Wide Receiver Matchups to Target in Week 12 (2025) - Amon-Ra St. Brown, Stefon Diggs, A.J. Brown, Zay Flowers, Luther Burden III

Kyle's favorite WR vs. CB matchups to exploit for Week 12 of 2025 - DFS wide receivers to target on DraftKings and FanDuel. These WR/CB matchups are GPP and cash game opportunities.

Welcome to the Wide Receiver Matchups to Target column for Week 12 of the 2025 NFL season. We now have 11 games to work with, so we'll use individual performance, matchup grades, pace of play, and implied totals to pinpoint the best WRs to target in daily fantasy lineups. Week 11 was an up-and-down ride as Jaxon Smith-Njigba, Nico Collins, and Michael Wilson all smashed, while Justin Jefferson and Rashee Rice gave us letdown performances.

This week, we'll break down the top five WR/CB matchups using Pro Football Focus (PFF) grades, along with key usage metrics that indicate which players can realistically hit three times their DraftKings salary. This is meant to serve as a guide for both cash games and GPPs -- these guys are in position to smash regardless of the contest type you're playing in.

Be sure to jump into our RotoBaller Discord! We have so many different channels devoted to whatever you're playing in fantasy football. We also have lots of great NFL DFS articles and NFL DFS tools to help you win MORE this season! Below are my top five WR vs. CB matchups for this week’s DFS main slate. Use these insights to fine-tune season-long lineups, player props, and DFS builds. Let’s get to it!

Amon-Ra St. Brown, Detroit Lions

• $8.0K on DraftKings, $9.2K on FanDuel
• Vs. Deonte Banks, Andru Phillips (New York Giants)

The immensely talented Amon-Ra St. Brown is the top choice at wide receiver in Week 12. He's coming off a brutal game in which he finished with two catches and 6.2 DK points against the Eagles, both season lows. However, his letdown wasn't due to a lack of volume, as he saw 12 targets, further contributing to his 31.4% target share (fifth among qualified WRs).

He ranks fourth in targets, second in red zone targets, third in first-read targets, fourth in receptions, eighth in receiving yards, seventh in yards after catch, and sixth in fantasy points per game among qualified receivers. He's going to be just fine, and this week's matchup is a golden opportunity for him to get back in the WR1 ranks.

Since entering the NFL in 2021, Amon-Ra St. Brown leads the NFL in crossing route targets (111), receptions (88), and is the only receiver with over 1,000 receiving yards on crossing routes in that span (1,084).#TBvsDET | #OnePridepic.twitter.com/w1670IynBX

— Next Gen Stats (@NextGenStats) October 20, 2025

The Giants have allowed the sixth-most fantasy points per game to WRs, rank 20th in pass DVOA, and rank 22nd in pass DVOA vs. WR1s. They've allowed the third-most receptions and the fourth-most receiving yards to the position. Deonte Banks (104th of 110 CBs) and Andru Phillips (83rd of 110 CBs) can't cover anyone, evidenced by their 70.2% and 87% catch rates, respectively. This is an absolute smash spot for St. Brown and the Lions offense at home, and I expect they'll be running up the score after their Week 11 letdown.

Stefon Diggs, New England Patriots

• $6.5K on DraftKings, $6.7K on FanDuel
• Vs. Dax Hill, Josh Newton (Cincinnati Bengals)

The mercurial veteran receiver is having himself an excellent season, logging 59 receptions for 659 yards and three scores in the Drake Maye-led offense. The three touchdowns have all come in the last four games, a stretch where Diggs has averaged 15.3 DK PPG with a ceiling game of 22.5 DK points in Week 11. He may have lost a little juice, but he has shown that he's still a dependable WR1 in the right scheme. He ranks 13th in red zone targets, seventh in receptions, 14th in receiving yards, eighth in yards per route run, and fourth in expected points added this season.

OH MY TOE TAP STEFON DIGGS 🤯

📺 CBS pic.twitter.com/M7Zm9LTh6c

— New England Patriots (@Patriots) November 9, 2025

The Bengals rank last in pass DVOA, last in PFF's defensive grade, and 27th in PFF's coverage grade. They're middle-of-the-pack in terms of fantasy points allowed to WRs, but that's only because their games tend to skew on the non-competitive side ever since Joe Burrow got hurt. Burrow is tracking to play, so this game should stay competitive and force the Patriots to throw.

Diggs will run a lot of routes out of the slot against Dax Hill (60th of 110 CBs), who has allowed a 76% catch rate, 251 receiving yards, and four touchdowns in his coverage this season. The Patriots have an implied total of 28.5 points, and the matchup has the highest on the slate at 51.5 points. Fire up Diggs in all daily formats this week.

A.J. Brown, Philadelphia Eagles

• $5.9K on DraftKings, $7.9K on FanDuel
• Vs. Caelen Carson, DaRon Bland (Dallas Cowboys)

A.J. Brown has had a very up-and-down season as the Eagles have floundered at times on offense. He has a disappointing 12 DK PPG average this year, but that doesn't tell the whole story. Brown exploded for 31.1 DK points with 121 yards and two scores in Week 7, but that was followed by a game where he caught 2-of-3 targets for 13 yards and 3.3 DK points. That's the type of season it has been for him, but if there's one thing we know for sure this year, it's that anyone can have success against this terrible Cowboys secondary.

Dallas has allowed the most fantasy points per game and total touchdowns (17) to WRs this year. They also rank 30th in pass DVOA, 30th in pass DVOA vs. WR1s, 30th in PFF's defense grade, and 29th in PFF's coverage grade.

Caelen Carson (unranked) and DaRon Bland (29th of 110 CBs) aren't striking fear into any receiver's hearts, with the latter having allowed 10 receptions on 12 targets for 143 yards and a score the last time he faced a team with WR1-level receivers (Arizona, Week 9). This is a smash spot for Brown and the Eagles offense; it's just a matter of them taking advantage of the mismatches.

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Zay Flowers, Baltimore Ravens

• $6.3K on DraftKings, $7.0K on FanDuel
• Vs. Jarvis Brownlee Jr., Qwan'tez Stiggers, Brandon Stephens (New York Jets)

We're going back to the well with Zay Flowers, who seems to be in favorable matchups at a reasonable salary more often than not this season. He has consistently finished in the double-digits for DK points, but the problem is that he has failed to produce any ceiling games following his monster Week 1. He has put up 14-ish DK points on three occasions, but that seems to be his ceiling, as he isn't heavily targeted and has only reached the end zone once this year.

That could change in Week 12. The Jets rank 31st in pass DVOA, 27th in pass DVOA vs. WR1s, and 23rd in PFF's coverage grade. They're much better against the run, so it stands to reason that the Ravens will try to beat them through the air. He should see the most snaps against Jarvis Brownlee Jr. (99th of 110 CBs), who has allowed an 80% catch rate over his two games played this season. This may be an uncompetitive game as Baltimore is favored by 13.5 points at home, but Flowers should be able to feast in this matchup.

Luther Burden III, Chicago Bears

• $3.6K on DraftKings, $4.7K on FanDuel (DraftKings Preferred)
• Vs. Darius Slay, Brandin Echols (Pittsburgh Steelers)

The exciting rookie out of Missouri has been kept under wraps, with veteran plodder Olamide Zaccheaus frustratingly playing over him for most of the season. However, the tides seem to be changing over the last few weeks. Burden III has played 49% and 44% of snaps in the previous two weeks, while Zaccheaus has played in 57% and just 13% over the same span.

Zaccheaus has done next to nothing lately, scoring 1.5 and 0 DK points, while Burden has outperformed him with 8.1 and 5.7 DK points. His eight targets in Week 10 and Week 11 rank second among receivers in Chicago, signaling that Burden III is emerging as the WR3 (and potentially WR2 over DJ Moore) in this high-powered offense.

Luther Burden III has Earned "Increased Snaps" https://t.co/CEFhwBLoK9

— RotoBaller NFL (@RotoBallerNFL) November 20, 2025

The matchup this week can't get much better, either. Pittsburgh has allowed the third-most fantasy points per game and ranks 25th in pass DVOA vs. WR3s this season. They've allowed the most receptions and the second-most receiving yards to WRs this season, despite having only played 10 games.

This should be a competitive game with the Bears favored by just 2.5 points at home, so there's a good shot we'll see Caleb Williams and the Bears have a successful fantasy day in Week 12. It also helps that Chicago ranks #1 in plays per game over their last three contests (71), which should translate to more chances for Burden III to make some noise at his bargain-bin salary.

Thanks for reading, and good luck with your DFS contests!

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