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DraftKings Daily Fantasy Baseball Picks (9/22/19): MLB DFS Lineups

The top daily fantasy baseball lineup picks for DraftKings on September 22nd, 2019. Austyn Varney's MLB DFS analysis and sleepers for building optimal DFS rosters.

Welcome to Sunday baseball! The NFL is kicking off at 1 PM today, but so is baseball! DraftKings is still giving us big tournaments and the edge remains with a ton of fresh money on the sites. You have options no matter your price point, and the prize pools are all still huge. This is a fun slate. Runs will be scored and plenty of pitchers will have solid outings.

We'll be looking for the best play at each position. I'll be putting together a value article as well, so make sure to check that out as well. Let's dive in and find a top play at each position.

In this article, I will be providing you with my daily fantasy baseball lineup picks for DraftKings on 9/22/19. The lineup picks will range from some of the elite players to mid-priced options and value plays. Be sure to also check out all the MLB Rosters for today's slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. .

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DraftKings DFS Starting Pitchers

Yu Darvish - CHC vs. STL - $11,600

The Cubs are in dire need of a win at this point and it will be on the shoulders of Yu Darvish. He’s been playing the best baseball of his Cubs career, striking out 14 and 13 in back to back games. He now gets a Cardinals team that’s middle of the road against righties and strikeout 22% of the time. It looks like Verlander will be the chalk on this slate, and while he’s a bit safer than Darvish, I don’t think the Astros will stretch him all the way out at this point. Darvish will go over 100 pitches if pitching well and Madden will get all he can out of Darvish after the bullpen has blown it back to back nights.

Reynaldo Lopez - CWS @ DET - $7,400

Reynaldo Lopez is extremely unreliable and up and down, but this is the best match-up he can possibly have and if there’s ever a time for his ceiling to poke through it’s here. The Tigers rank dead last in baseball against righties with a team .280 wOBA and 25% strikeout rate. We’ve seen Lopez go for seven innings and strikeout 10 before, so it really just comes down to whether or not he can locate his pitches. We’re hoping for five or six dominant innings, but there is upside for a lot more.

 

DraftKings DFS Infielders

C - Tom Murphy - SEA @ BAL (Means) - $4,200

When the Mariners face off with a lefty, Tom Murphy brings a big bat to the lineup. He’s sported a .400+ wOBA against southpaws on the season and is averaging nearly a home run every 12 at-bats. The Mariners face off with John Means today, who’s given up a .336 wOBA to opposing right-handers. There’s a reason Murphy is priced up. He’s proven himself as a real threat when in the lineup against a lefty.

1B - Freddie Freeman - ATL vs. SF (Webb) - $4,700

With the Braves holding an expected run total of six, Vegas obviously expects Logan Webb to struggle on the road here. He’s had trouble with both sides of the plate on the season, giving up a combined .368 wOBA. Freeman is the heart of this Braves lineup and he’ll be involved in at least a couple of those runs one way or another. Against righties, his wOBA remains over .380. Logan Webb has looked reverse splits a bit, but the 25 inning sample size is nowhere near enough to judge that.

2B - Whit Merrifield - KC @ MIN (Perez) - $4,300

Whit Merrifield flies under the radar on most slates as the Royals really aren’t too exciting of an offense. They face off with Martin Pérez today, who’s always had some HR Issues with righties. He’s only getting worse and worse at this point and his combined wOBA is up to .341. The Royals are a team I like today that will go completely un-owned. I’m a believer that if Martin Pérez these guys can hit a ton of home runs. Whit, Soler, and Dozier are a great mini stack on all sites.

Renato Nunez - BAL vs. SEA (Gonzalez) - $3,900

Marco Gonzales is already a bit shaky with the long ball, and now he moves to Camden Yards. Renato Nunez is back in the lineup and he’s been a lefty masher all year long. He’s fallen off a bit of late, but is still sporting a .339 wOBA against lefties with double digit home runs. The Orioles can put up a ton of runs, and they’re very rarely popular. This is another slate where you can get a low-owned Orioles stack in Camden Yards at an affordable price.

Alex Bregman - HOU vs. LAA (Rodriguez) - $5,400

Jose Rodriguez will get around 50 pitches before Jose Suarez takes over in this one. It’s really all semantics against this offense who’s going to rough up whoever is on the mound. If you’d like to know, Rodriguez is actually pretty good, but he’s also been very lucky. Jose Suarez on the other hand, has been one of the worst pitchers in all of baseball against opposing righties. They’re all pretty expensive on DraftKings, but rightfully so. Vegas expects another six plus runs and you know generally where the production is coming from. Bregman has been great against both sides of the plate, posting a .382 wOBA on the season with 38 home runs and a 13% strikeout rate. Bregman is safe with a ton of upside.

 

DraftKings DFS Outfielders

Giancarlo Stanton - NYY vs. TOR (Tepera) - $4,000

Stanton has been good since returning from injury, and he’s still too cheap. Make sure he’s in there as this is a day game, but he should be after homering last night. Ryan Tepera isn’t very good himself and the bullpen will follow after just a few innings. It’s always tough to predict bullpen games, but it’s clear to me that I’d rather have Stanton than any Blue Jays bullpen arm and I’m willing to take my chances that he connects on one at that price on DK.

Jason Heyward - CHC vs. STL (Mikolas) - $3,900

Jason Heyward is too cheap on DraftKings for a guy that should be leading off. Mikolas has struggled with lefties all season long and the Cubs have hit him around a few times themselves. Heyward has sported a .356 wOBA against righties and he’s only gotten better as the year has aged. I don’t love this entire game for offense, but I don’t mind taking a flier on a cheap Jason Heyward.

Things change quickly as lineups come out. If you have any questions, hit me up on Twitter @VarneyDFS and I'd be more than happy to help.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Odell Beckham Jr.

Giants Not Looking to Sign Odell Beckham Jr. Right Now
Bo Nix

Will be Full Speed Before Training Camp
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Joey Logano

Needs a Good Run at Watkins Glen
Duncan Robinson

Shines on Both Ends Saturday
Cade Cunningham

Records Second Career Postseason Triple-Double
Donovan Mitchell

Logs 35-Point Double-Double
James Harden

Plays Late Hero Saturday
OG Anunoby

Could Miss Another Game Sunday
Joel Embiid

Considered Probable for Sunday's Elimination Game
Jarred Vanderbilt

Active on Saturday Night
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
CHI

Blackhawks Bring in Roman Kantserov for Next Season
Mason McTavish

Set to Rejoin Ducks Lineup Sunday
Lukas Dostal

to Remain in Ducks Crease Sunday
Zach Bogosian

Back for Wild Saturday
Jesper Wallstedt

Starting Game 3 Against Avalanche
Joel Eriksson Ek

Not Ready to Return Saturday
Owen Tippett

Won't Play Saturday
Cooper Kupp

a Dynasty Hold into the Start of 2026 Season
Jaylen Warren

a Safe Dynasty Depth Piece with Insurance Upside
Christian McCaffrey

a Risky Dynasty Hold Who Still Exceeds His Trade Value
Brian Thomas Jr.

A Risky Buy-Low with Immense Upside
Tre' Harris

a Dynasty Hold That Could Require Patience
Braelon Allen

Dynasty Stock Takes a Hit After Teammate's Extension
Josh Allen

Still the Top Dynasty QB in his Prime
Kyler Murray

Suddenly a Rising Dynasty Target in Minnesota
Logan Webb

on Track to Start Against Dodgers on Monday
Mike Matheson

Leads by Example in Game 2 Win
Jakub Dobes

Rebounds After Loss Yet Again for Montreal
Rachaad White

Undervalued in Dynasty Leagues Despite a Path to Upside
Alex Newhook

Sets Tone in Big Montreal Victory
Stephon Castle

Overcomes Shooting Struggles Friday
Jake Tonges

Should by Now Be Rostered by Every Kittle Dynasty Manager
Anthony Edwards

Carries Heavy Usage in Defeat
Chig Okonkwo

a Clear Breakout Candidate in Washington
Lukas Dostal

Gets Pulled in Game 3 Loss on Friday
Victor Wembanyama

Joins Historic Playoff Company
Mikal Bridges

Continues Postseason Surge with 23-Point Game
Aaron Jones Sr.

Still a Low-Cost, Short-Term Dynasty Target
Kelly Oubre Jr.

Keeps Scoring Role Alive
Romeo Doubs

' Buy Window Could Soon Be Wide Open
Joel Embiid

Held to 18 Points in 76ers Game 3 Loss
Brett Howden

Notches Sixth Goal of the Postseason
Jalen Brunson

Tallies 33 Points to Take 3-0 Series Lead
VEG

Mitch Marner Hat Trick Helps Vegas Take Series Lead
Pat Bryant

Working With Training Staff This Offseason
Jacoby Brissett

in Communication With Cardinals Despite Skipping Workouts
Daniel Jones

Could Take Part in 7-on-7 Drills at OTAs
Tyler Glasnow

Dodgers Put Tyler Glasnow on Injured List With Back Spasms
Sam Merrill

Iffy for Game 3 on Saturday
Anthony Edwards

Rejoins Starting Lineup Friday
Kevin Huerter

Likely to Remain Out Saturday
Jarred Vanderbilt

Considered Questionable for Saturday
Jalen Williams

Ruled Out for Game 3 Against Lakers
Ayo Dosunmu

Cleared to Play Friday
Anthony Edwards

Available Friday Night
Mats Zuccarello

Expected to Play Saturday
Joel Eriksson Ek

to Be a Game-Time Decision Saturday
Jonas Brodin

Still Out Saturday
Josh Manson

Could Return Saturday
Kaedan Korczak

Scratched for Game 3 Against Ducks
Radko Gudas

Likely to Remain Out Friday
Sam Carrick

Won't Play Friday
Isiah Pacheco

Can Isiah Pacheco Re-Establish His Dynasty Value in Detroit?
Rico Dowdle

Dynasty Ceiling Limited By Backfield Committee in Pittsburgh
Rashid Shaheed

a High-Risk, High-Reward Buy-Low Candidate for Dynasty Managers
Blake Snell

to Make Season Debut for Dodgers on Saturday
Cole Ragans

Royals Place Cole Ragans on Injured List With Elbow Impingement
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
Nick Lodolo

Officially Activated, Making Season Debut on Friday
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
Dan Vladar

Looks to Return to Winning Ways Thursday
Roman Anthony

Heading for the Injured List
CFB

Sam Leavitt Expected to Be Full-Go for Fall Camp
Tarik Skubal

Could Return in 4-6 Weeks After Successful Elbow Surgery
Cole Ragans

Royals Hopeful That Cole Ragans Makes his Next Start
Emilio Pagán

Emilio Pagan has Grade 2 Hamstring Strain, Expected to Miss 4-8 Weeks
Joe Ryan

Listed as Scheduled Starter for Saturday Against Cleveland
Tyler Glasnow

Not Expected to Land on the Injured List
Framber Valdez

Suspension Reduced to Five Games
Framber Valdez

Suspended Six Games
Tyler Glasnow

Exits Early on Wednesday With Back Pain
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
CFB

Tanook Hines Stepping into WR1 Role for USC
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Brandon Woodruff

has Fluid Drained From his Right Shoulder
Brandon Woodruff

to Resume Throwing on Saturday, Return Imminent?
Carlos Correa

to Have Season-Ending Ankle Surgery
Jacob Misiorowski

Listed as Friday's Probable Starter
Logan Webb

Dealing With Knee Discomfort
Carlos Correa

Expected to Miss Significant Time With Ankle Injury
Collin Morikawa

Withdraws From Truist Championship
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

Secures Third Win of 2026 Season
Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
Adam Scott

Brings Strong Form to Quail Hollow
Robert MacIntyre

a Steady Option at Truist Championship
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Chris Gotterup

Looking to Bounce Back at Quail Hollow
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
CFB

LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
CFB

Notre Dame Leads College Football in Returning Snaps
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
Chase Elliott

Earns his Second Texas Motor Speedway Victory
Denny Hamlin

Misses Out on Winning at Texas
Alex Bowman

Finishes Third for the Second Week in a Row at Texas
Tyler Reddick

Earns Seventh Top-Five Finish of the Season at Texas
Chris Buescher

Scores his First Career Texas Finish in the Top Five
CFB

Bryce Underwood in Better Situation Entering Sophomore Season
CFB

Nico Iamaleava Emerging as Leader, Playmaker for UCLA
Jack Della Maddalena

Gets Dominated At UFC Perth
Carlos Prates

Shines At UFC Perth
Beneil Dariush

Suffers A First-Round TKO Loss
Quillan Salkilld

Remains Unbeaten In The UFC
Tim Elliott

Drops Decision At UFC Perth
Steve Erceg

Wins Back-To-Back Fights
Ollie Schmid

Suffers First-Round TKO Loss
Marwan Rahiki

Remains Unbeaten
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF