👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

49ers vs. Seahawks TNF Start 'Em, Sit 'Em: Brock Purdy, Jordan Mason, Deebo Samuel, George Kittle, Geno Smith, Kenneth Walker III, DK Metcalf, more

Fantasy football start 'em, sit 'em, and lineup advice for the 49ers and Seahawks on Thursday Night Football in Week 6 (2024). Detailed player breakdowns and TNF matchup analysis.

Thursday Night Football for Week 6 presents two bitter rivals from an NFC West division that has been turned on its head since the start of the 2024 NFL season. Many of the fantasy football options from this division (Christian McCaffrey, Cooper Kupp, Puka Nacua, and Trey McBride) have been hurt or have underperformed. In addition, not all teams are performing to preseason expectations.

Consider that the two teams projected to make the playoffs -- the 49ers and the Rams -- are in third and fourth place, respectively, and are a combined 3-7. Seattle and Arizona have exceeded expectations, but the division is upside down. These four teams are a combined 2-6 in their last eight games somehow. As the division matchups kick into high gear this week, will one team emerge as a favorite?

I will bring you Thursday Night Football analysis all year, focusing on who to start, who is on the fence, and who should find the bench. Let's dive into this next awesome Thursday night matchup for Week 6 of the 2024 season. Good luck, RotoBallers!

Featured Promo: Looking for some more fantasy football action? Adopt a dynasty orphan team over at FFPC. Sign up today and get $25 off any FFPC league. Sign Up Now!

 

San Francisco 49ers at Seattle Seahawks - 8:20 p.m. EDT

Notable Injuries:

 

49ers at Seahawks Matchup Breakdown

This matchup between the 49ers and Seahawks comes down to a tale of two teams in the red zone. If you just look at offensive touchdowns, you would think these teams are about equal on offense. Seattle scores 2.8 touchdowns per game compared to 2.2 for San Francisco.

But only one of these teams has been efficient near the end zone this season, and it's not the team that many were picking to win the Super Bowl. Seattle is scoring 2.8 touchdowns per game on 2.2 red-zone trips per game (30th in the NFL). San Francisco is scoring 2.2 touchdowns on 4.4 red-zone trips per game (third in the NFL).

The 49ers have scored touchdowns on just 40.9% of their red-zone trips this year, which is 29th in football. That has to change if they want to compete for the playoffs. Fortunately, this matchup against the Seattle defense might be the get-right spot.

Seattle lost 29-20 at home to the New York Giants last week, and it would have looked a lot worse if not for a goal-line fumble (that was returned for a touchdown) by New York. The game was a half-yard from being a 36-13 shellacking.

Seattle is 29th in football, allowing 3.8 red-zone scoring attempts per game. San Francisco has to convert in that area when it pushes Seattle that far.

 

Must-Starts for Fantasy Football Lineups

Brock Purdy (QB, SF)

After a 10-point dud in Week 1, Brock Purdy has at least 15 fantasy points in four straight games. He has all his pass-catchers healthy, and can still pick up points with his legs as well. Daniel Jones just dropped 22 points on Seattle with a backup running back and no Malik Nabers.

Jordan Mason (RB, SF)

What more needs to be said about Jordan Mason in Christian McCaffrey's absence? He is second in the NFL in rushing yards, first in attempts, and third in rushing yards per game. Despite never having anything like this kind of workload, Mason is averaging more than five yards per rush.

Deebo Samuel Sr. (WR, SF)

If last week was Brandon Aiyuk week, look for Deebo Samuel to bounce back in Week 6. After just one catch for 11 yards, Samuel remains a must-start because of his versatility, yards after the catch ability, and the fact that he is essentially the backup running back to Jordan Mason right now.

Brandon Aiyuk (WR, SF)

Brandon Aiyuk popped off against the Cardinals for eight catches for 147 yards on a season-high 12 targets. Most encouragingly, after a slow start due to the contract dispute, Aiyuk was up to 92% of snaps, which led all skill players for San Francisco.

George Kittle (TE, SF)

George Kittle has scored a touchdown in three straight games he played (he missed Week 3). In that time, he does not have fewer than four catches and 45 yards in any contest. As Brock Purdy's new favorite target, Kittle now has the second-best target share among tight ends (25.4%).

Kenneth Walker III (RB, SEA)

Just five rush attempts for Kenneth Walker III in a week after he scored three touchdowns seems almost criminal. But that's what he got on Sunday. He did receive eight targets and caught seven balls. Give him that usage in the passing game plus his routine 18-20 carries, and we could be talking about one of the best backs in all of fantasy football.

DK Metcalf (WR, SEA)

How has DK Metcalf earned his WR17 spot in half-PPR formats? Inconsistency, if we are being honest. His finishes by week so far have been: 2.9, 18.9, 16.4, 8.4, and 3.5. Still, we have to rely on the usage and trust that production will come. Metcalf is eighth in targets, fourth in routes run, fifth in air yards, and fourth in overall receiving yards.

 

Solid Starts for Fantasy Football Lineups

Jaxon Smith-Njigba (WR, SEA)

There is no doubt that JSN is a full-time player and is now an integral part of this Seattle offense. He is second on the team in targets with 40, just three behind Metcalf. However, it's been a roller coaster to get there. JSN has two games with 12 or more targets and two games with three or fewer.

Before he can graduate to must-start status in all leagues, there needs to be some consistency and touchdown upside. His four red-zone targets this year certainly help there.

Tyler Lockett (WR, SEA)

Tyler Lockett has taken a backseat to Smith-Njigba this season, but he is still routinely putting up flex-worthy performances. In only one game this season does Lockett not have at least five receptions or 75 yards.

Geno Smith (QB, SEA)

Why has Geno Smith ascended to a top-7 quarterback in fantasy football this season? He only has one game below 18 fantasy points this season. Smith leads the NFL in attempts, completions, and passing yards thanks to a new offense installed by Mike Macdonald.

He only has five passing touchdowns this year, but with this kind of volume, that is sure to change in the weeks ahead.

 

Consider Sitting for Fantasy Football Lineups

Jauan Jennings (WR, SF)

With just four targets and one catch on Sunday, what many feared might happen did occur when all of San Francisco's pass-catchers returned. Jennings dominated for two weeks while the 49ers battled injuries, but in Week 5, he played just half of their snaps.

Noah Fant (TE, SEA)

Despite a decent amount of preseason hype, Noah Fant is currently TE26 through five weeks. He has scored more than 3.9 fantasy points in half-PPR formats just once in five weeks.

Zach Charbonnet (RB, SEA)

Since playing more than 90% of the snaps in Weeks 2 and 3 when Kenneth Walker III was hurt, Charbonnet has reverted back into a part-time player. He was in on just 36% of Seattle's snaps on Sunday, and Walker also stole eight targets away from him in that game as well.

 

Kirksey’s Thursday Night Football Picks

Current Spread: San Francisco -3.5, Total: 47.5

Even this early in the season, the San Francisco 49ers -- who are the better team -- simply cannot fall two games behind Seattle in the division. Even more than that, they cannot give Seattle the advantage on the tiebreaker considering how competitive this division seems to be.

In the end, Seattle's defense is pushed to its ultimate limits by the plethora of playmakers on the 49ers. For the second week in a row, we get a shootout on Thursday Night Football.

The pick for Thursday Night Football this week is a desperate San Francisco 49ers team wins on the road, 30-24.

The Pick: San Francisco -3.5, OVER 47.5

2024 Record:
Spread (3-2), Over/Under (3-2)



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis




POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Drake Maye

Looking to Build Off MVP Finalist Campaign
Garrett Wilson

Could Continue to be Held Back by Quarterback Situation
Jaylen Waddle

Has Volume-Driven Upside Despite Quarterback Change
Jonathon Brooks

to Compete for Lead Role in Carolina?
Malik Nabers

Alone in Giants' Wide Receiver Room?
Josh Downs

to See Larger Role Going Forward?
Auston Matthews

Exits Game With Injury
Jimmy Snuggerud

Scores Twice Versus Carolina
Michael Misa

Delivers Multi-Point Performance on Thursday
Keyonte George

to Be Re-Evaluated in Two Weeks
Isaac Okoro

Remains Out Thursday
Ayo Dosunmu

Could Miss Second Straight Game Friday
Emari Demercado

Chiefs Sign Emari Demercado to One-Year Deal
Patrick Williams

Ruled Out Thursday
Zach Charbonnet

Knee Surgery Goes "Very Well"
LeBron James

Returns to Action Thursday
Guerschon Yabusele

Unavailable Thursday Night
George Holani

to Have Bigger Role in Seattle's Backfield?
Matas Buzelis

Will Play Against Lakers
Josh Giddey

Cleared to Face Lakers
Jalen Smith

Cleared to Play Thursday
Moses Moody

to Miss Fifth Straight Game Friday
Collin Sexton

Out Thursday Against Lakers
Quinten Post

Iffy for Friday
De'Anthony Melton

Listed as Questionable for Friday
Josh Hart

May Miss Another Game Friday
Day'Ron Sharpe

to Miss Remainder of Season
Karl-Anthony Towns

Questionable to Face Pacers Friday
Keyonte George

Sidelined Against Portland
Harrison Barnes

Returns to Spurs Lineup
Alperen Sengün

Alperen Sengun Questionable for Friday Due to Back Issue
Darius Garland

Ruled Out Friday Vs. Bulls
Derrick White

Misses Thursday's Game
Blake Snell

Around Six Weeks From Being Fully Built Up
Alijah Vera-Tucker

Expects to be Cleared for OTAs
Al-Quadin Muhammad

Buccaneers Sign Al-Quadin Muhammad to a One-Year Deal
Kylen Granson

Titans Sign Kylen Granson to One-Year Deal
Connor Heyward

Raiders Sign Fullback Connor Heyward
Jaquan Brisker

Steelers to Sign Jaquan Brisker
C.J. Gardner-Johnson

Signs a One-Year Deal with the Bills
Emanuel Wilson

Seahawks Sign Emanuel Wilson to a One-Year Deal
Calvin Austin III

Giants Sign Calvin Austin III
Brian Thomas Jr.

Jaguars Deny Shopping Brian Thomas Jr.
Kyler Murray

Vikings Sign Kyler Murray to a One-Year Deal
Bobby Brink

a Game-Time Decision for Meeting with Flyers
Evander Kane

Available Against Predators
Mark Stone

a Game-Time Call Thursday
Carter Verhaeghe

Anton Lundell Won't Play Thursday
Sam Reinhart

Returns to Action Thursday
Andrew Copp

to Sit Out Two Weeks
Dylan Larkin

Ruled Out for Two Weeks
Dre Greenlaw

49ers Reuniting With Dre Greenlaw on One-Year Deal
Tutu Atwell

Dolphins Sign Wideout Tutu Atwell to One-Year Deal
Zack Wheeler

to Face Hitters in Live Batting Practice on Saturday
Gerrit Cole

Could Pitch in a Spring Game Next Week
Matthew Boyd

Named the Cubs' Opening Day Starter
Francisco Lindor

Remains on Schedule for Opening Day
Spencer Knight

Available Thursday
William Eklund

Questionable to Play Thursday
Alex Ovechkin

Records Power-Play Assist
Lane Hutson

Extends Road Point Streak to 10 Games
Ivan Demidov

Bags Two Points in Wednesday's Win
Nick Schmaltz

Inks Eight-Year Extension With Mammoth
Owen Tippett

Multi-Point Effort Leads Philadelphia to a Victory
Drake Batherson

Scores Twice Versus Montreal
Bryce Miller

Shuts Down Bullpen Due to More Oblique Discomfort
Zac Gallen

Named Arizona's Opening Day Starter
Kyle Teel

Could Miss 4-6 Weeks With Hamstring Strain
Hideki Matsuyama

Brings Strong Course History to TPC Sawgrass
Josh Hader

to Start the Year on the Injured List
Adam Scott

in Strong Form Ahead of The Players
Shayne Gostisbehere

to Remain Out for "Couple of Games"
Robert Thomas

Blues Hopeful Robert Thomas Can Play Through Upper-Body Injury
Ross Colton

Suffers Upper-Body Injury Tuesday Night
Kyle Teel

Exits Tuesday's Game With Hamstring Injury
Rickie Fowler

on Quite the Run Heading to TPC Sawgrass
Sepp Straka

Needs to Forget What Happened Sunday at Bay Hill
Jordan Spieth

an Enigma Heading to The Players Championship
Justin Rose

Trying to Pick Up the Pieces in Florida
Maverick McNealy

Bounces Back at Arnold Palmer Invitational
Brooks Koepka

Continues His Florida Swing With Some Momentum
Nicolai Hojgaard

in Strong Form Ahead of The Players
Robert MacIntyre

a Volatile Option at The Players
Matt Fitzpatrick

Looks to Return to Top Form at The Players
Sam Burns

a High-Risk, High-Reward Option at The Players
Keegan Bradley

Hard to Trust at The Players
Xander Schauffele

Rounding into Form Heading to Players Championship
Rory McIlroy

Set to Return at Players Championship to Defend Title
Jake Knapp

Set to Return at Players Championship
Viktor Hovland

Continues Strong Start to 2026 Season
Rasmus Hojgaard

Looking for Bounce-Back at Players Championship
Tommy Fleetwood

Will Need to Find Putter to Compete at Players Championship
Akshay Bhatia

Continues Improving Heading to Players Championship
Merrill Kelly

Set to Make Spring Training Debut on Friday
Francisco Lindor

"100 Percent Optimistic" he Can be Ready for Opening Day
Justin Thomas

Continues Competitive Return at The Players Championship
Corbin Carroll

Set to Play in Cactus League Game on Wednesday
Kyle Stowers

to Make Grapefruit League Debut on Saturday
Hunter Greene

to be Sidelined Through July
Jesús Luzardo

Jesus Luzardo, Phillies Agree on Five-Year Extension
Corbin Carroll

Could Make Spring Debut This Week
Max Holloway

Drops Decision At UFC 326
Charles Oliveira

Becomes The New BMF Champion
Caio Borralho

Bounces Back
Reinier de Ridder

Reinier De Ridder Loses Back-To-Back Fights
Rob Font

Gets Dominated
Raul Rosas Jr.

Extends His Win Streak
Michael Johnson

Suffers Second-Round Knockout Loss
Drew Dober

Knocks Out Michael Johnson
Rafael Devers

Back in Cactus League Lineup on Monday
Ryan Blaney

Earns his Second Consecutive Phoenix Cup Series Win
Christopher Bell

Falls Short of Victory Despite Dominating at Phoenix
Kyle Larson

Earns Hard-Fought Finish of Third at Phoenix
Denny Hamlin

Quietly Gains Another Top-Five Finish at Phoenix
Joey Logano

Crashes out at Phoenix Despite Strong Run
Tarik Skubal

Could Make Another Start in World Baseball Classic
Jackson Chourio

Should Return to WBC Lineup on Monday
Byron Buxton

"Fine" After Being Hit by Pitch
Ryan Blaney

is Always A Top Favorite to Compete for the Win At Phoenix
Denny Hamlin

Is Denny Hamlin Worth Rostering for Phoenix?
Christopher Bell

is Likely to have Another Solid Phoenix Run
Chase Briscoe

has Plenty of Upside for DFS Lineups at Phoenix
Joey Logano

Could Dominate at Phoenix This Weekend
Chase Elliott

has Plenty of Upside for Sunday's Race at Phoenix
Chris Buescher

Is Chris Buescher Worth Rostering For Phoenix DFS Lineups?
Ross Chastain

Has Found Speed Again at Phoenix
Josh Berry

a Solid Sleeper at Phoenix
Brad Keselowski

Skips Qualifying After Practice Crash at Phoenix
Tyler Reddick

Spins in Practice at Phoenix
William Byron

Should Be a Contender at Phoenix
Kyle Larson

Is Always a Threat at Phoenix
NASCAR

Could Bubba Wallace Be Playable for Phoenix DFS Lineups?
Anthony Alfredo

Is A Favorable DFS Option In A Substitution Role At Phoenix
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF