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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

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DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




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REAL-TIME FANTASY NEWS

Ryan Nugent-Hopkins

a Game-Time Call Sunday
Corbin Carroll

to Resume Playing Defense This Week
John Carlson

Set for Ducks Debut
Francisco Lindor

Non-Committal About Status for Opening Day
Hayden Birdsong

Diagnosed with Grade 2 Forearm Strain and UCL Sprain
Jacksonville Jaguars

Jaguars Eyeing Defensive Linemen and a Tight End in the NFL Draft?
Davante Adams

Rams Explored Trading Davante Adams
Dallas Goedert

Eagles Bring Back Dallas Goedert on a One-Year Deal
Marvin Harrison Jr.

Continued to Disappoint in Year 2
Theo Johnson

Facing Increased Competition in New York
Kyle Monangai

Will Continue to Test Managers' Patience
Jayden Daniels

' Suppressed Dynasty Value Makes Him a Buy-Low Candidate
Zay Flowers

an Early Free Agency Winner
Joe Burrow

Can a Healthy Joe Burrow Challenge for QB1?
Amon-Ra St. Brown

Is Amon-Ra St. Brown the Safest Pick in Fantasy?
Xavier Worthy

Dynasty Value Continues to Tumble
Andrei Iosivas

Overshadowed by Two Stud Receivers in Cincy
Jaylen Wright

a Handcuff Option With Upside Going into Year 3
Tyjae Spears

Figures to be in Backup Pass-Catching Role Again in 2026
Tyler Shough

Looking to Build on Encouraging Close to 2025
Karl-Anthony Towns

Rejoins Knicks Lineup Sunday
Marcelo Mayer

Scratched With Left-Knee Soreness
Zach Neto

Tests Come Back Negative, Dealing With Sprained Hand
Ausar Thompson

Returns to Action Sunday
NFL

Emmett Johnson Could Develop into a Three-Down Workhorse in the NFL
Isaiah Hartenstein

Cleared to Return Sunday
NFL

Does Jordyn Tyson Carry Future WR1 Upside?
Anthony Edwards

Available Sunday
Ollie Gordon II

May Be Buried on Dolphins Running Back Depth Chart
Colby Parkinson

Can Colby Parkinson Build on Breakout 2025 Season?
Christopher Bell

Looking for Redemption, Wins Pole at Las Vegas
Josh Johnson

Signs With Bengals
Denny Hamlin

Should Contend for Another Vegas Win
Chase Briscoe

Qualifies 18th Despite Toyota Dominating at Las Vegas
Devin Duvernay

Signing With Cardinals on One-Year Deal
Chase Elliott

May Fly Under the Radar at Las Vegas
De'Anthony Melton

Held Out Sunday Versus New York
NASCAR

Ross Chastian Has Been As Solid As They Come at Las Vegas
Ty Gibbs

Could Ty Gibbs Finally Break Through With a Win at Las Vegas?
Kristaps Porzingis

Won't Play Sunday Versus Knicks
Brad Keselowski

a Solid DFS Pick at Las Vegas
Kevin Porter Jr.

Sidelined Sunday Versus Pacers
Jarrett Allen

to Miss Fifth Straight Game Sunday
Kyle Filipowski

to Sit Sunday for Rest
Kawhi Leonard

Leaves Saturday's Game with Ankle Injury
Ace Bailey

Ruled Out Sunday Against Kings
Francisco Lindor

is Making Spring Debut on Sunday
Carter Verhaeghe

Anton Lundell Expected to Return Sunday
Kyle Larson

Should Kyle Larson be Considered A Favorite for Las Vegas?
Sam Bennett

Considered Day-to-Day
William Byron

Could Compete for a Top-Five Finish at Las Vegas
Sam Reinhart

Not Traveling on Four-Game Road Trip
Ryan Blaney

Is Ryan Blaney Worth Rostering in Tournament DFS Lineups for Las Vegas?
Michael Rasmussen

Ruled Out for One Week
Tyler Reddick

Could Continue his Top-10 Streak at Las Vegas
Declan Carlile

to Miss 4-5 Weeks
Joey Logano

Should DFS Managers Underestimate Joey Logano for Las Vegas?
Igor Chernyshov

Exits Early Due to Injury Saturday
Chris Buescher

Is Chris Buescher Worth Rostering For Las Vegas DFS Lineups?
NASCAR

Bubba Wallace is A Risky DFS Option Who Could Pay Off at Las Vegas
Josh Berry

Has Plenty of Upside for Las Vegas DFS Lineups
Ryan Preece

Scores his First Las Vegas Top-10 Starting Spot in Qualifying
Justin Allgaier

Will Fill In for an Injured Alex Bowman at Las Vegas
Nico Hischier

has Four-Point Performance on Saturday
Seiya Suzuki

Leaves WBC Game on Saturday With Right-Knee Discomfort
Macklin Celebrini

Continues to Dominate With Three Points
Anze Kopitar

Becomes All-Time Leading Scorer for Kings
Linus Ullmark

Posts Shutout Against Ducks
Zach Neto

is Removed After Suffering Hand Injury
TB

Nicholas Paul Rejoins Lightning Lineup
Cole Caufield

Cleared to Play Saturday
Alex Tuch

Set to Return Saturday
Bobby Brink

Remains Out Saturday
J.T. Miller

Returns to Action Saturday
Joe Ryan

Won't Pitch in the World Baseball Classic
Zack Wheeler

Throws First Live BP Session on Saturday
Merrill Kelly

Expected to Open Season on the Injured List
Kevin Gausman

Named Toronto's Opening Day Starter
Kyle Stowers

Back in Grapefruit League Lineup
Kevin Porter Jr.

Questionable Against Hawks
Devin Carter

Out Saturday Against Clippers
Russell Westbrook

Set to Return Against Clippers
Derrick White

Expected to Play Saturday Against Wizards
Michael Porter Jr.

Likely to Miss Second Straight Game
Nicolas Claxton

to Rest Saturday Against Philadelphia
Ace Bailey

Leaves Friday's Game Early with Concussion
Radko Gudas

Handed a Five-Game Suspension
Auston Matthews

to Miss Rest of Season
Emil Heineman

Scores Twice Against the Kings
Joel Hofer

Shuts Down the Oilers
Giannis Antetokounmpo

Could Miss Saturday's Game Vs. Hawks
Keegan Murray

to Be Re-Evaluated in Two Weeks
Aaron Gordon

Expected Back Saturday Vs. Lakers
Francisco Lindor

Takes Full Batting Practice on Friday
Brandon Woodruff

Still TBD for Opening Day
Trevor Rogers

to Start on Opening Day for Orioles
Kevin Vallejos

Looks To Remain Undefeated In The UFC
Josh Emmett

In Dire Need Of Victory
Gillian Robertson

A Favorite At UFC Vegas 114
Amanda Lemos

Set For Co-Main Event
Oumar Sy

Looks To Win Back-To-Back Fights
Ion Cutelaba

Looks To Get Back In The Win Column
Blake Snell

Around Six Weeks From Being Fully Built Up
Zack Wheeler

to Face Hitters in Live Batting Practice on Saturday
Gerrit Cole

Could Pitch in a Spring Game Next Week
Matthew Boyd

Named the Cubs' Opening Day Starter
Francisco Lindor

Remains on Schedule for Opening Day
Hideki Matsuyama

Brings Strong Course History to TPC Sawgrass
Adam Scott

in Strong Form Ahead of The Players
Rickie Fowler

on Quite the Run Heading to TPC Sawgrass
Sepp Straka

Needs to Forget What Happened Sunday at Bay Hill
Jordan Spieth

an Enigma Heading to The Players Championship
Justin Rose

Trying to Pick Up the Pieces in Florida
Maverick McNealy

Bounces Back at Arnold Palmer Invitational
Brooks Koepka

Continues His Florida Swing With Some Momentum
Nicolai Hojgaard

in Strong Form Ahead of The Players
Robert MacIntyre

a Volatile Option at The Players
Matt Fitzpatrick

Looks to Return to Top Form at The Players
Sam Burns

a High-Risk, High-Reward Option at The Players
Keegan Bradley

Hard to Trust at The Players
Xander Schauffele

Rounding into Form Heading to Players Championship
Rory McIlroy

Set to Return at Players Championship to Defend Title
Jake Knapp

Set to Return at Players Championship
Viktor Hovland

Continues Strong Start to 2026 Season
Rasmus Hojgaard

Looking for Bounce-Back at Players Championship
Tommy Fleetwood

Will Need to Find Putter to Compete at Players Championship
Akshay Bhatia

Continues Improving Heading to Players Championship
Justin Thomas

Continues Competitive Return at The Players Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF