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FanDuel MLB DFS Lineup Picks (9/21/18): Daily Fantasy Baseball Advice

The Cubs have returned to their regular schedule of playing in the afternoon on Fridays, so we're back to a 14 game Main slate - but it's an attractive one! We've got a number of household names on the bump and a lot of important baseball to be played still (tight division races!), so tonight should be interesting.

I'll jump into my picks in a second, but first, Vegas lines! We've got a handful of absolutely enormous moneyline favorites to take into consideration when building lineups, starting with the Yankees (-320), Dodgers (-272), Astros (-225), and Cardinals (-165). As for implied run totals, the Yankees are up top there as well at 5.9, followed by the Mariners (5.6), Rangers (5.0) and the Astros at 4.9.

In this article, I will be providing you with my daily fantasy baseball lineup picks for FanDuel on 9/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS lineup picks for DraftKings and other sports too. If you have any questions or comments, feel free to contact me up on Twitter @kpLuch.

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FanDuel DFS Pitcher

Gerrit Cole - SP, vs LAA ($10,800)

A lot of top tier options to sort through tonight and consider, but Cole gets the call for me as my number one. He's facing a team he's been dominant against this season and he's peformed above salary based expectations in four straight starts. He has one of - if not the - highest point floors among the talent group tonight and has the type of matchup where he should limit run scoring and has a bright strikeout outlook. This Angels squad only has an implied run total of 3.2 and their projected lineup not only has a 25% strikeout rate split, but a lowly .292 wOBA as well. Those are big reasons why the Astros are one of the biggest favorites on Friday with a -225 moneyline. Cole and his fantastic 12.3 K/9 can be used in all formats tonight.

Luis Castillo - SP, at MIA ($8,500)

Castillo has had a handful of dominant performances this month looking at things through a tounrament lense - he's struck out 11, 9 and 7 in three of his last four starts. Home runs (1.5 HR/9) certainly are still an issue for him, but the elite strikeout upside is there and he has a matchup to exploit tonight in Miami. This park should help him keep the ball in the yard, and facing a Miami team without much pop certainly helps as well - their current implied run total is just 3.5. He has a 8.9 K/9 on the season and faces a team with the sixth highest strikeout rate in the majors over the past month, one whose projected lineup has a 25% K rate against righties paired with a .288 wOBA. Castillo is a strong tournament option for me this evening.

Also Consider: Rich Hill - SP, vs SDP ($9,200)

FanDuel DFS Infielders

Mike Zunino - C, at TEX ($2,000)

We can get some Mariners bats in our cash game lineups tonight at incredibly low prices - which is made extra appealing by their park upgrade and 5.6 implied run total. Zunino's wOBA split is nothing to write home about (.303), but he does possess big power against righties, highlighted by a .238 ISO split this season.

Dan Vogelbach - 1B, at TEX ($2,200)

Vogelbach is pretty hot right now, blasting two home runs in his last four games and posting a 57% hard hit rate over the past week. The big lefty is in a good spot tonight against the righty Connor Sadzeck, who's making a spot start for the Rangers and doesn't really have MLB quality stuff. Vogelbach owns a strong .377 wOBA split and a .219 ISO.

Rougned Odor - 2B, vs SEA ($3,600)

The upside is high tonight for Odor and his left-handed hitting teammates in Arlington. Opposing start Erasmo Ramirez has been rattled by lefties this year, allowing a 43% hard contact rate, a .399 wOBA and a .642 slugging percentage. Odor brings a .200 ISO split to the dish and has an average exit velocity of 93 miles per hour these past two weeks.

Todd Frazier - 3B, at WAS ($2,700)

You won't hear me complaining that FanDuel gave us so many nice, low-priced cash game options on a day where we basically need to spend up on one of the elite pitching options. Frazier has been particularly strong in righty-righty matchups in 2018, posting .201 ISO split that is 96 points higher than his mark against lefties.

Didi Gregorius - SS, vs BAL ($3,900)

Didi gets a platoon advantage matchup in a great hitter's park and gives us exposure to the top projected offense for just under 4k - not a bad deal! Gregorius has a 42% hard hit rate over the past two weeks and a desirable .234 ISO split.

FanDuel DFS Outfielders

Shin-Soo Choo - OF, vs SEA ($3,700)

Choo has been tearing the cover off the ball in the past 10 days (66% hard hit rate, average exit velocity of 98 miles per hour) and draws a matchup to target tonight in Arlington. He has a high floor created by his strong .383 wOBA split and good power upside too, highlighted by his .215 ISO split in 2018.

Chris Taylor - OF, vs SDP ($3,000)

Taylor is a really nice value tonight, especially for a hitter who draws the platoon advantage and should be hitting out of the leadoff spot tonight for a team with a top-5 implied run total (4.8). He's posted a strong .203 ISO split against southpaws this season.

MLB DFS News and Injury Alerts

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REAL-TIME FANTASY NEWS

Michael Porter Jr.

Likely to Miss Second Straight Game
Nicolas Claxton

to Rest Saturday Against Philadelphia
Ace Bailey

Leaves Friday's Game Early with Concussion
Radko Gudas

Handed a Five-Game Suspension
Auston Matthews

to Miss Rest of Season
Tory Horton

Faces Stiff Target Competition Again
Kaleb Johnson

a Cut Candidate in Dynasty Leagues?
DK Metcalf

Has More Competition for Targets in Pittsburgh
Trey McBride

to Repeat Incredible Season with Quarterback Returning?
Mark Andrews

Set Up for a Productive 2026 Season?
Giannis Antetokounmpo

Could Miss Saturday's Game Vs. Hawks
Keegan Murray

to Be Re-Evaluated in Two Weeks
Aaron Gordon

Expected Back Saturday Vs. Lakers
Jamal Murray

Expected to Suit Up Saturday
Collin Sexton

to Miss Third Straight Game
Jalen Smith

is Ruled Out for Friday's Game
Robert Williams III

is Unavailable for Friday's Contest
Cameron Ward

Cleared to Throw the Football
Draymond Green

is Downgraded to Out on Friday
De'Anthony Melton

to Play on Friday
Ayo Dosunmu

is Cleared for Friday's Game
Anthony Edwards

is Available on Friday
Roger McCreary

Lions Agree With Roger McCreary on One-Year Deal
Andre Cisco

Jets Agree With Andre Cisco on One-Year Deal
Geno Stone

Bills, Safety Geno Stone Agree to One-Year Deal
A.J. Brown

Futures of A.J. Brown, Dallas Goedert With Eagles are "Interconnected"
Norman Powell

is Tagged as Questionable for Saturday
Victor Wembanyama

Questionable Saturday Vs. Hornets
Andrew Wiggins

to Miss Fifth Straight Game
Alperen Sengün

Alperen Sengun Ruled Out Versus New Orleans
Tobias Harris

is Ruled Out for Friday's Game
Ausar Thompson

Still Out Friday Against Memphis
Sebastian Joseph-Day

Signs Two-Year Deal With Steelers
Josh Hart

is Unavailable on Friday
Laquon Treadwell

Colts Re-Sign Laquon Treadwell to a One-Year Deal
Dallas Goedert

Eagles, Dallas Goedert Push Back Void Date a Second Time to Monday
A.J. Brown

Eagles "Will Not Trade A.J. Brown at This Time"
Wan'Dale Robinson

Poised for Massive Target Volume with New Team in 2026
Tyler Warren

Profiles as the Clear Lead Target-Earner in Indianapolis
Francisco Lindor

Takes Full Batting Practice on Friday
Brock Purdy

Has a New No. 1 Wide Receiver to Work With in San Francisco
Jalen McMillan

Has Breakout Potential Heading into 2026
Cam Skattebo

Can Cam Skattebo Take on a Workhorse Role in 2026?
Brandon Woodruff

Still TBD for Opening Day
Tyler Conklin

Signs One-Year Deal With Lions
Rasheed Walker

Panthers Add Left Tackle Rasheed Walker on One-Year Deal
Trevor Rogers

to Start on Opening Day for Orioles
Kevin Vallejos

Looks To Remain Undefeated In The UFC
Josh Emmett

In Dire Need Of Victory
Gillian Robertson

A Favorite At UFC Vegas 114
Amanda Lemos

Set For Co-Main Event
Oumar Sy

Looks To Win Back-To-Back Fights
Ion Cutelaba

Looks To Get Back In The Win Column
Nathan MacKinnon

Racks Up Four Points in Victory Over Kraken
Alexis Lafrenière

Alexis Lafreniere Stays Hot in Winnipeg
Semyon Varlamov

Won't Return This Season
Alexander Romanov

Could Return for Playoffs
Declan Carlile

Hurt on Thursday Night
Wyatt Kaiser

Sustains Upper-Body Injury Thursday
Erik Gudbranson

Could Be an Option Saturday
Auston Matthews

Exits Game With Injury
Jimmy Snuggerud

Scores Twice Versus Carolina
Michael Misa

Delivers Multi-Point Performance on Thursday
Blake Snell

Around Six Weeks From Being Fully Built Up
Bobby Brink

a Game-Time Decision for Meeting with Flyers
Evander Kane

Available Against Predators
Mark Stone

a Game-Time Call Thursday
Carter Verhaeghe

Anton Lundell Won't Play Thursday
Sam Reinhart

Returns to Action Thursday
Andrew Copp

to Sit Out Two Weeks
Dylan Larkin

Ruled Out for Two Weeks
Zack Wheeler

to Face Hitters in Live Batting Practice on Saturday
Gerrit Cole

Could Pitch in a Spring Game Next Week
Matthew Boyd

Named the Cubs' Opening Day Starter
Francisco Lindor

Remains on Schedule for Opening Day
Spencer Knight

Available Thursday
William Eklund

Questionable to Play Thursday
Bryce Miller

Shuts Down Bullpen Due to More Oblique Discomfort
Zac Gallen

Named Arizona's Opening Day Starter
Kyle Teel

Could Miss 4-6 Weeks With Hamstring Strain
Hideki Matsuyama

Brings Strong Course History to TPC Sawgrass
Josh Hader

to Start the Year on the Injured List
Adam Scott

in Strong Form Ahead of The Players
Kyle Teel

Exits Tuesday's Game With Hamstring Injury
Rickie Fowler

on Quite the Run Heading to TPC Sawgrass
Sepp Straka

Needs to Forget What Happened Sunday at Bay Hill
Jordan Spieth

an Enigma Heading to The Players Championship
Justin Rose

Trying to Pick Up the Pieces in Florida
Maverick McNealy

Bounces Back at Arnold Palmer Invitational
Brooks Koepka

Continues His Florida Swing With Some Momentum
Nicolai Hojgaard

in Strong Form Ahead of The Players
Robert MacIntyre

a Volatile Option at The Players
Matt Fitzpatrick

Looks to Return to Top Form at The Players
Sam Burns

a High-Risk, High-Reward Option at The Players
Keegan Bradley

Hard to Trust at The Players
Xander Schauffele

Rounding into Form Heading to Players Championship
Rory McIlroy

Set to Return at Players Championship to Defend Title
Jake Knapp

Set to Return at Players Championship
Viktor Hovland

Continues Strong Start to 2026 Season
Rasmus Hojgaard

Looking for Bounce-Back at Players Championship
Tommy Fleetwood

Will Need to Find Putter to Compete at Players Championship
Akshay Bhatia

Continues Improving Heading to Players Championship
Merrill Kelly

Set to Make Spring Training Debut on Friday
Francisco Lindor

"100 Percent Optimistic" he Can be Ready for Opening Day
Justin Thomas

Continues Competitive Return at The Players Championship
Corbin Carroll

Set to Play in Cactus League Game on Wednesday
Kyle Stowers

to Make Grapefruit League Debut on Saturday
Hunter Greene

to be Sidelined Through July
Jesús Luzardo

Jesus Luzardo, Phillies Agree on Five-Year Extension
Corbin Carroll

Could Make Spring Debut This Week
Max Holloway

Drops Decision At UFC 326
Charles Oliveira

Becomes The New BMF Champion
Caio Borralho

Bounces Back
Reinier de Ridder

Reinier De Ridder Loses Back-To-Back Fights
Rob Font

Gets Dominated
Raul Rosas Jr.

Extends His Win Streak
Michael Johnson

Suffers Second-Round Knockout Loss
Drew Dober

Knocks Out Michael Johnson
Rafael Devers

Back in Cactus League Lineup on Monday
Ryan Blaney

Earns his Second Consecutive Phoenix Cup Series Win
Christopher Bell

Falls Short of Victory Despite Dominating at Phoenix
Kyle Larson

Earns Hard-Fought Finish of Third at Phoenix
Denny Hamlin

Quietly Gains Another Top-Five Finish at Phoenix
Joey Logano

Crashes out at Phoenix Despite Strong Run
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF