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Heroes and Zeroes - Week 10 Fantasy Football Picks

I just couldn't resist the urge, so you'll have to bear with me for a few more sentences while I gloat a bit. Sometimes it feels like we are wrong more than we are right in the world of fantasy football, yet we keep coming back or more like the addicts we are. Nothing feeds this compulsion more than the thrill of victory, but when you publicize your top picks and sleepers for all to see, then use several of those players in your own leagues and hit the nail right on the head, that's just like an injection of pure adrenaline straight into the veins. What I'm trying to see is I made a lot of good picks last week.

My only regret for Week 9 is not ranking Jared Goff even higher, but both he and Matthew Stafford were among the best QB picks last week and I think they each continue their ascent. Touchdowns by under-the-radar plays like Javorius Allen, Damien Williams, Mohamed Sanu, and Sammy Watkins (don't pretend you were still playing him) all justified my love, er, hero status. If only Jermaine Kearse had hit paydirt, I'd be looking at 100% batting average on the plus side, while Marshawn Lynch was the only zero to even be playable last week. Let's see if the good fortune continues, as we are done with the two-week Byepocalypse.

Now, let's get to my fantasy "heroes" and "zeroes" at each position for Week 10 of the NFL season. For a full set of rankings, look no further than our very own RotoBaller consensus weekly rankings.

Be sure to check all of our fantasy football rankings for 2025:

 

Week 10 Lineup Heroes

QUARTERBACK

Eli Manning, New York Giants

This is it. This is the week that we can play Eli Manning, maybe for one last time, and not kick ourselves in our own asses for doing so. Manning goes up against the defense that has allowed the most fantasy points to quarterbacks this season. The 49ers have a slew of injuries on both sides of the ball and are clearly playing for a high draft pick anyway. This won't be a shootout by any means, but the Giants don't have enough of a running game to bowl over the Niners that way. Expect tight end Evan Engram to be heavily involved while Manning throws multiple scores before finally ceding way to Geno Smith the rest of the season after they get clobbered by Kansas City next week. See you in the HOF, Eli!

Mitch Trubisky, Chicago Bears

It should go without saying that this recommendation is for superflex or two-QB leagues only. When you start scraping the bottom of the barrel for QB2 rankings, things look bleaker than ever this week. Philip Rivers faces the Jags (#1 Def vs. QB), Jacoby Brissett faces the Steelers (#2 Def vs. QB), Blake Bortles faces the Chargers (#9 Def vs. QB) and you really don't want to rely on CJ Beathard, Brock Osweiler, Brett Hundley or Ryan Fitzpatrick, do you? The week of rest and preparation and a matchup against the struggling Packers might provide the recipe for a breakout of sorts for the rookie. While it's doubtful the Bears will go all game without punting, Trubisky could turn to new receivers Dontrelle Inman and Tre McBride frequently.

 

RUNNING BACKS

Jerick McKinnon, Minnesota Vikings

In case you forgot how effective McKinnon had been before his team's bye week, here's how he finished each week since the Dalvin Cook injury: Week 5 - RB3,  Week 6 - RB4, Week 7 - RB31, Week 8 - RB3. Washington's run defense started out as one of the best units in football the first three weeks of the season, but various injuries and an ineffective run game of their own have conspired to reverse their fortunes. In the last three games, Washington has allowed 444 rush yards for an average of 148 YPG. He brings value as a receiver alone, but could have his best rushing game of the season to boot. He's a surefire RB1 this week and beyond.

Bilal Powell, New York Jets

Stacking against the Bucs has never looked like a better idea. They'll be without their starting QB and best WR, but are still stuck with the same bottom-dwelling defense. Matt Forte was my original pick here after he scored his first two touchdowns of the season in Week 9, but he's now been downgraded to doubtful. Why can't the Jets have nice things? Forte was up to almost 50% of the offensive snaps, relegating Bilal Powell to a 22% snap share, but now Powell may take over completley. If Forte sits, Powell definitely has RB2 potential in this matchup.

Duke Johnson, Cleveland Browns

If you're in a full-PPR league, you probably have a flex spot reserved for him each week anyway. The Browns will rely on him more than ever to try to move the chains while playing catch-up with a Lions team firing on all cylinders offensively.

 

WIDE RECEIVERS

Larry Fitzgerald, Arizona Cardinals

The first game without Carson Palmer didn't go too badly. The Cards won (yes, I know it was against the Niners) and Drew Stanton acquitted himself fairly well. Larry Legend came down with five of nine targets for 70 yards. While the matchup shifts from the second-worst team in football to one of the best, at least it's not in Seattle. Fitzgerald shouldn't be faded, though, because he will spend a lot of time against new slot corner Justin Coleman, avoiding Richard Sherman for much of the day.

JuJu Smith-Schuster, Pittsburgh Steelers

The bye couldn't have come at a worse time for the hype machine building around J²S² but he's back in action for Week 10. The speculation of how much time Martavis Bryant will get on the field can be safely ignored. The team knows what they have in their second-round pick and will continue to integrate him as the number two receiving target. He's got as easy a matchup as he'll face the rest of the season in career backup/journeyman Pierre Desir on the other side, so find a spot for him in your lineup.

Chris Godwin, Tampa Bay Buccaneers

You know, Ryan Fitzpatrick isn't terrible...  *ducks under desk 

Disgruntled Jets fans have cast him aside long ago, but for a backup QB he's got a lot more upside than most. He filled in admirably for Jameis Winston in Week 6 and in the second half of last week's game. Now gets the whole week to gameplan for his ex-team. While I wouldn't necessarily roll out Fitz in fantasy, there's another fill-in that might be worth using if you're the gambling type. Rookie Chris Godwin will take over for Fightin' Mike Evans and become the primary red zone target among WRs. He hasn't been targeted more than three times all year and has caught exactly one ball for less than 10 yards in each of the last five games, but that goes out the window now that his snap share will surge. Among other WR4/flex types like Eric Decker, Jordan Matthews, or Donte Moncrief, I'd take a chance that Godwin makes an impact first.

 

TIGHT END

Garrett Celek, San Francisco 49ers

Every week. Not most weeks, not 9 out of 10. EVERY WEEK a tight end scores a touchdown against the Giants. George Kittle would be the obvious play here, except that he's out of the lineup with an ankle injury and therefore has a 0% chance of scoring. Backup TE and brother to Brent, Mr. Celek has been very Chris Godwin-like in his production lately, catching exactly one pass in each of the last five games. He might only catch one pass in Week 10. It doesn't matter, because it'll be a touchdown.

Tyler Kroft, Cincinnati Bengals

He's never a "boom" play per se, but Kroft finds a way to contribute each week. He only saw two targets last week, but turned those into 79 yards. He only had 46 yards the previous week, but caught five passes. 23 yards before that, but he had a touchdown. You get the drift. Tennessee has plenty of soft spots in the defense that he can exploit and he's about due for a touchdown given his recent target/score ratio.

 

Week 10 Lineup Zeroes

QUARTERBACKS

Kirk Cousins, Washington Redskins

Captain Kirk led his team to a comeback victory last week, but Fat Rob took the fantasy glory with two touchdowns. Incidentally, why is it that the team with the worst name that should be banned by now has the players with the best nicknames? Anyway, the victory can't mask the fact that Cousins has only tossed one TD in the last two games and his schedule isn't letting up. Washington faces Minnesota on the road in Week 10, which drops Cousins to low-end QB2 status. The Vikings have allowed eight passing touchdowns all year and a total of six scores in five home games. Incidentally, you might want to bench Terrelle Pryor too. Just saying.

Jay Cutler, Miami Dolphins

They're not in the cellar any more! Sort of. The Dolphins still rank worst in the NFL in total points scored and yards per play, but they're only third-worst in passing offense now! Last week, Cutler looked like the vintage Denver version (that one year) but that was against the Raiders. This week's opponent, Carolina, allows the third-lowest scoring rate to opponents and will have the home field advantage. Pump your brakes before sending him into battle, even in your two-QB leagues. Instead, try Keenum, Bortles, or... Trubisky?

 

RUNNING BACKS

DeMarco Murray, Tennessee Titans

Knee, shoulder, and hip injuries have set back the Titans offensive skill players this season. Wait, my bad, that's just DeMarco Murray's recent health report. Murray has never been the model of good health and this season has been a frustrating one for fantasy owners. He hasn't actually missed multiple games, he's just been limited and/or ineffective in most of them. This week he is probable, but we know he's not 100%. The Bengals don't strike fear into the hearts of opposing teams with their defense, but they've only yielded two rushing touchdowns and three total to RB, making them a top-10 defense against the position. Derrick Henry keeps eating into his touches, making Murray an RB3 this week.

Frank Gore, Indianapolis Colts

I love me some Frank Gore, but not this week. The Colts will be behind the 8 ball early and the running game may not be too effective either. While Gore out-snapped Marlon Mack 60/40 last week, Mack had gotten more run the previous two weeks. Mack is still the better play down the stretch.

 

WIDE RECEIVERS

DeSean Jackson, Tampa Bay Buccaneers

While I'm bullish on Godwin garnering some value, I'm wary of Jackson. He's been remarkably inefficient this year, ranking fourth in total air yards, yet 33rd in yardage with a 49% catch rate. You might think his target share would go up this week, and it probably will, but that doesn't mean he'll do anything with them. Connecting on the deep ball requires practice and repetition, which is something he doesn't have down with backup QB Ryan Fitzpatrick.

Marqise Lee, Jacksonville Jaguars

He finally scored a touchdown and it only took eight games and 58 targets. Lee has never been a red zone threat, scoring just five touchdowns over his first three seasons, so we shouldn't be surprised that he's giving standard league owners hardly any value. He enters this contest with a gimpy knee already. If he does play, he'll get the shadow treatment from Casey Hayward. Avoid.

 

TIGHT END

Ed Dickson, Carolina Panthers

The starting tight end for Carolina was a complete zero last week, as in zero catches for zero yards. He had seen at least five targets in each of the previous four games, but was a mysterious non-factor in what should have been a good matchup. The Dolphins don't exactly lock down the tight end, but temptation to stream him should be resisted as this could be a low-scoring slogfest.

 

More Week 10 Lineup Prep




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REAL-TIME FANTASY NEWS

Dalton Kincaid

Yet to Practice Ahead of Week 11 Matchup
Paolo Banchero

Will Undergo an MRI
Sam LaPorta

Misses Thursday Practice, Questionable for Week 11?
Lamar Jackson

Returns to Practice Thursday
Jaylon Tyson

Will Miss a Second Straight Game on Thursday
Lonzo Ball

Will Not Play Thursday
Darius Garland

Ruled Out Thursday
Ochai Agbaji

Ruled Out Thursday vs. Cavaliers
Khalil Shakir

Dealing With Multiple Injuries
C.J. Stroud

Missing From Practice Again on Thursday
Brandon Aiyuk

in Danger of Missing the Entire Season?
Chris Godwin

Gets in Another Practice Session
Garrett Wilson

Injured Reserve a Possibility for Garrett Wilson
Matt Savoie

Collects Two Assists Wednesday
Artemi Panarin

Delivers Four Assists in Wednesday's Victory
Simon Nemec

Becomes Hat-Trick Hero Wednesday
Zack MacEwen

Exits Early Wednesday
Cody Glass

Exits With Injury Wednesday
Brandon Hagel

Injured in Wednesday's Loss
Kevin Love

Available Thursday
Ochai Agbaji

Iffy for Meeting With Cavaliers
Sandro Mamukelashvili

Uncertain for Thursday
Collin Murray-Boyles

Questionable for Thursday
Zion Williamson

Cleared for Contact
LeBron James

Practices With G-League Team
Christian Braun

Leaves Game with Ankle Injury
Jalen Brunson

Leaves The Garden in Walking Boot
Félix Bautista

Felix Bautista Could Return in Second Half in 2026
Kodai Senga

Attracting Trade Interest, Will the Mets Move him?
Jonathan Kuminga

Won't Return on Wednesday Evening
Paolo Banchero

Ruled Out for Remainder of Wednesday's Game
Yordan Alvarez

Expected to be Ready for Spring Training
Byron Buxton

Could Waive his No-Trade Clause
Paul Skenes

the Unanimous NL Cy Young Winner
Tarik Skubal

Wins AL Cy Young for Second Straight Year
Bilal Coulibaly

Without A Timetable For Return
Nickeil Alexander-Walker

Upgraded To Probable For Matchup Versus Kings
Jonathan Kuminga

Active Wednesday, Not In Starting Lineup
Dereck Lively II

Downgraded to Unavailable on Wednesday
Ja Morant

Unavailable Wednesday
Sam LaPorta

Misses Practice With Back Injury Wednesday
Isaiah Stewart

Sidelined Again on Wednesday
J.K. Dobbins

Not Practicing, IR Move Undecided
Zach Hyman

Nearing Season Debut
Davante Adams

Out Wednesday, Expected to Play in Week 11
Colten Ellis

to Make Second Career Start Wednesday
Adam Erne

to Miss "a Few Weeks"
Tyson Foerster

on Track to Return Wednesday
Kayshon Boutte

Ruled Out for Thursday Night
Andre Burakovsky

a Game-Time Call Wednesday
Frank Nazar

Out on Wednesday
Rhamondre Stevenson

Ruled Out For Thursday
Brock Purdy

Working Toward Starting Sunday
C.J. Stroud

Not at Practice, Set for Another Missed Game?
J.J. McCarthy

Nursing Hand Injury, Set to Play on Sunday
Romeo Doubs

"Should be Good to Go" on Sunday
Rico Dowdle

Held Out on Wednesday, Should Fantasy Managers be Worried?
Lamar Jackson

has Knee Soreness, "Should be Good" for Week 11
Garrett Wilson

Officially Ruled Out for Thursday Night
Brian Thomas Jr.

Practicing, on Track to Return in Week 11?
CFB

Still No Update on Jermod McCoy's Return Timeline
Sami Valimaki

Riding Momentum Into Bermuda
Matthieu Pavon

Struggling Through a Rough Season
Taylor Montgomery

Hopes to Get Back on Track at Port Royal
Ben Martin

a Risky Play at Bermuda Championship
Mark Hubbard

Primed for a Bounce-Back Week in Bermuda
Boone Jenner

Exits Win With Upper-Body Injury
Lee Hodges

Searching for a Spark in Bermuda
Frederik Andersen

Pulled by Concussion Spotter
Valeri Nichushkin

Sustains Lower-Body Injury in Win
Thatcher Demko

Suffers Lower-Body Injury Tuesday
Thomas Chabot

Injured Versus Stars
Anthony Stolarz

Exits Early Tuesday
Auston Matthews

Hurt in Tuesday's Loss
Stephen Vogt

Wins Back-to-Back AL Manager of the Year Honors
Milwaukee Brewers

Pat Murphy Named NL Manager of the Year Again
Patrick Fishburn

Looking to Bounce Back in Bermuda
Eric Cole

Carrying Momentum into Bermuda
Tommy Edman

to Have Ankle Surgery Next Week
Ketel Marte

Diamondbacks Unlikely to Trade Ketel Marte
Roman Anthony

to Have a Normal Offseason
Jarren Duran

Red Sox Think Jarren Duran Needs a Fresh Start
MacKenzie Gore

Nationals Expected to Trade MacKenzie Gore?
Sahith Theegala

Finishes Tied for 27th at Bank of Utah Championship
Sam Stevens

Finishes Tied for 36th at Baycurrent Classic
Patrick Rodgers

Finishes Tied For Sixth at World Wide Technology Championship
Luke List

Finishes 75th at World Wide Technology Championship
Ben Kohles

Finishes Tied for 63rd at World Wide Technology Championship
PGA

Nico Echavarria Finishes Tied for 14th at World Wide Technology Championship
Luke Clanton

Finishes Tied for 46th at World Wide Technology Championship
Blades Brown

Finishes Tied for 18th at Korn Ferry Tour Championship
Victor Hedman

Iffy for Wednesday
Ryan McDonagh

to Sit Out "a Few Games"
Tarik Skubal

Tigers Unlikely to Trade Tarik Skubal
Framber Valdez

Cubs Could Land Framber Valdez in Free Agency
Sandy Alcantara

Marlins Ready to Trade Sandy Alcantara
Ketel Marte

Diamondbacks Motivated to Move Ketel Marte
Hunter Greene

Reds to Listen to Offers on Hunter Greene
Paul Skenes

Pirates Won't Trade Paul Skenes
Pete Alonso

Mets Expected to Let Pete Alonso Walk in Free Agency
Kyle Tucker

to Sign With Yankees, Blue Jays, or Dodgers
CFB

Nic Anderson Could Return for LSU this Season
Randy Brown

Suffers Second-Round TKO Loss
Gabriel Bonfim

Extends His Win Streak
Joseph Morales

Gets First-Round Submission Win
Matt Schnell

Suffers First-Round Submission Loss
Muslim Salikhov

Suffers First-Round TKO Loss
Uros Medic

Wins Back-To-Back Fights
Ismael Bonfim

Loses Back-to-Back Fights
Chris Padilla

Remains Unbeaten In The UFC
Marco Tulio

Suffers His First UFC Loss
Christian Leroy Duncan

Scores Second-Round Knockout Victory

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