X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

NFL Week 6 Predictions: Picks for Every Game

Terry McLaurin - Fantasy Football Rankings, Draft Sleepers, NFL Injury News

Free NFL betting picks for every Week 6 matchup. Expert analysis and predictions for NFL Week 6. Who should you bet in Week 6? Analysis for every game on the slate.

Hello, football fans, and welcome to Week 6 of the NFL season. With one coach already fired, the pressure is undeniably cranking up across the league with each passing week.

The Week 6 slate is an interesting one that kicks off with a divisional clash between the Niners and Seahawks on Thursday night and wraps up with a juicy matchup between the Jets and Bills.

Good, bad, and ugly...we'll go through every Week 6 game in this article, offering picks, predictions, and analysis on each and every one. Thanks for joining us here at RotoBaller; let's dive into the slate!

Be sure to check all of our fantasy football rankings for 2025:

 

San Francisco 49ers 24, Seattle Seahawks 20

We kick off the Week 6 NFL slate with a clash between NFC West divisional rivals. Both San Francisco and Seattle limp into this matchup, licking their wounds from shocking home losses to inferior teams in Week 5, as the Niners fell to the Cardinals and the Seahawks were upended by the Giants.

For the 2-3 Niners - with two of those losses coming within the division - this is suddenly a must-win sort of game.

While traveling to Lumen Field on a Thursday night is no easy task, San Francisco has won five straight over Seattle, and although new Seahawks coach Mike Macdonald appears to have the 'Hawks flying in the right direction, they enter Week 6 with a plethora of injuries on the defensive side of the ball. Look for the Niners to level up to .500 in a tight one.

 

Chicago Bears 21, Jacksonville Jaguars 17 (London)

The NFL's International Series continues with a Week 6 meeting between the Bears and Jaguars in London. Both squads head across the pond after encouraging Week 5 outings. Chicago's offense finally started to click in a 36-10 win over the Panthers, while Jacksonville picked up their first victory of the season in a shootout with the Colts.

While Trevor Lawrence's play last week is cause for tempered optimism, he'll face a very different challenge against a Bears defense that's limiting opposing passers to just 174 yards per game.

On the other side of the ball is rookie quarterback Caleb Williams, who looks more comfortable each week and draws a Jags defense that ranks dead last in the NFL in passing yards allowed per game. The Bears should simply be better on both sides of the ball in this one.

 

Tampa Bay Bucs 24, New Orleans Saints 14

With Saints quarterback Derek Carr now expected to miss multiple weeks with an oblique injury suffered in Monday night's loss to the Chiefs, this always-tough divisional clash should theoretically get easier for the Bucs. As of this writing, it still isn't clear if New Orleans will start Jake Haener or rookie Spencer Rattler under center in Week 6.

The Bucs should be able to handle either, as despite suffering a heartbreaking overtime loss to the Falcons last week, Baker Mayfield and this offense continue to impress. Mayfield has thrown for 1,164 yards and 11 TDs with just two INTs through Tampa Bay's first five.

While New Orleans will likely do everything in their power to slow this game down, look for the Bucs to find enough big plays to outpace whoever New Orleans rolls out at QB.

 

Green Bay Packers 28, Arizona Cardinals 20

Will the real Arizona Cardinals please stand up? After being destroyed 42-14 by the Commanders two weeks ago, Arizona pulled off a shocking win over the 49ers in Week 5 behind a solid game from Kyler Murray and some timely defensive plays.

The Packers also returned to the win column last week in Jordan Love's second start since returning from an injury that forced him to miss two games. He's developing a nice rapport with wide receiver Jayden Reed and emerging tight end Tucker Kraft.

Though the Cardinals have proven themselves to be a fairly scrappy bunch, a trip to Lambeau Field isn't an easy task for any squad. Look for Green Bay to continue to feed Josh Jacobs on the ground against an Arizona unit that ranks 28th in the NFL in rushing yards allowed per game.

 

Indianapolis Colts 20, Tennessee Titans 17

Ok... I'm just gonna come out and say it: the Colts are a better team with Joe Flacco under center. I understand that Anthony Richardson is the team's future and how much draft capital they have invested, etc., but Flacco does give Indy their best shot at winning games right now.

All that said, it might not matter who is under center for the Colts in Week 6 if the Tennessee Titans can't get their own quarterback issues sorted out. With Tennessee coming off a bye week, Will Levis appears set to return after suffering a shoulder injury in Week 4.

That's not necessarily great news if you're a Titans fan, as Levis has been a turnover machine this season, throwing six interceptions and coughing up three fumbles. Until Levis proves he can take care of the football, this Tennessee team is impossible to trust (or pick), and if they don't show some offensive spark against a putrid Indy defense, it simply might not happen in 2024.

 

Philadelphia Eagles 21, Cleveland Browns 13

It's nothing Cleveland fans don't already know, but the Deshaun Watson debacle is dragging the Browns down to the bottom of the league. Unfortunately, there's no end in sight with Browns head coach Kevin Stefanski maintaining earlier this week that Watson will remain under center.

The Eagles come in off a Week 5 bye and expect to have multiple stars, including A.J. Brown and DeVonta Smith, back in the lineup this week. While Philly has been experiencing its own share of issues in a 2-2 start, they should be able to power past the sinking ship that is the Browns.

 

Houston Texans 20, New England Patriots 10

After rolling with veteran Jacoby Brissett for the first five games of the season, the Patriots will trot out Drake Maye against the Texans in Week 6. It's inarguably a difficult spot for the third overall pick of the 2024 NFL Draft to make his first start as a pro, as he'll be surrounded by a horrible offensive line and a group of no-name pass catchers in this Patriots offense.

Off to a 4-1 start, Houston will be without star wide receiver Nico Collins, who was recently placed on IR. Running back Joe Mixon, who has yet to practice this week, also looks doubtful for this tilt with the Pats. The Texans could probably be short a few more stars and still be favored in this one, as a DeMeco Ryans' defense that's allowing just 154 passing yards per game will likely wreak havoc on the rookie Maye.

 

Baltimore Ravens 31, Washington Commanders 27

Sunday's marquee matchup features two of the NFL's most exciting quarterbacks, Lamar Jackson and Jayden Daniels. Jackson comes in off a spectacular overtime win over the Bengals in which he threw for 348 yards and four TDs.

Daniels has been the league's most impressive rookie while displaying accuracy, deep-ball touch, and elite rushing ability en route to leading the long-dormant Commanders to a 4-1 start.

It's safe to expect offensive fireworks in this one, as these two talented QBs square off against defenses that are each allowing over 23 points per game in 2024. While Daniels will undoubtedly make multiple splash plays, look for the more experienced Jackson - with some help from Derrick Henry - to top the rising star this week.

 

Denver Broncos 16, Los Angeles Chargers 13

Denver rides what is perhaps the NFL's most surprising three-game win streak into this home clash with the Chargers. The Broncos have been content to win with defense and rookie quarterback Bo Nix playing ultra-conservatively. Patrick Surtain II and company haven't allowed more than 18 points to an opponent since Week 1.

Jim Harbaugh's squad comes in off a much-needed bye week, as the Bolts have multiple stars such as Justin Herbert, Joe Alt, Rashawn Slater, and Joey Bosa nursing assorted injuries. Look for a tightly contested and low-scoring battle between these defensive-minded division rivals, but don't be shocked if the Broncos come out on top in Mile High, where they've won five straight over the Chargers.

 

Pittsburgh Steelers 20, Las Vegas Raiders 13

Yet another Week 6 matchup between two teams who seem allergic to offensive success. The Steelers dropped a Sunday night heartbreaker to the Cowboys in Week 5, while the Raiders were suffocated by the Broncos defense at Mile High.

Las Vegas will square off against a Pittsburgh defense that's allowing just 14.6 points per game while dealing with a quarterback job that neither Gardner Minshew nor Aidan O'Connell appears capable of winning, as well as the absence of star wide receiver Davante Adams. It's not a good combination when facing the Steelers.

 

Atlanta Falcons 35, Carolina Panthers 17

Well rested off an exciting Week 5 overtime win over the Bucs on Thursday Night Football, the Falcons will look to keep the hammer down against the lowly Panthers this week.

High-priced offseason acquisition Kirk Cousins looked worth every penny while throwing for a career-high 509 yards and four TDs against Tampa Bay last week. There's little reason to believe he'll slow down against a putrid Carolina defense that's allowing the most points per game in the NFL.

 

Detroit Lions 28, Dallas Cowboys 27

After a last-second win over the Steelers on Sunday Night Football, the Cowboys won't get to relax for long, as they host Dan Campbell's 3-1 Lions squad in Week 6. Detroit dismantled the Seattle Seahawks ahead of their Week 5 bye and will look to stay hot against a Dallas defense that's allowing just over 24 points per game.

The Lions have their own issues on the defensive side of the ball, as an offseason retooling of the secondary has yet to pay dividends. Dak Prescott and CeeDee Lamb should find success. Jared Goff and Detroit's rushing attack should find success. The bottom line...there will be plenty of points scored by these offenses, but the Lions will edge the 'Boys in a shootout.

 

Cincinnati Bengals 27, New York Giants 21

The Sunday night primetime matchup features two squads with a combined record of 3-7. Despite the win/loss totals, this could be a fun one, as we'll see two of the NFL's best wide receivers in Ja'Marr Chase and Malik Nabers.

Week 5's 41-38 overtime loss to the Ravens reinforced what we already knew about the Bengals - great offense, zero defense. Joe Burrow and company head into Week 6, averaging 28 points per game, yet this team is fighting to save its season.

The Giants were able to pull off a shocker in Seattle last week to pull to 2-3, but it still feels as though Brian Daboll is holding this thing together with duct tape and popsicle sticks.

 

Buffalo Bills 20, New York Jets 17

In a somewhat surprising move, the Jets fired head coach Robert Saleh earlier this week following the team's 2-3 start and Week 5 loss to the Vikings in London. Defensive coordinator Jeff Ulbrich has been named New York's interim head coach.

While it's understandable that the Jets ownership and front office want to try to salvage the season, will Saleh's removal matter all that much as long as Nathaniel Hackett is still calling the plays for the Jets' sputtering offense?

It wouldn't be surprising to see New York playing with a high-energy level in front of a home crowd on Monday night, but Josh Allen and the Bills won't be a pushover opponent.

The losers of two straight, Buffalo badly needs to right its own ship this week, and while the Bills offense hasn't been firing on all cylinders in the last couple of weeks, it feels closer to "good" than what Aaron Rodgers and the Jets have shown so far.



Download Our Free News & Alerts Mobile App

Like what you see? Download our updated fantasy football app for iPhone and Android with 24x7 player news, injury alerts, rankings, starts/sits & more. All free!

More Fantasy Football Analysis




POPULAR FANTASY TOOLS

Expert Advice
Articles & Tools
Import Your Leagues
Draft Rankings
Draft Simulator
Enter League Settings
Value Picks
Compare Any Players
News and Alerts

RANKINGS

QB
RB
WR
TE
K
DEF
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

REAL-TIME FANTASY NEWS

Kyle Tucker

Leaves With Calf Tightness on Tuesday
Alexandre Sarr

to Miss Rest of EuroBasket
Max Scherzer

Blue Jays Confident Max Scherzer Will Make Sunday Start Despite Back Tightness
Roman Anthony

Leaves Early With Back Injury
Jared McCain

"On Pace" for Training Camp
Lourdes Gurriel Jr.

Done for the Year With Torn ACL
Luke Hughes

Devils Optimistic About Signing Luke Hughes
Martin Fehérváry

Martin Fehervary on Track to Be Ready for Training Camp
Dylan Holloway

Good to Go for Start of Season
Nick Kurtz

Back in Action on Tuesday
Josh Morrissey

Fully Healthy for Start of Season
Dennis Hildeby

Signs Three-Year Extension With Maple Leafs
Nick Lodolo

Scratched With Illness
Dalton Kincaid

Role Not Expected to Grow?
Quinshon Judkins

Zero Chance Quinshon Judkins Plays Against Bengals?
Najee Harris

Says He's Expecting to Play Against Chiefs
Adolis García

Adolis Garcia Departs Monday with Quad Injury
Franz Wagner

Collects Double-Double in Blowout Win
Alperen Sengün

Alperen Sengun Achieves Rare Numbers at EuroBasket
Nikola Vučević

Nikola Vucevic Dominates Against Sweden
Stefon Diggs

Expected to Suit Up in Week 1
Kristaps Porzingis

Finding Form at EuroBasket
Nikola Jović

Nikola Jovic Suffers Minor Injury at EuroBasket
DJ Moore

Bears Experimenting with DJ Moore in Backfield
Rome Odunze

Could Move All Around the Offense
Carolina Panthers

Dave Canales Comfortable With Panthers' Young Receivers
Quinshon Judkins

Not Considering NCAA Return
Dallas Goedert

Healthy for Week 1
Marvin Mims Jr.

Returns to Practice Monday
Lourdes Gurriel Jr.

Carted Off Monday With Knee Injury
Jason Adam

Diagnosed With Ruptured Left Quadriceps Tendon
Victor Wembanyama

Looking "Quite Stellar"
Fernando Tatis Jr.

Scratched on Monday
Matthew Stafford

Expected to Start in Week 1
Edward Cabrera

Heading to Injured List With Elbow Sprain
Najee Harris

Cleared for Contact, Could Play in Week 1
Denny Hamlin

Ends Eventful Day at Darlington in Seventh Place
NASCAR

Bubba Wallace Almost Earns a Top-Five Finish at Darlington
John Hunter Nemechek

has His Best 2025 Performance at Darlington
Ryan Blaney

Has An Underwhelming Performance At Darlington
Josh Berry

Crashes Early and Suffers A Playoff Setback at Darlington
Harry Ford

Called Up for Major-League Debut
Victor Scott II

Activated From Injured List
Fernando Tatis Jr.

Dealing With Hamstring Tightness, Expects to Play Monday
Giannis Antetokounmpo

"Staying in Milwaukee"
Thanasis Antetokounmpo

Agrees to a One-Year Contract with Milwaukee
Kyrie Irving

"Healing Up Great"
Dante Exum

Mavs Agree on a One-Year Deal
Jaylen Warren

Agrees to Two-Year Extension With Steelers
De'Von Achane

Practicing Monday, on Track to Play in Week 1
Quinshon Judkins

Could Report to Browns This Week
Kansas City Chiefs

Chiefs, Trent McDuffie Not Expected to Finalize Extension
Chase Elliott

Under Playoff Pressure After 17th-Place Darlington Finish
Kyle Larson

Despite Hendrick Mediocrity, Kyle Larson Remains Pretty Safe in Playoffs
Alex Bowman

Opening-Lap Crash and Botched Pit Stop May Have Sunk Alex Bowman's Playoff Hopes
Erik Jones

Darlington Master Erik Jones Comes Up Short but Still Finishes Third
AJ Allmendinger

A.J. Allmendinger Impresses at Southern 500
Dameon Pierce

Ahead of Schedule, Ready for Season
Jordan Love

May Wear Thumb Brace During Season
Chicago Bears

Bears Head Coach Admits Offense Could Face Learning Curve
Matt Chapman

Leaves Early on Sunday, Expects to Play Monday
A.J. Brown

Says He'll Be Active For Season Opener
Luis Garcia

to Make Season Debut on Monday
Max Scherzer

Exits Due to Back Tightness
Taylor Ward

Exits Early After Collison
Braelon Allen

Says He Has a Lot Left to Prove
Sal Stewart

Reds Promoting Sal Stewart to Majors
Daniel Suarez

is A DFS Risk for Darlington Lineups?
Randy Rodríguez

Randy Rodriguez to Undergo Tommy John Surgery
Noah Gragson

Should Fantasy Managers Roster Noah Gragson for Darlington?
Ty Dillon

is an Excellent Punt Option for Darlington DFS Lineups
Bogdan Bogdanović

Bogdan Bogdanovic to Miss the Rest of EuroBasket
Denny Hamlin

Picking Up Where He Left Off At Darlington
Kyle Larson

The Sky Is The Limit for Kyle Larson at Darlington
Ryan Blaney

a Strong DFS Play at Darlington This Weekend
Tyler Reddick

Shouldn't Be Overlooked at Darlington This Weekend
Alex Bowman

An Easy Place-Differential Play in DFS This Weekend
Ty Gibbs

Could Be Strong at Darlington This Weekend
Erik Jones

Has Best Darlington Qualifying Effort Since Last Win
Zane Smith

Hopeful For Another Solid Run At Darlington
Aroldis Chapman

Agrees to Contract Extension
Dallas Mavericks

Olivier-Maxence Prosper Waived by the Mavs
Lauri Markkanen

Dominant in Win Over Great Britain
Nikola Jović

Nikola Jovic Leads Serbia to a Win
Nikola Jokić

Nikola Jokic Shines Versus Portugal
Jose Alvarado

"Good" After Recent Fall
Lauri Markkanen

Torches Sweden
Neemias Queta

Dominates in EuroBasket Opener
Kawhi Leonard

Clippers Not Allowing Kawhi Leonard to Play Back-to-Backs