Week 4 DraftKings NFL DFS Lineup Picks (2022): Break The Slate

Joe Nicely's DraftKings NFL DFS picks and lineup sleepers for Week 4 (2022). His top daily fantasy football lineups to target for DraftKings DFS contests.

Hello RotoBallers and welcome back to Break The Slate, our DraftKings NFL DFS Lineup Picks for Week 4! I appreciate you joining me in our season-long quest to find the best plays at each position for every DraftKings Main Slate.

After a Week 3 slate that was heavy on marquee matchups and projected points, we get a Week 4 board that features just one true headliner in Buffalo vs Baltimore. While we're still waiting on updates as the week progresses, this feels like the first slate where injuries will play a large role, especially at the RB position. With so many moving parts and so few obvious spots, this is the type of NFL DFS slate this will test our mettle as DFS players, and I personally #CantWait.

These DraftKings lineup recommendations are based on matchups, projected ownership, overall upside/talent levels, opportunity, and other factors such as Vegas odds, home-field advantage, and more. There are quite a few great plays available, especially with the extra soft pricing on DK for Week 4. Also, be sure to also check out our weekly FanDuel DFS lineup picks and lots of other great NFL DFS articles and NFL DFS tools to help you win big! Good luck with your DraftKings DFS lineups - let's Break The Slate together!

• 2025 fantasy football rankings
• Running back (RB) fantasy football rankings
• Wide receiver (WR) fantasy football rankings
• Tight end (TE) fantasy football rankings
• Quarterback (QB) fantasy football rankings
• FLEX fantasy football rankings
• Defense (D/ST) fantasy football rankings
• Kicker (K) fantasy football rankings
• Dynasty fantasy football rankings

DraftKings Quarterbacks - Week 4 DFS Picks

Josh Allen & Lamar Jackson - BUF @ BAL ($8,400 & $8,300)

As mentioned in the intro, this Week 4 slate is one with few obvious spots. However, this matchup might as well be up on a marquee in flashing neon lights, as it features not only the slate's highest O/U (51) but also the NFL's two most explosive fantasy quarterbacks in Josh Allen and Lamar Jackson.

I won't waste column space by diving into all the stats and will just say that Jackson & Allen rank first and second in the NFL in overall DraftKings points scored this season. Both are facing off against defenses that are traditionally solid but have been bitten by the injury bug this season. This game features multiple stacking options that can be paired with Allen or Jackson and both QBs should be in heavy consideration on this slate.

Jalen Hurts - JAX @ PHI ($8,200)

Philly’s Jalen Hurts has quickly become a fade-at-your-own-risk DFS entity. The Eagles’ signal caller has done it all to this point, as Hurts leads all QBs in rushing attempts (37) and TDs (3), while trailing just Lamar Jackson in rushing yards (167). 

While his efficiency on the ground offers a tremendous DFS floor, he’s been no one-trick pony. Entering his third season in the NFL, Hurts appears to have taken a huge leap as a passer. He currently leads the league in Yards Per Attempt (9.3) and he stands near the league leaders in both total passing yards (916) and completion percentage (67.3%). 

While his DraftKings price tag has risen to $8.2k, Hurts offers us tons of DFS flexibility. He can be used as a one-off lock-button option in cash games or stacked with his talented supporting cast in GPP formats.

Marcus Mariota - CLE @ ATL ($5,600)

Surprisingly, CLE vs ATL comes in with the third-highest O/U projection (47.5) on the Main Slate. This matchup represents a way to grab some under-the-radar DFS plays, with Atlanta’s Marcus Mariota standing out as one of the most desirable value plays on the board and a terrific way to save salary at the expensive QB position.

Mariota comes in with a dirt-cheap $5.6k price tag, despite averaging a very respectable 18.3 DK points per game. In his first season as Atlanta’s signal caller, the Oregon product hasn’t been afraid to look downfield to his talented, young pass catchers, Drake London and Kyle Pitts. Never a true deep-ball thrower for either of his previous teams, Mariota surprisingly ranks third in the NFL in aDOT (11.2) this season, which raises his DFS ceiling, while his fantasy floor remains stable thanks to his ability on the ground. He ranks top-six in the NFL in QB rushing attempts (25), rushing yards (92), and rushing TDs (2). 

DraftKings Running Backs - Week 4 DFS Picks

Jamaal Williams - SEA @ DET ($6,100)

As the season progresses, we are beginning to feel the impact of injuries. That's especially the case at the RB position this week. With D’Andre Swift’s status for Week 4 heavily in doubt as I write this, Detroit’s “1A” RB – and spiritual leader – Jamaal Williams jumps to the forefront of this slate.

Not content to piss on the porch, Williams has already been playing like a big dog this season with his 47.7 DK points standing as the fifth-most scored by a RB through three games. Even with backfield mate Swift popping in and out of Detroit’s high-energy offense, Williams is tied for the NFL lead in both Red Zone rushing attempts (11) and RZ rushing TDs (4). 

His usage last week with Swift severely limited – 20 carries and two targets – is likely a nice predictor of things to come in a plus matchup against Seattle in Week 4. The Seahawks have been gashed on the ground to this point. They have allowed the second-most rushing yards in the NFL (394) to the RB position, as well as a massive  5.12 Yards Per Carry to opposing RBs.

Khalil Herbert - CHI @ NYG ($5,700)

Khalil Herbert stands out as another injury-dependent, slam-dunk spot at the RB position. David Montgomery was forced out of last week's game against the Texans in the first quarter and Herbert announced his presence almost immediately with a rushing TD, ultimately finishing with 169 total yards and a pair of scores on 22 touches against Houston.

A sixth-round pick for the Bears in 2021, Herbert looked sharp in limited action as a rookie last year, finishing the year with a chunky 4.2 Yards Per Carry on 103 carries. During a four-game stretch last year, he averaged a massive 22 opportunities per game while filling in for an injured Montgomery. With Montgomery now banged up again and yet to practice this week, the second-year back looks once again set to take on the primary role in this run-first Chicago offense against the New York Giants in Week 4. It profiles as a terrific spot, as the G-Men have struggled to slow down opposing RBs and are relinquishing an eye-opening 5.57 Yards Per Carry...the second-worst mark in the NFL.

DraftKings Wide Receivers - Week 4 DFS Picks

CeeDee Lamb - WAS @ DAL ($6,700)

While current Dallas QB Cooper Rush is no Dak Prescott, he has led the Cowboys to back-to-back victories in Prescott’s absence. More importantly for DFS purposes, Rush has been able to keep CeeDee Lamb’s DFS value alive and well. Lamb has now been targeted a whopping 23 times in Rush’s two starts this year, logging a combined 15 catches for 162 yards and a score across those outings.

The superstar wideout now draws a superstar matchup against Washington in Week 4. The Commanders have hemorrhaged production to receivers this season. They rank bottom-five in the NFL in DraftKings points (52.2), receptions (45) receiving yards (652), and receiving TDs (5) allowed to the WR position. With Rush proving himself to be a competent passer that's willing to target Lamb heavily, the OU alum should cut through this Washington secondary like a hot knife through butter.

Amari Cooper - CLE @ ATL ($6,300)

I’ll look to grab some exposure to this CLE vs ATL matchup that comes in with a sneaky-high O/U (47.5). Amari Cooper offers a unique way to do just that, as most will target the likes of Nick Chubb or Kareem Hunt on this Browns offense. While Cleveland is indeed notoriously run-heavy, Cooper hasn’t gone ignored in his first season with the organization, as he owns a massive 30.8% team target share and leads the NFL in team Air Yards share at 53.2%. 

The veteran is coming off a Week 3 outing in which he was targeted 11 times and racked up a 7/101/1 stat line against a stingy Pittsburgh Steelers defense. Coop now draws a juicy matchup against an Atlanta secondary that has relinquished the most receiving TDs in the league to opposing WRs and has already allowed two individual receivers to go for over 100 yards against them this year.

Romeo Doubs - NE @ GB ($4,500)

The darling of the Packers' training camp and preseason, Romeo Doubs had been relatively quiet through Green Bay's first two. However, Week 3 looked like a true breakout performance for the fourth-round rookie, as he put forth a legitimate "alpha" receiver outing against Tampa Bay, catching all eight of his targets for 73 yards and a score.

Doubs has received a $700 price bump this week but he remains a high-upside value option, especially if his role in this Green Bay offense remains anywhere near what it was in Week 3 when he logged a career-high 89% snap rate against the Bucs. The Packers are starved for talent in the receiving corps, and with Sammy Watkins now on IR, the rookie sensation should continue to see an uptick in usage, even with fellow rookie Christian Watson expected to return from injury this week against New England.

DraftKings Tight Ends - Week 4 DFS Picks

Mark Andrews - BUF @ BAL ($7,100)

The NFL’s most explosive TE playing in the game with the slate’s highest projected point total…sign me up. Mark Andrews has been the best tight end in the league through the first three games of the season and it hasn’t been particularly close.

The 27-year-old leads the TE position in almost every statistical metric. Both his usage and production have been elite, with his 31 targets and 376 Air Yards leading all TEs, while his ridiculous 36.7% team target share leads the entire NFL across all positions. To give some context to just how good Andrews’ fantasy production has been…his 67.8 DraftKings points would place him third among RBs and sixth among WRs in DK scoring.

His matchup against Buffalo isn’t one we’d normally go out of our way to target, as the Bills have been an extremely tough draw for TEs over the last few years. However, the unit is banged up and is coming off a draining contest in sauna-like conditions in Miami last week. All told, Andrews is as close as it gets to matchup-proof thanks to his talent, usage in this offense, and rapport with Lamar Jackson. With no Travis Kelce on the Main Slate, no other TE can match his lofty DFS ceiling.

Tyler Conklin - NYJ @ PIT ($3,600)

The offseason acquisition by way of Minnesota has been a very pleasant surprise for the Jets. Tyler Conklin’s 38 DraftKings points through three games trail only Mark Andrews and Travis Kelce at the TE position. 

Conklin has logged a 90% snap rate for his new squad and his 24 targets are tied for the third-most in the NFL among TEs. This Jets offense has surprised on a couple of fronts, most notably their fast pace of play (third in NFL in plays per game) and pass-happy play calling (first in NFL in overall pass rate), despite having back-up Joe Flacco at the helm through their first three.

While Zach Wilson’s expected return to the lineup does bring some unknowns to the equation for this New York passing attack, Conklin’s value-friendly $3.6k price tag eases any concerns about his viability as one of the slate’s top salary savers. 

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