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FanDuel MLB DFS Lineup Picks (9/21/18): Daily Fantasy Baseball Advice

The Cubs have returned to their regular schedule of playing in the afternoon on Fridays, so we're back to a 14 game Main slate - but it's an attractive one! We've got a number of household names on the bump and a lot of important baseball to be played still (tight division races!), so tonight should be interesting.

I'll jump into my picks in a second, but first, Vegas lines! We've got a handful of absolutely enormous moneyline favorites to take into consideration when building lineups, starting with the Yankees (-320), Dodgers (-272), Astros (-225), and Cardinals (-165). As for implied run totals, the Yankees are up top there as well at 5.9, followed by the Mariners (5.6), Rangers (5.0) and the Astros at 4.9.

In this article, I will be providing you with my daily fantasy baseball lineup picks for FanDuel on 9/21/18. The lineup picks will range from some of the elite players to mid-priced options and value plays. You can also read more DFS lineup picks for DraftKings and other sports too. If you have any questions or comments, feel free to contact me up on Twitter @kpLuch.

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FanDuel DFS Pitcher

Gerrit Cole - SP, vs LAA ($10,800)

A lot of top tier options to sort through tonight and consider, but Cole gets the call for me as my number one. He's facing a team he's been dominant against this season and he's peformed above salary based expectations in four straight starts. He has one of - if not the - highest point floors among the talent group tonight and has the type of matchup where he should limit run scoring and has a bright strikeout outlook. This Angels squad only has an implied run total of 3.2 and their projected lineup not only has a 25% strikeout rate split, but a lowly .292 wOBA as well. Those are big reasons why the Astros are one of the biggest favorites on Friday with a -225 moneyline. Cole and his fantastic 12.3 K/9 can be used in all formats tonight.

Luis Castillo - SP, at MIA ($8,500)

Castillo has had a handful of dominant performances this month looking at things through a tounrament lense - he's struck out 11, 9 and 7 in three of his last four starts. Home runs (1.5 HR/9) certainly are still an issue for him, but the elite strikeout upside is there and he has a matchup to exploit tonight in Miami. This park should help him keep the ball in the yard, and facing a Miami team without much pop certainly helps as well - their current implied run total is just 3.5. He has a 8.9 K/9 on the season and faces a team with the sixth highest strikeout rate in the majors over the past month, one whose projected lineup has a 25% K rate against righties paired with a .288 wOBA. Castillo is a strong tournament option for me this evening.

Also Consider: Rich Hill - SP, vs SDP ($9,200)

FanDuel DFS Infielders

Mike Zunino - C, at TEX ($2,000)

We can get some Mariners bats in our cash game lineups tonight at incredibly low prices - which is made extra appealing by their park upgrade and 5.6 implied run total. Zunino's wOBA split is nothing to write home about (.303), but he does possess big power against righties, highlighted by a .238 ISO split this season.

Dan Vogelbach - 1B, at TEX ($2,200)

Vogelbach is pretty hot right now, blasting two home runs in his last four games and posting a 57% hard hit rate over the past week. The big lefty is in a good spot tonight against the righty Connor Sadzeck, who's making a spot start for the Rangers and doesn't really have MLB quality stuff. Vogelbach owns a strong .377 wOBA split and a .219 ISO.

Rougned Odor - 2B, vs SEA ($3,600)

The upside is high tonight for Odor and his left-handed hitting teammates in Arlington. Opposing start Erasmo Ramirez has been rattled by lefties this year, allowing a 43% hard contact rate, a .399 wOBA and a .642 slugging percentage. Odor brings a .200 ISO split to the dish and has an average exit velocity of 93 miles per hour these past two weeks.

Todd Frazier - 3B, at WAS ($2,700)

You won't hear me complaining that FanDuel gave us so many nice, low-priced cash game options on a day where we basically need to spend up on one of the elite pitching options. Frazier has been particularly strong in righty-righty matchups in 2018, posting .201 ISO split that is 96 points higher than his mark against lefties.

Didi Gregorius - SS, vs BAL ($3,900)

Didi gets a platoon advantage matchup in a great hitter's park and gives us exposure to the top projected offense for just under 4k - not a bad deal! Gregorius has a 42% hard hit rate over the past two weeks and a desirable .234 ISO split.

FanDuel DFS Outfielders

Shin-Soo Choo - OF, vs SEA ($3,700)

Choo has been tearing the cover off the ball in the past 10 days (66% hard hit rate, average exit velocity of 98 miles per hour) and draws a matchup to target tonight in Arlington. He has a high floor created by his strong .383 wOBA split and good power upside too, highlighted by his .215 ISO split in 2018.

Chris Taylor - OF, vs SDP ($3,000)

Taylor is a really nice value tonight, especially for a hitter who draws the platoon advantage and should be hitting out of the leadoff spot tonight for a team with a top-5 implied run total (4.8). He's posted a strong .203 ISO split against southpaws this season.

MLB DFS News and Injury Alerts

REAL-TIME FANTASY NEWS

Sean Tucker

Dynasty Upside Remains Limited by Crowded Backfield Picture in Tampa Bay
Puka Nacua

Is Puka Nacua's Dynasty Value Impacted by Potential Off-Field Concerns?
Alec Pierce

Can Alec Pierce Build on Encouraging 2025 Production in 2026 and Beyond?
Keenan Allen

Dynasty Stock Falling with NFL Future in Limbo
Drake London

Remains a Dynasty WR1 Entering 2026
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Bucky Irving

Potentially Undervalued After Disappointing Sophomore Season
Austin Reaves

Nears Double-Double In Game 3 Loss
Davante Adams

a Dynasty Hold Who Could See His Value Slip
LeBron James

Facing Sweep With Game 4 on Monday
Emeka Egbuka

The Pendulum Swinging Back on Emeka Egbuka's Dynasty Value
Ajay Mitchell

Posts Career Playoff Night in Game 3
Chet Holmgren

Helps Thunder Move to Brink of Conference Finals
Michael Pittman Jr.

Undervalued in an Environment Fit for His Skill Set
Tobias Harris

Extends 20-Point Streak in Saturday's Loss
Evan Mobley

Keeps Defensive Production Rolling Saturday
Rhamondre Stevenson

a Quality Dynasty Target in a Still-Improving Offense
Golden State Warriors

Warriors Extend Steve Kerr into his 13th Season
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Odell Beckham Jr.

Giants Not Looking to Sign Odell Beckham Jr. Right Now
Bo Nix

Will be Full Speed Before Training Camp
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Joey Logano

Needs a Good Run at Watkins Glen
Luis Castillo

Mariners Intend to Piggyback Luis Castillo, Bryce Miller
Duncan Robinson

Shines on Both Ends Saturday
Cade Cunningham

Records Second Career Postseason Triple-Double
Donovan Mitchell

Logs 35-Point Double-Double
James Harden

Plays Late Hero Saturday
OG Anunoby

Could Miss Another Game Sunday
Joel Embiid

Considered Probable for Sunday's Elimination Game
Jarred Vanderbilt

Active on Saturday Night
Logan Webb

Placed on 15-Day Injured List With Knee Bursitis
Bryce Miller

is Set to Return on Wednesday
Jeff Hoffman

Could Return to Closer Role
CHI

Blackhawks Bring in Roman Kantserov for Next Season
Mason McTavish

Set to Rejoin Ducks Lineup Sunday
Lukas Dostal

to Remain in Ducks Crease Sunday
Zach Bogosian

Back for Wild Saturday
Jesper Wallstedt

Starting Game 3 Against Avalanche
Joel Eriksson Ek

Not Ready to Return Saturday
Owen Tippett

Won't Play Saturday
Cooper Kupp

a Dynasty Hold into the Start of 2026 Season
Jaylen Warren

a Safe Dynasty Depth Piece with Insurance Upside
Christian McCaffrey

a Risky Dynasty Hold Who Still Exceeds His Trade Value
Brian Thomas Jr.

A Risky Buy-Low with Immense Upside
Tre' Harris

a Dynasty Hold That Could Require Patience
Taj Bradley

Hits the Injured List With Pectoral Inflammation
Braelon Allen

Dynasty Stock Takes a Hit After Teammate's Extension
Josh Allen

Still the Top Dynasty QB in his Prime
Kyler Murray

Suddenly a Rising Dynasty Target in Minnesota
Kyle Bradish

has Nice Bounce-Back Performance With 10 K's
Casey Mize

Throws Bullpen on Friday, Return Not Imminent
Ronald Acuña Jr.

Ronald Acuna Jr. Optimistic About Returning Next Wednesday
Mike Matheson

Leads by Example in Game 2 Win
Jakub Dobes

Rebounds After Loss Yet Again for Montreal
Rachaad White

Undervalued in Dynasty Leagues Despite a Path to Upside
Alex Newhook

Sets Tone in Big Montreal Victory
Stephon Castle

Overcomes Shooting Struggles Friday
Anthony Edwards

Carries Heavy Usage in Defeat
Lukas Dostal

Gets Pulled in Game 3 Loss on Friday
Victor Wembanyama

Joins Historic Playoff Company
Mikal Bridges

Continues Postseason Surge with 23-Point Game
Kelly Oubre Jr.

Keeps Scoring Role Alive
Joel Embiid

Held to 18 Points in 76ers Game 3 Loss
Brett Howden

Notches Sixth Goal of the Postseason
Jalen Brunson

Tallies 33 Points to Take 3-0 Series Lead
VEG

Mitch Marner Hat Trick Helps Vegas Take Series Lead
Tyler Glasnow

Dodgers Put Tyler Glasnow on Injured List With Back Spasms
Mats Zuccarello

Expected to Play Saturday
Joel Eriksson Ek

to Be a Game-Time Decision Saturday
Jonas Brodin

Still Out Saturday
Josh Manson

Could Return Saturday
Kaedan Korczak

Scratched for Game 3 Against Ducks
Radko Gudas

Likely to Remain Out Friday
Sam Carrick

Won't Play Friday
Blake Snell

to Make Season Debut for Dodgers on Saturday
Cole Ragans

Royals Place Cole Ragans on Injured List With Elbow Impingement
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
Nick Lodolo

Officially Activated, Making Season Debut on Friday
CFB

Walker Lyons Could be Go-To Target for Bear Bachmeier
CFB

Ty Benefield a Potential Game-Changer for LSU Defense
CFB

Hayden Lowe Set for Significant Role Following Miami's NFL Departures
CFB

Taylor Wein in Position for Big Season on Oklahoma's Defensive Line
CFB

Rasheem Biles an Instant Impact Player for Texas
Dan Vladar

Looks to Return to Winning Ways Thursday
Roman Anthony

Heading for the Injured List
CFB

Sam Leavitt Expected to Be Full-Go for Fall Camp
Tarik Skubal

Could Return in 4-6 Weeks After Successful Elbow Surgery
Cole Ragans

Royals Hopeful That Cole Ragans Makes his Next Start
Emilio Pagán

Emilio Pagan has Grade 2 Hamstring Strain, Expected to Miss 4-8 Weeks
Joe Ryan

Listed as Scheduled Starter for Saturday Against Cleveland
Tyler Glasnow

Not Expected to Land on the Injured List
Framber Valdez

Suspension Reduced to Five Games
Framber Valdez

Suspended Six Games
CFB

Brauntae Johnson the Next Star in Notre Dame's Secondary?
CFB

Ethan Barbour a Name to Know in Georgia's Tight End Room
CFB

Payton Pierce Next Up at Linebacker for Ohio State
CFB

Javin Gordon to Play Significant Role for Tennessee?
CFB

Tanook Hines Stepping into WR1 Role for USC
CFB

Rueben Owens II has "Star Potential" in Fourth Campaign
Collin Morikawa

Withdraws From Truist Championship
Xander Schauffele

Carries Elite Form Into Quail Hollow
Hideki Matsuyama

Looks to Bounce Back at Truist Championship
Matt Fitzpatrick

Secures Third Win of 2026 Season
Patrick Cantlay

Continues Playing Well Heading to Truist Championship
Ludvig Aberg

Returns to Action For Truist Championship
Justin Thomas

Searching for Consistency at Quail Hollow
Jordan Spieth

Looks to Break Through at Quail Hollow
Adam Scott

Brings Strong Form to Quail Hollow
Robert MacIntyre

a Steady Option at Truist Championship
Jason Day

Looks to Overcome Approach Struggles at Quail Hollow
Akshay Bhatia

Looks for Complete Game at Truist Championship
Justin Rose

to Continue Mid-Season Club Change at Truist Championship
Si Woo Kim

is Back to Peak Form Ahead of Truist Championship
Sam Burns

to Bounce Back at Truist Championship
Cameron Young

Looks to Carry Dominance to Quail Hollow
Rory McIlroy

Returns to Familiar Stomping Grounds This Week at Quail Hollow
Chris Gotterup

Looking to Bounce Back at Quail Hollow
Tommy Fleetwood

Looking For Better Iron Play at Quail Hollow
CFB

Mario Craver Enters No. 1 Wide Receiver Role for Marcel Reed
CFB

LaNorris Sellers a Strong Rebound Candidate in 2026
CFB

Cam Coleman Poised for Monster Year at Texas?
CFB

Will Hammond Pushing to Be Ready for Week 1
Alex Fitzpatrick

Looking to Keep Up Ball-Striking Output at Quail Hollow
CFB

Notre Dame Leads College Football in Returning Snaps
CFB

Two Ole Miss Football Players Arrested, Charged with DUI
Ben Griffin

Looks Solid on the Surface Heading to Charlotte
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF