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DraftKings Daily Fantasy Baseball Picks (9/22/19): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on September 22nd, 2019. Austyn Varney's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome to Sunday baseball! The NFL is kicking off at 1 PM today, but so is baseball! DraftKings is still giving us big tournaments and the edge remains with a ton of fresh money on the sites. You have options no matter your price point, and the prize pools are all still huge. This is a fun slate. Runs will be scored and plenty of pitchers will have solid outings.

We'll be looking for the best play at each position. I'll be putting together a value article as well, so make sure to check that out as well. Let's dive in and find a top play at each position.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 9/22/19. The lineup picks will range from some of the elite players to mid-priced options and value plays. Be sure to also check out all the MLB Rosters for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. .

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DraftKings DFS Starting Pitchers

Yu Darvish - CHC vs. STL - $11,600

The Cubs are in dire need of a win at this point and it will be on the shoulders of Yu Darvish. He’s been playing the best baseball of his Cubs career, striking out 14 and 13 in back to back games. He now gets a Cardinals team that’s middle of the road against righties and strikeout 22% of the time. It looks like Verlander will be the chalk on this slate, and while he’s a bit safer than Darvish, I don’t think the Astros will stretch him all the way out at this point. Darvish will go over 100 pitches if pitching well and Madden will get all he can out of Darvish after the bullpen has blown it back to back nights.

Reynaldo Lopez - CWS @ DET - $7,400

Reynaldo Lopez is extremely unreliable and up and down, but this is the best match-up he can possibly have and if there’s ever a time for his ceiling to poke through it’s here. The Tigers rank dead last in baseball against righties with a team .280 wOBA and 25% strikeout rate. We’ve seen Lopez go for seven innings and strikeout 10 before, so it really just comes down to whether or not he can locate his pitches. We’re hoping for five or six dominant innings, but there is upside for a lot more.

 

DraftKings DFS Infielders

C - Tom Murphy - SEA @ BAL (Means) - $4,200

When the Mariners face off with a lefty, Tom Murphy brings a big bat to the lineup. He’s sported a .400+ wOBA against southpaws on the season and is averaging nearly a home run every 12 at-bats. The Mariners face off with John Means today, who’s given up a .336 wOBA to opposing right-handers. There’s a reason Murphy is priced up. He’s proven himself as a real threat when in the lineup against a lefty.

1B - Freddie Freeman - ATL vs. SF (Webb) - $4,700

With the Braves holding an expected run total of six, Vegas obviously expects Logan Webb to struggle on the road here. He’s had trouble with both sides of the plate on the season, giving up a combined .368 wOBA. Freeman is the heart of this Braves lineup and he’ll be involved in at least a couple of those runs one way or another. Against righties, his wOBA remains over .380. Logan Webb has looked reverse splits a bit, but the 25 inning sample size is nowhere near enough to judge that.

2B - Whit Merrifield - KC @ MIN (Perez) - $4,300

Whit Merrifield flies under the radar on most slates as the Royals really aren’t too exciting of an offense. They face off with Martin Pérez today, who’s always had some HR Issues with righties. He’s only getting worse and worse at this point and his combined wOBA is up to .341. The Royals are a team I like today that will go completely un-owned. I’m a believer that if Martin Pérez these guys can hit a ton of home runs. Whit, Soler, and Dozier are a great mini stack on all sites.

Renato Nunez - BAL vs. SEA (Gonzalez) - $3,900

Marco Gonzales is already a bit shaky with the long ball, and now he moves to Camden Yards. Renato Nunez is back in the lineup and he’s been a lefty masher all year long. He’s fallen off a bit of late, but is still sporting a .339 wOBA against lefties with double digit home runs. The Orioles can put up a ton of runs, and they’re very rarely popular. This is another slate where you can get a low-owned Orioles stack in Camden Yards at an affordable price.

Alex Bregman - HOU vs. LAA (Rodriguez) - $5,400

Jose Rodriguez will get around 50 pitches before Jose Suarez takes over in this one. It’s really all semantics against this offense who’s going to rough up whoever is on the mound. If you’d like to know, Rodriguez is actually pretty good, but he’s also been very lucky. Jose Suarez on the other hand, has been one of the worst pitchers in all of baseball against opposing righties. They’re all pretty expensive on DraftKings, but rightfully so. Vegas expects another six plus runs and you know generally where the production is coming from. Bregman has been great against both sides of the plate, posting a .382 wOBA on the season with 38 home runs and a 13% strikeout rate. Bregman is safe with a ton of upside.

 

DraftKings DFS Outfielders

Giancarlo Stanton - NYY vs. TOR (Tepera) - $4,000

Stanton has been good since returning from injury, and he’s still too cheap. Make sure he’s in there as this is a day game, but he should be after homering last night. Ryan Tepera isn’t very good himself and the bullpen will follow after just a few innings. It’s always tough to predict bullpen games, but it’s clear to me that I’d rather have Stanton than any Blue Jays bullpen arm and I’m willing to take my chances that he connects on one at that price on DK.

Jason Heyward - CHC vs. STL (Mikolas) - $3,900

Jason Heyward is too cheap on DraftKings for a guy that should be leading off. Mikolas has struggled with lefties all season long and the Cubs have hit him around a few times themselves. Heyward has sported a .356 wOBA against righties and he’s only gotten better as the year has aged. I don’t love this entire game for offense, but I don’t mind taking a flier on a cheap Jason Heyward.

Things change quickly as lineups come out. If you have any questions, hit me up on Twitter @VarneyDFS and I'd be more than happy to help.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Drake Baldwin

Could Return During Braves Next Homestand
Garrett Crochet

Diagnosed With Low-Grade Lat Strain
Tetairoa McMillan

Dealing With Foot Injury During OTAs
Aaron Donald

Considering Coming Out of Retirement?
PGA

Russell Hensley Coming to Ohio on the Heels of Latest Victory
Drake London

Falcons Agree on Four-Year Extension
Michael Wilson

Will be "Closer to the Core" in Z Receiver Role
Marvin Harrison Jr.

Will Play the X Role for Cardinals
Tommy Fleetwood

Looking for Better Iron Play at Memorial Tournament
Patrick Cantlay

Looks to Continue Dominance at Muirfield Village
Ludvig Aberg

a Great Fit for Muirfield Village
Isaiah Hartenstein

Hopeful to Stay with Oklahoma City
Luguentz Dort

Wants to Remain with Thunder
Mitchell Robinson

is Questionable for Game 1
Moussa Diabaté

Moussa Diabate Has Contract Guaranteed for 2026-2027 Season
Oso Ighodaro

Gets Guaranteed Contract for Next Season
NAS

Chris MacFarland Joins Predators as President and General Manager
VAN

Canucks Name Manny Malhotra as New Head Coach
Brendan Gallagher

to Leave Canadiens This Offseason
Patrik Laine

Looking Forward to Free Agency
Jeremy Lauzon

Returns to Action Tuesday
Zach Werenski

Wins 2025-26 Norris Trophy
Aaron Judge

Out on Tuesday With Rib/Shoulder Injury
Adam Randall

Well-Positioned for Dynasty Success in Baltimore?
Nicholas Singleton

Could Be the Running Back of the Future in Tennessee
Bryce Lance

Is Bryce Lance Currently Undervalued by Dynasty Managers?
Mike Washington Jr.

Carries Dynasty Sleeper Appeal Entering 2026
Adonai Mitchell

Is Adonai Mitchell Still Worthy of a Dynasty Roster Spot?
Tony Pollard

Dynasty Stock Rising in Improving Tennessee Offense?
Josh Hader

Set to Return from Injured List on Tuesday
Chris Brazzell II

a Year 1 Breakout Candidate in Carolina?
Ja'Kobi Lane

a Great Fit for Ravens, Potential Steal in Rookie Drafts
Josh Jacobs

Back at Practice on Tuesday
Max Klare

Crowded Tight End Room Impacting Max Klare's Dynasty Stock?
Romeo Doubs

Still a Solid Dynasty Option in New England?
CFB

SEC Coach Calls Buster Faulkner a "Home-Run Hire"
CFB

Auburn a Sleeper in the SEC Under Alex Golesh?
CFB

Noah Fifita Primed for Strong 2026 Campaign
CFB

Oregon Assistant Coach Charged with DUII, Reckless Driving
Makai Lemon

Set for Major Role in Debut Season?
CFB

Tight End Nick Pollack Commits to Clemson
Drake Maye

Does Latest Addition Put Drake Maye Among the Upper Echelon of Fantasy Elite?
Jalen Hurts

Could Face Regression After Loss of Top Pass Catcher
DeVonta Smith

Poised for WR1 Role in the Aftermath of Trade?
Daniel Jones

Participating in 7-on-7s
Akshay Bhatia

Needs the Driver to be True in Ohio
Aaron Rai

Primed to take on the Memorial Tournament
J.J. Spaun

Rebounded at Charles Schwab Challenge
Xander Schauffele

One to Watch This Week in Ohio
Hideki Matsuyama

Putter Could be Vital at the Memorial
Nicolai Hojgaard

Rust Concerns at Muirfield Village
Ryan Gerard

Surfaces After Long Cold Stretch with Top 10 Result
Wyndham Clark

May Struggle at the Memorial Tournament
Elly De La Cruz

to Miss 2-4 Weeks of Action
Chase Burns

is Scratched Due to Illness
Deiveson Figueiredo

Suffers Second-Round Submission Loss
Song Yadong

Gets Second-Round Submission Win
Zhang Mingyang

Suffers Back-To-Back Losses
Alonzo Menifield

Gets Back In The Win Column
Tallison Teixeira

Suffers First-Round Knockout Loss
Sergei Pavlovich

Scores First-Round Knockout Win
Cameron Smotherman

Suffers Third Loss In A Row
Edwin Arroyo

Reds Promote Top Infield Prospect Edwin Arroyo, Viewed as Priority Pick Up Ahead of MLB Debut
Kai Asakura

Earns His First UFC Win
Elly De La Cruz

Placed on IL with Right Hamstring Tightness
Denny Hamlin

Earns the first Nashville Cup Series Victory of his Career on Sunday
Christopher Bell

Finishes as the Runner-Up at Nashville
Chase Briscoe

Earns First Career Podium Finish at Nashville
Ryan Blaney

Scores A Solid Top-10 Finish at Nashville
Kyle Larson

Top-10 Streak at Nashville Ends after Late Flat Tire Spin
Elly De La Cruz

Exits with Hamstring Tightness
Tyler Reddick

Is One of the Top Favorites to Win at Nashville
Kyle Larson

May Continue his Top-10 Consistency at Nashville this week
Christopher Bell

Is One of the Top Competitors for the Win at Nashville
Chase Briscoe

Is A Must Start for Nashville DFS Lineups
Chase Elliott

has Plenty of Upside for Nashville DFS Lineups
William Byron

Is William Byron A Playable DFS Option for Nashville Lineups?
Carson Hocevar

Is Likely to have Another Solid Result at Nashville
NASCAR

Should Fantasy Players Roster Bubba Wallace at Nashville?
Chris Buescher

Is A Decent All-Around DFS Option for Nashville Lineups
Daniel Suarez

is Likely to Drop Positions during the Cracker Barrel 400
Garrett Crochet

Suffers Setback, Likely to Undergo MRI for Lat Tightness
Denny Hamlin

Could Denny Hamlin Dominate at Nashville?
Ryan Blaney

Is a DFS Tournament Option at Nashville
Ty Gibbs

Don't Overlook Ty Gibbs at Nashville
Joey Logano

Could Show Life at Nashville
Ross Chastain

Needs a Good Run at Nashville
Chet Holmgren

Fails to Step Up in the Season Finale
Cason Wallace

Ends Postseason with Strong Showing
Shai Gilgeous-Alexander

Caps MVP Season with Game 7 Exit
Stephon Castle

Continues Postseason Run with 16 Points
Julian Champagnie

Shines in Series-Clinching Win
De'Aaron Fox

Provides Secondary Punch in Game 7 Triumph
Victor Wembanyama

Earns Conference Finals MVP in Spurs' Game 7 Win
NBA

Warriors Prioritize Depth Around Returning Steve Kerr
Donovan Mitchell

Remains Cleveland's Top Priority
Adou Thiero

Remains a Lakers Development Project
NBA

76ers Hire Mike Gansey as President of Basketball Operations
NBA

Chicago Bulls Explore Kevin Young as Coaching Candidate
Kyrie Irving

Reports He's Nearing Full Strength in ACL Recovery
Lane Hutson

Posts a Power-Play Assist in Game 5 Loss
Cole Caufield

Nets a Power-Play Goal in Season-Ending Loss
Seth Jarvis

Closes Out East Finals With Multi-Point Game
Logan Stankoven

Notches Three Points in Big Game 5 Win
Taylor Hall

Racks Up Three Points in Series-Clinching Win
Frederik Andersen

Remains Stellar as Hurricanes Clinch Finals Berth
Jacob Gonzalez

is Heading to the Big Leagues
Munetaka Murakami

Exits with Hamstring Tightness
Mitchell Robinson

Plans to Play in Game 1 After Finger Surgery
Ajay Mitchell

Ruled Out for Game 7
Jalen Williams

Unavailable in Decisive Game 7
Eury Pérez

Eury Perez is Placed on 15-Day Injured List
Deiveson Figueiredo

Set For UFC Macau Main Event
MMA

Yadong Song Returns At UFC Macau
Alonzo Menifield

An Underdog At UFC Macau
Zhang Mingyang

Set For UFC Macau Co-Main Event
Tallison Teixeira

Looks To Win Back-To-Back Fights
Sergei Pavlovich

A Favorite At UFC Macau
Cameron Smotherman

Looks To Bounce Back
Kai Asakura

Looks To Get Back In The Win Column
CFB

Faizon Brandon In Position to Start Week 1
CFB

Dane Weber Commits to Cal
CFB

Joey McGuire Attempts to Add Texas to Schedule
CFB

Mike Leach on 2027 College Football Hall of Fame Ballot
CFB

Maryland, Baylor Schedule Home-and-Home
CFB

Taron Dickens Decommits From North Carolina
MLB

MLB Proposes Hard Salary Cap as Part of Next CBA
Kenley Jansen

Tigers Place Kenley Jansen on Injured List With Pelvic Inflammation
Teoscar Hernández

Teoscar Hernandez Heading to Injured List With Hamstring Strain
MON

Lane Hutson Struggles in Game 4 Loss
CAR

Logan Stankoven Nets Eighth Postseason Goal
CAR

Sebastian Aho Pots Game-Winner on Power Play
CAR

Nikolaj Ehlers Tallies Two Helpers in Impressive Road Win
CAR

Shayne Gostisbehere Records Two Assists in Game 4 Win
CAR

Frederik Andersen Establishes Hurricanes New Postseason Shutout Record
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF