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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

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DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




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REAL-TIME FANTASY NEWS

Jake DeBrusk

to Miss Monday's Game as Healthy Scratch
Shane Pinto

Available Monday
Pius Suter

to Miss at Least Four Weeks
Pyotr Kochetkov

Likely Done for the Season
Josh Morrissey

Expected to Play Monday
Jay Huff

Available Versus Rockets
Karel Vejmelka

Moved to Injured Reserve
Rasmus Dahlin

Expected to Rejoin Sabres Lineup Monday
T.J. McConnell

Available on Monday
Yegor Chinakhov

Penguins Acquire Yegor Chinakhov From Blue Jackets
Al Horford

Back on the Sidelines Monday Night
Ryan Dunn

to Miss Second Straight Game with Knee Injury
Justin Herbert

Won't Face Broncos in Week 18
Jose Alvarado

Serving Suspension on Monday Night
Jerami Grant

Achilles Injury Continues to Sideline Jerami Grant
Jakob Poeltl

Continues to Miss Time with Back Issue
RJ Barrett

Sitting Out Second Night of a Back-to-Back
Marcus Mariota

Considered "a Stretch" to Play in Week 18
Geno Smith

Dealing With Significant Ankle Injury
Mark Williams

Suspended for One Game, Won't Face Washington
Dak Prescott

Will Play in Week 18
Mitchell Robinson

Sidelined Against New Orleans
Jalen Johnson

Under The Weather, Ruled Out on Monday
Lamar Jackson

Week 18 Status "to be Determined"
Khris Middleton

Resting Versus Phoenix
Kyshawn George

Out Again on Monday
Isaiah Hartenstein

Won't Suit Up On Monday
Alperen Sengün

Alperen Sengun Sitting Out Another Game Monday
Trae Young

Ruled Out Monday
Joe Mixon

Won't Return This Season
T.J. Watt

a Long Shot to Play in Week 18?
CFB

Penn State Working to Hire D'Anton Lynn as Next Defensive Coordinator
Joe Burrow

Will Play in Week 18 Against the Browns
CFB

Omar Cooper Expected to be Full-Go for Rose Bowl
CFB

Marcus Freeman Staying with Notre Dame for 2026 Season
CFB

Star Wideout Cam Coleman Entering Transfer Portal
Luther Burden III

Set to Undergo Additional Testing on Quad Injury
Trae Young

Questionable Monday With Quad Contusion
Kirill Marchenko

Scores Twice in Sunday's Win
Josh Giddey

Expected to Suit Up Monday
Alperen Sengün

Alperen Sengun Could Miss Another Game Monday
Justin Brazeau

Pots First Career Hat Trick Sunday
Anthony Davis

Listed as Questionable for Monday
Juraj Slafkovsky

Collects Season-High Three Points in Sunday's Loss
Jalen Suggs

Poised to Miss Seventh Straight Game
Eeli Tolvanen

Continues Scoring Surge With Three-Point Effort
Jack Eichel

to Remain Out Monday
Adam Fox

Nearing Return, Considered Day-to-Day
Josh Morrissey

Considered Day-to-Day After Missing Practice
D'Andre Swift

Finds End Zone Twice in Sunday Night Loss
Luther Burden III

Posts Season-High 138 Yards, Touchdown in Loss
Christian McCaffrey

Racks Up 181 Total Yards, Touchdown in Win Over Bears
Brock Purdy

Delivers Second Straight Five-Touchdown Performance
Parker Washington

Leads Jaguars in Targets, Receptions, and Receiving Yards
Wan'Dale Robinson

Posts Season-High 11 Receptions in Week 17
Josh Allen

Seen Limping From X-Ray Room, Says Foot Injury Didn't Affect Him
Geno Smith

Diagnosed With High-Ankle Sprain
Trey McBride

Sets All-Time Tight End Receptions Record
Geno Smith

Exits Early With Ankle Injury
DJ Moore

Suiting Up Against 49ers on Sunday Night
Ricky Pearsall

Officially Active for Week 17 Against Bears
Matthew Tkachuk

Returns to Practice
Linus Ullmark

Takes Leave of Absence
Travis Sanheim

Good to Go Against Kraken
Nick Foligno

Set to Return Sunday
William Nylander

Out Against Red Wings
Jared McCann

Available Sunday
CFB

Jay Hill Expected to be Next Michigan Defensive Coordinator
CFB

Michigan Targeting Kyle Whittingham as Next Head Coach
CFB

Texas Leading Rusher Quintrevion Wisner Set to Transfer
Pete Fairbanks

Marlins Agree on One-Year Deal
Brooks Koepka

Leaving LIV Golf
Ryan O'Hearn

Pirates Agree on Two-Year Deal

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