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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

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DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




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REAL-TIME FANTASY NEWS

Luis Arraez

Signs One-Year Deal with Giants
Troy Terry

Ready to Return Sunday
Victor Hedman

Set to Return Sunday
Connor McMichael

Out Week-to-Week
Kris Letang

Out for Four Weeks
Nico Hischier

a Game-Time Call Saturday
Jack Hughes

Won't Play Saturday
Linus Ullmark

Returns to Action Saturday
Blake Snell

Dodgers Plan to Have Blake Snell Ready for Opening Day
Paul George

Suspended for 25 Games
Shohei Ohtani

Will be Ready to Pitch to Start the 2026 Season
Francisco Lindor

Won't Play in WBC After Elbow Surgery
Nikola Vučević

Nikola Vucevic Unlikely to Play Against Miami
Tre Jones

Still Sidelined as Bulls Face Miami
Tyler Herro

Remains Sidelined Saturday vs. Bulls
Norman Powell

Ruled Out vs. Bulls
Jeremy Sochan

Still Sidelined as Spurs Visit Charlotte
Keyonte George

Injures Ankle Late in Loss to Nets
Stephen Curry

Exits Early Against Pistons with Knee Issue
Charlie Coyle

Pots Second Career Hat Trick
Filip Hronek

Expected to Play Saturday
Pavel Zacha

Not Traveling With Bruins
Elias Lindholm

to Miss at Least Two More Games
William Nylander

on Track to Return Saturday
Kris Letang

Misses Practice, Uncertain for Saturday
Evgeni Malkin

Iffy for Saturday
Cade Cunningham

Ready to Rock Friday
Gui Santos

Available Against Pistons
Caris LeVert

Remains Sidelined Friday
Craig Porter Jr.

Out Against Suns
Jonas Valančiūnas

Jonas Valanciunas Active Friday
Jamal Murray

Upgraded to Available Friday
Nikola Jokić

Nikola Jokic Officially Available Friday
Vinnie Pasquantino

Royals Agree on Two-Year Contract
Neemias Queta

Back in Action Friday
Miles McBride

Misses Friday's Game
Josh Hart

Active Against Trail Blazers
Tre Johnson

Out Against Lakers
Khris Middleton

Sits Out Meeting With Lakers
Austin Reaves

Remains Out Friday
Jacob Wilson

Signs Seven-Year Extension
Diego Lopes

An Underdog At UFC 325
Alexander Volkanovski

Set For UFC 325 Main Event
Benoît Saint Denis

Benoit Saint Denis Looks To Extend His Win Streak
Dan Hooker

Set For UFC 325 Co-Main Event
Mauricio Ruffy

Looks To Get Back In The Win Column
Rafael Fiziev

Returns At UFC 325
CFB

Texas Lands Wake Forest Transfer Sterling Berkhalter
Samuel Ersson

Sustains Lower-Body Injury Thursday
Pavel Zacha

Exits Early Thursday
Charlie Lindgren

Hurt Versus Red Wings
Jack Hughes

Exits With Lower-Body Injury Thursday
Brad Marchand

Suffers New Injury Blow
Patrick Kane

Becomes NHL's Highest-Scoring U.S-Born Player
Ukko-Pekka Luukkonen

Expected to Miss a Week
Tommy Edman

Will Have Delayed Start to Spring Training, Could Miss Opening Day
Kirk Cousins

Falcons Expected to Release Kirk Cousins
Chase Brown

Working on Extension With Bengals
Michael Penix Jr.

Hopes to be Ready for Week 1
Isaac Paredes

Not a Lock for Opening Day Lineup?
Dalton Kincaid

Doesn't Need Offseason Surgery
Josh Allen

Undergoes Foot Surgery
Josh Allen

on Crutches, Wearing Walking Boot
Corbin Carroll

a Top Fantasy Outfielder After Joining 30-30 Club
Jonah Tong

Won't Pitch in the World Baseball Classic
CFB

Michigan RB Bryson Kuzdzal Withdrawing from Transfer Portal
Aaron Judge

Appears to be Past his Elbow Issues
Bo Nix

Expected to Resume Training in 4-6 Weeks
Michael Penix Jr.

Thinks he'll be Ready by April
Evan Carter

Establishes a Goal to Steal 30 Bases
Edouard Julien

Traded to the Rockies
Cleveland Browns

Browns Hiring Todd Monken as Next Head Coach
Sahith Theegala

Off to Much Better 2026 Start
Gary Woodland

an Intriguing Option at Torrey Pines This Week
CJ Abrams

Giants Offer "Aggressive Pitch" for CJ Abrams
Andrew Putnam

Hopes to Keep Momentum Rolling This Week
Matthieu Pavon

Seeks to Return to 2024 Form at Torrey Pines
Luke List

Still Looking For Birdies at Torrey Pines
Jake Knapp

Faces Stiff Challenge at Farmers Insurance Open
Rasmus Hojgaard

Needs to Play Better at Torrey Pines
Christiaan Bezuidenhout

Could Struggle at Farmers Insurance Open
J.J. Spaun

A Steady Option At Farmers Insurance Open
Andrew Novak

Looking For More Success At Torrey Pines
Denny McCarthy

A Wild Card At Farmers Insurance Open
Max Homa

Looks To Keep Resurgence Going At Torrey Pines
Joe Highsmith

Struggling Heading Into Torrey Pines
Wyndham Clark

Looks To Carry Momentum Into Farmers Insurance Open
Tony Finau

Aims To Turn Things Around At Torrey Pines
Akshay Bhatia

Looks to Bounce Back at Torrey Pines
Paul Goldschmidt

Yankees Expressing Interest in Re-Signing Paul Goldschmidt
Bo Bichette

Won't Play in World Baseball Classic
NFL

Bill Belichick Won't be First-Ballot Hall of Famer
Carlos Correa

Won't Play for Puerto Rico in World Baseball Classic
Si Woo Kim

Looks to Continue Incredible Run at Torrey Pines
Jason Day

has a Good Chance to Keep Momentum This Weekend
Keegan Bradley

has Good Course History at Torrey Pines
Billy Horschel

Isn't a Great DFS Option at Torrey Pines
Aaron Rodgers

Mike McCarthy Says he Wants Aaron Rodgers to Return
Will Zalatoris

Has a Shot to Challenge at the Farmers Insurance Open
Drake Maye

Expected to be Fine for Super Bowl
Tennessee Titans

Titans Set to Hire Brian Daboll as New Offensive Coordinator
Buffalo Bills

Bills Promote Joe Brady to Head Coach
CFB

Quarterback Brayden Fowler-Nicolosi Signs with Michigan
CFB

Darian Mensah Reaches Settlement with Duke, Expected to Land at Miami
Eugenio Suárez

Eugenio Suarez Not Drawing Interest on Open Market?
Shedeur Sanders

Named as Pro Bowl Replacement
Framber Valdez

Among Many High-End Pitchers on Free-Agent Market
Jose Altuve

Won't Participate in World Baseball Classic
Harrison Bader

Agrees With Giants on Two-Year Deal
Paddy Pimblett

Drops Decision
Justin Gaethje

Becomes the New Interim-Lightweight Champion
Song Yadong

Suffers Unanimous Decision Loss
MMA

Sean O'Malley Gets Back In The Win Column
Waldo Cortes-Acosta

Extends His Win Streak
Derrick Lewis

Suffers Second-Round TKO Loss
Los Angeles Chargers

Chargers Officially Hire Mike McDaniel as Offensive Coordinator
Jaxon Smith-Njigba

Dominates in NFC Championship Game Win

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP