. man (second).

Rashee Rice Is Still A Must-Start Player Despite Tough Matchup In Denver https://t.co/S3Kq7orDIk

— RotoBaller NFL (@RotoBallerNFL) November 15, 2025

The Broncos run a lot of man relative to other teams at 39%, which is significant for a few reasons. First, as stated above, Rice excels against man coverage. Second, Denver will be without their star shutdown cornerback, Patrick Surtain II. This leaves Riley Moss (79th of 112 CBs) and Ja'Quan McMillian (44th of 112 CBs) tasked with slowing down Rice. This is obviously a boon to Rice's Week 11 prospects, and we should prioritize him in all formats.

Michael Wilson, Arizona Cardinals

• $3.8K on DraftKings, $5.5K on FanDuel (DraftKings Only)
• Vs. Upton Stout (San Francisco 49ers)

This is more of an "underpriced WR stepping into a presumed WR1 role" than anything else. Michael Wilson hasn't done much as the distant third option for Arizona behind Marvin Harrison Jr. and Trey McBride, but he will move into the de facto WR1 role with Harrison Jr. having been ruled out for Week 11.

He has been serviceable in his low-volume role this season, particularly as of late, with an 8.0 DK PPG average over his last four games. He has been the WR2 all season in terms of snap share, so we can safely presume that he'll step into the WR1 role with the underwhelming Greg Dortch and the unknown Xavier Weaver slotting in behind him.

The matchup is excellent, too. The 49ers have allowed the 13th-most fantasy points per game to WRs, rank 25th in pass DVOA, and have allowed the fifth-most receiving yards to WRs this season. Upton Stout (111th of 112 CBs) has been a regular in this article as he hasn't covered anyone all season, permitting a sky-high 81.8% catch rate and 345 receiving yards in his coverage this year.

This game should feature plenty of fantasy points, too, as it holds a high 48.5-point implied total. He'll likely be chalky as an obvious pay-down option, but he's a player we need to get in our lineups if we want the top dogs - like JSN - in our lineups.

Thanks for reading, and good luck with your DFS contests!

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