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DraftKings Daily Fantasy Baseball Picks (4/5/21): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on 4/5/21. Euan Leith's MLB DFS analysis and sleepers for building optimal DFS rosters.

Happy Monday, RotoBallers! We kick off the first whole week of baseball with a seven-game featured slate on DraftKings. I would've loved to have the Orioles-Yankees contest here, but there will still be some great picks to add to our rosters as we kick off the week.

We get the surprising addition of Jacob deGrom to add to our options at pitcher tonight. It will be hard to get away from him with the lack of other aces on the mound. Of course, you can use his high roster percentage as leverage against him in tournaments, but you'll be hard-pressed to get in the money without him in cash games.

This article will provide you with my daily fantasy baseball lineup picks for DraftKings on 4/5/2021. The lineup will range from some of the elite players to mid-priced options and value plays. You can also check out today's FanDuel MLB DFS lineup picks and read more DFS advice and lineup picks for other sports too. It’s also important to monitor injury news and today's MLB starting lineups. If you have any questions or comments, contact me on Twitter.

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DraftKings DFS Starting Pitchers

Jacob deGrom - P, NYM at PHI ($10,700)

With the Nationals and Mets series postponed over the week due to COVID-19 concerns, we have the option to play Jacob deGrom on a day where some teams are rolling out their third, fourth, or fifth starters. He's $1,900 more than Dustin May, and he is worth the premium on this seven-game schedule. In the shortened 2020, the 32-year old posted a career-high 38.8 percent strikeout rate and accumulated 104 strikeouts in 68 innings. DeGrom reached 200 IP in three straight seasons from 2017-2019, and last season he went at least six innings in eight of his 12 starts. New York is heavily favored (-220) in this season-opening contest and should put deGrom in a great spot to pick up the win.

Carlos Rodon - P, CWS at SEA ($6,700)

If we are going with a top-of-the-line ace like deGrom, we need to find a bargain-bin option if we want the chance to fit in some quality bats on Monday. Rodon is questionable at best, but the matchup is superb. The Mariners couldn't hit water if they fell out of a boat against lefties in 2020. Last season, they slashed .190/.279/.331 as a team versus southpaws and struck out 27.26 percent of the time. The White Sox scored 22 runs in four games over the weekend and will give Rodon plenty of run support to get the win as long as he gets through five innings.

Other Options: Trevor Williams vs. MIL ($8,300), Michael Wacha at BOS ($7,200)

 

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DraftKings DFS Infielders

James McCann - C, NYM at PHI ($3,700)

McCann will make his New York Mets debut on Monday against left-handed hurler Matt Moore and the Philadelphia Phillies. McCann will be batting near the bottom of a dangerous Mets lineup and have the righty-lefty advantage in his first game. It will put him in an excellent spot to make a good first impression. McCann has a .356 wOBA and 124 wRC+ versus southpaws compared to a .277 wOBA and 70 wRC+ against righties for his career.

Yuli Gurriel - 1B, HOU at LAA ($3,700)

I'll have a fair share of the Houston offense in my Monday lineups. Their lineup came out of the gates firing on all cylinders for 2021. They put up 35 runs on Oakland over four games. For context, they scored 25 runs in 10 games against the A's last season. Gurriel wasn't the most electric Astros over the four-game series, but he made his presence felt. The 36-year old went 7-for-15 with two runs, three RBI, a double, a home run while showing some plate discipline with four walks to one strikeout. He's batting fifth in a potent Astros lineup and should have plenty of chances to drive in some runs tonight.

Jake Cronenworth - 1B/2B, SD vs. SF ($3,400)

If you sat out the 2020 MLB DFS season, then you may have missed the phenom that is Jake Cronenworth. He exploded onto the baseball scene as a righty-smasher and was second in the National League Rookie of the Year voting. Last season, Cronenworth slashed .316/.382/.581 against righties and was, at times, a DFS cheat code. He slotted in as the sixth hitter during the first two games of the season but hit fifth on Saturday and, in a highly encouraging sign, second yesterday. If he can stay in the two-hole versus right handers (like Anthony DeSclafani tonight), Cronenworth's price won't be $3,400 for much longer.

Francisco Lindor - SS, NYM at PHI ($4,700)

I'm in on the Mets today. Lindor will be batting second ahead of a dangerous lineup in a hitter-friendly park and always has the platoon advantage with him being a switch hitter. I don't believe that Matt Moore will be throwing deep into this one, which means Lindor can get some looks against this Phillies bullpen. I realize they didn't give up a single run in their opening series versus the Braves, but I will need a little more of a sample size before I fade this unit. Lindor is priced down at the position for Monday. I also considered the red-hot Corey Seager ($5,600) but preferred the $800 in savings to spend elsewhere for tonight's slate.

Alex Bregman - 3B, HOU at LAA ($5,500)

Bregman delivered the goods on Friday with a home run and I'll look for him to come through again tonight. He'll have the righty-on-lefty matchup we love to exploit, and Quintana hasn't fared great versus right-handed batters in recent years. In 2019, Quintana allowed 19 home runs and a .290/.336/.466 slash line in 129.2 innings. As previously mentioned, the Houston offense is off to a red-hot start, and Bregman is right in the middle of the action.

 

DraftKings DFS Outfielders

Austin Meadows - OF, TB at BOS ($4,400)

Meadows is sitting at the top of the Tampa Bay offense so far in 2021, and the early returns look extremely promising. He batted first or second in every game during the opening weekend and produced a 3-for-11 line with two home runs, two RBI, and two walks. He'll face right-handed hurler Nick Pivetta in Fenway, and Meadows should excel. During his breakout 2019, the 25-year old slashed .298/.384/.576 against righties with 24 home runs. This game has an over/under of 9.5 runs, and there will be fireworks with some not-so-great pitching on the mound.

Jared Walsh - 1B/OF, LAA vs. HOU ($3,900)

Walsh was the walk-off hero for the Angels on Sunday night with a three-run bomb to clinch the series over the Chicago White Sox. He started the final two games of the weekend and went 4-for-8 with three runs, six RBI, a triple, and two home runs. Now, Walsh will welcome the Houston Astros and rookie pitcher Luis Garcia to Anaheim. He batted fifth in both those games and, if that sticks, he will be in a tremendous run-producing role. The Astros are a hot offense right now, but their starters didn't pitch more than six innings in any start. Their bullpen was used a lot and could give some promising late-inning opportunities to kick off the week.

Chas McCormick - OF, HOU at LAA ($2,000)

McCormick will be an exciting test of the DFS strategy for price vs. lineup slot. He hit ninth for the Astros in yesterday's game after Michael Brantley (wrist) sat out, and McCormick provided incredible returns on one swing of the bat. He went 1-for-3, but it was a three-run blast off Yusmeiro Petit in the sixth inning. He's $2,000, and it will give any DFS roster a leg up to empty their wallets at other spots in the lineup. Also, he'll be batting right ahead of Jose Altuve, Kyle Tucker, and Alex Bregman with a lefty on the mound. Sometimes the ninth spot isn't all that bad.



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REAL-TIME FANTASY NEWS

Bobby Portis

Questionable to Play Friday
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Named Offensive Rookie of the Year
Myles Garrett

Unanimously Wins Defensive Player of the Year Award
Nikola Vučević

Nikola Vucevic Set for Celtics Debut Friday
Joel Embiid

Good to Go Against Lakers
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Ready to Return Friday
George Lombard Jr.

Yankees Invite George Lombard Jr. to Spring Training
Pascal Siakam

Available Friday
David Bañuelos

Twins Sign David Banuelos to Minor-League Deal
Ty Jerome

to Sit Out Friday's Action
Deni Avdija

Considered Questionable for Friday's Matchup
Cole Carrigg

Rockies Invite Cole Carrigg to Spring Training
De'Anthony Melton

Will Play Against Suns
Charlie Condon

Invited to Big-League Spring Training
Jalen Duren

Exits Early Thursday
Emmanuel Clase

Accused of Rigging Pitches in 48 Games
Darius Garland

Unavailable Friday Night
Domantas Sabonis

Iffy for Friday
Josh Okogie

Tari Eason Out Thursday
Kelly Olynyk

Luke Kornet Out, Kelly Olynyk In Thursday
Julius Randle

Still Dealing With Thumb Issue, Questionable for Friday
OG Anunoby

Listed as Probable for Friday
Marvin Bagley III

Not Available Thursday for Dallas
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Cleared to Play Thursday
Dylan Cardwell

Earns Four-Year Contract With Sacramento
Jock Landale

Makes Hawks Debut as Starter
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to Mostly Work in the Outfield
Brandon Williams

Unavailable Thursday
Daniel Gafford

Set to Play vs. San Antonio
Brad Marchand

Evan Rodrigues Among Panthers Absentees Thursday
Calum Ritchie

Rejoins Islanders Lineup as Second-Line Center
Zach Benson

Sits Out Second Straight Game
Pierre-Luc Dubois

Available Against Predators
Rickard Rakell

Out Thursday
Brayden Point

Won't Play in Olympics
Jonathan Huberdeau

to Have Season-Ending Hip Surgery
Kade Strowd

Diamondbacks Pick Up Kade Strowd, Two Minor-Leaguers
Blaze Alexander

Orioles Acquire Blaze Alexander From Diamondbacks
Osvaldo Bido

Yankees Claim Osvaldo Bido Off Waivers From Angels
Ken Waldichuk

Nationals Claim Ken Waldichuk Off Waivers From Rays
Tarik Skubal

Wins Arbitration Case, to Make $32 Million in 2026
Colt Emerson

to Begin the Year in the Minors?
Cole Young

Appears to be the Favorite to Start at Second Base
Brendan Donovan

Expected to Mostly Play 3B in Seattle
Luke Maile

Royals Re-Sign Luke Maile to Minor-League Deal
CFB

Houston, Vanderbilt, Tennessee Land Top-Three QBs in 2026 Class
Joe Mixon

Committed to Playing in 2026
CFB

Michigan Signs Top-15 Recruiting Class Despite Coaching Change
José Urquidy

Pirates Sign Jose Urquidy to One-Year Deal on Thursday
Corbin Burnes

No Setbacks for Corbin Burnes, Aiming for July Return
CFB

USC Finishes with No. 1 Signing Class in 2026
Angel Genao

Ready to Rebound in 2026?
Marcelo Mayer

Expected to See More At-Bats Against Lefties
Zac Gallen

Targeted by the Orioles?
Brice Turang

Brings Big Upside at a Thin Position
Valeri Nichushkin

Sets Up Three Goals Wednesday
CFB

Trinidad Chambliss Denied Medical Redshirt Waiver By NCAA
Ryan O'Reilly

Delivers Three Assists in Overtime Loss
Matt Boldy

Records Historically Fast Hat Trick Wednesday
Jet Greaves

Gives Blue Jackets Second Straight Shutout
Wyatt Kaiser

Hurt Against Blue Jackets
Sandis Vilmanis

Injured in Wednesday's Win
Jack Hughes

Out Thursday
Marcus Foligno

Out Wednesday Against Predators
Kiefer Sherwood

Set for Sharks Debut on First Line
Martin Necas

Misses Third Consecutive Game
Kirill Marchenko

a Game-Time Call Wednesday
Sam Bennett

Anton Lundell Available for Panthers Wednesday
Nick Bjugstad

Devils Add Nick Bjugstad in Trade
Artemi Panarin

Traded to Kings, Signs Two-Year Extension
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Sam Leavitt to be Limited In Spring Practice
Jordan Love

Avoids Offseason Surgery
Matt Fitzpatrick

Back in Action at WM Phoenix Open
Sahith Theegala

Riding Hot Start Into WM Phoenix Open
J.J. Spaun

Looks to Regain Form at WM Phoenix Open
Viktor Hovland

a Volatile Option at WM Phoenix Open
Rasmus Hojgaard

Aims to Build on Solid Start to 2026
Brian Harman

Looks to Find Form at WM Phoenix Open
Daniel Berger

Has the Tools to Go One Step Higher at Scottsdale
Max Greyserman

Searching for Consistency at WM Phoenix Open
Jake Knapp

Wants Revenge at WM Phoenix Open
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Joey Aguilar Granted Temporary Restraining Order Against NCAA
Joel Dahmen

Carrying Momentum Into WM Phoenix Open
Corey Conners

Unlikely to Contend at Scottsdale
Sepp Straka

Seeks a Rebound After The American Express
Jordan Spieth

Healthy Heading to WM Phoenix Open
Keith Mitchell

Building Momentum for Event in Scottsdale
Tom Hoge

The Tom Hoge Roller Coaster Heads to Scottsdale for WM Phoenix Open
Rickie Fowler

Worth a Look at WM Phoenix Open
Xander Schauffele

Making Second Appearance at Phoenix Open
Collin Morikawa

Needs a Bounce-Back at Waste Management Phoenix Open
Hideki Matsuyama

Has a Shot to Challenge at the Waste Management Phoenix Open
Max Homa

Playing Well Heading to Waste Management Phoenix Open
Ben Griffin

Will Need to Find Approach Game to Compete in Phoenix
Michael Penix Jr.

Matt Ryan Not Committing to Michael Penix Jr. as the Starting QB
NASCAR

Billy Horschel Unlikely to Right the Ship in Phoenix
Matthew Stafford

Doesn't Need Offseason Back Surgery
CFB

Joey Aguilar Files New Lawsuit Against NCAA Seeking Sixth Year of Eligibility
Davante Adams

Expected to Return to Rams in 2026
Los Angeles Rams

Rams Sign Sean McVay, Les Snead to Contract Extensions
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Alexander Volkanovski

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Dan Hooker

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Benoit Saint Denis Extends His Win Streak
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Maurício Ruffy Gets Back In The Win Column
San Francisco 49ers

49ers Set to Name Raheem Morris Their Defensive Coordinator
Las Vegas Raiders

Raiders Close to Naming Klint Kubiak the Next Head Coach
Arizona Cardinals

Cardinals Finalizing Deal to Make Mike LaFleur the Next Head Coach
CFB

Gus Malzahn Retiring from Coaching
Breece Hall

Jets Want to Re-Sign Breece Hall, Could Use Franchise Tag
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF