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DraftKings Daily Fantasy Baseball Picks (4/22/18): MLB DFS Lineups

Happy Sunday! We’ve got an 11-game featured slate on DraftKings today, one that excludes the west coast games. That still leaves us with Coors Field, Corey Kluber, and a lot of terrible, horrible starting pitchers.

It will be tough to fit the Klubot and the Coors Field bats in our lineup today, but there is plenty of value to be had in the middle and lower price range that will help us navigate through the Sunday slate. With so many bad pitchers on the mound today we won’t have to load up on Coors Field hitters to get some offense.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 4/22/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @ElliottBaasBB.

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DraftKings Starting Pitchers

Corey Kluber, CLE (@ BAL) - $12,800

There are a few good pitchers on the slate today, but none of them compare to Corey Kluber. Through his first four starts Kluber has a 30.3% strikeout rate, 1.52 ERA, 2.40 FIP, and .155 average against. Kluber also goes deep into games, having gone no less than 6.2 innings in every start thus far. When one pitcher stands above the rest it’s usually worth getting him in your lineup at all costs, at least in cash games. As a bonus this is a good matchup for Kluber. No team has struck out at a higher rate than the opposing Baltimore Orioles, who strike out 27.8% of the time collectively. The Orioles also have a .278 wOBA and 72 wRC+ against right-handed pitchers.

Luis Castillo, CIN (@ STL) - $7,200

Luis Castillo is better than his 6.75 ERA through four starts. His 3.62 xFIP and 3.76 SIERA suggest that. He also has a 51.3% strand rate, which is exceptionally unlucky even in a small sample size. Castillo also got a raw deal his last start out against the Brewers. He left with two earned runs over 6.2 innings, but reliver Cody Reed allowed two inherited runners to score, inflating Castillo’s final line. On the young season Castillo has actually increased his already impressive whiff rate. He currently has a 15.2% swinging strike rate on the season, suggesting he could improve on his 21.9% strikeout rate. Castillo is a great high upside SP2 to pair with Kluber.

 

DraftKings Infielders

C – Wilson Ramos, TB (vs. MIN) - $2,900

Phil Hughes is making his 2018 debut on Sunday, and we can’t let him go untouched. Last season Hughes had a 5.87 ERA, 5,41 FIP, and 2.01 HR/9. Hughes was once lauded for his control, but over the past few years his refusal to walk batters has gotten him punished in the strike zone. Hughes has allowed 52 homers in 268 innings since 2015, or 1.75 HR/9. Ramos is probably the best Ray to take advantage of Hughes. Ramos has a .188 ISO over the last two seasons and gives a power hitter at a generally weak position for a good price.

1B – Miguel Cabrera, DET (vs. KC) - $3,900

A rainout postponed Eric Skoglund’s start and ruined our Angels stack last week, and it’s time for revenge. When he finally made his start Skoglund got hammered for five runs on eight hits against the Blue Jays, which somehow lowered his career ERA from 9.53 to 9.43. Skoglund’s best attribute as a prospect was command, yet he has a 4.88 BB/9 over his career. He doesn’t have the stuff or the dominance to overcome such poor control. Miggy has bounced back nicely to begin the season, with an .830 OPS and 123 wRC+ on the young season. Even in a down year Miggy demolished left-handed pitchers. In 2017 he had a 149 wRC+ and .928 OPS against southpaws.

2B – Scooter Gennett, CIN (@ STL) - $3,100
For his career Gennett has been an above average hitter against righties, with a 109 wRC+ all time against them. During last year’s breakout he clobbered right-handers with a 133 wRC+, .261 ISO, and 23 of his 27 homers against them. He’ll face Cardinals righty Miles Mikolas, who has coughed up four homers in his first three starts this season. Gennett hasn’t homered yet this season, but he’s in a good position to catch one Sunday.

3B Jeimer Candelario, DET (vs. KC) - $3,400

We definitely want a little more exposure to Skoglund, and Candelario offers that at an affordable price. He has exploded over the last nine days, going 12-for-26 with three home runs during that span. Candelario is on fire and Skoglund is lighter fluid.

SS – Jean Segura, SEA (@ TEX) - $3,500

DraftKings pricing algorithm seems to hate Jean Segura. He is consistently under $4,000 despite back to back seasons with a wRC+ over 110, a batting average over .300, and more than 20 steals. Segura is off to a nice start this season, with a .303 average and three steals through 79 plate appearances. What really makes Segura a good play, despite the price, is his matchup against Martin Perez. Perez has been among the most hittable pitchers in the league thus far. He has a 13.14 ERA, 8.17 FIP, 1.00 K/BB, and 2.92 HR/9. He has the highest ERA and third highest FIP among pitchers with at least 10 innings this season. He may be achieving new lows, but Perez has never been good. Over 688.1 career innings Perez has a 4.59 ERA and 4.35 FIP.

 

DraftKings Outfielders

OF – Nelson Cruz, SEA (@ TEX) - $4,400

Remember all those reasons to play Jean Segura? The same apply to Nelson Cruz. He is Seattle’s best power hitter, and one of the elite power hitters in the game. Cruz is good against everybody, but he absolutely destroys left-handed pitchers. For his career he has .258 ISO and .392 wOBA against lefties. Globe Life Park was also the second most hitter friendly ballpark last season per ESPN park factors, so we are free to fade Coors with situations like the one in Arlington on Sunday.

OF – Mitch Haniger, SEA (@ TEX) - $3,700

Haniger has exploded out of the gate for five home runs and a .274 ISO in his first 73 plate appearances. Haniger had a .209 ISO and .360 wOBA last season in his first year as a big league regular. Like Segura, Haniger is underpriced given the matchup and in a great position on Sunday.

OF – Giancarlo Stanton, NYY (vs. TOR) - $4,900

Opposing starter Jaime Garcia may have a 3.86 ERA, but it comes with a 5.53 FIP and 2.20 HR/9. His 25.4% strikeout rate seems fluky given his 7.5% swinging strike rate. Despite a slump, Stanton still has a .233 ISO and four home runs in 83 plate appearances. Stanton is as big a home run threat as any player in baseball and is facing a pitcher that hasn’t been able to keep the ball in the yard consistently. Garcia has a 1.25 HR/9 over the last three seasons.

 

MLB DFS News and Injury Alerts

REAL-TIME FANTASY NEWS

Philadelphia Eagles

Eagles Offense to Borrow From Kyle Shanahan, Sean McVay in 2026?
Taysom Hill

Saints Haven't Offered a Contract to Taysom Hill
Kayshon Boutte

Working Out Away From the Team
Lamar Jackson

Expected to Return to OTAs Soon
Dalton Kincaid

Taking Part in OTAs This Week
Josh Allen

"Good to Go" for Offseason Workouts
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Rashee Rice

to Miss Two Months After Clean-Up Surgery on his Knee
Dean Wade

Returns to Starting Unit Tuesday
OG Anunoby

Starting on Tuesday
Tobias Harris

May Remain in Motown
Jalen Duren

Pistons Eager to Keep Jalen Duren
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Dallas Mavericks

Jason Kidd Fired as Mavericks Head Coach
De'Aaron Fox

Officially Listed as Questionable for Game 2 Against Thunder
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Tank Bigsby

Is Tank Bigsby a Worthy Dynasty Stash Entering 2026?
Hunter Henry

Profiles as a Dynasty Sell-High Candidate Entering 2026
Gerrit Cole

to Make Season Debut on Friday Against Rays
Matthew Golden

Can Matthew Golden Re-Establish His Dynasty Value in 2026?
Jalen Coker

a Prime Buy-Low Dynasty Target
Dak Prescott

Remains a High-Floor Dynasty Quarterback
CeeDee Lamb

Is CeeDee Lamb's Dynasty Value Poised to Rise in 2026?
Keon Coleman

Joe Brady Likes What he's Seen From Keon Coleman
Deshaun Watson

Hitting it Off With Todd Monken?
Jacoby Brissett

Not Present for First OTA Practice
Tua Tagovailoa

Michael Penix Jr. Splitting First-Team Reps at OTAs
Rashee Rice

Tests Positive for Marijuana, Violating his Probation
Cam Skattebo

Says he'll be Ready for Week 1
De'Von Achane

Present for Start of OTAs This Week
Malik Washington

an Affordable Trade Target in Dynasty Leagues
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
Alex Caruso

Erupts for 31 Points in Game 1 Loss to Spurs
CFB

Kemario Taylor a Breakout Candidate at Quarterback
Jalen Williams

Productive in Comeback Game
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
Shai Gilgeous-Alexander

Records First Double-Double of Postseason
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Stephon Castle

Opens Conference Finals With Double-Double
Dylan Harper

Makes Outstanding Two-Way Impact in Game 1 Win
Victor Wembanyama

Dominates Game 1 Against Thunder
Mattias Samuelsson

Picks Up an Assist in Season-Ending Loss
Rasmus Dahlin

Nets Fourth Postseason Goal
Jakub Dobes

Records 37 Saves in Game 7 Win
Lane Hutson

Contributes Power-Play Assist in Game 7 Victory
Nick Suzuki

Extends Road Point Streak
Alex Newhook

Scores Series-Clincher in Overtime
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Larry Nance Jr.

is Questionable for Game 1 on Tuesday
OG Anunoby

is Probable for Tuesday's Game 1
Luke Kornet

is Cleared for Game 1
New Orleans Pelicans

Jamahl Mosley Agrees to Become Pelicans Next Head Coach
De'Aaron Fox

is Ruled Out for Game 1 on Monday
Ukko-Pekka Luukkonen

Set to Start Game 7
Corey Seager

Going on Injured List With Back Injury
Tage Thompson

Can Match Franchise Record With Another Multi-Point Game
Nick Suzuki

Seeks More Road Success Monday
Lane Hutson

Riding a Five-Game Assist Streak Into Game 7
Filip Gustavsson

Needs Offseason Surgery
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Tobias Harris

Goes Cold in Game 7 Loss
Quinn Hughes

Open to Signing Extension This Offseason
Jalen Duren

Finishes Game 7 with Quiet Line
Cade Cunningham

Endures Cold Shooting Night Sunday
Joel Eriksson Ek

Misses Second Round Due to Heel Injury
Sam Merrill

Catches Fire in Game 7 Win
Jonas Brodin

Sits Out Round 2 Due to Toe Injury
Sam Malinski

Practices Fully Sunday
Josh Manson

Rejoins Practice
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF