DraftKings CFB DFS Lineup Picks: Daily College Fantasy Football Friday Slate (11/14/25)

Mike Marteny's DraftKings daily fantasy college football lineup picks for the Friday (11/14/25) slate in Week 12. His CFB DFS lineup picks and DFS sleepers will help you win.

It's a small-but-mighty Friday night DFS slate. All four teams are power teams, and two of them are ranked. One of them is in the top 10. What more can we ask for in college football's version of Friday Night Lights?

We start this in Louisville with a beleaguered Clemson team facing a battered Louisville team. Does this mean more chaos for the ACC? Probably. We end this out at the Zoo with Minnesota visiting Oregon.

In this article, I will provide you with my daily fantasy college football lineup picks for the DraftKings slate on 11/14/25, starting at 7:30 pm Eastern. I’ll give multiple player suggestions for quarterbacks, running backs, and wide receivers, highlighting one option at each end of the salary scale. Good luck, RotoBallers!

DraftKings CFB DFS Picks - Quarterbacks

Cade Klubnik, Clemson ($8.5K)

Cade Klubnik has played some great football since the start of October.

He’s gutted it out with injuries too.

Here’s some stats:

8 TDs, 1 INT

Four straight games with a completion percentage of 70% or better.

3-1 record. (one loss was a 45 point outing)

— Grayson Mann (@gray_mann21) November 9, 2025

Lost in Clemson's lost season is how well Klubnik has played over the two months or so. The only difference from last year is that Clemson isn't winning. You can't pin it all on Clemson. We just live in a culture where it's cool to hate on someone who is hyped up. It's ridiculous, and it definitely has no place in our DFS decision-making.

Klubnik has only had one game under 22 DraftKings points since the Troy game in Week 2. That was the 18.9-point outing before the bye against Florida State. Klubnik is averaging 24.73 DK points per game since the Troy game.

Louisville's defense is not to be trifled with. I would generally agree, but Jaron-Keawe Sagapolutele lit up the Cardinals' secondary last week with lesser receivers. The Clemson offense is much more polished and could smash Louisville's secondary if it has another off day.

Miller Moss, Louisville ($7.5K)

This is a tough sell. If you can't afford to pay up for both Klubnik and Dante Moore, this may be a slate just to forego the second quarterback in place of another back.

Moss has only thrown two touchdowns total in the last three games. He has three on the ground to help his totals, but it's hard to rely on rushing touchdowns from a guy who doesn't run much.

The best-case scenario for running Moss is hoping for a high-scoring game or a game where Clemson leads early and Louisville has to throw to catch up. That could be a blessing or a curse.

Also consider these QBs

• Dante Moore, Oregon ($8.1K)
• Drake Lindsey, Minnesota ($6.8K)

DraftKings CFB DFS Picks - Running Backs

Keyjuan Brown, Louisville ($5.6K)

Louisville stud running back, Isaac Brown, could be out this weekend which gives the Tiger faithful some additional hope. However, don’t sleep on running back Keyjuan Brown as the Cardinal ball carrier is averaging 6.9 yards per carry and 11.6 yards per reception.

Tom Allen and… pic.twitter.com/660Iq3yomD

— William Cockerill (@walkonmoose) November 12, 2025

Louisville caused quite a stir when they "inadvertently" left Isaac Brown off the injury report. Brown had a monster game against Clemson last year, and Clemson's faithful were getting worried. The issue was corrected about an hour later, which makes me wonder if Louisville wasn't just playing some head games.

At any rate, facing Keyjuan Brown isn't much of a reprieve. He was a load even with Isaac in the lineup. Keyjuan has 60.7 DK points in the last three games. He's good enough to give Clemson fits, and he's remarkably cheap compared to the top backs (in worse matchups or timeshares) on this slate.

Gideon Davidson, Clemson ($4.5K)

The freshman garnered a lot of headlines in camp, but has been a non-factor this season until recently. Davidson has 22 carries and five receptions over the last two games as Clemson is giving Adam Randall a bit more rest.

This is also a lost season for Clemson, so they want to see if Davidson can carry the load. The returns are mostly positive so far. He's not going to supplant Randall anytime soon, but Davidson has shown himself to be a good receiver out of the backfield. We could see some decent numbers thanks to the PPR scoring on DraftKings.

Also consider these RBs

• Adam Randall, Clemson ($6.4K)
• Darius Taylor, Minnesota ($5.3K)
• Dierre Hill Jr., Oregon ($4.3K)

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DraftKings CFB DFS Picks - Wide Receivers

Chris Bell, Louisville ($6.6K)

Chris Bell #Louisville (6’2”, 220) is a MENACE on crossers. 9.4% crosser rate, tops in the class. Big body, easy separation on drags, runaway YAC. Damn good player. #NFLDraft pic.twitter.com/WSteRoh510

— Ray G (@RayGQue) November 11, 2025

The post above highlights what issues Clemson will have containing him. Clemson doesn't have the speed at linebacker to cover him on the cross patterns, and once he gets up to speed, the secondary may not catch him.

Teams have had some success by positioning the safeties where they can contain Bell from long gains. There has been some success on this front, but Bell still has 14 receptions in the last two games. The only real success teams have had is keeping him out of the end zone.

Antonio Williams, Clemson ($63K)

I will go ahead and highlight two expensive receivers just in case you want to go with a one-quarterback lineup in GPPs. I'm going to try it at least once because of the star receivers that are worth playing on this slate.

Williams has been a nightmare for opponents since making his return on September 20. He has at least five receptions in every game and is now scoring touchdowns. Williams has the highest ceiling among non-quarterbacks on the slate.

T.J. Moore, Clemson ($4.5K)

The recent play of Klubnik has gone unnoticed by many, but it makes his receivers worth using. Williams is the target hog, but Moore has proven to be a good deep threat. He's a little touchdown-dependent, but the price is right, especially if you're running a Clemson stack.

Le'Meke Brockington, Minnesota ($4.3K)

If Minnesota falls behind quickly, it will mean another busy day for Brockington. He has double-digit DK points in four straight and six of the last seven games. Lindsey looks for Brockington first, making him the Minnesota receiver to take your stand with.

Also consider these WRs:

• Caullin Lacy, Louisville ($5.2K)
• Dakorien Moore, Oregon ($4.9K)
• Javon Tracy, Minnesota ($3.6K)

DraftKings CFB Stacks

Clemson vs. Louisville

This is mostly based on Louisville's struggles with the Cal passing game last week. I'll go heavily on the Clemson passing game as a result. Klubnik and Williams are going to be a popular pair in many lineups, but I'll add T.J. Moore to mine as well.

Using Gideon Davidson in place of Randall is a contrarian play. You can use both, but I like the upside of Davidson and will use Tristan Smith instead of Randall. You could use Randall instead of Davidson, but you will have to go cheap elsewhere.

Also consider these stacks: 

• Louisville
• Oregon (GPP only)

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