👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

Rams vs 49ers Start 'Em, Sit 'Em: Cam Akers, Darrell Henderson, George Kittle, Tyler Higbee, Brandon Aiyuk, Jeff Wilson Jr.

Matthew Stafford - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Fantasy football start em, sit em and lineups advice for the Rams v. 49ers Monday Night game in Week 4 (2022). MNF matchups analysis with detailed breakdowns.

Welcome back RotoBallers to Week 4 and our Monday Night Football matchups analysis! It's been an exciting Week 4 of NFL and fantasy football action, filled with plenty of booms, busts, and injuries, and now we get one more game on Monday night to finish it off.

Below you will find our matchups analysis for the Monday Night Football game between the Los Angeles Rams and San Francisco 49ers.

Read our fantasy football breakdowns for these games -- the recommended starts, sits, and matchups we love heading into the Week 4 matchups. Good luck RotoBallers!

Featured Promo: Looking for some more fantasy football action? Adopt a dynasty orphan team over at FFPC. Sign up today and get $25 off any FFPC league. Sign Up Now!

 

Los Angeles Rams at San Francisco 49ers - 8:15 pm ET 

Spread: 49ers -1.5
Implied Total: Rams (20.75) vs. 49ers (22.25)
Pace: Rams (20th) vs. 49ers (29th)
Rams Off. DVOA: 5.2% Pass (16th), -3.2% Rush (14th)
49ers Off. DVOA: 3.9% Pass (19th), -16.2% Rush (20th)
Rams Def. DVOA:
16.4% Pass (22nd), -30.6% Rush (4th)
49ers Def. DVOA: -24.7% Pass (5th), -32.6% Rush (3rd)

 

Fantasy Football Start 'Em, Sit 'Em - Monday Night Football

Matchups We Love:

George Kittle (TE, SF)

Kittle played 91% of snaps in his season debut, commanding five targets. With a full week of practice, he should be able to produce with a higher target share. Additionally, Los Angeles has given up some big performances to the opposing team's best receiving options, evidenced by their 22nd rank pass DOVA. He's a top-10 tight end in this matchup.

 

Matchups We Hate:

Cam Akers (RB, LAR)

Akers took another step towards a workhorse role, accounting for 12 of the 16 (75%) running back carries, and also found the end zone. It's very possible he's still regaining his explosiveness and comfort on the NFL field, which would mean he'll continue to get stronger and more productive each week.  He'll need a full complement of work in this one to have a big day because the 49ers are a difficult matchup. He's a top-30 back with upside if he finds the end zone.

Darrell Henderson (RB, LAR)

Henderson is still taking away carries from Akers but seems to be losing his grip on the timeshare. Henderson is best viewed as a player relegated to being a backup whose value lies with an injury to the starter.

Jeff Wilson Jr. (RB, SF)

Wilson Jr. is clearly the lead back but still has to contend with Deebo Samuel in the backfield. He was over 100 scrimmage yards again last week with 12 carries and three receptions. Los Angeles has an elite rush defense with the third-highest DVOA and third-fewest fantasy points allowed to running backs. He receives enough volume to keep him inside the top-30 despite the matchup.

Matthew Stafford (QB, LAR)

Stafford was unable to exploit the Arizona pass defense, throwing for only 249 yards with no touchdowns. Given their vulnerable secondary, this is a disappointing result. He stays in the division but goes to one of the league's most difficult matchups in San Francisco. The 49ers have the fifth-highest pass DVOA and have allowed the second-fewest fantasy point to quarterbacks. Stafford to fall outside the top-12 in this challenging matchup.

 

Other Matchups:

Cooper Kupp (WR, LAR)

Kupp had a strange performance, doing his damage on a 20-yard touchdown run while being limited to only four catches for 44 yards. The final result was okay but the usage was problematic. We have way too much of a sample size to react to this as anything more than an outlier performance for one of the best wideouts in the NFL. As referenced above, the matchup is a tough one but Kupp is too good to bench or even fade.

Deebo Samuel (WR, SF)

Samuel has yet to produce the type of blowup game he would frequently have in 2021. We could point to Trey Lance for the first week and a half but Jimmy Garoppolo returned as the starter part way through Week 2. We could also reference the difficult matchup against Denver last week, which may hold true. Nonetheless, this will be an opportunity for Samuel to bounce back with a big game against a beatable Rams defense. His hybrid role keeps him inside the top-15.

Brandon Aiyuk (WR, SF)

Aiyuk received eight targets against the Broncos, tying Samuel for the most in that game. It was Kittle's first game back so it's hard to assess how much work he'll receive moving forward, given that Kittle is expected to be the No. 2 option in the offense. The Rams have given up the most fantasy points to the receiver position, keeping Aiyuk in play as a top-36 receiver.

Tyler Higbee (TE, LAR)

Higbee produced another satisfactory game with four grabs for 61 yards. He's averaging five receptions per game, which is very impressive for a tight end. Despite a difficult matchup, the scarcity of quality options at the position pushes him inside the top-12.

 

Key Injuries:

Van Jefferson (knee)
Elijah Mitchell (knee)
Tyrion Davis-Price (ankle)



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Compare Any Players
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Shai Gilgeous-Alexander

Posts 25 in Series Opener
Paul George

Delivers 17 Points Against Boston
Tyrese Maxey

Leads 76ers in Game 1 Defeat
Jaylen Brown

Scores 26 Points in Game 1 Victory
Jayson Tatum

Posts Double-Double in Game 1 Win
Peyton Watson

Still Sidelined for Game 2
Anthony Richardson Sr.

Dynasty Value at All-Time Low
NFL

David Bailey Visits Several Teams Leading Up to the NFL Draft
Anthony Edwards

Listed as Questionable for Game 2
NFL

Oscar Delp Takes Several Visits Ahead of Draft
NFL

Chiefs Talking with Cardinals About the No. 3 Pick
Carson Beck

Steelers Eyeing Carson Beck in the Draft?
Thomas Bryant

to Remain Out Monday
Juan Soto

is on Track to Return Next Homestand
Cade Cunningham

Playing Without Minutes Restriction Sunday
Corbin Carroll

Exits Sunday's Game with Back Tightness
OG Anunoby

Tagged as Probable for Monday
Onyeka Okongwu

Might Miss Game 2 Against Knicks
Immanuel Quickley

Questionable for Game 2
Jordan Goodwin

Ruled Out for Rest of Game 1
Jonathan Isaac

Ruled Out for Sunday
Desmond Bane

Available for Game 1
Artem Zub

Uncertain for Game 2
Karel Vejmelka

Makes Playoff Debut Sunday
Carter Hart

in Vegas Crease for Playoff Opener
Jeremy Swayman

Begins Fifth Postseason Campaign
Alex Lyon

Available for Game 1
Dominic James

Activated From Injured Reserve
NFL

Zachariah Branch Arrested for Misdemeanor Obstruction
New York Giants

Sonny Styles One of the Top Targets for Giants at No. 5 in NFL Draft
Renardo Green

49ers Looking to Trade Renardo Green?
Keenan Allen

Chargers Not Closing the Door on a Reunion With Keenan Allen
Grayson Allen

is Available for Game 1 on Sunday
A.J. Brown

Eagles Preparing for A.J. Brown's Departure?
Peter Skoronski

Titans to Pick Up Peter Skoronski's Fifth-Year Option
Breece Hall

Dynasty Upside Remains Limited by Offensive Environment in New York
Cincinnati Bengals

Dexter Lawrence Signing One-Year Extension With Bengals
Kristaps Porzingis

Unsure About Returning to Golden State
Drake London

Dynasty Upside Remains Limited by Quarterback Questions in Atlanta
Mark Williams

is Ruled Out for Game 1 on Sunday
Chris Olave

Dynasty Value Rising After Resurgent 2025 Season
Coby White

Hornets Want to Bring Back Coby White
Bucky Irving

Can Bucky Irving Bounce Back After Injury-Marred 2025?
Kenneth Walker III

a Major Dynasty Riser After Offseason Move to Kansas City
Desmond Bane

Considered Probable for Game 1
Bo Nix

Dynasty Value in Question Coming Off Injury?
Tarik Skubal

Fans 10 in Win Over Red Sox on Saturday
Raisel Iglesias

Dealing With Shoulder Issue
Davante Adams

Glaring Opportunity to Sell High on Davante Adams?
Jordan Addison

Can Jordan Addison Overcome Ugly Quarterback Situation?
Emeka Egbuka

a Trade Target in Some Dynasty Leagues
Kyle Larson

Should not be Underestimated for the Win at Kansas
Denny Hamlin

Can Denny Hamlin Dominate at Kansas Again?
NASCAR

Christoper Bell Should Contend for First Win at Kansas
Joel Eriksson Ek

Powers Minnesota Past Dallas in Opening Game
Tyler Reddick

Fastest in Practice and Qualifying for Kansas Race
Ryan Blaney

Could Score another Top-10 Finish at Kansas
Ty Gibbs

Poised to Continue Hot Streak at Kansas
Logan Stankoven

Makes Big Impact in Carolina's Game 1 Victory
Chris Buescher

Always Consistent, Has Speed Heading Into Kansas
William Byron

is A Solid DFS Option for Kansas Lineups
Carson Hocevar

Poised for Career-Best Run at Kansas
Porter Martone

Nets Game-Winning Goal to Defeat Pittsburgh
Frederik Andersen

Shuts Out Ottawa in Game 1
Chase Briscoe

Is Chase Briscoe Worth Rostering for DFS at Kansas?
Chase Elliott

Is A Favorable DFS Option for Kansas Lineups
Matt Boldy

Delivers Huge Game 1 Performance in Win
Joey Logano

Could Joey Logano be Considered Playable In DFS This Week at Kansas?
NASCAR

Bubba Wallace is A Favorable Driver to Consider for Kansas Lineups
Ross Chastain

Is Ross Chastain A Worthy DFS Option for Kansas?
Brad Keselowski

Could Brad Keselowski be A Sneaky DFS Option for Kansas?
Daniel Suarez

Should DFS Managers Roster Daniel Suarez at Kansas?
Dylan Harper

is Ready for Sunday's Game
Stuart Skinner

Starting Game 1 Against Flyers
Alexandre Carrier

Back at Practice
Jared McCann

Undergoes Lower-Body Procedure
Andrei Kuzmenko

Activated From Injured Reserve
Victor Hedman

Out for Game 1 on Sunday
William Karlsson

Unavailable for Start of First-Round Series
Quinn Hughes

Available Saturday
Miro Heiskanen

Cleared for Game 1
Jhoan Duran

Placed on 15-Day Injured List With Oblique Strain
Kyle Stowers

Will be Activated on Sunday
Jesper Wallstedt

to Start in Goal for Minnesota on Saturday
Logan Stankoven

Presumed Ready for Game 1
Max Muncy

has Another Multi-Homer Game at Coors Field
Lourdes Gurriel Jr.

Expected to Make Season Debut on Saturday
Austin Riley

Hits Two Home Runs in Shutout Win Over Phillies
Daulton Varsho

Removed Early on Friday With Knee Discomfort
Edwin Uceta

Having More Shoulder Issues, "Shut Down for a Few Days"
Josh Hader

Moved to 60-Day Injured List
Willson Contreras

Returns to Red Sox Lineup on Friday
Daniel Palencia

Goes on 15-Day Injured List With Oblique Strain
Juan Soto

Still on Track to Return Next Week
Los Angeles Angels

Garret Anderson Dies at 53 Years Old
Mike Malott

A Favorite At UFC Winnipeg
Gilbert Burns

Set For UFC Winnipeg Main Event
Kyler Phillips

Set UFC Winnipeg Co-Main Event
Charles Jourdain

Looks To Extend His Win Streak
Jai Herbert

An Underdog At UFC Winnipeg
Mandel Nallo

Set For His UFC Debut
Karine Silva

Looks To Get Back In The Win Column
Jasmine Jasudavicius

Looks To Bounce Back
Parker Messick

Flirts With No-Hitter in Latest Gem Against Orioles
Mike Trout

Hits Five Homers in Series Versus Yankees
Spencer Arrighetti

Fans 10 in Season Debut, to Remain a Focal Point in Rotation?
Nick Pivetta

Dealing With Flexor Strain, Could Miss Months
Nico Hoerner

Homers, Drive in Five in Win Over Phillies
CFB

Michigan Lands Commitment From Quarterback Kamden Lopati
Sahith Theegala

Brings Strong Form Into Harbour Town
Wyndham Clark

Needs Putter to Show Up at RBC Heritage
Jacob Bridgeman

Looks to Return to Elite Form at Harbour Town
J.J. Spaun

a Volatile Option at RBC Heritage
PGA

Sungjae Im Offers High-Upside Value at RBC Heritage
Matt Fitzpatrick

Set for Another Strong Showing at RBC Heritage
Jason Day

Eyes Bounce-Back After Sunday Struggles at the Masters
Akshay Bhatia

Looking to Rebound at Harbour Town
Cameron Young

Hoping to Secure Second Win of Season at RBC Heritage
Scottie Scheffler

Looks to Win Again at RBC Heritage
Shane Lowry

Has Disappointing Final Round at Masters
Viktor Hovland

Hoping to Build on Final Round at Masters
Brian Harman

Struggling For Consistency Heading to RBC Heritage
Chris Gotterup

Putting Together Outstanding 2026 Season
Justin Thomas

Looks to Defend in Hilton Head
Jordan Spieth

in Search of Improved Putting at RBC Heritage
Marco Penge

May Continue Up-and-Down Ride at the RBC Heritage
Xander Schauffele

Could Get The Job Done at RBC Heritage
Jake Knapp

Keeps Building Strong Results in 2026
Kurt Kitayama

Trying to Regain Form From Florida
Collin Morikawa

Continues to be a Scary DFS Play at RBC Heritage
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF