👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

49ers vs. Seahawks TNF Start 'Em, Sit 'Em: Brock Purdy, Jordan Mason, Deebo Samuel, George Kittle, Geno Smith, Kenneth Walker III, DK Metcalf, more

Fantasy football start 'em, sit 'em, and lineup advice for the 49ers and Seahawks on Thursday Night Football in Week 6 (2024). Detailed player breakdowns and TNF matchup analysis.

Thursday Night Football for Week 6 presents two bitter rivals from an NFC West division that has been turned on its head since the start of the 2024 NFL season. Many of the fantasy football options from this division (Christian McCaffrey, Cooper Kupp, Puka Nacua, and Trey McBride) have been hurt or have underperformed. In addition, not all teams are performing to preseason expectations.

Consider that the two teams projected to make the playoffs -- the 49ers and the Rams -- are in third and fourth place, respectively, and are a combined 3-7. Seattle and Arizona have exceeded expectations, but the division is upside down. These four teams are a combined 2-6 in their last eight games somehow. As the division matchups kick into high gear this week, will one team emerge as a favorite?

I will bring you Thursday Night Football analysis all year, focusing on who to start, who is on the fence, and who should find the bench. Let's dive into this next awesome Thursday night matchup for Week 6 of the 2024 season. Good luck, RotoBallers!

Featured Promo: Looking for some more fantasy football action? Adopt a dynasty orphan team over at FFPC. Sign up today and get $25 off any FFPC league. Sign Up Now!

 

San Francisco 49ers at Seattle Seahawks - 8:20 p.m. EDT

Notable Injuries:

 

49ers at Seahawks Matchup Breakdown

This matchup between the 49ers and Seahawks comes down to a tale of two teams in the red zone. If you just look at offensive touchdowns, you would think these teams are about equal on offense. Seattle scores 2.8 touchdowns per game compared to 2.2 for San Francisco.

But only one of these teams has been efficient near the end zone this season, and it's not the team that many were picking to win the Super Bowl. Seattle is scoring 2.8 touchdowns per game on 2.2 red-zone trips per game (30th in the NFL). San Francisco is scoring 2.2 touchdowns on 4.4 red-zone trips per game (third in the NFL).

The 49ers have scored touchdowns on just 40.9% of their red-zone trips this year, which is 29th in football. That has to change if they want to compete for the playoffs. Fortunately, this matchup against the Seattle defense might be the get-right spot.

Seattle lost 29-20 at home to the New York Giants last week, and it would have looked a lot worse if not for a goal-line fumble (that was returned for a touchdown) by New York. The game was a half-yard from being a 36-13 shellacking.

Seattle is 29th in football, allowing 3.8 red-zone scoring attempts per game. San Francisco has to convert in that area when it pushes Seattle that far.

 

Must-Starts for Fantasy Football Lineups

Brock Purdy (QB, SF)

After a 10-point dud in Week 1, Brock Purdy has at least 15 fantasy points in four straight games. He has all his pass-catchers healthy, and can still pick up points with his legs as well. Daniel Jones just dropped 22 points on Seattle with a backup running back and no Malik Nabers.

Jordan Mason (RB, SF)

What more needs to be said about Jordan Mason in Christian McCaffrey's absence? He is second in the NFL in rushing yards, first in attempts, and third in rushing yards per game. Despite never having anything like this kind of workload, Mason is averaging more than five yards per rush.

Deebo Samuel Sr. (WR, SF)

If last week was Brandon Aiyuk week, look for Deebo Samuel to bounce back in Week 6. After just one catch for 11 yards, Samuel remains a must-start because of his versatility, yards after the catch ability, and the fact that he is essentially the backup running back to Jordan Mason right now.

Brandon Aiyuk (WR, SF)

Brandon Aiyuk popped off against the Cardinals for eight catches for 147 yards on a season-high 12 targets. Most encouragingly, after a slow start due to the contract dispute, Aiyuk was up to 92% of snaps, which led all skill players for San Francisco.

George Kittle (TE, SF)

George Kittle has scored a touchdown in three straight games he played (he missed Week 3). In that time, he does not have fewer than four catches and 45 yards in any contest. As Brock Purdy's new favorite target, Kittle now has the second-best target share among tight ends (25.4%).

Kenneth Walker III (RB, SEA)

Just five rush attempts for Kenneth Walker III in a week after he scored three touchdowns seems almost criminal. But that's what he got on Sunday. He did receive eight targets and caught seven balls. Give him that usage in the passing game plus his routine 18-20 carries, and we could be talking about one of the best backs in all of fantasy football.

DK Metcalf (WR, SEA)

How has DK Metcalf earned his WR17 spot in half-PPR formats? Inconsistency, if we are being honest. His finishes by week so far have been: 2.9, 18.9, 16.4, 8.4, and 3.5. Still, we have to rely on the usage and trust that production will come. Metcalf is eighth in targets, fourth in routes run, fifth in air yards, and fourth in overall receiving yards.

 

Solid Starts for Fantasy Football Lineups

Jaxon Smith-Njigba (WR, SEA)

There is no doubt that JSN is a full-time player and is now an integral part of this Seattle offense. He is second on the team in targets with 40, just three behind Metcalf. However, it's been a roller coaster to get there. JSN has two games with 12 or more targets and two games with three or fewer.

Before he can graduate to must-start status in all leagues, there needs to be some consistency and touchdown upside. His four red-zone targets this year certainly help there.

Tyler Lockett (WR, SEA)

Tyler Lockett has taken a backseat to Smith-Njigba this season, but he is still routinely putting up flex-worthy performances. In only one game this season does Lockett not have at least five receptions or 75 yards.

Geno Smith (QB, SEA)

Why has Geno Smith ascended to a top-7 quarterback in fantasy football this season? He only has one game below 18 fantasy points this season. Smith leads the NFL in attempts, completions, and passing yards thanks to a new offense installed by Mike Macdonald.

He only has five passing touchdowns this year, but with this kind of volume, that is sure to change in the weeks ahead.

 

Consider Sitting for Fantasy Football Lineups

Jauan Jennings (WR, SF)

With just four targets and one catch on Sunday, what many feared might happen did occur when all of San Francisco's pass-catchers returned. Jennings dominated for two weeks while the 49ers battled injuries, but in Week 5, he played just half of their snaps.

Noah Fant (TE, SEA)

Despite a decent amount of preseason hype, Noah Fant is currently TE26 through five weeks. He has scored more than 3.9 fantasy points in half-PPR formats just once in five weeks.

Zach Charbonnet (RB, SEA)

Since playing more than 90% of the snaps in Weeks 2 and 3 when Kenneth Walker III was hurt, Charbonnet has reverted back into a part-time player. He was in on just 36% of Seattle's snaps on Sunday, and Walker also stole eight targets away from him in that game as well.

 

Kirksey’s Thursday Night Football Picks

Current Spread: San Francisco -3.5, Total: 47.5

Even this early in the season, the San Francisco 49ers -- who are the better team -- simply cannot fall two games behind Seattle in the division. Even more than that, they cannot give Seattle the advantage on the tiebreaker considering how competitive this division seems to be.

In the end, Seattle's defense is pushed to its ultimate limits by the plethora of playmakers on the 49ers. For the second week in a row, we get a shootout on Thursday Night Football.

The pick for Thursday Night Football this week is a desperate San Francisco 49ers team wins on the road, 30-24.

The Pick: San Francisco -3.5, OVER 47.5

2024 Record:
Spread (3-2), Over/Under (3-2)



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis




POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Cody Williams

is Upgraded to Available
Jahmai Mashack

Remains Sidelined Wednesday
Jalen Smith

Won't Return to Wednesday's Game
Javon Small

Cleared to Play Wednesday
Kyle Filipowski

is Downgraded to Out
Ayo Dosunmu

Won't Play Wednesday Night
Jaylon Tyson

to Miss Third Straight Game
Keon Ellis

Joins Starting Lineup Against Heat
Max Strus

Won't Play on Wednesday
Dylan Harper

Moves Into First Unit Wednesday
Kyshawn George

to be Re-Evaluated in One Week
Dean Wade

Won't Play Wednesday
Larry Nance Jr.

is Available on Wednesday
Jalen Duren

Available Against Hawks
Deandre Ayton

Won't Play Wednesday, Jaxson Hayes Starts
Pascal Siakam

Will Play Against Lakers
Jalen Johnson

Cleared for Action Wednesday
Joel Embiid

Available Wednesday
Nicolas Roy

to Be Out For "a Little Bit"
Anton Lundell

Likely Out for Rest of Regular Season
Anthony Mantha

Day-to-Day With Lower-Body Injury
Evgeni Malkin

to Remain Out Thursday
Mattias Samuelsson

a Game-Time Call Wednesday
Quentin Grimes

Cleared for Wednesday
Jonathan Quick

Remains Unavailable Wednesday
Victor Hedman

Takes Leave of Absence
Jake Bates

Lions Officially Re-Sign Jake Bates
Patrick Mahomes

Chiefs "Optimistic" That Patrick Mahomes Can Take Part in Offseason Practices
Jordan Miller

Sidelined on Wednesday
Najee Harris

Visits With Seahawks
Tristan Vukcevic

Out Against Jazz
Sean Murphy

Lands on 10-Day Injured List
Bryce Miller

Placed on 15-Day Injured List With Oblique Strain
Lars Nootbaar

Will Begin the Season on 60-Day Injured List
Jackson Holliday

Placed on 10-Day Injured List
New York Jets

Ty Simpson to Hold Private Workout With Jets on Friday
Ronnie Rivers

Rams Re-Sign Ronnie Rivers to One-Year Deal
Las Vegas Raiders

Raiders to Host Fernando Mendoza for a Top-30 Visit in Two Weeks
Tua Tagovailoa

Open to Being a QB Mentor in Atlanta
Zay Flowers

Ravens Want to Extend Zay Flowers Soon
Jeremy Peña

Jeremy Pena on the Astros Opening Day Roster
Blake Snell

Dodgers Place Blake Snell on 15-Day Injured List
John Carlson

Sets Up Three Goals Tuesday Night
Joel Hofer

Picks Up Sixth Shutout of the Season
John Tavares

Records Three Assists in Tuesday's Win
NJ

Arseni Gritsyuk Scheduled for Imaging Wednesday
Jordan Mason

Could Benefit from Quarterback Change
Tony DeAngelo

Suffers Lower-Body Injury Tuesday
Aaron Rodgers

Mike McCarthy Would Welcome an Aaron Rodgers Reunion
Emmitt Finnie

Enters Concussion Protocol
Ryan Fox

a High-Upside Value in Houston
Barrett Hayton

Sustains Upper-Body Injury Tuesday
Dak Prescott

Remains Egregiously Undervalued
Marco Penge

a Boom-or-Bust Option in Houston
CeeDee Lamb

Cowboys' Offensive Cohesion Could Lead to Another Big Year from CeeDee Lamb
NFL

Jeremiyah Love Does Not Participate at Notre Dame Pro Day
Puka Nacua

Accused of Biting a Woman, Making Antisemitic Remarks
Aaron Rai

Looks to Bounce Back in Houston
Luther Burden III

Ascending Into Major Role on Offense?
Jason Day

a Volatile Option at the Texas Children's Houston Open
Joe Mixon

Remains a Free Agent as April Approaches
Kirby Yates

Angels Place Kirby Yates on 15-Day Injured List
Elijah Moore

Eagles Sign Elijah Moore to a One-Year Deal
Harris English

Eyes a Bounce-Back at the Texas Children's Houston Open
Ben Griffin

Looks for Turnaround at the Texas Children's Houston Open
Kirk Cousins

an Option as Backup Quarterback in Green Bay?
Zach Wilson

Saints Sign Zach Wilson to a One-Year Deal
Rickie Fowler

Brings Strong Form Into Texas Children's Houston Open
Brady Tkachuk

Collects Two More Points on Tuesday
Martin Necas

Scores Twice Against Penguins
Nick Lodolo

Will Open 2026 on the Injured List Due to Finger Ailment
Pete Crow-Armstrong

Agrees to Six-Year, $115 Million Extension With the Cubs
Igor Chernyshov

Returns to Sharks Lineup
Dylan Larkin

Good to Go Tuesday
Ross Colton

Logan O'Connor, Ross Colton Available Tuesday
Morgan Rielly

Back in Action Tuesday
Joel Eriksson Ek

Kirill Kaprizov, Joel Eriksson Ek Returning Tuesday
Joe Flacco

Reaches Agreement to Return to Bengals
Marvin Mims Jr.

Now a Trade Candidate in Denver?
Francisco Lindor

Likely to be Ready for Opening Day
Ryan Gerard

Can Continue Rolling at Texas Children's Houston Open
Pierceson Coody

Bounces Back at Valspar Championship
Rasmus Hojgaard

Trying to Get Back on Track at Texas Children's Houston Open
Michael Thorbjornsen

Playing Well Heading to Texas Children's Houston Open
Harry Hall

Looking for Consistency at Texas Children's Houston Open
Brooks Koepka

Continues Building Momentum
Roki Sasaki

to Stick in Rotation Despite Spring Struggles
Kevin McGonigle

Makes Tigers Opening Day Roster
Scottie Scheffler

Withdraws From Texas Children's Houston Open
Ryan Pepiot

Placed on Injured List to Open the Season
J.J. Wetherholt

JJ Wetherholt Likely to Hit Leadoff on Opening Day
Connelly Early

to Make First Start on Sunday
Luke Clanton

Might Have a Problem in Houston
Sam Stevens

Happy to See Houston This Week
Keith Mitchell

Tries to Rebound After The Players Championship
Will Zalatoris

Returning This Week at Houston
Wyndham Clark

Trending in the Wrong Direction Heading to Houston
Shane Lowry

Seeking Better Luck in Houston This Weekend
Kurt Kitayama

Poised to Bounce Back at the Houston Open
Pete Crow-Armstrong

Cubs, Pete Crow-Armstrong Finalizing Long-Term Extension
Blake Snell

Targeting a May Return
Hunter Greene

Reds Place Hunter Greene on 60-Day Injured List
J.J. Wetherholt

JJ Wetherholt Makes Cardinals Opening Day Roster
Nick Pivetta

to Start on Opening Day for Padres
Brandon Woodruff

Makes Brewers Opening Day Rotation
Lerone Murphy

Suffers His First Loss
Movsar Evloev

Edges Out Lerone Murphy
CFB

Notre Dame Ranks No. 1 in Returning Production for 2026
Michael Aswell

Jr. Drops Decision At UFC London
Michael Aswell

Luke Riley Outclasses Michael Aswell Jr.
Sam Patterson

Suffers Unanimous-Decision Loss
Michael Page

Wins Lackluster Decision
Austen Lane

Suffers First-Round TKO Loss
Iwo Baraniewski

Delivers 28-Second TKO
Tyler Reddick

Overcomes Adversity for Fourth Victory of the Season At Darlington
Brad Keselowski

Falls Short of Darlington Victory Despite Domination
Ryan Blaney

Recovers From Pit-Road Struggles to Score Career-Best Darlington Finish
Carson Hocevar

Rallies to Finish Fourth at Darlington
Kyle Larson

Decent Performance Ends with Technical Issues At Darlington
Tyler Reddick

the Clear Favorite at Darlington
Kyle Larson

a High-Risk, High-Reward Driver at Darlington
Ryan Blaney

Is Getting Better at Darlington
NASCAR

Bubba Wallace Not Slowing Down at Darlington
Chris Buescher

Should be a Top-10 Contender at Darlington
Austin Cindric

a Sleeper at Darlington
Erik Jones

Quickest in Practice at Darlington
Denny Hamlin

Qualifies Ninth for this Week's Cup Race at Darlington
Chase Briscoe

Is One of the Top DFS Options of the Week for Darlington
William Byron

Is William Byron A Playable DFS Option for Darlington Lineups?
Christopher Bell

Could Christopher Bell be Considered A Decent DFS Option for Darlington?
Chase Elliott

Is Chase Elliott Worth Rostering At Darlington This Week For DFS?
Joey Logano

May Not Have the Speed to Warrant A Darlington DFS Lineup Spot
Ross Chastain

Should DFS Players Trust Ross Chastain at Darlington?
Kyle Busch

Could Kyle Busch Be A Worthy DFS Option for Darlington?
Brad Keselowski

May be A Contriarian DFS Tournament Option At Darlington
Lerone Murphy

Set For UFC London Main Event
Movsar Evloev

Looks To Remain Unbeaten
Michael Aswell

Jr. An Underdog At UFC London
Luke Riley

Set For UFC London Co-Main Event
Sam Patterson

Looks To Extend His Win Streak
Michael Page

Set For Welterweight Bout
Austen Lane

In Dire Need Of Victory
Iwo Baraniewski

A Favorite At UFC London
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF