Wide Receiver Matchups to Target For Week 13 (2025) - Jaxon Smith-Njigba, Puka Nacua, Jaylen Waddle, Khalil Shakir, John Metchie III

Kyle's favorite WR vs. CB matchups to exploit for Week 13 of 2025 - DFS wide receivers to target on DraftKings and FanDuel. These WR/CB matchups are GPP and cash game opportunities.

Welcome to the Wide Receiver Matchups to Target column for Week 13 of the 2025 NFL season. We're nearing the end of the season, so we have all the data in the world at our disposal. We'll use individual performance, matchup grades, pace of play, and implied totals to pinpoint the best WRs to target in daily fantasy lineups. Amon-Ra St. Brown and A.J. Brown were big hits from this article in Week 12 as they both crushed value, but Stefon Diggs, Zay Flowers, and Luther Burden III didn't quite come through for us.

This week, we'll break down the top five WR/CB matchups using Pro Football Focus (PFF) grades, along with key usage metrics that indicate which players can realistically hit three times their DraftKings salary. This is meant to serve as a guide for both cash games and GPPs -- these guys are in position to smash regardless of the contest type you're playing in.

Be sure to jump into our RotoBaller Discord! We have so many different channels devoted to whatever you're playing in fantasy football. We also have lots of great NFL DFS articles and NFL DFS tools to help you win MORE this season! Below are my top five WR vs. CB matchups for this week’s DFS main slate. Use these insights to fine-tune season-long lineups, player props, and DFS builds. Let’s get to it!

Jaxon Smith-Njigba, Seattle Seahawks

• $9.5K on DraftKings, $10K on FanDuel
• Vs. Isaiah Rodgers (Minnesota Vikings)

What Jaxon Smith-Njigba is doing in his third NFL season is absolutely insane. He's WR1 in the fake football game we all play, but he also ranks: #1 in target share (37.4%), #1 in air yards (122.4 per game), #1 in receptions (7.3 per game), #1 in receiving yards (119.4 per game), #1 in yards per route run (4.53), #1 in explosive rating (159.6), #1 in fantasy points per route run, #2 in yards per target, #2 in deep targets, and #5 in yards after catch. He is dominating in every matchup, so we're going to target him heavily in favorable matchups like the one he has this week.

JSN 63-YARD TOUCHDOWN.

SEAvsTEN on FOX/FOX Onehttps://t.co/HkKw7uXVnt pic.twitter.com/wtqsQxa5rk

— NFL (@NFL) November 23, 2025

The Vikings rank 20th in pass DVOA, 27th in DVOA vs. WR1s, 20th in PFF's defense grade, and 30th in PFF's coverage grade. JSN will primarily match up against Isaiah Rodgers (37th of 113 CBs), who ranks well via PFF, but has noticeably struggled against top-tier receivers (27.9 coverage grade vs. PHI, 47.2 coverage grade vs. DET).

The Vikings are better against the run, so the Seahawks may need to lean on JSN and the passing attack to produce in Week 13. With a high 26.5-point implied total at home, we should be overweight in our exposure to the star receiver in DFS contests.

Puka Nacua, Los Angeles Rams

• $9K on DraftKings, $9.3K on FanDuel
• Vs. Mike Jackson, Akayleb Evans (Carolina Panthers)

The Panthers have been surprisingly solid defensively this season, but they don't stand a chance at containing Puka Nacua. They rank 20th in PFF's defense grade, 14th in PFF's coverage grade, and have allowed the second-least fantasy points per game to WRs this season.

However, they don't fare as well in the predictive metrics, ranking 25th in pass DVOA, 25th in DVOA vs. WR1s, and 25th in defensive EPA. The Panthers will be without starting cornerback Jaycee Horn, leaving journeyman Akayleb Evans (unranked) and Mike Jackson (23rd of 113 CBs) tasked with covering the superstar.

Nacua has averaged a usable 18.1 DK PPG over his last four games, but he hasn't produced a true "ceiling" game since Week 5 (24.5 DK points) against the 49ers. Part of the problem is that Davante Adams is running scorching-hot in the touchdown department, something that's due to regress to the mean at some point. Adams will probably have his chances again in this one, but with the Rams holding a lofty 27.5-point implied total, there should be plenty of meat on the bones for Nacua to remind everyone how special he truly is. Fire him up in all formats in Week 13.

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Jaylen Waddle, Miami Dolphins

• $6.8K on DraftKings, $7K on FanDuel (DraftKings Preferred)
• Vs. Quincy Riley, Kool-Aid McKinstry, Alontae Taylor (New Orleans Saints)

Waddle didn't do much in a favorable Week 11 spot (8.2 DK points vs. WAS), but he averaged 18.2 DK PPG over his previous three contests, and he's set up for another big game in Week 13. The Dolphins hold a solid 23.5-point implied total in a game where they're six-point favorites, which means the game should stay competitive enough for Miami to have to throw the ball. Waddle holds a high 29.6% target share since Tyreek Hill got injured in Week 4, and that type of usage is going to translate into ceiling fantasy performances against weak defenses more often than not.

The Jaylen Waddle disrespect on this app is CRAZY. In 22 games without Tyreek Hill, Waddle has:

- 136 receptions
- 1,558 yards
- 10 TD

He is a true WR1 when he’s asked to be. pic.twitter.com/up03GnnH1u

— King of Phinland🐬👑 (@KingOfPhinland) November 2, 2025

New Orleans ranks 24th in pass DVOA, 19th in DVOA vs. WR1s, and 23rd in defensive EPA. They rank well in terms of fantasy points allowed against WRs (sixth-least), but the WR-vs-CB matchups decidedly favor Waddle.

Quincy Riley (73rd of 113 CBs) will be his primary defender, and he has allowed one of the highest average depth of target (aDOT) on the slate at 15.5. Kool-Aid McKinstry (70th of 113 CBs) will also see snaps against him, a defender who has allowed 520 receiving yards (14.4 yards per reception) and seven touchdowns this season. Waddle can go nuclear here, but he should be reserved for tournaments/GPPs.

Khalil Shakir, Buffalo Bills

• $5.5K on DraftKings, $6.3K on FanDuel
• Vs. Brandin Echols (Pittsburgh Steelers)

Shakir feels like he's priced too low here, particularly on DraftKings. He has produced two games with at least 20.8 DK points over his last five contests, and he holds a team-high 27% target rate over his last four games. He gets a lot of short targets out of the slot (62% slot snap rate), but he ranks #1 in the NFL in yards after catch (426 yards). This should translate into a big fantasy game against the Steelers, who have allowed the third-most fantasy points per game to WRs this season.

They're a middle-of-the-pack defense in terms of PFF's grading, DVOA, and EPA, but this is the type of matchup Shakir can thrive in. They play man defense 35% of the time, which is a high rate in the NFL and advantageous for a slot-heavy receiver like Shakir. With the Bills being just three-point favorites while holding a high 24.25-point implied total on the road in Pittsburgh, I expect them to have to air it out a bit to come out with a win in a pivotal game. Plug in Shakir as a sneaky, underpriced tournament option.

John Metchie III, New York Jets

• $3.8K on DraftKings, $5.7K on FanDuel (DraftKings Preferred)
• Vs. Dee Alford (Atlanta Falcons)

Metchie III is everyone's favorite value pick of the week, but he absolutely should be. The former Eagles' benchwarmer has crushed value over the last two weeks, scoring 13.5 and 18.5 DK points with a combined nine receptions, 110 receiving yards, and two scores. He's tied with Adonai Mitchell for the team-high target share over that stretch at 25.9%, and the Jets' offense at least looks more playable with veteran Tyrod Taylor now running the show.

Tanner Engstrand talks about what John Metchie has shown since being traded to the Jets:

"Metchie's showed me a lot - dedication, grit, willingness to take information and run with it. And we obviously saw production the last couple of weeks with a couple of touchdowns and some… pic.twitter.com/hfkVtqNPEz

— Jets Videos (@snyjets) November 28, 2025

They get the Falcons this week, a team that ranks 26th in DVOA vs. WR1s and has allowed the 15th-most fantasy points per game to WRs. They've been OK, but it's the individual matchup Metchie will see that really makes him appealing. Dee Alford (93rd of 113 CBs) has struggled mightily this season, and he has allowed a 73% catch rate and 208 receiving yards over his last four games (MIA, NE, IND, NO). We're playing Metchie because of his role and his price, but he has a favorable matchup that could unlock a monster game in Week 13.

Thanks for reading, and good luck with your DFS contests!

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