X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

DraftKings Daily Fantasy Baseball Picks (4/25/21): MLB DFS Lineups

Brandon Woodruff - Fantasy Baseball Rankings, MLB Injury News, DFS Lineup Picks

The top daily fantasy baseball lineup picks for DraftKings on 4/25/21. Euan Leith's MLB DFS analysis and sleepers for building optimal DFS rosters.

We've got a giant main slate with a dozen games starting at 1:05 pm Eastern. The Braves and Diamondbacks have a double dipper in Atlanta, so their game in this set will only go seven innings. In the grand scheme of things that may only cost us one at-bat, but we have seen ownership plummet for these seven inning games. That's a way to gain some leverage.

Rain is going to be a problem in the northeast today. I'll be shocked if Boston plays at all. I'm cutting this slate down to 11 games right now. That one is too risky for me to mess with. They can play in New York if they wait the rain out, but we have teams less willing to do that this year. There is a chance of light snow in Minneapolis. That's not going to be a good game with the cold and wind blowing in anyway. The wind is also blowing in in Wrigley and Cleveland. We do have a nice wind blowing out in Detroit and Atlanta though.

This article will provide you with my daily fantasy baseball lineup picks for DraftKings on 4/25/2021. The lineup will range from some of the elite players to mid-priced options and value plays. You can also check out today's FanDuel MLB DFS lineup picks and read more DFS advice and lineup picks for other sports too. It’s also important to monitor injury news and today's MLB starting lineups. If you have any questions or comments, contact me on Twitter.

Featured Promo! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

DraftKings DFS Starting Pitchers

Brandon Woodruff - MIL at CHC ($9,400)

This will be Woodruff's 11th career start against the Cubs, but he only has one decision against them. Part of it is bullpen issues. Part of it was Woodruff not lasting long in starts, particularly early on in his career. The current Cubs roster is hitting a dismal .147 in 109 at-bats against Woodruff, so it's not a fluke. He has a career 2.95 ERA at Wrigley Field. With the wind blowing in, this looks like an elite spot for Woodruff with the way that he's been pitching this year. Woodruff has sparkling numbers across the board. A big reason for that is he has not allowed a ball hit on the barrel of an opponents bat yet. As you would expect, the hard hit percentage is also way down. I expect a really strong start out of Woodruff here.

Danny Duffy - KC at DET ($8,000)

Duffy has allowed just one earned run in 18 innings so far this year with 19 strikeouts. We have seen flashes of brilliance from Duffy here and there throughout his career. He has always been a highly-touted prospect, but has never really put anything together. There is some reason for optimism this year. Duffy's velocity is up across the board and there is a lot more movement on his four-seamer and curveball. And honestly, this is a dream matchup for Duffy. The Tigers are hitting a dismal .179 against southpaws this year and were completely shut down by fellow lefty Mike Minor on Friday. The Tigers are striking out an alarming 35.9% against lefties this year. Duffy may regress at some point, but it shouldn't start here.

Other Options: John Means ($8,900), Kohei Arihara ($7,000), Michael Kopech ($6,900)

 

Want more MLB DFS tools and content? Our MLB Premium package includes our daily DFS Cheat Sheets, Research Station, Optimizer, and access to our Premium Slack Chatrooms where members can chat with our MLB analysts. Check out this recent big win from RotoBaller's RealTalkRaph on DraftKings - join in on the winning!

 

DraftKings DFS Infielders

Andrew Knizner - C, STL vs. CIN ($2,200)

Predicting who catches on Sunday afternoons can be a daunting task, but the Cardinals are still without Yadier Molina and Knizner has filled in pretty well for him. The price is low despite Luis Castillo getting absolutely destroyed by the Cardinals on Opening Day, and really not looking good in a start since. Knizner homered off of Castillo in the only game that he has started against him. For this low of a price, it's worth seeing if he can do it again.

Joey Votto - 1B, CIN at STL ($4,400)

Is Votto back? The four homers in a nice touch, but the .225 average leaves something to be desired. His walk rate is also the lowest of his career. Now the good news: The hard hit percentage is by far the best of his career and a .312 xBA suggests that Votto has been a little unlucky so far this year. The launch angle, exit velocity, and hard hit percentage are all at or above his marks during his heyday. Votto is absolutely mashing fastballs this year, which is exactly where Jack Flaherty has been struggling. History is on Votto's side too. He is 6-13 in his career against Flaherty.

Adam Frazier - 2B, PIT at MN ($4,400)

Frazier is firmly entrenched atop this Pirates lineup and has been one of the few bright spots in it thus far. Matt Shoemaker has always been a junkballer, but is has caught up to him in recent years. His 6.28 ERA looks bad, but the xERA of 7.23 suggests that he should be even worse. Opponents have a staggering 17% barrel percentage against Shoemaker so far. Frazier profiles well against Shoemaker's best pitches, the sinker and splitter. The other Frazier (Todd) is the only Pirate that profiles better, but you have to have some stones to run with the Toddfather right now.

J.D. Davis - 3B, NYM vs. WAS ($3,400)

Something is off with Patrick Corbin. His strikeout rate so far is by far the lowest rate of his career. Though the 10.95 ERA is a little bloated, his xERA is still a catastrophic 7.06. If there weren't a good track record attached to Corbin, he wouldn't even be in the majors right now. It's not even a velocity issue for Corbin. His velocity is fine. Hitters just aren't chasing his pitches anymore. His fastball and slider are getting crushed right now. I'll have a few five-man Mets stacks, but they will all start with Davis. Not only does Corbin struggle with right handed power, Davis has a .462 ISO with three homers in 26 career at-bats against Corbin. He may as well be hitting off a tee.

Eugenio Suarez - SS, CIN at STL ($5,300)

Normally I wouldn't go out of my way to run hitters at guys like Luis Castillo and Jack Flaherty, but they are both off this year. Both are suffering about a 1.5 MPH loss on the fastball from last year. What's even more concerning for Flaherty is that he is missing a lot of movement on his slider and fastball. The only thing worse than throwing a pitch slower is not having it move effectively. Suarez homered off of Flaherty on Opening Day, his third off of Jack in just 15 at-bats. This is DFS, people. If we aren't chasing homers, what the hell are we even doing out here?

 

DraftKings DFS Outfielders

Byron Buxton - OF, MN vs. PIT ($5,600)

I have been a Buxton truther since my beloved Twins drafted him and I caught a game that he played for Cedar Rapids back in 2013. His tools have never translated to major league success due to injuries and a free-swinging style that would make Kirby Puckett proud. The difference is that Kirby would swing at damn near everything, but he always made contact. That is what has eluded Buxton until now. His chase rate and K rate are far below his career numbers, even though he still doesn't walk. Buxton has an impossible 30.6 barrel percentage - the best in the majors - and is in the 100th percentile in xwOBA, xBA, xSLG, xISO, and hard hit percentage. Oh, and he's facing a pitcher that has given up 12 runs in nine major league innings. This is yet another smash spot for Buxton. Ride him until he cools off.

Michael Conforto - OF, NYM vs. WAS ($4,100)

Allow me to highlight one of the less obvious pieces of my Mets stack. Yes, I realize that Corbin has handled lefties fairly well in his career. Every lefty but Michael Conforto, that is. Conforto is 9-25 with five homers, 12 RBI, and a .640 ISO. Most will be on the right handed side of this Mets stack, but Conforto may be forgotten since he's a lefty. He is one of the few that has managed to get to Corbin.

Jorge Soler - OF, KC at DET ($3,900)

Michael Fulmer throws a lot of fastballs and Soler is one of the better fastball hitters around. Just like Pedro Cerrano, straight ball he hit very much. Much like Cerrano, Soler could use some of Jobu's help with the curveball, but that's a pitch that Fulmer rarely throws anyway. Soler's ISO against Fulmer's brand of fastball is .727. The ISO on the slider and sinker are nearly .300. He's the guy that is most likely to get a hold of a Fulmer offering today, according to the metrics.

 

DraftKings DFS Stacks

  • New York Mets vs. Patrick Corbin
  • Minnesota Twins vs. Wil Crowe
  • Sneaky Stack: St. Louis Cardinals vs. Luis Castillo

 



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy baseball app for iPhone and Android with 24x7 player news, injury alerts, sleepers, prospects & more. All free!




MLB DFS News and Injury Alerts


More DFS Lineup Picks and Analysis




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Jauan Jennings

Asking for Too Much Money?
Brandon Aiyuk

Nothing Imminent With Brandon Aiyuk
Luther Burden III

Bears Want to Continue to Get the Ball to Luther Burden III
Jesús Luzardo

Jesus Luzardo Dominates Rockies on Saturday
Byron Buxton

Back in Sunday's Lineup
Mookie Betts

Heading to the Injured List With Oblique Strain
A.J. Brown

to be Traded to Patriots on June 2?
Cade Horton

Cubs Place Cade Horton on 15-Day Injured List With Forearm Strain
Jordan Spieth

2026 Masters Tournament: PGA Betting and Fantasy Preview - Key Stats, Course Breakdown, Tournament Trends, TV Times, and More
Isaiah Collier

Out Again Sunday
Immanuel Quickley

Still Sidelined Sunday
Nicolas Claxton

Won't Play Sunday
Evan Mobley

Sidelined Sunday
Jarrett Allen

Won't Play Against Indiana
Pascal Siakam

Ruled Out Sunday
Clayton Keller

Collects Four Points Against Canucks
Andrew Nembhard

Ruled Out Vs. Cleveland
Jack Eichel

Records Three Assists in Saturday's Win
Gabe Perreault

Nets First Career Hat Trick
Nicolas Hague

Exits Early Against Sharks
MacKenzie Weegar

Listed as Day-to-Day
Jack McBain

Considered Week-to-Week
Justin Faulk

Questionable Sunday
Michael Wilson

Dynasty Fantasy Football Trades: 14 Players/Picks to Buy or Sell (2026)
MarShawn Lloyd

a Dynasty Trade Target with Long-Term Upside?
Emanuel Wilson

a Low-Risk Trade Target in Dynasty Leagues?
Jalen Nailor

Seems Likely to Face Competition
Adrian Kempe

Delivers a Four-Point Performance
Dylan Sampson

a Candidate for Standalone Value in 2026?
Jaylin Noel

Still the Texans' WR4 for 2026?
Evgeni Malkin

Collects Four Points on Saturday
Keenan Allen

Remains a Free Agent in Early April
Mookie Betts

Considered Day-to-Day, Heading for an MRI on Saturday
Juan Soto

Day-to-Day With Minor Groin Strain, No Decision on IL Yet
Anthony Edwards

Questionable for Sunday
Andre Drummond

Kelly Oubre Jr., Andre Drummond Join Starting Lineup Saturday
Marcus Sasser

Upgraded to Available
Atlanta Falcons

Mike Washington Jr. Visits With Falcons
Tobias Harris

Cleared to Play Saturday
Jalen Duren

Available Saturday
Arizona Cardinals

Cardinals "Pushing Hard" for Jeremiyah Love
Paul George

Ready to Rock Saturday
Bruce Brown

Suffers Leg Injury Saturday
Shedeur Sanders

the Favorite to Win Browns QB Job?
Kirk Cousins

Could Make Starts for Raiders in 2026
Austin Reaves

Out for Remainder of Regular Season
Travon Walker

Jaguars Sign Travon Walker to Four-Year Extension
Nick Lardis

Available Against Kraken
Oliver Ekman-Larsson

Won't Play Saturday
MLB

Cubs-Guardians Game Postponed on Saturday
Mookie Betts

Leaves Early With Back Injury
Tyler Kleven

Out Week-to-Week
Mason Marchment

Expected to Return Saturday
Aliaksei Protas

Returns on Saturday
Zach Hyman

Could Miss Two Weeks
Damon Severson

Undergoes Season-Ending Surgery
Jalen Duren

Added to Injury Report Saturday
Bubba Watson

The Masters Bible - PGA DFS Outlooks For Every Player In The 2026 Masters Field
Paul George

Probable Saturday
Tyler Herro

a Late Scratch Saturday, Simone Fontecchio Starts
Joel Embiid

Will Sit Out Saturday's Game
George Holani

Time as Seahawks RB1 Looks to Be Short-Lived
Justin Champagnie

Active Saturday
Bilal Coulibaly

Tre Johnson Available Against Heat
Harold Fannin Jr.

Is Harold Fannin Jr. a Top-Five Dynasty Tight End?
Brenton Strange

Easily Overlooked Among Jacksonville Pass Catchers
Kendre Miller

a Dynasty Cut Candidate
Marvin Harrison Jr.

Can Marvin Harrison Jr. Deliver on Pre-Draft Hype in Year 3?
Alejandro Kirk

Placed on 10-Day Injured List With Thumb Fracture
Juan Soto

Mets Concerned About Juan Soto's Calf Injury
NHL

NHL DFS Picks and Heat Map (Premium Content) - April 4, 2026
Juan Soto

Removed with Calf Tightness
PHI

Daniel Vladar Defeats the Islanders
Matvei Michkov

Has Three-Point Game on Friday
Byron Buxton

is Day-to-Day with Forearm Contusion
Byron Buxton

Leaves on Friday After Being Hit by a Pitch
Cade Horton

Headed for Injured List Stint
Isaac Paredes

Placed on Bereavement List
Jordan Lawlar

Suffers Fractured Wrist, Set to Miss 6-8 Weeks
Alejandro Kirk

Having X-Rays on his Thumb
Cade Horton

Exits Friday's Start with Forearm Tightness
Chase DeLauter

Returns to Lineup on Friday After Injury Scare
Chris Duncan

Set For UFC Vegas 115 Main Event
Renato Moicano

An Underdog At UFC Vegas 115
Tabatha Ricci

Set For UFC Vegas 115 Co-Main Event
Virna Jandiroba

Looks To Bounce Back
Brendson Ribeiro

In Desperate Need Of Win
Abdul-Rakhman Yakhyaev

Looks To Remain Unbeaten
Ethyn Ewing

Set For His Second UFC Bout
Rafael Estevam

Looks To Remain Undefeated
Patrick Kane

Becomes NHL's Highest-Scoring American
Elias Salomonsson

Lands in Concussion Protocol
Konnor Griffin

Secures $140M Deal; Pittsburgh Building Around Young Star
Konnor Griffin

Being Promoted to MLB Roster Ahead of Friday's Contest
Rickie Fowler

PGA Betting Expert Roundtable: RotoBaller Staff Picks - 2026 Valero Texas Open (Premium)
CFB

Gunner Stockton Looking "Great" After Offseason Injury
CFB

Sam Leavitt Showing "Encouraging Signs" at LSU Practice
Brooks Koepka

RotoBaller's One And Done Picks To Consider - Valero Texas Open (Premium Content)
J.J. Spaun

Needs the Putter to Cooperate in San Antonio
Thorbjorn Olesen

Trending Up in San Antonio
Stephan Jaeger

PGA Best Bets: Novig Matchup Picks and Finishing Position Props for Valero Texas Open
Denny McCarthy

Carrying Momentum into San Antonio
Brooks Koepka

DraftKings Core Four: PGA DFS - 2026 Valero Texas Open (Premium Content)
Chris Kirk

Has Course History on His Side in San Antonio
Billy Horschel

a Volatile Option at the Valero Texas Open
Joe Highsmith

Still Searching for Form in San Antonio
Christiaan Bezuidenhout

Looks to Find Form at the Valero Texas Open
Adam Scott

Patrick's Picks: Top Betting Plays for 2026 Valero Texas Open (Premium)
Jordan Spieth

a Horse for Course History at TPC San Antonio
Robert MacIntyre

Has One Flaw to Overcome at Valero Texas Open to be a Must-Play
Maverick McNealy

In Exceptional Form This Season
Michael Thorbjornsen

Playing Well But Still Searching For A Win
Hideki Matsuyama

Playing Well Heading to the Valero Texas Open
Si Woo Kim

Heads to Valero Texas Open For Final Tune-Up Before Masters
Hideki Matsuyama

DraftKings PGA DFS Lineup Picks - Valero Texas Open (2026)
Chase Elliott

Takes Advantage of Pit Strategies for Second Career Martinsville Win
Denny Hamlin

Dominates but Finishes Second at Martinsville
Joey Logano

Bounces Back with Third-Place Finish at Martinsville
Ty Gibbs

Gains his Fourth Top-Five Finish of the Season at Martinsville
William Byron

Scores Another Top-Five Finish at Martinsville
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF