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DraftKings Daily Fantasy Football Lineup Picks (Week 6): NFL DFS Advice

Welcome to RotoBaller's Daily Fantasy football DraftKings lineup picks for Week 6 of the NFL season. In this article, I, Jason Bales, will be taking you, the reader, through the best DraftKings DFS plays of the week for this upcoming Sunday.

These DraftKings lineup recommendations are based on matchups, recent performances, overall upside/talent levels, and other factors such as Vegas odds, home field advantage, and more. There are still quite a few great value plays available, so read on to find out which players are the best for Week 6. Good luck with your DraftKings DFS lineups!

Editor's Note: If you like DraftKings, be sure to also check out FantasyAces. New users that sign up on Fantasy Aces and make a $20 deposit will receive RotoBaller's full season NFL Premium Pass for free (including Premium DFS), normally a $59.99 value. Expert DFS research, sample lineups, matchup ratings and lots more!

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DraftKings Quarterbacks - Week 6 DFS Picks

Cam Newton (at NO, $8,100)

Cam Newton is recovering from a concussion, but it looks like he will be set to start for the Carolina Panthers this week against the New Orleans Saints. At home, Drew Brees is one of the best quarterbacks in the league, and the Panthers have been slipping since the beginning of the season. If they want to salvage their season, this is very close to a must win game. The Saints are going to score early and often. Newton is going to have to matchup them. The Saints' pass defense is horrendous, so the Panthers should not have too many issues finding open wide receivers, or tight ends. Newton has a rushing touchdown in two of his last four games, so fire him up due to his consistency and upside, in both 50/50 contests and tournaments.

 

DraftKings Running Backs - Week 6 DFS Picks

LeSean McCoy (vs SF, $6,900)

LeSean McCoy is one of the best running backs in the league right now. He has over 20 fantasy points in three straight games now, and this week, he gets a great matchup against the San Francisco 49ers and Chip Kelly's lightning speed offense. McCoy should have more carries and targets than he usually gets, and he has been producing with limited numbers. The Buffalo Bills are likely going to win this game, which means that McCoy will see a lot of carries in the fourth quarter. His price tag is very reasonable, and he has the upside of Le'Veon Bell and DeMarco Murray.

Carlos Hyde (at BUF, $5,100)

Carlos Hyde should not be used in the same lineup as LeSean McCoy, as both running backs are not likely going to see 20 plus carries, but he does make for a great roster move in tournaments. His upside is very high, as he has over 20 fantasy points in two of his last three starts. Against the Seattle Seahawks, a very tough rush defense, he posted 28.5 fantasy points on 21 carries. If he continues to get worked into the passing attack for the 49ers, he is going to be a semi-elite level running back within the next couple of weeks. His price tag is bound to come up at some point, so roster him while he is cheap.

 

DraftKings Wide Receivers - Week 6 DFS Picks

A.J. Green (at NE, $8,600)

A.J. Green has been fantastic so far this season with 36 receptions, 518 receiving yards, and two touchdowns. If he starts to find the end zone a little bit more frequently, he will quickly turn into a top five wide out. Two games ago, he posted over 35 fantasy points on 12 targets and 10 receptions. Unfortunately, he only does that every so often. In his last five starts, he has over 35 fantasy points twice. That upside is as high as Antonio Brown and Julio Jones, but his price tag is lower. The New England Patriots are going to score. The Bengals will be playing from behind, which should bode well for Green. After his poor performance last week, they should be attempting to get him involved in the game plan a little bit more often.

Jeremy Maclin (at OAK, $6,300)

According to Vegas, the Kansas City Chiefs are going to walk into Oakland and beat the Raiders. That is very surprising, but Vegas tends to know more than anyone else. Jeremy Maclin has been a very consistent fantasy option at the wide receiver position, so using him in 50/50 contests is the correct move. However, this week, he can also be used in tournaments. The Chiefs are going to have to score to beat the Raiders, and Maclin is their go-to target. He has over 10 fantasy points in three of his last four starts, and he only found the end zone once this season. Over 20 fantasy points is definitely possible, if he sniffs out the goal line early.

 

DraftKings Tight Ends - Week 6 DFS Picks

Coby Fleener (vs CAR, $3,500)

Coby Fleener is a very high-upside tight end option for tournaments this week against the Carolina Panthers. The Panthers are not good defensively against the tight end position, and Fleener recently posted over 25 fantasy points against the Atlanta Falcons. As previously mentioned, Drew Brees is outstanding at home, which increases Fleener's upside. He is starting to see more targets, and if the Saints are winning the game, he should see even more targets. The Saints tend to check down before running the ball. It is just how their offense works. Use Fleener in tournaments, but his consistency has not been there. As a side note, Vernon Davis (with Jordan Reed out of the Redskins' lineup) makes for a fantastic low-priced tight end option.

 




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REAL-TIME FANTASY NEWS

Kirk Cousins

Falcons Plan to Release Kirk Cousins
Zach Ertz

Plans to Return for 14th Season
Jameson Taillon

Can Be a Sneaky Late-Round Value
Matt Wallner

Ready for a Breakout Season?
Jaxson Hayes

Unlikely to Play Tuesday
Jonathan Kuminga

Questionable Against Wizards
Andrés Giménez

Andres Gimenez Looking for Healthy 2026
Jae'Sean Tate

to Be Re-Evaluated in Two Weeks
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Expected to Play a Major Role in Toronto
Ryan Kalkbrenner

Listed as Probable Against Bulls
Tristan Vukcevic

Could Miss Second Straight Game
Chris Sale

Signs Extension With Braves
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Could Miss Game Vs. New Orleans
Vince Williams Jr.

Feared to Have Significant Knee Injury
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Questionable to Face Celtics
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Could Miss Third Straight Game
Draymond Green

Iffy for Tuesday's Matchup
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Struggling to Find Birdies as Florida Looms
Kristaps Porzingis

to Miss Two More Games
Naz Reid

in Danger of Missing Another Contest
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Not Quite Cutting It in 2026
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Won't Play Tuesday
Andrew Nembhard

Questionable Tuesday
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Wants to Build Momentum from Scottsdale
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Returns After Extended Break for Florida Event
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Might Miss Tuesday's Meeting with Toronto
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Signs Minor-League Deal With Pirates
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Signs Minor-League Contract With Giants
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Undergoes Imaging for Forearm Tightness
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a Strong Candidate to Hit Second in 2026
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Could Begin Season as the Closer
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Exits Grapefruit League Game With Hamstring Tightness
Trevor Megill

had Offseason PRP Injections
Merrill Kelly

is Awaiting MRI Results
José Berríos

Jose Berrios Feels Fully Healthy Now
CFB

Gunner Rivers Follows His Father, Commits To North Carolina State
Anfernee Simons

Ruled Out Tuesday
Pascal Siakam

Doubtful for Tuesday
Los Angeles Chargers

Bradley Bozeman Announces his Retirement
Joel Embiid

Questionable Vs. Pacers
Jaylen Brown

Considered Questionable for Tuesday
Ty Jerome

Unlikely to Play Monday
Cooper Flagg

Set to Miss Tuesday's Matchup With Nets
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Set to Make Tournament Debut at Cognizant Classic
Linus Ullmark

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Trending Up at the Cognizant Classic
Ryan Reaves

Sharks Activate Ryan Reaves From Injured Reserve
Charlie Lindgren

Activated From Injured Reserve Monday
Josh Norris

Cleared to Return Wednesday
Max McGreevy

Will Need to Improve on the Greens to Compete
Rico Hoey

Returns to Cognizant Classic
Austin Eckroat

Looks to Bounce Back at Cognizant Classic
Aaron Rai

Bounces Back After Rough Start to 2026 Season
Shane Lowry

Continues Playing Well Heading to Cognizant Classic
Max Homa

Has Opportunity to Continue Building Momentum at the Cognizant Classic
Ryan Gerard

Strong Approach Play Behind his Hot Start in 2026
Luke Clanton

Making Fourth Start of 2026 at Cognizant Classic
Kevin Lankinen

Unlikely to Play Wednesday
Josh Morrissey

to Miss Start of Road Trip
Mikko Rantanen

Expected to Miss Time
Jared Jones

Aiming to be Ready in Late May
Matt Brash

Not Feeling Great After Tooth Removal
Tarik Skubal

to Make One Start in World Baseball Classic
Blake Snell

Opening Day Not a Target for Blake Snell
Hagen Smith

to Face Hitters on Tuesday
Brandon Woodruff

Opening Day "Up in the Air" for Brandon Woodruff
Andrew Putnam

Looks to Jumpstart His Season at Cognizant Classic
Adam Scott

Looks For Continued Success at PGA National
Anthony Hernandez

Suffers Third-Round TKO Loss
Sean Strickland

Gets Back In The Win Column
Kyle Pitts Sr.

Falcons Planning to Use Franchise Tag on Kyle Pitts Sr.
Geoff Neal

Suffers Back-To-Back Knockout Losses
Uros Medic

Shines At UFC Houston
Dan Ige

Gets Finished For The First Time In His Career
Melquizael Costa

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NASCAR

Bubba Wallace Falls Short of Victory at EchoPark Speedway
Carson Hocevar

Rallies to Fourth At EchoPark Speedway After Early Struggles
Ross Chastain

Finishes Third At EchoPark Speedway
Chase Briscoe

Scores First Career Top-Five Finish at EchoPark Speedway
Tyler Reddick

Nabs His Second Win of the Season At EchoPark Speedway
Joey Logano

Will Be Popular DFS Pick at EchoPark Speedway
Tyler Reddick

on Pole After Qualifying Rained Out at EchoPark Speedway
Chase Elliott

Could Chase Elliott Be Worth Rostering At EchoPark Speedway?
Ryan Blaney

Is Ryan Blaney Worth Rostering for DFS at EchoPark Speedway?
William Byron

Is William Byron Worth Rostering for DFS at EchoPark Speedway?
Rondale Moore

Passes Away
Denny Hamlin

Is Worth Consideration for EchoPark Speedway DFS Lineups
Brad Keselowski

Is A Tournament Option for DFS At EchoPark Speedway
NASCAR

Is Bubba Wallace Rosterable In DFS At EchoPark Speedway?
Austin Cindric

Should DFS Managers Roster Austin Cindric at EchoPark Speedway?
Ross Chastain

Is Ross Chastain A Sneaky DFS Option for EchoPark Speedway?
Ricky Stenhouse Jr

Is Ricky Stenhouse Jr. Worth Rostering for DFS at EchoPark Speedway?
Alex Bowman

Will Start Towards the Rear At EchoPark Speedway
Javonte Williams

Cowboys Sign Javonte Williams to Three-Year, $24 Million Extension
Joel Armia

Wraps Up Olympics With Three-Point Performance
Daniil Tarasov

Available for Panthers
Evan Rodrigues

Set to Return Next Week
Aaron Ekblad

Expected to Play Thursday
Pavel Zacha

Cleared for Action
VAN

Jonathan Lekkerimaki Needs Season-Ending Shoulder Surgery
Mikko Rantanen

Misses Bronze-Medal Game With Lower-Body Injury
Blake Coleman

Activated From Injured Reserve
Matt Rempe

Heading to Injured Reserve After Second Thumb Procedure
Sidney Crosby

a Game-Time Call for Olympic Final
Josh Morrissey

Won't Play Sunday
Filip Chytil

Out Indefinitely With Facial Fracture
Connor McDavid

Makes History With Another Multi-Point Outing
Tage Thompson

Expected to Play in Olympic Final
Travis Etienne Jr.

has "Legitimate Interest" in Joining Chiefs
Zach Charbonnet

Undergoes Knee Surgery on Friday
CFB

Curt Cignetti Agrees to New Deal With Indiana, Will Earn $13.2 Million Per Year
Anthony Hernandez

Set For UFC Houston Main Event
Sean Strickland

Looks To Get Back In The Win Column
Uros Medic

Set For UFC Houston Co-Main Event
Geoff Neal

Looks To Get Back In The Win Column
Melquizael Costa

A Favorite At UFC Houston
Dan Ige

An Underdog At UFC Houston
Rashee Rice

Accused of Assault by Long-Time Girlfriend
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