X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings Daily Fantasy Baseball Picks (4/25/21): MLB DFS Lineups

Brandon Woodruff - Fantasy Baseball Rankings, MLB Injury News, DFS Lineup Picks

The top daily fantasy baseball lineup picks for DraftKings on 4/25/21. Euan Leith's MLB DFS analysis and sleepers for building optimal DFS rosters.

We've got a giant main slate with a dozen games starting at 1:05 pm Eastern. The Braves and Diamondbacks have a double dipper in Atlanta, so their game in this set will only go seven innings. In the grand scheme of things that may only cost us one at-bat, but we have seen ownership plummet for these seven inning games. That's a way to gain some leverage.

Rain is going to be a problem in the northeast today. I'll be shocked if Boston plays at all. I'm cutting this slate down to 11 games right now. That one is too risky for me to mess with. They can play in New York if they wait the rain out, but we have teams less willing to do that this year. There is a chance of light snow in Minneapolis. That's not going to be a good game with the cold and wind blowing in anyway. The wind is also blowing in in Wrigley and Cleveland. We do have a nice wind blowing out in Detroit and Atlanta though.

This article will provide you with my daily fantasy baseball lineup picks for DraftKings on 4/25/2021. The lineup will range from some of the elite players to mid-priced options and value plays. You can also check out today's FanDuel MLB DFS lineup picks and read more DFS advice and lineup picks for other sports too. It’s also important to monitor injury news and today's MLB starting lineups. If you have any questions or comments, contact me on Twitter.

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

DraftKings DFS Starting Pitchers

Brandon Woodruff - MIL at CHC ($9,400)

This will be Woodruff's 11th career start against the Cubs, but he only has one decision against them. Part of it is bullpen issues. Part of it was Woodruff not lasting long in starts, particularly early on in his career. The current Cubs roster is hitting a dismal .147 in 109 at-bats against Woodruff, so it's not a fluke. He has a career 2.95 ERA at Wrigley Field. With the wind blowing in, this looks like an elite spot for Woodruff with the way that he's been pitching this year. Woodruff has sparkling numbers across the board. A big reason for that is he has not allowed a ball hit on the barrel of an opponents bat yet. As you would expect, the hard hit percentage is also way down. I expect a really strong start out of Woodruff here.

Danny Duffy - KC at DET ($8,000)

Duffy has allowed just one earned run in 18 innings so far this year with 19 strikeouts. We have seen flashes of brilliance from Duffy here and there throughout his career. He has always been a highly-touted prospect, but has never really put anything together. There is some reason for optimism this year. Duffy's velocity is up across the board and there is a lot more movement on his four-seamer and curveball. And honestly, this is a dream matchup for Duffy. The Tigers are hitting a dismal .179 against southpaws this year and were completely shut down by fellow lefty Mike Minor on Friday. The Tigers are striking out an alarming 35.9% against lefties this year. Duffy may regress at some point, but it shouldn't start here.

Other Options: John Means ($8,900), Kohei Arihara ($7,000), Michael Kopech ($6,900)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings DFS Infielders

Andrew Knizner - C, STL vs. CIN ($2,200)

Predicting who catches on Sunday afternoons can be a daunting task, but the Cardinals are still without Yadier Molina and Knizner has filled in pretty well for him. The price is low despite Luis Castillo getting absolutely destroyed by the Cardinals on Opening Day, and really not looking good in a start since. Knizner homered off of Castillo in the only game that he has started against him. For this low of a price, it's worth seeing if he can do it again.

Joey Votto - 1B, CIN at STL ($4,400)

Is Votto back? The four homers in a nice touch, but the .225 average leaves something to be desired. His walk rate is also the lowest of his career. Now the good news: The hard hit percentage is by far the best of his career and a .312 xBA suggests that Votto has been a little unlucky so far this year. The launch angle, exit velocity, and hard hit percentage are all at or above his marks during his heyday. Votto is absolutely mashing fastballs this year, which is exactly where Jack Flaherty has been struggling. History is on Votto's side too. He is 6-13 in his career against Flaherty.

Adam Frazier - 2B, PIT at MN ($4,400)

Frazier is firmly entrenched atop this Pirates lineup and has been one of the few bright spots in it thus far. Matt Shoemaker has always been a junkballer, but is has caught up to him in recent years. His 6.28 ERA looks bad, but the xERA of 7.23 suggests that he should be even worse. Opponents have a staggering 17% barrel percentage against Shoemaker so far. Frazier profiles well against Shoemaker's best pitches, the sinker and splitter. The other Frazier (Todd) is the only Pirate that profiles better, but you have to have some stones to run with the Toddfather right now.

J.D. Davis - 3B, NYM vs. WAS ($3,400)

Something is off with Patrick Corbin. His strikeout rate so far is by far the lowest rate of his career. Though the 10.95 ERA is a little bloated, his xERA is still a catastrophic 7.06. If there weren't a good track record attached to Corbin, he wouldn't even be in the majors right now. It's not even a velocity issue for Corbin. His velocity is fine. Hitters just aren't chasing his pitches anymore. His fastball and slider are getting crushed right now. I'll have a few five-man Mets stacks, but they will all start with Davis. Not only does Corbin struggle with right handed power, Davis has a .462 ISO with three homers in 26 career at-bats against Corbin. He may as well be hitting off a tee.

Eugenio Suarez - SS, CIN at STL ($5,300)

Normally I wouldn't go out of my way to run hitters at guys like Luis Castillo and Jack Flaherty, but they are both off this year. Both are suffering about a 1.5 MPH loss on the fastball from last year. What's even more concerning for Flaherty is that he is missing a lot of movement on his slider and fastball. The only thing worse than throwing a pitch slower is not having it move effectively. Suarez homered off of Flaherty on Opening Day, his third off of Jack in just 15 at-bats. This is DFS, people. If we aren't chasing homers, what the hell are we even doing out here?

 

DraftKings DFS Outfielders

Byron Buxton - OF, MN vs. PIT ($5,600)

I have been a Buxton truther since my beloved Twins drafted him and I caught a game that he played for Cedar Rapids back in 2013. His tools have never translated to major league success due to injuries and a free-swinging style that would make Kirby Puckett proud. The difference is that Kirby would swing at damn near everything, but he always made contact. That is what has eluded Buxton until now. His chase rate and K rate are far below his career numbers, even though he still doesn't walk. Buxton has an impossible 30.6 barrel percentage - the best in the majors - and is in the 100th percentile in xwOBA, xBA, xSLG, xISO, and hard hit percentage. Oh, and he's facing a pitcher that has given up 12 runs in nine major league innings. This is yet another smash spot for Buxton. Ride him until he cools off.

Michael Conforto - OF, NYM vs. WAS ($4,100)

Allow me to highlight one of the less obvious pieces of my Mets stack. Yes, I realize that Corbin has handled lefties fairly well in his career. Every lefty but Michael Conforto, that is. Conforto is 9-25 with five homers, 12 RBI, and a .640 ISO. Most will be on the right handed side of this Mets stack, but Conforto may be forgotten since he's a lefty. He is one of the few that has managed to get to Corbin.

Jorge Soler - OF, KC at DET ($3,900)

Michael Fulmer throws a lot of fastballs and Soler is one of the better fastball hitters around. Just like Pedro Cerrano, straight ball he hit very much. Much like Cerrano, Soler could use some of Jobu's help with the curveball, but that's a pitch that Fulmer rarely throws anyway. Soler's ISO against Fulmer's brand of fastball is .727. The ISO on the slider and sinker are nearly .300. He's the guy that is most likely to get a hold of a Fulmer offering today, according to the metrics.

 

DraftKings DFS Stacks

  • New York Mets vs. Patrick Corbin
  • Minnesota Twins vs. Wil Crowe
  • Sneaky Stack: St. Louis Cardinals vs. Luis Castillo

 



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Evander Kane

Dealing With Upper-Body Injury
Max Greyserman

Gradually Improving Each Week in Florida
Oliver Moore

Expected to Miss "Significant Time"
PGA

Nico Echavarria Roller Coaster Heads to The Players Championship
Andrew Wiggins

Misses Third Straight Game
Ludvig Aberg

Threat to Contend at The Players Championship
Norman Powell

Remains Out Tuesday
Collin Sexton

Considered Questionable Tuesday
Daniel Berger

PGA DFS DraftKings Value Plays - 2026 THE PLAYERS Championship(Premium Content)
Will Smith

Undervalued and Overvalued Fantasy Baseball Catchers - Targets and Avoids at ADP (2026)
Matas Buzelis

Expected to Play Tuesday
Pete Crow-Armstrong

5 Second-Year Fantasy Baseball Breakout Hitters (2026)
Chris Sale

5 Overvalued Fantasy Baseball Starting Pitchers - Avoid These ADPs in 2026 Drafts
Josh Giddey

Probable Tuesday
Coby White

Sits Out First Game of Back-to-Back
Andrew Nembhard

Doubtful Tuesday
Pascal Siakam

Won't Suit Up Tuesday
Joel Embiid

Today's NBA DFS Picks: DraftKings, FanDuel DFS Lineups, Values, Stacks (Tuesday, 3/10/26)
NHL

NHL DFS Picks and Heat Map (Premium Content) - March 10, 2026
Anton Forsberg

Escapes With Overtime Victory
Tyler Linderbaum

Joins Raiders on a Three-Year Deal
Artemi Panarin

Collects Two Points Against Former Team
Adrian Kempe

Scores Two Goals in Victory
Igor Shesterkin

Stifles the Flyers on Monday
Mika Zibanejad

Scores Twice Versus Philadelphia
Harris English

Hopes to Find Any Sort of Success at TPC Sawgrass
Pierceson Coody

Looks to Get Back on Track in First Players Appearance
Daniel Berger

Presses On at The Players Championship
Joshua Baez

Cardinals Send Joshua Baez to Minor-League Camp
Alvin Kamara

Teams Monitoring Alvin Kamara's Availability for Trade
Cedric Mullins

Chandler Simpson, Cedric Mullins Expected to Play Tuesday
Joey Wentz

Suffers Season-Ending Torn ACL
Min Woo Lee

an Intriguing Option at the Players
Sahith Theegala

Looks to Continue Strong Form at the Players
Jonathan Kuminga

in Danger of Missing Third Consecutive Game
John Collins

Won't Play This Week
Quinten Post

Starting Monday Night
DeMar DeRozan

Overcomes Illness, Available Tuesday
LeBron James

Listed as Questionable for Tuesday
Payton Pritchard

Iffy to Face Spurs Tuesday
Jason Day

Needs to Find Form Again at Players Championship
Patrick Cantlay

Hasn't Found Consistency This Season
Jakob Poeltl

Questionable for Matchup With Rockets
Rickie Fowler

Horse For The Course: PGA DFS Course History - 2026 The Players Championship
Grayson Allen

Could Miss Another Game Tuesday
Kevin Porter Jr.

to Remain Out Tuesday
Elmer Rodríguez

Yankees Reassign Elmer Rodriguez to Minor-League Camp
Kyle Kuzma

Available Against Suns Tuesday
Giannis Antetokounmpo

Ready for Action Tuesday
Keyonte George

Available Against Warriors
Rico Dowdle

Steelers Signing Rico Dowdle on Monday
Spencer Jones

Yankees Send Spencer Jones to Minor-League Camp
Patrick Reed

DraftKings PGA DFS Lineup Picks - The PLAYERS Championship (2026)
Jesús Luzardo

Jesus Luzardo, Phillies Agree on Five-Year Extension
Logan Henderson

Dealing With Mild Elbow Soreness
Corbin Carroll

Could Make Spring Debut This Week
James Reimer

Starting Monday Night
Jacoby Brissett

Cardinals Plan to Keep Jacoby Brissett as Their Starting QB
Joel Hanley

Returns to Action Against Capitals
Tua Tagovailoa

Plans to Sign One-Year Deal With Falcons
Evander Kane

Brock Boeser, Evander Kane Iffy Monday
Travis Kelce

Officially Re-Signs With Chiefs
Spencer Knight

Out Against Mammoth
Jaden Schwartz

Out Indefinitely
Brad Marchand

to Miss "Weeks"
Jake Sanderson

Considered Week-to-Week
J.K. Dobbins

Broncos Agree on Two-Year Deal to Bring J.K. Dobbins Back
Rickie Fowler

Spencer Aguiar's DraftKings PGA DFS Overview - The PLAYERS Championship (Premium Content)
Jordan Spieth

2026 The PLAYERS Championship PGA Power Rankings: Top 10 Golfers To Watch
Bryce Eldridge

to Begin Season at Triple-A?
Triston Casas

Won't Play in Any Grapefruit League Games
Max Holloway

Drops Decision At UFC 326
Mike Evans

Agrees to Join the 49ers
Evan Carter

to See Full-Time At-Bats?
Charles Oliveira

Becomes The New BMF Champion
Caio Borralho

Bounces Back
Wan'Dale Robinson

Signing With Titans
Reinier de Ridder

Reinier De Ridder Loses Back-To-Back Fights
Kevin McGonigle

Still in Big League Camp After Latest Roster Cuts
Rob Font

Gets Dominated
Raul Rosas Jr.

Extends His Win Streak
Max Clark

Reassigned to Minor-League Camp
Travis Etienne Jr.

Saints Signing Travis Etienne Jr.
Michael Johnson

Suffers Second-Round Knockout Loss
Drew Dober

Knocks Out Michael Johnson
Tyler Allgeier

Cardinals Agree on Two-Year Deal With Tyler Allgeier
Kenneth Gainwell

Signing Two-Year Deal With Buccaneers
Isaiah Likely

Giants Signing Isaiah Likely to Three-Year Deal
Malik Willis

Dolphins Signing Malik Willis to a Three-Year Deal
Michael Pittman Jr.

Steelers Acquire Michael Pittman Jr. From the Colts
Kenneth Walker III

Signing With the Chiefs
J.P. Crawford

Back at Shortstop on Monday
Alec Pierce

Returning to Colts on Four-Year Deal
Rafael Devers

Back in Cactus League Lineup on Monday
Tua Tagovailoa

Falcons Expected to Make a "Strong Push" for Tua Tagovailoa
Ryan Blaney

Earns his Second Consecutive Phoenix Cup Series Win
Christopher Bell

Falls Short of Victory Despite Dominating at Phoenix
Kyle Larson

Earns Hard-Fought Finish of Third at Phoenix
Denny Hamlin

Quietly Gains Another Top-Five Finish at Phoenix
Joey Logano

Crashes out at Phoenix Despite Strong Run
Zack Gelof

Making Cactus League Debut on Monday
Travis Kelce

Expected to Return to Chiefs in 2026
Josh Hader

to Throw a Bullpen on Tuesday
Minkah Fitzpatrick

Traded to Jets
Nick Seeler

Could Return Monday
Travis Konecny

a Game-Time Call Monday
Tua Tagovailoa

to be Released by Dolphins
Taylor Raddysh

to Miss Two Games
John Gibson

"Should Be Fine" After Early Exit Sunday
Filip Forsberg

NHL Power Rankings: Where Do All 32 Teams Stand Ahead of Week 21?
Oliver Moore

Ruled Out for Monday
PGA

TeeOffSports' PGA DFS Rankings Wizard Model - The PLAYERS Championship (Premium Content)
Ryan Blaney

is Always A Top Favorite to Compete for the Win At Phoenix
Denny Hamlin

Is Denny Hamlin Worth Rostering for Phoenix?
Christopher Bell

is Likely to have Another Solid Phoenix Run
Chase Briscoe

has Plenty of Upside for DFS Lineups at Phoenix
Joey Logano

Could Dominate at Phoenix This Weekend
Chase Elliott

has Plenty of Upside for Sunday's Race at Phoenix
Chris Buescher

Is Chris Buescher Worth Rostering For Phoenix DFS Lineups?
Ross Chastain

Has Found Speed Again at Phoenix
Josh Berry

a Solid Sleeper at Phoenix
Brad Keselowski

Skips Qualifying After Practice Crash at Phoenix
Tyler Reddick

Spins in Practice at Phoenix
William Byron

Should Be a Contender at Phoenix
Kyle Larson

Is Always a Threat at Phoenix
NASCAR

Could Bubba Wallace Be Playable for Phoenix DFS Lineups?
Anthony Alfredo

Is A Favorable DFS Option In A Substitution Role At Phoenix
Billy Horschel

In-Tournament PGA Model - Round 4 Picks for The Arnold Palmer Invitational (Premium Content)
Rickie Fowler

In-Tournament PGA Model - Round 3 Picks for The Arnold Palmer Invitational (Premium Content)
Max Holloway

A Favorite At UFC 326
Charles Oliveira

Set For BMF Title Fight
Reinier de Ridder

Reinier De Ridder Looks To Bounce Back
Caio Borralho

Set For UFC 326 Co-Main Event
Rob Font

Looks To Get Back In The Win Column
Raul Rosas Jr.

Looks For His Fifth Consecutive Win
Drew Dober

Returns At UFC 326
Michael Johnson

Looks To Extend His Win Streak
Rickie Fowler

In-Tournament PGA Model - Round 2 Picks For The Arnold Palmer Invitational (Premium Content)
Brooks Koepka

Spencer Aguiar's Top One And Done Picks To Consider - The 2026 Arnold Palmer (Premium Content)
PGA

TeeOffSports' PGA DFS Rankings Wizard In-Tournament FanDuel Model Included - The 2026 Arnold Palmer (Premium Content)
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF