DraftKings CFB DFS Lineup Picks: Daily College Fantasy Football Saturday Main Slate (11/22/25)

November 21, 2025

Mike Marteny's DraftKings daily fantasy college football lineup picks for the Saturday (11/22/25) main slate in Week 13. His CFB DFS lineup picks and DFS sleepers will help you win.

We've got another big Saturday main slate on tap. Some SEC teams are slumming, so we don't have as many marquee matchups. Missouri is in Norman early, with Oklahoma trying to get revenge on Missouri, scoring twice in the last 65 seconds of the game last year. The undercards are still enticing. Derby City is in Dallas to take on the Ponies. How ironic! Miami is in Blacksburg, where "Enter Sandman" doesn't hit the same at noon as at night. Rutgers is the sacrifice at the altar of Julian Sayin's Heisman campaign.

The afternoon sees Baylor in Tucson in a low-key, great passing matchup. UConn is in Boca for an even lower-key one. Arkansas is at DKR for an old SWC rivalry game. Kentucky is in Nashville for some broads on Broadway, and maybe some football. Duke is at the Dean Dome (we could only hope). USC is in Eugene to face Duck U. TCU is in Houston, where the Cougars have been more like house cats. We end in Salt Lake City with K-State in town.

In this article, I will provide you with my daily fantasy college football lineup picks for the main DraftKings slate on 11/22/25, starting at noon Eastern. I’ll give multiple player suggestions for quarterbacks, running backs, and wide receivers, aiming to highlight one option at each end of the salary scale, from high to low. Good luck, RotoBallers.

DraftKings CFB DFS Picks - Quarterbacks

Diego Pavia, Vanderbilt ($9.2K)

🏈 SEC Offensive Player of the Week | WK 11

⚓️ Diego Pavia, @VandyFootball #SECFB | presented by @Allstate pic.twitter.com/TzxBJx7YXf

— Southeastern Conference (@SEC) November 10, 2025

This is what happened the last time that Diego Pavia was on a football field. He went nuts on a stout Auburn defense. It feels like Pavia has started playing at a very high level since ESECPN started hyping him for the Heisman. It was gross negligence when it started, but Pavia's play lately makes it seem plausible.

Pavia has set new personal passing yards records in back-to-back games. He also ran for 112 yards on Auburn and 43 on Texas. Pavia has at least one rushing touchdown in each of the last four games.

This isn't the best matchup, but it doesn't have to be. Pavia's ceiling is still the highest on the slate, especially with the Vanderbilt offense running through him right now.

Joe Fagnano, Connecticut ($8.5K)

Fagnano struggled last week against Air Force, but it was more the Falcons controlling the ball and giving UConn fewer chances on offense than usual. He did throw his first interception of the season, so that brought down the total a little.

This won't be one of those games. FAU throws A LOT (Caden Veltkamp threw 57 passes last week), so they won't play keep-away. This is going to be a back-and-forth game and has the highest implied total on the slate. Fagnano should clear 30 DraftKings points in this one.

Taylen Green, Arkansas ($7.5K)

This hasn't been the talk of a lot of shows lately because of the (rightfully) questioned validity of the CFP rankings, but the Texas pass defense hasn't played well lately. Diego Pavia set a career high against them earlier this month, and Gunner Stockton had his way with them last week.

Green's strength isn't passing, but he is certainly a capable passer. He threw for 305 yards against Mississippi earlier this year. Texas took away Pavia's rushing ability, so he beat them through the air. Can they do the same to Green, and if so, will the result be the same? For this price, it's worth finding out.

Gio Lopez, North Carolina ($5.5K)

Duke has allowed 291.2 passing yards per game this year. That's 134th out of 136 FBS teams. Lopez has had a couple of real clunkers this year and struggled with Cal upon his return from injury. The last two weeks have been a different story.

Lopez has 37.4 DraftKings points over the last two games. Yeah, many quarterbacks can flirt with that mark in a single game, but how many of them are priced this cheaply? If Lopez can get us around 20 DK points again (against this defense, he should), he'll be one of the best bargains on the slate.

Also consider these QBs:

• Arch Manning, Texas ($9K)
• Conner Weigman, Houston ($8.6K)
• Caden Veltkamp, Florida Atlantic ($8K)
• Carson Beck, Miami (FL) ($6.9K)
• Noah Fifita, Arizona ($6.4K)
• Darian Mensah, Duke ($6.3K)

Want some more CFB DFS tools? If you like what you see here, don't forget to sign up for your RotoBaller CFB DFS Premium Pass. Use code MARTENY and receive 10% off your purchase! You'll love the College Football DFS Lineup Optimizer, DFS Cheat Sheets, and Premium Slack Chatrooms to help you out in real time.

DraftKings CFB DFS Picks - Running Backs

Ahmad Hardy, Missouri ($7.7K)

He’s not draft eligible til next year, but I’m fully addicted to #Mizzou RB Ahmad Hardy’s tape

This kid’s fast, patient and powerful, and it only takes him like 3 steps to reach his top speed

🎥: He rushed for 300 yards and 3 TDs this past week vs Mississippi St👇 pic.twitter.com/aoqnCiYy3f

— The Draft Room (@TheDraftRoomNFL) November 20, 2025

On paper, this is a horrible matchup. However, if you've watched every Oklahoma game (and every Missouri game, for that matter) like I have, you realize that Texas ran the ball on the Sooners. Even Alabama had a couple of long runs. Mississippi's Kewan Lacy didn't hit 100 yards, but he did score twice.

The Oklahoma defense is not impenetrable. Add in Hardy's insane volume since Beau Pribula went down (43 touches in two games), and there is a path to success here. It should also come at low ownership since most won't play Hardy because of Oklahoma's defensive metrics. He is the ultimate GPP leverage play.

Cam Edwards, Connecticut ($6.9K)

Florida Atlantic has allowed a staggering 213.8 rushing yards per game this year. That's 130th out of 136 teams. Also going in Cam's favor is that his quarterback doesn't steal carries like many others do.

Edwards has at least 15 touches in each of the last five games. He should be around that area again this week. Against this rush defense, Edwards can break a slate. Everyone is going to play Edwards (especially in cash games), so you'll have to get different elsewhere.

Wayshawn Parker, Utah ($6.2K)

It took half the season for Utah to finally figure out its running back rotation, but it finally seems that Parker is getting most of the work (as he should). Parker has 43 carries for 378 yards and three touchdowns in the last three games alone.

Kansas State has a middling run defense, but what gives Parker some extra juice is the poor tackling that has plagued the Wildcats in the back and middle of the defense. Parker is slippery. If he gets out of a tackle or two, he's going for a couple of long touchdowns.

Ismail Mahdi, Arizona ($4.1K)

I know that conventional wisdom frowns on stacking a backfield on a slate this large, but I might do it. Kedrick Reescano is only $100 more than Mahdi, and both scored touchdowns last week. Baylor has allowed 209.2 rushing yards per game, which is 127th in FBS. One will have a big game here. Both could.

I prefer Mahdi because he gets a couple more carries per game on average, but Reescano is more of the big-play hitter. Both are excellent plays in this situation.

Also consider these RBs:

• Nate Sheppard, Duke ($7.8K)
• Bo Jackson, Ohio State ($6.6K)
• Quintrevion Wisner, Texas ($5.9K)
• Bryson Washington, Baylor ($5.7K)
• TJ Harden, SMU ($5.3K)
• Xavier Robinson, Oklahoma ($5K)

DraftKings CFB DFS Picks - Wide Receivers

Skyler Bell, Connecticut ($7.4K)

The UConn passing game struggled last week against Air Force, and Bell still racked up 15 DK points. It was his first time under 30 since October 4. He should be back on track in a high-scoring tilt against Florida Atlantic. Bell is tied for the FBS lead in targets with San Jose State's Danny Scudero.

Easton Messer, Florida Atlantic ($7K)

Messer is seventh in FBS in targets, so he's firmly on my radar as well. I would even consider him over Bell since FAU throws at a 62.4% rate. That's third in FBS. If this is a high-scoring game as expected, Messer and Bell are going to make a great game stack/runback option. I'm glad we have some cheap backs this week. WR is loaded!

Jordan Hudson, SMU ($5.3K)

Hudson has 16 receptions for 240 yards and a touchdown in the two games since the offensive disaster against Wake Forest. This isn't a great matchup for SMU, but it's good enough, especially if we wind up in a close game.

Kendrick Law, Kentucky ($4.6K)

Freshman quarterback Cutter Boley has taken a liking to Law. He has 77.5 DK points in the last four games, which coincides with Boley finding his stride in the Kentucky offense. Law is too cheap for what he's producing. I'll have several shares this week.

Emmett Mosley V, Texas ($4.4K)

It took a bit for Mosley to find his groove in the Texas offense, but he has over the last three games. Mosley has 14 receptions for 188 yards and three touchdowns in that span. His ceiling isn't as high as some, but the floor is higher. Mosley is better in cash games, but I can find room for him in SE and GPP lines as well.

Also consider these WRs:

• Makai Lemon, USC ($7.6K)
• Cooper Barkate, Duke ($7.3K)
• Chris Bell, Louisville ($6.8K)
• Jordan Shipp, North Carolina ($5.8K)
• Jaron Tibbs, Kansas State ($4.8K)
• Kole Wilson, Baylor ($4.1K)
• Keelan Marion, Miami (FL) ($3.7K)

DraftKings CFB DFS Stacks

Connecticut vs. Florida Atlantic - Game Stack

This is by far the highest implied total on the slate (64.5 points). We'll break this down with the full stack by team first, then see what a possible game stack looks like. Pricing makes it harder, but I have an idea...

For Connecticut, it's pretty simple. We'll see a lot of Fagnano/Bell lineups. I'll have Cam Edwards in all of my UConn lines as well. It's usually not a good idea to full-stack on a slate this size, and it definitely isn't with UConn. If you add Juice Vereen (if he plays) to the three-man, you'll have 80% of UConn's offensive production.

FAU is a little different since they throw so much. Veltkamp and Messer will be popular, often with Fagnano/Bell lines. Asaad Waseem and Jayshon Platt both see plenty of targets to consider in a stack. For a fifth piece, consider Gemari Sands at running back.

He's much like a Hawaii running back. He doesn't get a lot of carries, but Sands is involved in the passing game. He has four or more receptions in three of the last five games.

Now the fun part. Game stacking will be tricky, but could be lucrative in a GPP. Fagnano/Veltkamp/Bell/Messer leaves you only $19.1K for the other four positions. Since I'm in on Cam Edwards as well, that takes it down to just over $4K per position.

I really want Vereen if he plays, but then you have to pick one Arizona back and not the other. I'd rather use both Arizona backs and Keelan Marion from Miami.

Arizona vs. Baylor

The Baylor defense has been bad enough to attack the whole thing. Besides, the Arizona backfield situation makes it perfect for a full five-man stack. Fifita and the two backs only set you back $14.7K. That leaves plenty of room for Kris Hutson and Javin Whatley.

Also consider these stacks:

• Texas
• Miami (FL) (GPP only)
• Ohio State (GPP only)

More College Football Analysis

Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!