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The San Francisco 49ers' D/ST unit has been an ineffective option for most of 2025, and Week 10 will likely be more of the same. The Niners have allowed more than 21 points in five of their last six games, have just one interception this season, and have the lowest quarterback pressure rate (25.5%) and second-lowest sack rate (3.3%) in the league. Fueling the futility has been a litany of injuries. Last week, Mykel Williams (knee) tore his ACL, becoming the second lineman from San Francisco (after Nick Bosa) to do so. Fellow lineman Yetur Gross-Matos (knee) and linebacker Fred Warner (ankle) are both on injured reserve. In Week 10, linemen Alfred Collins (hip), Kalia Davis (ankle), and Keion White (groin) are questionable, as are linebackers Dee Winters (knee) and Tatum Bethune (thigh). Leave San Francisco's D/ST out of fantasy lineups in Week 10, as those who remain will be hard-pressed to slow down the Rams' offense.--Dan Stephens
Source: 49ers.com
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