NFL DFS Game Stacks: Week 4 (Premium Content)

September 25, 2025

RotoBaller's Week 4 Premium NFL DFS Tournament Stacks for daily fantasy football on FanDuel, DraftKings, and Yahoo. Win big in DFS with our expert research and advice.

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This column provides a detailed analysis of three highly stackable games for Daily Fantasy Sports (DFS) contests each week.

NFL DFS STACKS OF THE WEEK

Indianapolis Colts (3-0) vs. LA Rams (2-1) 

Current Spread: Rams -3.5 

Game Total: 49.5

DFS Shootout Alert: 

This Week 4 matchup has the highest projected total on the main slate for a reason: it’s a full-fledged shootout between two high-powered offenses. The narrative is simple: Daniel Jones’ Colts have been an unexpected juggernaut, and the Rams’ defense is a known liability against the pass. This game is a DFS goldmine, and we need to be heavily invested in the passing attacks.

Colts: Passing Volume is Inevitable

Daniel Jones, now dubbed "Indiana Jones," has led the Colts to a surprising 3-0 start, currently ranking 3rd in the NFL with 816 passing yards. His superb job spreading the ball around has opened up the running game for Jonathan Taylor, who leads the league with 338 rushing yards. The Colts are a prime example of complementary football.

The Rams’ defensive game plan in Week 4 will be simple: limit Taylor on the ground, just as they successfully limited Saquon Barkley (46 yards on 18 carries) in Week 3. This defensive focus on the run will force Jones to beat them through the air.

The Rams' secondary is coming off a game where they crumbled in the second half, struggling against both A.J. Brown and DeVonta Smith. I expect them to struggle again against the Colts’ receiving corps, which sets up perfectly for a high-volume day from the main targets:

• Michael Pittman Jr. (WR1): The lead receiver is poised to feast against a secondary that couldn't contain A.J. Brown on the outside last week.
• Tyler Warren (Rookie TE): The budding star rookie tight end has emerged as Jones’ safety blanket, leading the team with 14 receptions. He is an elite DFS target for his volume at a position (TE) that is hard to predict. DeVonta Smith killed the Rams on shallow to intermediate routes in Week 3; Warren will do the same.

Rams: Stafford and the Target Monster

While the run game is essential for any team, this Rams offense runs through Matthew Stafford and his dominant wide receiver, Puka Nacua.

Nacua isn't just a volume play; he's the league's top yard getter. He leads the NFL in both receptions (29) and receiving yards (333) through three weeks.. In a projected high-scoring game with the Colts offense forcing the pace, Nacua is a no-brainer play and will be heavily owned in DFS formats.

The Rams did finally get a solid run game performance from Kyren Williams in Week 3 (94 rushing yards), but the core of their attack remains the veteran QB feeding his elite WR. The Colts' defense has yet to be truly tested by an explosive passing attack, and they face a massive challenge against the Stafford-to-Nacua connection.

DFS Stack Options

• Jones / Pittman
• Jones / Warren
• Jones / Pittman / Warren (The full Colts passing stack)
• Stafford / Nacua
• (High Upside): Jones / Pittman (or Warren) / Nacua
• Game Stack (Max Correlation): Stafford / Nacua / Pittman (or Warren)

Tampa Bay Buccaneers (3-0) vs. Philadelphia Eagles (3-0) 

Current Spread: Eagles -3.5 

Game Total: 43.5

We have two top-tier offenses and a clear path to production for their key players. While both teams have looked impressive, a closer look at the film and recent news reveals a high-volume passing game for both sides, which is exactly what we're looking for in DFS.

Eagles: Don't Fade the Passing Game

The biggest takeaway from the Eagles' Week 3 victory was the passing offense. After trailing the L.A. Rams 19-7 at halftime, the Eagles were forced to abandon their typical run-heavy attack. The Rams' defense successfully limited Saquon Barkley to just 46 yards on 18 carries, which opened the door for Jalen Hurts to prove that he is more than just a runner.

Not only did Hurts shut the door on criticism that he "can't throw," he exploded in the second half. Completing 21 of 32 passes for 226 yards and 3 scores, the Eagles put the league on notice. The defending champions haven't taken a step back in 2025; they simply haven't needed to throw the ball until now.

In that second-half comeback, both A.J. Brown and DeVonta Smith were heavily targeted. It was Brown who made the most of the opportunity, finishing with 6 catches for 109 yards and a score. The Buccaneers' defense is a solid unit, but in Week 3, they let the Jets' WR1, Garrett Wilson, finish with 10 catches for 81 yards and a score. The opportunity for Brown is clear. Hurts' rushing touchdowns are always the icing on the cake, but his potential passing volume against a vulnerable secondary makes him an elite play.

Buccaneers: A New WR1 Emerges

Big news out of Tampa Bay: Mike Evans is out for multiple weeks with a hamstring injury. While this is a blow to the offense, I don't believe it will negatively affect Baker Mayfield's fantasy production all that much. In fact, the Bucs expect WR Chris Godwin JR. to return from last year's ACL injury in Week 4, and Evans' absence unlocks a massive opportunity for the team's new alpha wide receiver.

The emergence of rookie superstar Emeka Egbuka has allowed this Tampa offense to take a huge step forward in 2025. In their last game, Egbuka led the team in receptions (6) and receiving yards (85). Through three games, he's first on the team in nearly every receiving category. The only category he falls to second in is targets (behind Evans). With Evans now sidelined, Egbuka is primed for a much higher target share as the team's undisputed WR1.

Due to the injury to Evans, the Eagles will likely focus on containing the Bucs' running game led by Bucky Irving, which means Mayfield will need to put the ball in the air if the Buccaneers are going to win this game. He will be looking for his new go-to receiver early and often.

DFS Stack Options

• Mayfield/Egbuka
  • The clear-cut value stack with Evans out.
• Hurts/Brown
  • After his big Week 3, Brown is the top option for a high-ceiling stack.
• Hurts/Smith/Egbuka
  • If the Bucs focus on containing Brown, Smith is a fantastic play who will see plenty of targets.

LA Chargers (3-0) vs. New York Giants (0-3) 

Current Spread: Chargers -6.5 

Game Total: 44.5

The news out of New York that the Giants are sitting veteran quarterback Russell Wilson in favor of their first-round draft pick, Jaxson Dart, has created a great buzz and fantasy confusion. Dart is heading into his first NFL start against arguably the best defense in the league. While many DFS players will avoid the Giants at all costs, I am looking to target some key players in this game who offer great value.

Chargers Offensive Outlook

The Chargers' offense has been terrific. The resurgence of wide receiver Quentin Johnston, a player many had labeled a "bust", and the return of one of the best receivers in Chargers history, Keenan Allen, have truly unlocked Justin Herbert.

Through the first three weeks, no player has thrown for more yards than Justin Herbert (860). Herbert has done a terrific job spreading the ball around, with three players each having over 160 yards and at least 14 receptions. No one saw the emergence of Johnston coming, but his breakout looks legit. He leads the team with 239 yards and is tied for the most touchdown receptions with 3.

I firmly believe the reason this offense is humming is because the Chargers brought back their former captain and fan favorite, Keenan Allen. Allen brings an intangible to this offense, a sense of calm for Justin Herbert. His veteran presence and guidance have obviously helped Johnston find his footing in the NFL, but that's not all he brought back. Allen is leading the team in targets (28), receptions (19), and is tied for first in touchdowns (3).

In Week 4, the Chargers will play the second-worst defense in the NFL, which is averaging 405 yards against per game, with 252 of those coming through the air. The Chargers' offense is going to roll, making their key players great plays in all fantasy formats.

Giants: The High-Volume Value Plays

On the other side of the ball, the New York Giants are starting a rookie quarterback they hope is their future. My strategy here is simple: target the high-volume weapons on a team that's expected to be playing from behind.

While avoiding Dart in his first career start is the smart play, I am targeting his weapons: Malik Nabers and fellow rookie Cameron Skattebo. The Giants' offensive line has been terrible, and they will struggle to move the ball on the ground. On top of that, as mentioned earlier, their defense is horrendous.

I am banking on the fact that Jaxson Dart is going to show something in his first start, and if that's the case, it all starts and ends with getting the ball to Malik Nabers. After just 13 yards on 2 catches in Week 3, Nabers is still tied for fourth in the NFL with 251 receiving yards. With Dart taking over and the Giants likely trailing early, Dart is going to look to Nabers on every play possible, and he should.

My angle for Skattebo is simple: when Nabers is triple-covered and the run game is struggling, Skattebo is the team's second-best playmaker. They will look to get him the ball on screens and dump-offs. With the two major DFS platforms being PPR (DraftKings full point / FanDuel 0.5 point), there's no reason why you would fade Skattebo, who is going to get all the work he can handle after Tyrone Tracy went down in Week 3 with a shoulder injury. In fact, Skattebo led the Giants in Week 3 in both receptions (6) and receiving yards (61).

The Giants' coaching staff is on the hot seat. The only chance they have of surviving 2025 and returning in 2026 is if they can demonstrate that their young offensive core (Dart, Nabers, Skattebo) can produce at a high level and improve each week.

DFS Stack Options

• Herbert/Allen
• Herbert/Johnston
• Herbert/Allen/Johnston
• Herbert/Nabers/Allen (or Johnston)
• Herbert/Skattebo/Nabers (or Allen or Johnston)

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