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Oct 2, 2026, 2:49 PM ET

New England Patriots cornerback Christian Gonzalez (shoulder) has been ruled out for his team's Week 4 matchup against the Buffalo Bills, per Ari Meirov of The 33rd Team. A second-team All-Pro in 2024 and a Pro Bowler in 2025, Gonzalez has gotten off to a strong start to the 2026 season with five passes defensed across his first three games played. His absence is a huge blow to the Patriots' secondary, which now looks significantly more vulnerable in a tough matchup against Bills quarterback Josh Allen. Without Gonzalez on the field, fantasy managers should have more confidence starting top Bills wide receiver DJ Moore in Week 4 against New England.--Will Brady
Source: The 33rd Team - Ari Meirov
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Oct 2, 2026, 2:44 PM ET

Los Angeles Rams wide receiver Puka Nacua (groin) will play in his team's Week 4 matchup against the Philadelphia Eagles, per Sarah Barshop of ESPN. However, Barshop adds that Rams head coach Sean McVay said the team is "still working through" how it will navigate Nacua's snap count. Nacua has missed Los Angeles' last two games with a groin injury. While he returned to practice this week and appears to be getting closer to full health, it seems he will not play his usual full-time role in Week 4. The 25-year-old was ridiculously productive for the Rams in 2025, recording 129 catches for 1,715 yards and 10 touchdowns on 166 targets across 16 games. Even with potentially diminished usage, Nacua remains a must-start fantasy wide receiver as long as he's active. Still, fantasy managers may need to downgrade expectations for the star wideout's production against the Eagles on Sunday.--Will Brady
Source: ESPN - Sarah Barshop
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Oct 2, 2026, 2:35 PM ET

Minnesota Vikings head coach Kevin O'Connell said that wide receiver Justin Jefferson (ankle) has been ruled out for Week 4, per Alec Lewis of The Athletic. Jefferson suffered an ankle injury during Minnesota's Week 3 win over the Tampa Bay Buccaneers that knocked him out of the game and prevented him from practicing in any capacity this week. Even while missing most of Week 3, the 27-year-old has recorded 13 catches for 179 yards and two touchdowns on a team-high 17 targets so far this season. With Jefferson sidelined, Vikings wide receiver Jordan Addison jumps up into borderline must-start territory, and veteran wideout Jauan Jennings becomes a semi-intriguing deep-league flex option. Minnesota tight end T.J. Hockenson could be a worthy tight end streamer for fantasy managers in a favorable matchup against Miami as well.--Will Brady
Source: The Athletic - Alec Lewis
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Oct 2, 2026, 2:25 PM ET

San Francisco 49ers principal owner Jed York has been suspended for six games and fined $500,000 for violating the NFL's Personal Conduct Policy, per Tom Pelissero of The Ringer. York was arrested in Ohio in August on suspicion of engaging in prostitution. The original charges were then amended to disorderly conduct and possessing criminal tools, to which York has since pleaded no contest. York took over as the owner, president, and CEO of the 49ers in 2009. Under his control, San Francisco has compiled a 150-129-1 record and made the playoffs eight times, including three Super Bowl appearances. Pelissero reports that York has "stayed away" from the 49ers' first three games, which count towards his suspension. He is first eligible to return to the team on October 20.--Will Brady
Source: The Ringer - Tom Pelissero
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Oct 2, 2026, 2:18 PM ET

New York Giants head coach John Harbaugh said that quarterback J.J. McCarthy spent "most of his time" this week learning New York's offense, and that the team is "still trying to figure out" whether he will be the Giants' QB2 or QB3, per ESPN's Jordan Raanan. With Giants quarterback Jaxson Dart (knee) out for the season, New York acquired McCarthy from the Minnesota Vikings on Monday. McCarthy could eventually take over as the starter for the Giants, but veteran Jameis Winston remains the QB1 in the short term. A former first-round pick, McCarthy threw for 1,632 yards, 10 touchdowns, and 11 interceptions across 10 starts with Minnesota in 2025. While the 23-year-old has struggled to this point in his NFL career, his mobility may make him a more natural replacement than Winston for Dart in the Giants' system. If McCarthy eventually takes over as the starter in New York, he could be worth starting in the right matchups in two-quarterback fantasy formats.--Will Brady
Source: ESPN - Jordan Raanan
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Oct 2, 2026, 2:09 PM ET

Indianapolis Colts wide receiver Keenan Allen (groin) is officially questionable to play in his team's Week 4 matchup against the Washington Commanders with a groin injury, per Nathan Brown of The Indianapolis Star. Allen is coming off his best game of the young season, recording six catches for 63 yards and a touchdown on nine targets in Week 3 against the Houston Texans. With Colts wide receiver Alec Pierce (heel) currently on Injured Reserve, a healthy Allen profiles as the team's WR2 alongside Josh Downs. However, Allen was listed as a non-participant in the Colts' walkthrough on Friday and could be in real danger of being inactive on Sunday. If Allen is sidelined, Downs and Colts tight end Tyler Warren could absolutely dominate the team's target share in Week 4 against Washington.--Will Brady
Source: The Indianapolis Star - Nathan Brown
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Oct 2, 2026, 2:00 PM ET

Minnesota Vikings All-Pro wide receiver Justin Jefferson (ankle) left the team's Week 3 win over the Buccaneers with an ankle injury, and while the initial messaging after the game suggested he was close to returning to action, he has not practiced since and was absent again on Friday. With his Week 4 availability in serious question, fourth-year wide receiver Jordan Addison becomes a usable flex play after leading the team with 90 receiving yards and a touchdown in Jefferson's absence. While the Vikings are 10.5-point favorites over the Dolphins, the potentially lopsided matchup could significantly lower Addison's ceiling, even if serving in the primary pass-catching role. Miami has been the third-worst matchup for fantasy receivers, as they've offered little resistance on the ground.--Patrick McGrath
Source: Kevin Seifert
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Oct 2, 2026, 1:49 PM ET

After suffering a shoulder injury in the team's Week 3 win over the Seahawks, Washington Commanders running back Rachaad White (shoulder) failed to make a practice appearance this week and has now been ruled out for a Week 4 matchup with the Colts, to be played in London, England. White has handled the second-most carries on the team, behind Jacory Croskey-Merritt, and his absence could open the door to increased opportunity for sixth-round rookie Kaytron Allen. Quarterback Jayden Daniels (elbow) has already been ruled out for his second straight game, while wide receiver Terry McLaurin injured his hamstring during Friday's practice and is now listed as questionable. Against a suddenly undermanned Commanders offense, the Colts DST becomes an interesting streaming option in Week 4.--Patrick McGrath
Source: John Keim
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Oct 2, 2026, 1:38 PM ET

Following a physical Monday night win over the Eagles, Chicago Bears running back D'Andre Swift (knee) popped up on the Week 4 injury report, missing Thursday's practice with a knee issue. On Friday, head coach Ben Johnson told reporters that his lead running back is "still feeling the effects of a Monday night football game." Still, he offered optimism about Swift's Week 4 availability, sharing that he is expected to practice today. Swift has arguably been the Bears' best offensive player through three games, and he comes into the week as the fantasy RB6. Ahead of a matchup with the Jets, who rank in the bottom half of the league against fantasy backs, he is RotoBaller's RB15, but his status will need to be monitored when the Bears release their final injury report of the week.--Patrick McGrath
Source: Brad Biggs
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Oct 2, 2026, 1:26 PM ET

As has been the case since injuring his shoulder in a Week 2 matchup with the Lions, Buffalo Bills wide receiver DJ Moore (shoulder) was still sporting a red non-contact jersey at Friday's practice, as spotted by team reporter Sal Capaccio. A week after sandwiching two limited practices around a DNP, Moore has been present at every practice ahead of a divisional clash with the Patriots and is trending toward another full workload after leading the Bills with 10 targets in a Week 3 win over the Chargers. With Patriots All-Pro cornerback Christian Gonzalez (shoulder) dealing with his own shoulder injury and absent from the first two practices of the week, Moore could be in line for a big day and is RotoBaller's WR21 for the week.--Patrick McGrath
Source: Sal Capaccio
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Oct 2, 2026, 1:14 PM ET

Washington Commanders wide receiver Terry McLaurin (hamstring) suffered a hamstring injury during Friday's practice and is now questionable for the team's Week 4 matchup with the Colts in London, England, according to beat reporter Tashan Reed. McLaurin missed significant time in 2025 while dealing with a recurring quadriceps injury, but he has led the Commanders receiver room with a 77.6% snap participation through three weeks. If McLaurin is unable to play in what projects as a favorable matchup, veteran Stefon Diggs would see an obvious boost, but with quarterback Jayden Daniels (elbow) already ruled out for his second consecutive contest, it may be best to simply fade the Commanders offense as a whole.--Patrick McGrath
Source: Tashan Reed
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Oct 2, 2026, 12:58 PM ET

Chicago Bears quarterback Caleb Williams (hamstring) has been ruled out for Week 4's matchup against the New York Jets. Williams suffered a hamstring strain in Week 2's loss to the Minnesota Vikings and will now miss his second straight game. In two games this season, Williams has completed 36 of 55 passes for 407 yards, with two touchdowns and one interception, and has added 107 rushing yards and two touchdowns on 15 carries. With Williams out, the team has not yet announced who will start in Week 4, though both Tyson Bagent and Case Keenum are healthy. While there is no timeline for Williams' return, their Week 5 game against their division rival, the Green Bay Packers, could be a possible return date.--Nathan Harvey
Source: Brad Biggs
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Oct 2, 2026, 12:52 PM ET

Cleveland Browns defensive tackle Mason Graham (knee/ankle) is expected to miss time due to a sprained MCL and ankle. Graham was tangled up on a run play in the second quarter and couldn't return in the 27-24 win over division rival Pittsburgh Steelers. In the first three games of the 2026 season, Graham had four sacks, 15 tackles, and six tackles for loss, all ranking near the top among defensive tackles. With Graham expected to miss a few weeks, Adin Huntington and Mike Hall Jr. will see increased snaps in his absence. Given Graham's strengths in the run game, fantasy managers should be more inclined to target the Browns' run defense in the coming weeks.--Nathan Harvey
Source: Ian Rapoport - ESPN/NFL Network
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Oct 2, 2026, 12:50 PM ET

Carolina Panthers wide receiver Xavier Legette (knee) has been ruled out for Week 4's matchup against the Detroit Lions. After missing all of practice this week, Legette will miss his second straight week due to the knee injury. In two games this season, he has caught two of six targets for 64 yards, playing 53% of snaps and running 61% of routes. With Legette out and Jalen Coker (quad) questionable, the Panthers could be thin at wide receiver behind second-year Tetairoa McMillan. With their bye week coming up in Week 5, Legette's next chance to return would be Week 6, when they travel to take on the Philadelphia Eagles.--Nathan Harvey
Source: Joe Person - The Athletic
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Oct 2, 2026, 12:49 PM ET

Seattle Seahawks quarterback Sam Darnold is a potential streamer in Week 4 against a Los Angeles Chargers defense that has fallen short of expectations this season. The Chargers are allowing 244.7 passing yards per game to opposing quarterbacks. Darnold is fresh off a 379-yard outing in Washington and will return home with a need for a win. Darnold's chemistry with wide receiver Jaxon Smith-Njigba is undeniable. He should find JSN early and often. Given the Chargers' defensive woes, Darnold has a chance to toss a couple of touchdown passes as well. While he may not carry a massive ceiling, Darnold certainly enters this week with a nice floor. If you are reeling with quarterback injuries or poor play, you can turn to Darnold this week. Darnold is readily available on waivers and generally not considered a starting option, so you should be able to grab him and plug him in immediately.--Quincy Milton III - RotoBaller
Source: RotoBaller

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