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The San Francisco 49ers' D/ST unit has been a disappointment in fantasy in 2025, in no small part due to its inability to force turnovers or get to opposing quarterbacks. They may get some help in that regard in Week 11 when they meet with the Arizona Cardinals. Arizona has given up six turnovers in its last two games and is allowing the seventh-highest pressure rate and fifth-highest sack rate in the league. The 49ers won't see Cardinals wide receiver Marvin Harrison Jr. (illness), who had his appendix removed earlier this week. Running back Bam Knight (ankle) is listed as questionable after three straight limited practices, further dampening the Cardinals' prospects on offense. On the Niners' side, starting cornerback Deommodore Lenoir (calf) is listed as questionable after downgrading from a limited practice to a DNP on Friday. San Francisco's track record doesn't offer much optimism, but they are a serviceable streaming option given their matchup in Week 11.--Dan Stephens
Source: 49ers.com
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