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DraftKings Daily Fantasy Baseball Picks (9/25/19): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on September 25th, 2019. Austyn Varney's MLB DFS analysis and sleepers for building optimal DFS rosters.

We have a nice 12-gamer on our hands tonight with plenty to look at. Without a game in Coors Field, we at least have some balance to things. There are four or five pitchers worth targeting and we'll have to narrow them down. There are another four or five offenses that are in great spots, and we'll have to disect those as we move along.

Let's dive in to some of the top plays on this slate!

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 9/25/19. The lineup picks will range from some of the elite players to mid-priced options and value plays. Be sure to also check out all the MLB Rosters for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too.

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DraftKings DFS Starting Pitchers

Jacob deGrom - NYM vs. MIA - $12,000

This is pretty easy. Jacob deGrom has been right up there with Gerrit Cole in the second half as the best pitcher in all of baseball. You can almost pencil in seven innings and as many strikeouts. He's striking out 11 batters per nine on the season and is walking just 1.96. He now draws the Marlins, who rank dead last in baseball against right-handed pitching with a .277 team wOBA. They got to Matz and Syndergaard a bit the last two nights, but the fun ends tonight when deGrom slams the door.

Frankie Montas - OAK @ LAA - $10,100

Frankie Montas is returning from suspension today, and is supposedly all the way stretched out. Montas was dominant prior to being suspended, and he wasn't on an HGH that would have lead to much performance enhancement. He draws the Angels today, who rank in the bottom five of baseball against righties without Mike Trout in the lineup. Montas has struck out 9.70 batters per nine and has posted a sub .2885 wOBA against both lefties and righties. The upside is huge and I doubt many will be on him in his first game back. He's certainly a bit risky, but the upside is huge if I'm right and there is no pitch count.

 

DraftKings DFS Infielders

Roberto Perez - CLE @ CWS (Detwiler) - $3,900

Perez is a guy I’ve rostered a ton this year, as he’s an excellent source of power at an affordable tag. He’s now up to 23 home runs on the season and his price is still solid. He’s better against lefties, and has more power against them. The Indians are facing off with Ross Detwiler tonight, who’s legitimately been one of the worst pitchers in all of baseball. A 5.57 xFIP and 18 home runs allowed in 55 innings of work tells you all you need to know. Perez is affordable on DK and will come up at least once with some RISP.

Anthony Rizzo - CHC @ PIT (Agrazal) - $5,100

This Cubs team is all but out of the playoff race, but the offense won't stop producing. They're facing off with Dario Agrazal tonight, who's an absolutely terrible pitcher all season long. Against lefties, he’s posted a 6.26 xFIP and strikes out just five batters per nine innings. Rizzo is as good as it gets against righties, sporting a .408 wOBA and blasting 21 homers on the season. PNC Park is better for lefties and Rizzo is a great play in all formats.

Ozzie Albies - ATL @ KC (Montgomery) - $4,900

Rinse and repeat with Ozzie Albies and lefties. The .396 batting average is crazy in itself, but the .455 wOBA is even more impressive. The Braves struggled last night, but Mike Montgomery should help get them going. He’s given up a .358 wOBA to righties and 14 home runs in just 68 innings of work. Albies will be in the two-hole and makes for the top play at second base, regardless of price.

Anthony Rendon - WSH vs. PHI (Smyly) - $5,400

Rendon is expensive here, but this is one of my favorite spots for him on the entire season. Drew Smyly has been a bit better recently, but he’s had a brutal year in every measure. The most glaring and telling stat is 31 home runs allowed in just over 100 innings pitched. It’s fair to expect at least one or two of these Nats to go deep. Rendon has held a .410 wOBA against southpaws and has as much upside as anyone on the slate. In cash games, he’s my bat of choice.

Kevin Newman - PIT vs. CHC (Lester) - $4,200

I’ve been recommending some pricey options, so let’s look at a bit of a salary saver in Kevin Newman. The Pirates are facing off with Jon Lester, who’s a shell of himself at this point and he’s struggled with righties (.342 wOBA). The Pirates will throw seven or eight righties his way and they should be able to connect on a few homers. Newman has posted a .327 wOBA against lefties on the season and will be leading off. He’s solid in all formats. If you’re looking to pay up, the hot bat of Trea Turner is hard to get away from against Drew Smyly.

 

DraftKings DFS Outfielders

J.D. Martinez - BOS @ TEX (Allard) - $5,000

I don’t know if it’s just me, but J.D. Martinez still flies under the radar against left-handed pitching. The .536 wOBA in over 140 plate appearances is completely unheard of. He now goes to hitter-friendly Arlington and faces off with a guy in Kolby Allard that’s struggled with right-handed power. There are a lot of bats to pay up for tonight, but it’s hard to see anyone outside of Rendon with the upside Martinez has.

Yasiel Puig - CLE @ CWS (Detwiler) - $4,500

We’ll bookend the outfield with another Cleveland Indians bat that has a ton of upside. We looked at Roberto Perez at C, and now Yasiel Puig in the outfield. Puig has been swinging a hot bat lately and that matters more than it does for most. Ross Detwiler is putrid against righties, and he has a huge issue with giving up hard contact. That’s where Puig excels. He won’t be over 10% owned and is my pick for home run of the night. Good luck and feel free to reach out on Twitter with any questions!

Things change quickly as lineups come out. If you have any questions, hit me up on Twitter @VarneyDFS and I'd be more than happy to help.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Out Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Isaac TeSlaa

Can Isaac TeSlaa Carve Out a Larger Role in Detroit Going Forward?
Troy Franklin

Facing Uphill Battle for Playing Time in Denver
Trevor Lawrence

Should Trevor Lawrence Be Valued as a Dynasty QB1?
Courtland Sutton

in Line for Reduced Role in Denver?
KC Concepcion

Can KC Concepcion Immediately Assume the WR1 Role in Cleveland?
George Pickens

' Dynasty Outlook Clouded by Uncertain Future in Dallas
Trevor Story

Hits the Injured List With Groin Injury
Brandon Aiyuk

a Huge Question Mark for Dynasty Managers
Deebo Samuel Sr.

Now Only a Gadget Player/Kick Returner?
Elic Ayomanor

Offseason Additions Hurt Elic Ayomanor's Dynasty Outlook
Tyler Warren

a Clear Top-Five Dynasty Tight End
Jonathon Brooks

a Dynasty RB to Target Despite Injury History?
Blake Snell

Likely to Need Elbow Surgery
Tyler Allgeier

Currently in a Dynasty Buy Window Amid Rollercoaster Offseason
A.J. Brown

Timing Becoming Key to Acquiring A.J. Brown in Dynasty
Quentin Johnston

Is Quentin Johnston on the Verge of a Dynasty Breakout?
Jahmyr Gibbs

Is Jahmyr Gibbs the Dynasty RB1?
Isaiah Likely

The Long-Called-For Isaiah Likely Breakout Could Finally Arrive in 2026
Duncan Robinson

Nets 14 Points With Four Triples
Cade Cunningham

Contributes 21 Points in Game 6 Win
Jalen Duren

Bounces Back With Double-Double
Anthony Edwards

Finishes Season-Ending Loss With 24 Points
Victor Wembanyama

Tallies 19 Points in Friday's Win
De'Aaron Fox

Highly Effective in Blowout Win
Stephon Castle

Shines in Series-Clincher
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Austin Reaves

Could Command $40M Per Year With New Contract
Jalen Duren

Available to Finish Game 6
Yanic Konan Niederhauser

Not Expected to Be Ready for Start of Next Season
Jalen Williams

Declares Himself Healthy for Conference Finals
Terrence Shannon Jr.

Will Play Friday Night
Kevin Huerter

is Available for Game 6
Duncan Robinson

is Returning for Game 6
Caris LeVert

is Cleared for Game 6 on Friday
OG Anunoby

Practices in Full on Friday
Terrence Shannon Jr.

is Tagged as Questionable for Friday
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Luther Burden III

Does Luther Burden III Have WR1 Dynasty Upside in Chicago?
MarShawn Lloyd

Can MarShawn Lloyd Emerge as a Top Dynasty Handcuff Option?
Emanuel Wilson

Can Emanuel Wilson Carve Out a Consistent Role in Seattle?
Max Fried

Heading to Injured List With Elbow Bone Bruise
Jaylin Noel

Playing-Time Outlook in Houston Remains Unclear
Dylan Sampson

Role in Cleveland Looks Secure Heading into 2026
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Karl-Anthony Towns

Making an Impact as Playmaker in Playoffs
Jalen Duren

Determined to Improve
Kevin Huerter

Tagged as Questionable for Game 6 Against Cavaliers
Caris LeVert

Considered Questionable for Friday
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
Radko Gudas

Unlikely to Play Thursday
Jeremy Lauzon

Remains Out Thursday
Mark Stone

Misses Third Consecutive Game
EDM

Kris Knoblauch Fired as Oilers Head Coach
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Quinn Hughes

Finishes Postseason With 15 Points
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF