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The San Francisco 49ers' D/ST has been hard to trust in 2025. Injuries have taken a significant toll on the unit and continue to do so. Nick Bosa (knee) was placed on injured reserve in September, followed by linebacker Fred Warner (ankle) in October, and linemen Yetur Gross-Matos (knee) and Mykel Williams (knee) in early November. Even the fill-in players aren't safe, with lineman Sam Okuayinonu (ankle) and linebacker Tatum Bethune (ankle) both out for this Sunday's game against the Browns. At least the matchup favors the 49ers, as Cleveland's offense has been managing just 15.8 points per game (fourth-worst in the NFL) and will feature rookie quarterback Shedeur Sanders in his second career start. Sanders had a 55% completion rate and put up an interception (his second this season) against the Raiders in Week 12. Poor weather should help keep scoring in check and make San Francisco's D/ST stream-worthy in Week 13.--Dan Stephens
Source: 49ers.com
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