NFL Week 10 Predictions: Picks and Analysis for Every Football Game

November 9, 2025

Free NFL betting picks for every Week 10 matchup in 2025. Expert analysis and predictions for NFL Week 10. Who should you bet in Week 10? Analysis for every game on the slate.

The NFL season is entering the real proving ground of the schedule. With Week 10 here, contenders will look to solidify their postseason outlooks, while the pretenders will largely start to fade away.

This is a powerful slate that features divisional rivalries and potential playoff matchup previews, starting with an AFC West tilt on Thursday Night Football, and ending with a possible NFC Championship Game preview.

Through the good, bad, and ugly, we'll dive into all the unique spots on this slate, as we go through every Week 10 game in this article, offering picks, predictions, and analysis for each and every one. Thanks for joining us here at RotoBaller; let's dive in!

Denver Broncos 27, Las Vegas Raiders 13 (Thursday Night)

We kick off Week 10 with a Thursday night matchup of divisional rivals, as the Las Vegas Raiders travel to Mile High to face the Denver Broncos. The recent trade of Jakobi Meyers signals that the 2-6 Raiders are basically punting the remainder of the 2025 season, while the 7-2 Broncos have very serious postseason aspirations.

Welcome to the Rockies 🏔️ #TNFonPrime pic.twitter.com/GDN9e9Vo8T

— NFL on Prime Video (@NFLonPrime) November 5, 2025

Offseason acquisition Geno Smith had his best outing as a Raider in last week's overtime loss to Jacksonville. However, a sharp regression to the mean is likely for Smith this week against an elite Denver defense that's holding opponents to just over 306 total yards and 18 points per game. Divisional matchups can often be tougher than expected, but look for the Broncos to take care of business at home.

Indianapolis Colts 27, Atlanta Falcons 23 (International Series - Berlin)

The pace-setting Colts coughed up six turnovers in their Week 9 loss to the Steelers. Since that defeat, they made an all-in trade for star cornerback Sauce Gardner, and must now travel to Berlin to face the Falcons as part of the NFL's International Series.

Last week's outing against Pittsburgh was unquestionably Daniel Jones' worst performance since being named the Colts starting QB ahead of Week 1. Despite that setback, I expect a rebound performance from what's been the league's best and most efficient offense against Atlanta.

That said, the unpredictable Falcons will field a defensive unit that's been largely improved this season, so look for this one to be a little tighter than the experts think.

Baltimore Ravens 24, Minnesota Vikings 20

Both of these squads picked up much-needed wins in Week 9. Baltimore routed the Dolphins on Thursday night, while the Vikings upset the Lions in Detroit. This matchup is a pivotal one for each of these teams, as they look to get back into the playoff hunt.

With Lamar Jackson back under center, and several members of their injury-riddled defense returning, the Ravens are the healthiest they've been all year. A Baltimore defensive unit that's been one of the league's worst statistically, should continue to gel as the season progresses.

Rookie Minnesota quarterback J.J. McCarthy was surprisingly effective in last week's upset of the Lions, but I'm still not a true believer in his ability to play at a consistently mistake-free level against quality opponents such as the Ravens.

Tampa Bay Bucs 28, New England Patriots 27

I'm not taking away from anything that the Patriots have accomplished, but a look at their schedule reveals the likes of New Orleans, Tennessee, and Cleveland during their current six-game winning streak. Mike Vrabel's squad will face their first true test since a Week 5 win over the Bills when they travel to Tampa to meet the Bucs this week.

Baker Mayfield and company come into this one well rested following a Week 9 bye. The winners of three of their last four, Tampa Bay's high-octane attack should find some success against a Pats defense that's rarely been tested in recent weeks.

Houston Texans 20, Jacksonville Jaguars 17

Lots of question marks linger around this AFC South divisional matchup, as Texans QB C.J. Stroud has been ruled out due to suffering a concussion in Week 9, while Jags wideout Brian Thomas Jr. is also listed as questionable with an ankle sprain.

Texans QB C.J. Stroud ruled out in Week 10 vs. Jaguars. Davis Mills will start. pic.twitter.com/dAmn2HzBtG

— NFL (@NFL) November 5, 2025

Injuries have been a recurring theme for Jags pass catchers, as BTJ joins Travis Hunter, Dyami Brown, and Brenton Strange as part of Trevor Lawrence's banged-up bunch. Houston will be highly motivated to avenge a Week 3 loss to Jacksonville, and while the Texans have their own offensive issues with Stroud sidelined, DeMeco Ryans' elite defense that's allowed the NFL fewest total yards and points per game should shut down this injury-riddled Jags attack.

Cleveland Browns 17, New York Jets 14

The 1-7 Jets cleaned house at the trade deadline, shipping both Sauce Gardner and Quinnen Williams out of the Big Apple in exchange for multiple first-round picks. What's left is a floundering Jets roster that's left to play out the remainder of this disappointing 2025 campaign.

Things haven't been much better for the 2-6 Browns, though Cleveland appears to still be fighting, at least for the moment. Despite their woeful record, Myles Garrett has remained in beast mode for a Browns defense that's allowing the NFL's second-fewest total yards per game. That defensive toughness will be enough to carry them to a win over the woeful and retooling Jets.

Carolina Panthers 21, New Orleans Saints 10

The surging Panthers have won three of their last four, including a shocking upset win over the Packers at Lambeau Field last week. Carolina will look to stay hot in Week 10, as they host the cellar-dwelling Saints.

New Orleans turned to rookie QB Tyler Shough last week, though the results were disappointing, as the Saints managed just 10 points in their Week 10 loss to the Rams. Carolina will come after Shough and this now-Rashid Shaheed-less offense with an improved defensive unit that ranks in the top half of the NFL in total yards, passing yards, and points allowed per game.

Carolina has finally entrusted Rico Dowdle with a workhorse role. He should find plenty of room to run against a New Orleans front that's being gashed for nearly 130 rushing yards per game this season.

New York Giants 27, Chicago Bears 24

A Week 6 win over the Philadelphia Eagles appears to have been a mirage for the G-Men, who have now lost three straight since that Thursday night triumph. We can chalk some of that up to their strength of schedule, as they've faced the Broncos, Eagles, and Niners on their current losing streak.

While the much-improved Bears sit at 5-3, it's fair to question just how sturdy the foundation of this squad is. They escaped Cincinnati with a Week 9 victory, but Caleb Williams and company have been able to win five of their last six largely due to soft opponents and fortunate bounces.

pic.twitter.com/LPvs3ECPv7

— No Context Chicago Bears 🐻 (@BearsNoContext) November 3, 2025

The Giants head to the Windy City playing with a chip on their shoulder and I'm eyeing a small upset in this one over the vulnerable Bears.

Buffalo Bills 28, Miami Dolphins 21

The Bills will look to avoid a letdown in South Beach, as they travel south to face the divisional-rival Dolphins following a huge home win over the Chiefs last week. For all the issues in the Miami organization, the humidity of Hard Rock Stadium can present challenges for visitors.

Taking that into consideration, Josh Allen and company should still get things done against an inferior Miami squad, though perhaps not as easily as the experts think.

Seattle Seahawks 27, Arizona Cardinals 17

What a week it's been for the Seahawks. Seattle completely dismantled the Commanders in a Sunday night Week 9 matchup and followed that up with a move to acquire downfield speedster Rashid Shaheed from the Saints at the trade deadline. The winners of six of their last seven, the 'Hawks have serious postseason aspirations.

Cardinals HC Jonathan Gannon announces QB Kyler Murray (foot) placed on IR. pic.twitter.com/yUh9DAJMPc

— NFL (@NFL) November 5, 2025

Despite a Monday night victory over the Cowboys, things aren't quite as dreamy in the desert. Arizona has "soft benched" franchise QB Kyler Murray in favor of journeyman Jacoby Brissett. I don't know that either Cardinals quarterback would be able to find much success in this matchup against an elite Seattle defensive unit. Mike Macdonald's bunch has held opponents to 20 points or fewer in seven of their eight games this season.

San Francisco 49ers 23, Los Angeles Rams 20

We can expect a slobberknocker between these two NFC West contenders when the 6-2 Rams visit the 6-3 Niners. Despite dealing with an outrageous number of injuries, Kyle Shanahan's crew has found a way to keep scratching out wins - including a surprising one in Week 5 over these same Rams.

Meanwhile, L.A. has been on cruise control in recent weeks, scoring stress-free victories over the Saints, Jags, and Ravens across their last three. Puka Nacua's availability is in doubt as of this writing, and his presence will be a pressure point of this game. It seems to always feel like a coinflip spot when these two stout teams square off. I'll take the Niners and the points at home.

Detroit Lions 31, Washington Commanders 20

Some of Detroit's weaknesses were exposed in last week's surprising home loss to the Vikings. However, I look for Dan Campbell's resilient bunch to rebound in Week 10 against a Washington squad that is currently adrift and will be without superstar signal caller Jayden Daniels for the foreseeable future.

Prayers up for Jayden Daniels 🙏 pic.twitter.com/nKnGg3vAuz

— FOX Sports: NFL (@NFLonFOX) November 3, 2025

Daniels suffered a significant elbow injury late in the Commanders Week 9 blowout loss to Seattle. Veteran Marcus Mariota will lead a Washington team that's now lost four straight against a Lions squad that boasts not only an explosive offense that's second in the NFL at 29.9 points per game, but also possesses a defense that stands second in the league with 3.5 sacks per game. This is a get-right spot for Detroit and the final score will likely reflect that.

Los Angeles Chargers 23, Pittsburgh Steelers 21 (Sunday Night)

Two of the NFL's most unpredictable teams close out the Week 10 Sunday slate with a primetime matchup in Los Angeles. While the Steelers (5-3) and Chargers (6-3) both enter this one with strong records, both have been involved in puzzling losses and impressive wins this season.

Pittsburgh heads into Week 10 off their biggest victory of the year - a 27-20 win over the Colts. For the first time in 2025, the Steelers defense looked aggressive and capable of causing chaos. That's got to be a serious concern for a Chargers team that lost elite tackle Joe Alt to a season-ending ankle injury last week.

Despite Pittsburgh's impressive defensive performance last week, this is still a squad with serious concerns in the secondary. L.A. is uniquely suited to capitalize on those issues with Justin Herbert, Ladd McConkey, Keenan Allen, and their other top-notch pass catchers.

Philadelphia Eagles 27, Green Bay Packers 24 (Monday Night)

We close out Week 10 with one of the best possible matchups. The defending Super Bowl-champion Eagles travel to Lambeau Field to face the Packers - a team with serious postseason aspirations of their own. Philly is well rested following a Week 9 bye, while Green Bay will look to rebound from a stunning home loss to the Panthers.

The Green Bay offensive attack was dealt a serious blow when they lost tight end Tucker Kraft to a season-ending ACL injury last week. It's just the latest setback to a group of banged-up pass catchers for the Pack.

Get Well Soon, Tucker Kraft🕊️

We know you'll come back stronger pic.twitter.com/wUCqMCrj3Q

— IKE Packers Podcast (@IKE_Packers) November 3, 2025

The Eagles have emerged from a two-game swoon to win each of their last two outings. Philly's offense appears to be trending in the right direction and has tallied 66 total points across their last two games. This is a potential NFC Championship preview, and I like the big-game experience Jalen Hurts and the Eagles bring into this environment.

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