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FanDuel MLB DFS Lineup Picks (9/21/18): Daily Fantasy Baseball Advice

The Cubs have returned to their regular schedule of playing in the afternoon on Fridays, so we're back to a 14 game Main slate - but it's an attractive one! We've got a number of household names on the bump and a lot of important baseball to be played still (tight division races!), so tonight should be interesting.

I'll jump into my picks in a second, but first, Vegas lines! We've got a handful of absolutely enormous moneyline favorites to take into consideration when building lineups, starting with the Yankees (-320), Dodgers (-272), Astros (-225), and Cardinals (-165). As for implied run totals, the Yankees are up top there as well at 5.9, followed by the Mariners (5.6), Rangers (5.0) and the Astros at 4.9.

In this article, I will be providing you with my daily fantasy baseball lineup picks for FanDuel on 9/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS lineup picks for DraftKings and other sports too. If you have any questions or comments, feel free to contact me up on Twitter @kpLuch.

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FanDuel DFS Pitcher

Gerrit Cole - SP, vs LAA ($10,800)

A lot of top tier options to sort through tonight and consider, but Cole gets the call for me as my number one. He's facing a team he's been dominant against this season and he's peformed above salary based expectations in four straight starts. He has one of - if not the - highest point floors among the talent group tonight and has the type of matchup where he should limit run scoring and has a bright strikeout outlook. This Angels squad only has an implied run total of 3.2 and their projected lineup not only has a 25% strikeout rate split, but a lowly .292 wOBA as well. Those are big reasons why the Astros are one of the biggest favorites on Friday with a -225 moneyline. Cole and his fantastic 12.3 K/9 can be used in all formats tonight.

Luis Castillo - SP, at MIA ($8,500)

Castillo has had a handful of dominant performances this month looking at things through a tounrament lense - he's struck out 11, 9 and 7 in three of his last four starts. Home runs (1.5 HR/9) certainly are still an issue for him, but the elite strikeout upside is there and he has a matchup to exploit tonight in Miami. This park should help him keep the ball in the yard, and facing a Miami team without much pop certainly helps as well - their current implied run total is just 3.5. He has a 8.9 K/9 on the season and faces a team with the sixth highest strikeout rate in the majors over the past month, one whose projected lineup has a 25% K rate against righties paired with a .288 wOBA. Castillo is a strong tournament option for me this evening.

Also Consider: Rich Hill - SP, vs SDP ($9,200)

FanDuel DFS Infielders

Mike Zunino - C, at TEX ($2,000)

We can get some Mariners bats in our cash game lineups tonight at incredibly low prices - which is made extra appealing by their park upgrade and 5.6 implied run total. Zunino's wOBA split is nothing to write home about (.303), but he does possess big power against righties, highlighted by a .238 ISO split this season.

Dan Vogelbach - 1B, at TEX ($2,200)

Vogelbach is pretty hot right now, blasting two home runs in his last four games and posting a 57% hard hit rate over the past week. The big lefty is in a good spot tonight against the righty Connor Sadzeck, who's making a spot start for the Rangers and doesn't really have MLB quality stuff. Vogelbach owns a strong .377 wOBA split and a .219 ISO.

Rougned Odor - 2B, vs SEA ($3,600)

The upside is high tonight for Odor and his left-handed hitting teammates in Arlington. Opposing start Erasmo Ramirez has been rattled by lefties this year, allowing a 43% hard contact rate, a .399 wOBA and a .642 slugging percentage. Odor brings a .200 ISO split to the dish and has an average exit velocity of 93 miles per hour these past two weeks.

Todd Frazier - 3B, at WAS ($2,700)

You won't hear me complaining that FanDuel gave us so many nice, low-priced cash game options on a day where we basically need to spend up on one of the elite pitching options. Frazier has been particularly strong in righty-righty matchups in 2018, posting .201 ISO split that is 96 points higher than his mark against lefties.

Didi Gregorius - SS, vs BAL ($3,900)

Didi gets a platoon advantage matchup in a great hitter's park and gives us exposure to the top projected offense for just under 4k - not a bad deal! Gregorius has a 42% hard hit rate over the past two weeks and a desirable .234 ISO split.

FanDuel DFS Outfielders

Shin-Soo Choo - OF, vs SEA ($3,700)

Choo has been tearing the cover off the ball in the past 10 days (66% hard hit rate, average exit velocity of 98 miles per hour) and draws a matchup to target tonight in Arlington. He has a high floor created by his strong .383 wOBA split and good power upside too, highlighted by his .215 ISO split in 2018.

Chris Taylor - OF, vs SDP ($3,000)

Taylor is a really nice value tonight, especially for a hitter who draws the platoon advantage and should be hitting out of the leadoff spot tonight for a team with a top-5 implied run total (4.8). He's posted a strong .203 ISO split against southpaws this season.

MLB DFS News and Injury Alerts

REAL-TIME FANTASY NEWS

Woody Marks

Should Have Plenty of Opportunities to Catch Passes
Drew Allar

Working as QB4 in First OTA Session
Aaron Rodgers

Reports to Steelers Facilities on Monday
Alvin Kamara

Saints Remain Non-Committal on Alvin Kamara's Future
Chris Olave

Saints Continue to Work on Extension With Chris Olave
Parker Washington

a Sneaky Trade Target in Dynasty Leagues?
Melquizael Costa

Drops Decision At UFC Vegas 117
Jarquez Hunter

Can Jarquez Hunter's Dynasty Outlook Improve in Year 2?
Arnold Allen

Bounces Back
James Conner

Off the Dynasty Radar Entirely?
Elijah Arroyo

Will Elijah Arroyo Continue to Have Trouble Getting on the Field?
Daniel Santos

Suffers Second-Round TKO Loss
Tre Tucker

Not a Long-Term Solution in Dynasty Leagues
MMA

Dohoo Choi Wins His Third Consecutive Fight
Malcolm Wellmaker

Suffers His Second Loss In A Row
Juan Diaz

Scores Second-Round Submission
Christian Edwards

Defeated At UFC Vegas 117
CFB

Transfer Running Back Arnold Barnes Visiting Iowa State on Monday
Modestas Bukauskas

Gets Split-Decision Win
Jack Bech

a Dynasty Hold as New-Look Raiders Offense Takes Shape
Jaydon Blue

a Low-Value Dynasty Stash Until Depth Charts are Settled
Makai Lemon

a Top-Five Pick in Dynasty Rookie Drafts
George Kittle

a Dynasty Buy with League-Winning Potential
Jhostynxon Garcia

Expected to Join the Pirates on Tuesday
Chris Rodriguez Jr.

a Dynasty Sleeper with High Touchdown Potential
Tobias Harris

Goes Cold in Game 7 Loss
Quinn Hughes

Open to Signing Extension This Offseason
Jalen Duren

Finishes Game 7 with Quiet Line
Cade Cunningham

Endures Cold Shooting Night Sunday
Joel Eriksson Ek

Misses Second Round Due to Heel Injury
Sam Merrill

Catches Fire in Game 7 Win
Evan Mobley

Posts Versatile Double-Double in Game 7
Jonas Brodin

Sits Out Round 2 Due to Toe Injury
Donovan Mitchell

Guides Cavaliers Into East Finals
Sam Malinski

Practices Fully Sunday
Jarrett Allen

Scores 23 Points in Cavs' Game 7 Rout of Pistons
Josh Manson

Rejoins Practice
Kevin Huerter

Active on Sunday Night
Caris LeVert

Duncan Robinson, Caris LeVert Available Sunday
Dean Wade

Max Strus Replaces Dean Wade in Starting Lineup Sunday
Luke Kornet

Iffy for Monday
Larry Nance Jr.

Won't Play Sunday
De'Aaron Fox

Listed as Questionable for Monday's Action
Jalen Williams

Officially Available for Game 1 Against Spurs
Shai Gilgeous-Alexander

Named MVP for Second Straight Year
Jonah Coleman

is an Intriguing Power Back to Target in Dynasty Leagues
Colt Emerson

Mariners Promoting Top Prospect Colt Emerson to Major Leagues
Darius Slayton

Lacking Long-Term Upside for Dynasty Managers
Keaton Mitchell

a Prime Dynasty Handcuff Option Entering First Season in L.A.
Jadarian Price

Looks Like the Running Back of the Future in Seattle
Isaiah Bond

Dynasty Outlook Clouded by Uncertain Role in Cleveland
James Cook III

Remains a High-End Dynasty RB1 Entering 2026
Bones Hyland

Wants to Stay in Minnesota
Mike Conley

Hints He Will Continue Playing Next Season
Kevin Huerter

Iffy for Sunday Night
Caris LeVert

Questionable for Game 7
Duncan Robinson

Back on Injury Report Ahead of Game 7
Larry Nance Jr.

Likely Out Sunday Due to Illness
Munetaka Murakami

Fantastic First Season Continues With Two More Homers
Cristopher Sánchez

Cristopher Sanchez Dazzles With 13-Strikeout Complete Game on Saturday
Blake Snell

to Undergo Elbow Surgery on Tuesday
Clay Holmes

Could Miss Around Three Months
Jose Altuve

Exits After Swing
Corey Seager

Absent With Back Spasms on Saturday
Jeremy Lauzon

Misses Saturday's Practice
Mark Stone

Doesn't Practice Saturday
Josh Manson

Misses Practice, Considered Day-to-Day
Brent Burns

Day-to-Day Ahead of Conference Finals
Cale Makar

Considered Day-to-Day
Alex Lyon

Likely to Start Game 6 Against Canadiens
Owen Power

Available Saturday
Trevor Story

Hits the Injured List With Groin Injury
Blake Snell

Likely to Need Elbow Surgery
Kyle Schwarber

on a Heater, Hits Two More Homers to Take Major-League Lead
Clay Holmes

Suffers Fractured Fibula on Friday Night
Blake Snell

Heads to 15-Day Injured List
Blake Snell

Scratched From Start on Friday for Undisclosed Reasons
Max Fried

Heading to Injured List With Elbow Bone Bruise
CFB

Julian Sayin Looking To Build Off Of Strong Debut Season
CFB

College GameDay Set for First Three Weeks
CFB

Jeremiah Smith Aiming For Ohio State Receiving Records
CFB

Keshaun Singleton Projects as Auburn's WR1
CFB

Jeremiah Cobb Impresses New Auburn Staff
CFB

Alberto Mendoza Very Likely to Start for Georgia Tech
CFB

Charles Woodson Jr. Commits to Michigan
Jordan Westburg

to Have Season-Ending Elbow Surgery
Melquizael Costa

Set For UFC Vegas 117 Main Event
Arnold Allen

A Favorite At UFC Vegas 117
Daniel Santos

Set For UFC Vegas 117 Co-Main Event
MMA

Dohoo Choi Returns At UFC Vegas 117
Juan Diaz

Set To Make His UFC Debut
Malcolm Wellmaker

Looks To Bounce Back
Christian Edwards

Set For His UFC Debut
Modestas Bukauskas

Looks To Get Back In The Win Column
Tarik Skubal

Resumes Playing Catch, Ahead of Schedule?
Lane Hutson

Contributes Two Assists in Game 5 Victory
Nick Suzuki

Amasses Three Points in Crucial Victory Thursday
Juraj Slafkovsky

Dishes Out Three Assists in Game 5 Win
Carter Hart

Stops 31 Pucks in Series-Clinching Win
Pavel Dorofeyev

Enjoys Second Consecutive Multi-Goal Game
Shea Theodore

Records Two Points in Game 6 Win
Mitchell Marner

Scores Special Goal in Series-Clincher
Ryan Johnson

Takes Over as Canucks GM, Sedins Promoted to Co-Presidents
Drew Helleson

Won't Play Thursday
CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Harris English

Will Need His Putter to Thrive at Aronimink
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF