👉 TAP TO SAVE 50% WITH CODE SPRING
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


49ers vs. Seahawks TNF Start 'Em, Sit 'Em: Brock Purdy, Jordan Mason, Deebo Samuel, George Kittle, Geno Smith, Kenneth Walker III, DK Metcalf, more

Fantasy football start 'em, sit 'em, and lineup advice for the 49ers and Seahawks on Thursday Night Football in Week 6 (2024). Detailed player breakdowns and TNF matchup analysis.

Thursday Night Football for Week 6 presents two bitter rivals from an NFC West division that has been turned on its head since the start of the 2024 NFL season. Many of the fantasy football options from this division (Christian McCaffrey, Cooper Kupp, Puka Nacua, and Trey McBride) have been hurt or have underperformed. In addition, not all teams are performing to preseason expectations.

Consider that the two teams projected to make the playoffs -- the 49ers and the Rams -- are in third and fourth place, respectively, and are a combined 3-7. Seattle and Arizona have exceeded expectations, but the division is upside down. These four teams are a combined 2-6 in their last eight games somehow. As the division matchups kick into high gear this week, will one team emerge as a favorite?

I will bring you Thursday Night Football analysis all year, focusing on who to start, who is on the fence, and who should find the bench. Let's dive into this next awesome Thursday night matchup for Week 6 of the 2024 season. Good luck, RotoBallers!

Editor's Note: The FFPC Baby Gorilla Tournament is now open, featuring a $100,000 grand prize and a $675,450 total prize pool! This 12-team, Tight End Premium contest uses a 20-round draft format, with the overall winners determined by total points scored during Weeks 15–17. Get $25 to use toward your first entry by signing up through our link. Grab your team now! Sign Up Now!

 

San Francisco 49ers at Seattle Seahawks - 8:20 p.m. EDT

Notable Injuries:

 

49ers at Seahawks Matchup Breakdown

This matchup between the 49ers and Seahawks comes down to a tale of two teams in the red zone. If you just look at offensive touchdowns, you would think these teams are about equal on offense. Seattle scores 2.8 touchdowns per game compared to 2.2 for San Francisco.

But only one of these teams has been efficient near the end zone this season, and it's not the team that many were picking to win the Super Bowl. Seattle is scoring 2.8 touchdowns per game on 2.2 red-zone trips per game (30th in the NFL). San Francisco is scoring 2.2 touchdowns on 4.4 red-zone trips per game (third in the NFL).

The 49ers have scored touchdowns on just 40.9% of their red-zone trips this year, which is 29th in football. That has to change if they want to compete for the playoffs. Fortunately, this matchup against the Seattle defense might be the get-right spot.

Seattle lost 29-20 at home to the New York Giants last week, and it would have looked a lot worse if not for a goal-line fumble (that was returned for a touchdown) by New York. The game was a half-yard from being a 36-13 shellacking.

Seattle is 29th in football, allowing 3.8 red-zone scoring attempts per game. San Francisco has to convert in that area when it pushes Seattle that far.

 

Must-Starts for Fantasy Football Lineups

Brock Purdy (QB, SF)

After a 10-point dud in Week 1, Brock Purdy has at least 15 fantasy points in four straight games. He has all his pass-catchers healthy, and can still pick up points with his legs as well. Daniel Jones just dropped 22 points on Seattle with a backup running back and no Malik Nabers.

Jordan Mason (RB, SF)

What more needs to be said about Jordan Mason in Christian McCaffrey's absence? He is second in the NFL in rushing yards, first in attempts, and third in rushing yards per game. Despite never having anything like this kind of workload, Mason is averaging more than five yards per rush.

Deebo Samuel Sr. (WR, SF)

If last week was Brandon Aiyuk week, look for Deebo Samuel to bounce back in Week 6. After just one catch for 11 yards, Samuel remains a must-start because of his versatility, yards after the catch ability, and the fact that he is essentially the backup running back to Jordan Mason right now.

Brandon Aiyuk (WR, SF)

Brandon Aiyuk popped off against the Cardinals for eight catches for 147 yards on a season-high 12 targets. Most encouragingly, after a slow start due to the contract dispute, Aiyuk was up to 92% of snaps, which led all skill players for San Francisco.

George Kittle (TE, SF)

George Kittle has scored a touchdown in three straight games he played (he missed Week 3). In that time, he does not have fewer than four catches and 45 yards in any contest. As Brock Purdy's new favorite target, Kittle now has the second-best target share among tight ends (25.4%).

Kenneth Walker III (RB, SEA)

Just five rush attempts for Kenneth Walker III in a week after he scored three touchdowns seems almost criminal. But that's what he got on Sunday. He did receive eight targets and caught seven balls. Give him that usage in the passing game plus his routine 18-20 carries, and we could be talking about one of the best backs in all of fantasy football.

DK Metcalf (WR, SEA)

How has DK Metcalf earned his WR17 spot in half-PPR formats? Inconsistency, if we are being honest. His finishes by week so far have been: 2.9, 18.9, 16.4, 8.4, and 3.5. Still, we have to rely on the usage and trust that production will come. Metcalf is eighth in targets, fourth in routes run, fifth in air yards, and fourth in overall receiving yards.

 

Solid Starts for Fantasy Football Lineups

Jaxon Smith-Njigba (WR, SEA)

There is no doubt that JSN is a full-time player and is now an integral part of this Seattle offense. He is second on the team in targets with 40, just three behind Metcalf. However, it's been a roller coaster to get there. JSN has two games with 12 or more targets and two games with three or fewer.

Before he can graduate to must-start status in all leagues, there needs to be some consistency and touchdown upside. His four red-zone targets this year certainly help there.

Tyler Lockett (WR, SEA)

Tyler Lockett has taken a backseat to Smith-Njigba this season, but he is still routinely putting up flex-worthy performances. In only one game this season does Lockett not have at least five receptions or 75 yards.

Geno Smith (QB, SEA)

Why has Geno Smith ascended to a top-7 quarterback in fantasy football this season? He only has one game below 18 fantasy points this season. Smith leads the NFL in attempts, completions, and passing yards thanks to a new offense installed by Mike Macdonald.

He only has five passing touchdowns this year, but with this kind of volume, that is sure to change in the weeks ahead.

 

Consider Sitting for Fantasy Football Lineups

Jauan Jennings (WR, SF)

With just four targets and one catch on Sunday, what many feared might happen did occur when all of San Francisco's pass-catchers returned. Jennings dominated for two weeks while the 49ers battled injuries, but in Week 5, he played just half of their snaps.

Noah Fant (TE, SEA)

Despite a decent amount of preseason hype, Noah Fant is currently TE26 through five weeks. He has scored more than 3.9 fantasy points in half-PPR formats just once in five weeks.

Zach Charbonnet (RB, SEA)

Since playing more than 90% of the snaps in Weeks 2 and 3 when Kenneth Walker III was hurt, Charbonnet has reverted back into a part-time player. He was in on just 36% of Seattle's snaps on Sunday, and Walker also stole eight targets away from him in that game as well.

 

Kirksey’s Thursday Night Football Picks

Current Spread: San Francisco -3.5, Total: 47.5

Even this early in the season, the San Francisco 49ers -- who are the better team -- simply cannot fall two games behind Seattle in the division. Even more than that, they cannot give Seattle the advantage on the tiebreaker considering how competitive this division seems to be.

In the end, Seattle's defense is pushed to its ultimate limits by the plethora of playmakers on the 49ers. For the second week in a row, we get a shootout on Thursday Night Football.

The pick for Thursday Night Football this week is a desperate San Francisco 49ers team wins on the road, 30-24.

The Pick: San Francisco -3.5, OVER 47.5

2024 Record:
Spread (3-2), Over/Under (3-2)



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis




REAL-TIME FANTASY NEWS

Kenneth Walker III

One of Dynasty's Biggest Risers for 2026
NFL

D'Andre Swift an Underappreciated Dynasty Buy Candidate
Ray Davis

Still a Dynasty Stash Despite a Lack of Standalone Value
Travis Kelce

Now a Low-Cost Dynasty Rental
DJ Moore

a Reasonable Buy Candidate Now That Dynasty Market Has Cooled
MLB

Rays-Yankees Postponed on Saturday
Devin Vassell

Posts 20 Points in Game 3 Loss
De'Aaron Fox

Struggles From Deep in Friday's Loss
Victor Wembanyama

Held to Four Rebounds in Game 3 Loss
Jaylin Williams

Catches Fire From Deep Friday
Jared McCain

Drops Playoff-High 24 Points in Game 3
Nazem Kadri

Contributes an Assist in Losing Effort
Shai Gilgeous-Alexander

Guides Thunder to 2-1 Series Lead
Ajay Mitchell

Does Not Return in Game 3 Win
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Jordan James

Most Likely to be 49ers' RB2 in 2026
Mickey Moniak

Heads to Injured List With Ankle Sprain
Rudy Gobert

Earns Eighth All-Defensive First-Team Selection
Victor Wembanyama

Headlines 2025-26 All-Defensive First Team
Ajay Mitchell

Starting Game 3 Against Spurs
Dylan Harper

Available for Game 3 Against Thunder
De'Aaron Fox

Returns to Action Friday
Jalen Williams

Won't Play Friday Night
Derrick Henry

Remains in RB1 Discussion
Ladd McConkey

is Solid Buy-Low Candidate
Ryan Flournoy

an Intriguing Dynasty Stash Option
Jalen Nailor

is Expected to Have Larger Role in Las Vegas
Frederik Andersen

Hurricanes Keep Faith in Frederik Andersen
Devon Levi

Attracting Interest From Senators
Jacoby Brissett

Cardinals Not Close to a Reworked Deal
Scott Wedgewood

Starting Game 2 Against Golden Knights
Ben Hutton

Scratched for Game 2 Against Avalanche
Mark Stone

Won't Play Friday
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
Cale Makar

Remains Out Friday
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
NFL

Evan Stewart Pushing Oregon Receiving Corps
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
New York Giants

Giants, GM Joe Schoen Agree on a Multi-Year Extension
Andrew Thomas

Giants Managing Multiple Injuries for Andrew Thomas
Cam Ward

Loses 10 Pounds in the Offseason
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Tucker Kraft

a Top Trade Target in Dynasty Leagues?
Cedric Tillman

Falling Out of Favor in Cleveland
Emmett Johnson

the Handcuff to Roster in Kansas City?
Devaughn Vele

Could Dynasty Managers Sell High on Devaughn Vele Early in the Season?
Brenen Thompson

a Perfect Fit for Chargers, Rising in Dynasty Leagues?
Jonathan Taylor

Is Jonathan Taylor Still a High-End Dynasty Option?
Evan Mobley

Fills the Box Score in Game 2 Loss
James Harden

Held to Two Assists Thursday
Donovan Mitchell

Leads Cavaliers in Scoring in Game 2 Defeat
Karl-Anthony Towns

Records Double-Double in Game 2 Win
Sebastian Aho

Picks Up an Assist in Series-Opening Loss
Mikal Bridges

Adds 19 Points as Knicks Grab 2-0 Lead
Jalen Brunson

Hands Out 14 Assists in Game 2 Win
Seth Jarvis

Needs 33 Seconds to Score in Game 1 Loss
Josh Hart

Erupts for Playoff Career-High 26 Points in Game 2
Jaccob Slavin

Struggles in Game 1 Against Canadiens
Jakub Dobes

Sharp in Game 1 Victory
Cole Caufield

Bags Two Points in Impressive Road Win
Juraj Slafkovsky

Opens Conference Finals With Three-Point Performance
Nick Suzuki

Notches Three Assists in Game 1 Win Over Hurricanes
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Jrue Holiday

Wants to Stay in Portland
Alex Tuch

Hopes to Remain in Buffalo
Sidney Crosby

Wants to Play for "as Many Years as Possible"
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Corey Seager

Going on Injured List With Back Injury
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
Melquizael Costa

Drops Decision At UFC Vegas 117
Arnold Allen

Bounces Back
Daniel Santos

Suffers Second-Round TKO Loss
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF