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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

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DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




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REAL-TIME FANTASY NEWS

Jusuf Nurkić

Jusuf Nurkic Dealing with Toe Injury Ahead of Saturday
Lauri Markkanen

Could Miss Second Straight Game
Keyonte George

Could Miss Another Game with Illness
Bam Adebayo

Likely Available Saturday vs. Minnesota
Joel Embiid

Expected to Suit Up Saturday vs. Knicks
Draymond Green

Set to Return Saturday After Rest Day
Cason Wallace

Exits Early with Knee Contusion
Maxime Raynaud

Leaves Game with Apparent Knee Injury
Josh Hart

to Miss at Least Another Week
Ace Bailey

to Miss Another Game Saturday vs. Warriors
Ivica Zubac

Cleared to Play Saturday vs. Celtics
Jake DeBrusk

Records Season-High Three Points Friday
Danila Yurov

Scores Twice in Friday's Win
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Alexis Lafreniere Sets Up Three Goals in Winter Classic Win
Mika Zibanejad

Produces Historic Winter Classic Performance
Mackenzie Blackwood

Placed on Injured Reserve
Seth Jones

Sustains Upper-Body Injury in Winter Classic Loss
Linus Karlsson

Celebrates New Contract With Goal
Franz Wagner

Expected to Return "Within the Next Week"
T.J. Watt

Cleared to Play in Week 18
Giannis Antetokounmpo

Available Versus Charlotte
Karl-Anthony Towns

Out on Friday Night
Trevor Moore

Likely to Return Saturday
John Klingberg

Doubtful to Play Saturday
Isiah Pacheco

Could be Rested Against Raiders
Radko Gudas

on Track to Return Friday
Amon-Ra St. Brown

Officially Questionable for Week 18
Brayden McNabb

Considered Week-to-Week
De'Von Achane

Doubtful to Face the Patriots
Zach Werenski

Ready to Return Saturday
Ilya Sorokin

Comes Off Injured Reserve
Bo Horvat

Ruled Out for at Least One Week
Stephen Curry

Sidelined with Ankle Sprain on Friday
Jimmy Butler III

Will Not Play Against Thunder
Aaron Jones Sr.

Won't Play in Week 18
Seth Curry

Sidelined on Friday Vs. Thunder
Omarion Hampton

Ruled Out for Week 18
Draymond Green

Getting a Rest Day Against Thunder
Dallas Goedert

Ruled Out With Knee Injury
J.J. McCarthy

Will Start in Week 18
Jerami Grant

Still Watching From Sidelines on Friday
Javonte Williams

Ruled Out for Sunday
Zach Collins

Remains Out on Friday
Michael Porter Jr.

Remains Sidelined on Friday
Alvin Kamara

Will Remain Out in Week 18
Davante Adams

Questionable to Play in Week 18
Kyren Williams

Questionable to Play in Week 18
Kyle Pitts Sr.

Questionable for Sunday
Drake London

Questionable for Season Finale
Harold Fannin Jr.

Ruled Out in Week 18
Harold Fannin Jr.

Unlikely to Play in Week 18
Jaylen Waddle

Questionable to Play in Week 18
Josh Allen

"Good to Go" Vs. Jets
CFB

Joey Aguilar Undergoes Surgery to Remove Tumor on Friday
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Texas the "Team to Beat" for Transfer Running Back Isaac Brown
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Rocco Becht to Follow Matt Campbell to Penn State?
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Texas Targeting Cam Coleman in Transfer Portal
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Former Texas Running Back CJ Baxter Visiting Kentucky
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Beau Pribula Visiting Virginia Tech, Georgia Tech
Sebastian Aho

Records Season-High Five Points Thursday
Auston Matthews

Opens 2026 With Four-Point Effort
Dylan Guenther

Posts First Career Hat Trick During Four-Point Night
Josh Anderson

Exits Early After Scoring
Bo Horvat

Sustains Lower-Body Injury Thursday
Noah Laba

Out Week-to-Week
Conor Sheary

Lands on Long-Term Injured Reserve
Bo Bichette

Yankees Showing Interest in Bo Bichette
George Kittle

Listed as Questionable for Week 18
Amon-Ra St. Brown

Trending Towards Playing
Dak Prescott

May Not Play Full Game in Week 18
Houston Astros

Astros Sign Tatsuya Imai to Three-Year Deal
CFB

Lane Kiffin Interested in Sam Leavitt, Brendan Sorsby at LSU
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Deuce Knight Officially Entering Transfer Portal
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Kewan Lacy Expected to Be Full-Go Against Georgia
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Chip Kelly Named Northwestern Offensive Coordinator
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Penn State Working to Hire D'Anton Lynn as Next Defensive Coordinator
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Omar Cooper Expected to be Full-Go for Rose Bowl
CFB

Marcus Freeman Staying with Notre Dame for 2026 Season
CFB

Star Wideout Cam Coleman Entering Transfer Portal
CFB

Jay Hill Expected to be Next Michigan Defensive Coordinator

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