🖥 TAP TO SAVE 50% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

NFL Betting Picks for Week 4 - Best Bets, Expert Odds and Predictions

Christian McCaffrey - Fantasy Football Rankings, NFL Injury News, DFS Lineup Picks

Mitch Blatt gives his picks against the spread, over/under, and on the moneyline. These are the best bets for Week 4. Who will win in the game of the week? Who will win on Monday Night Football? Who should you bet on?

Who bet the Dolphins vs. Broncos game to go over 48.5 points last week? Good call, everyone. That was also my top over/under pick of the week. The Dolphins hit it all by themselves in the third quarter.

I went 3-0 on over/under picks last week. My other calls were the Vikings vs. Chargers game going under an absurdly high 54 and the Raiders and Steelers together failing to hit 43. This season has been relatively balanced for over/under picks. Twelve teams have seen most of their games go over the spread, and twenty are more inclined to go under. Last season, only five teams were involved in going over in over 50% of the games, and five more went over 50% of the time.

This week, I am picking the over in my featured game again. The high-powered San Francisco 49ers offense has a favorable matchup to put up points against the Arizona Cardinals. Read on to see all of my Week 4 NFL best bets.

Editor's Note: The FFPC Playoff Challenge #2 is back with a massive $100,000 grand prize and $203,250 total prize pool, paying down to 100th place. Here's the deal: no salary cap, no draft, no pickups, no subs. Choose 8 players, and as NFL teams get knocked out so will your players, so choose your team wisely. The entries will sell out quickly, and registrations will close on Saturday January 17th at 4:30 pm ET . Don't wait - get your team now and end your fantasy football season with a shot at $100,000! Sign Up Now!

 

Week 4 NFL Betting Picks - Moneyline

Last Week: 1-0 on Moneyline, 1-1 Against the Spread, 3-0 on Over/Under Picks

Season-long Record: 2-1 on Moneyline, 3-5 Against the Spread, 5-0 on Over/Under Picks

 

Cincinnati Bengals @ Tennessee Titans (CIN -2.5)

Sunday, 1:00 pm | O/U: 41

The Bengals defense is starting to look better. In Week 3 against the Los Angeles Rams, the Bengals achieved an 84.3 pass-rush grade after only grading in the 50s in the first two weeks. Five Bengals recorded sacks, including two for Trey Hendrickson. The Rams' offensive line was one of the worst in the league in preseason rankings, and Hendrickson was dominating backup left tackle Zach Thomas, who allowed five pressures.

The Titans offensive line is also one of the worst in the league. While Tennessee's line overperformed in Weeks 1 and 2, they still only rank 30th in PFF's Week 4 OL rankings. Titans left tackle Andre Dillard has been getting destroyed this season. He's allowed six sacks and ten total pressures in the past three games. Ryan Tannehill is one of the worst quarterbacks under pressure. He has a 38.1% completion percentage, zero touchdowns, two interceptions, and a 10.3 passer rating when pressured.

The Titans are not a particularly good team at home despite having won their one home game so far this year. Last season, the Titans went 3-8 at home.

Pick: Bengals ML (-148), Bet 1 Unit

 

Week 4 NFL Betting Picks - Against the Spread

Los Angeles Rams @ Indianapolis Colts (IND -1)

Sunday, 1:00 pm | O/U: 46.5

The Bengals defense came to life against the talent-deprived Rams offensive line last week. The Rams also suffered in-game injuries against the Bengals, making their line even worse than it was. Rams left tackle Alaric Jackson did not practice on Wednesday or Thursday, so the Rams might have to start Zach Thomas again.

The Colts have been graded as the eight-best pass-rush team this season, so they will have a significant advantage against the Rams.

Besides their poor offensive line, the Rams' offense has been overperforming preseason expectations. Their wide receivers, especially Puka Nacua, look like they are truly as talented as their numbers suggest. Puka can get open and get yards after the catch. But running back Kyren Williams, despite having had fantasy value due to his three rushing touchdowns in the first two weeks, is subpar. He is only averaging 3.6 yards per carry.

Colts QB Anthony Richardson is back at practice, and he will lead a dynamic Titans rush-heavy attack that will upset the Rams and win outright.

Pick: Colts +1

Others:

Bengals -2.5 over Titans

Not only will the Bengals beat the Titans, they will win big. They just need to win by three.

Chiefs -9.5 over Jets

The Chiefs are playing up to their level now. Taylor Swift brings her magic to the Chiefs. The Jets' defense is supposed to be elite, but it really isn't. Their pass rush is only ranked No. 14. They caused 16 pressures but no sacks last week against Mac Jones. Their pass coverage is considerably better, but as long as Patrick Mahomes has time, he will find open receivers and dice up the Jets defense.

 

Week 4 NFL Betting Picks - Over/Under

Arizona Cardinals @ San Francisco 49ers

Sunday, 4:25 pm | O/U: 44.5

The 49ers have a 3-0 record of scoring 30 points in a game. The Cardinals have scored over 14 points in all three of their games, including 28 points in each of the past two. The 49ers are allowing an average of 14.0 points per game.

The 49ers are probably the best defense the Cardinals have faced, but they have allowed 12 or more points in the past two games. The Giants scored 12 on the 49ers, but they are only averaging 14.3 points per game. The Cardinals are averaging 24.0 points per game.

Arizona's offense is actually not bad. Joshua Dobbs is a good game manager, and he can rip off some big passes to Marquise "Hollywood" Brown and Michael Wilson when he needs to. Just watch the 49ers win this game 30-14, and I lose by 0.5 points. But, more likely, the 49ers will finally break their 30-point ceiling, and the Cardinals might add a field goal to two touchdowns.

Pick: Over 44.5 Points, Bet 1 Unit



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Waiver Wire Pickups and Advice




POPULAR FANTASY TOOLS

Expert Advice
Import Your Leagues
Weekly Rankings
Compare Any Players
Projections
Articles & Tools
Weekly Planner
24x7 News and Alerts

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

REAL-TIME FANTASY NEWS

Collin Morikawa

Isn't The Safe Play He Used to Be Ahead of Sony Open
Luka Dončić

Luka Doncic Available Tuesday Night
Kurt Kitayama

Needs His Putting to Turn Around For Success at Year's First Event
Max Christie

Could Miss Wednesday's Game Due to Illness
LeBron James

Cleared to Play Tuesday
P.J. Washington

Listed as Questionable for Wednesday
Egor Demin

Back in Action Wednesday
Cam Thomas

Available Wednesday
Jakob Poeltl

Unavailable Versus Pacers
RJ Barrett

to Miss Third Straight Game Wednesday
Trae Young

Won't Play Wednesday
Rui Hachimura

to Be Limited to 18 Minutes Tuesday
Ivica Zubac

Iffy for Wednesday
Kawhi Leonard

Questionable for Wednesday
Jerami Grant

Ruled Out Tuesday
VJ Edgecombe

Considered Probable for Wednesday
Paul George

Listed as Probable for Wednesday
Joel Embiid

Expected to Suit Up Wednesday
Anthony Davis

Won't Have Surgery, Out for Six Weeks
Ryan Weathers

Yankees Add Rotation Depth, Acquire Ryan Weathers in Four-Player Deal
Norman Powell

Good to Go on Tuesday
Robert Thomas

Out Tuesday
Luguentz Dort

Ruled Out For Tuesday's Matchup With Spurs
Jake Walman

Available Against Predators
Troy Terry

a Game-Time Decision Tuesday
Justin Sourdif

Won't Play Tuesday
Jaxson Hayes

Unavailable Against Hawks
Jakob Chychrun

a Game-Time Call Tuesday
Morgan Geekie

Available Tuesday
Luke Kennard

Sidelined Tuesday
Bryan Rust

Returns to Action Tuesday
Erik Karlsson

Penguins Place Erik Karlsson on Injured Reserve
Los Angeles Chargers

Chargers Fire Offensive Coordinator Greg Roman
Pittsburgh Steelers

Mike Tomlin Stepping Down as Steelers Head Coach
CFB

Georgia Tech the Favorite to Land Justice Haynes?
Nolan Arenado

Cardinals Trade Nolan Arenado to Diamondbacks
Tom Kim

Desperately Needs a Solid Week at Sony Open
Billy Horschel

Hoping For a Fast Start to New Season at Sony Open
Corey Conners

Looks to Have a Return to Form in 2026
PGA

Chris Gotterup a Decent Play at Sony Open
Philip Broberg

Likely Out Tuesday
Jacob Trouba

on Track to Return Tuesday
Gary Woodland

Could Prosper at the Sony Open
Will Smith

Upgraded to Day-to-Day
Connor McDavid

Stretches Point Streak to 19 Games
Keith Mitchell

Unlikely to Contend at Sony Open
Teuvo Teravainen

Makes Early Exit Monday
Robert MacIntyre

Looking for a Good Performance at the Sony Open
Nicholas Robertson

Hurt Versus Avalanche
Brayden Point

Injured in Monday's Win
Michael Kim

Hopes to Start Sony Open Better This Week
Tom Hoge

Tries to Erase Poor 2025 Second Half in Hawaii
Brian Harman

Seeks Fresh Start in Hawaii
Eric Cole

Looks to Last Year for Success at Sony Open
Daniel Berger

Starts Off 2026 at Sony Open
Nico Collins

Suffers Concussion Against Steelers
Nico Collins

Carted to Locker Room for Concussion Evaluation
Kyle Tucker

Mets Meet With Kyle Tucker
Dalton Kincaid

"Should be Fine" for Divisional Round
Conor Garland

Returns From Five-Game Absence
Kiefer Sherwood

Out Monday, Could Miss Several Weeks
Marco Rossi

to Miss 2-3 More Weeks
Louis Crevier

Back for Blackhawks Monday
Jordan Eberle

Available Against Rangers
Joel Eriksson Ek

Out Monday
Brooks Koepka

Officially Returning To PGA Tour
Tucker Kraft

Hopes to be Ready for Week 1 of Next Season
CFB

Georgia Lands Kentucky Transfer Dante Dowdell
Matthew Stafford

has "Little Sprain," Should be "Good to Go"
CFB

Sam Leavitt Expected to Sign with LSU
Green Bay Packers

Packers Expected to Work Out New Deal With Matt LaFleur in the "Coming Days"
CFB

Dylan Raiola Commits to Oregon
CFB

Isaiah Horton Landing with Texas A&M
George Kittle

Suffers Torn Achilles on Sunday
Omarion Hampton

Active for Wild-Card Round Against Patriots
George Kittle

Ruled Out After Non-Contact Achilles Injury
Las Vegas Raiders

Raiders Request Interview With Ejiro Evero
Los Angeles Rams

Mike LaFleur to Interview With Raiders and Cardinals
Aaron Rodgers

Steelers Open to Re-Signing Aaron Rodgers?
Matthew Stafford

X-Rays Come Back Negative
MacKenzie Gore

Yankees Pursuing Trade for MacKenzie Gore
Alex Bregman

Cubs Sign Alex Bregman to Five-Year, $175 Millon Contract
Freddie Freeman

Withdraws from World Baseball Classic
Max Kepler

Receives 80-Game PED Suspension
CFB

Cam Coleman Visiting Alabama on Friday
Omarion Hampton

Expects to Play Sunday Night
CFB

Eric Singleton Jr. Enters Transfer Portal, Trending to Land at Florida
CFB

NCAA Denies Trinidad Chambliss a Sixth Year of Eligibility
Omarion Hampton

Questionable for Wild-Card Weekend
Kyle Tucker

Mets Remain in Mix for Kyle Tucker
Ketel Marte

Will Remain With Diamondbacks
Rashee Rice

to be Reviewed Under League's Conduct Policy
Daniel Jones

Colts Plan to Re-Sign Daniel Jones
Davante Adams

Off the Injury Report, Will Play Against Carolina
Bo Bichette

Phillies to Meet With Bo Bichette
Rome Odunze

Will Return for Wild-Card Game on Saturday
CFB

DJ Lagway Commits to Baylor