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FanDuel MLB DFS Lineup Picks (4/21/19): Daily Fantasy Baseball Advice

Troy Klauder highlights the top FanDuel MLB DFS lineup picks for 4/21/19, and a couple of sleepers to consider while building daily rosters.

Today's main slate starts at 1:05 pm eastern and covers nine games. There's also an all day slate starting at the same time, featuring a glorious 15 game slate.

In this article, I will be providing you with my daily fantasy baseball lineup picks for FanDuel on 4/21/2019. The lineup picks will range from some of the elite players to mid-priced options and value plays.

If you have any questions or comments, feel free to hit me up on Twitter @TroyKlauder.

Happy New Year! Save 30% on any Premium Pass using discount code NEW. Win more with our DFS, Betting and Season-Long Pass, get expert tools and advice from proven winners! GAIN ACCESS

 

FanDuel DFS Pitchers

James Paxton, NYY vs KC ($9,600)

Paxton was absolutely brilliant his last time out, throwing eight scoreless innings with twelve strikeouts against the Red Sox. He's now got a beastly 32.6% K-rate on the season and gets a very easy matchup in the Royals, who have just a .278 wOBA versus left-handed pitching this year. Paxton should be regarded as an ace, and this may be your last chance to get him at a discounted price.

Kyle Gibson, MIN at BAL ($6,100)

Gibson is the third-cheapest starter on FanDuel today because he's been downright awful this year. However, he's got serious upside in a matchup against the Orioles. Much of Baltimore's lineup simply isn't major league caliber, resulting in a .290 wOBA versus righties this season. It's worth noting that Gibson is coming off a year where he threw nearly 200 innings with a 3.62 ERA, so there's absolutely a chance for a bounce-back performance. Gibson is attractive in GPP contests, especially considering that he'll allow you to spend lots of salary on high-end hitters.

 

FanDuel DFS Infielders

Jose Abreu, CWS vs DET ($2,900)

Abreu is off to a rough start, but there's no reason to worry about a 19 game sample. He obliterated lefties last year with a 144 wRC+ and should have a big day against Tigers southpaw Daniel Norris. Norris has pitched poorly in 8 1/3 innings this season, with just four strikeouts and three walks, as well as three homers allowed. Abreu is a fantastic value at his price.

Robinson Cano, NYM at STL ($3,400)

Cano is another slow starter whose price we can take advantage of. He is in a great spot batting third for the Mets, where he will see lots of run and RBI opportunities against Dakota Hudson. Hudson has been chewed up by opposing lineups and has a 6.08 ERA, so Cano can certainly be used as part of a Mets stack.

Corey Seager, LAD at MIL ($3,400)

Seager is an exciting play in Miller Park, an extreme hitter's environment where the Dodgers can score lots of runs. Regardless of whether he's batting second or third in the Dodgers order, Seager will be in a position to produce at a low price.

Alex Bregman, HOU at TEX ($4,000)

Bregman is an elite fantasy commodity who has picked up right where he left off last year, entering Sunday with a .916 OPS. He is in line for a enormous game against Shelby Miller, who has had a catastrophic 2019 campaign consisting of 11 walks in 10 innings with a 9.00 ERA.

 

FanDuel DFS Outfielders

Mookie Betts, BOS at TB ($3,900)

It was just last year that Betts was fantasy baseball's top performer, and we're already seeing him below $4,000? It's only April! Slow start or not, tough matchup or not - Betts needs to be in your lineups at this price.

Nelson Cruz, MIN at BAL ($3,400)

While his teammate Eddie Rosario took the spotlight yesterday, Nelson Cruz had a monster day of his own with two home runs. Cruz will be at it again from the cleanup spot against Dylan Bundy, who is one of the most homer-prone pitchers in all of baseball. Cruz continues to be undervalued, as he's rocking an elite 179 wRC+.

Ian Desmond, COL vs PHI ($2,900)

Don't you wish you could get some high-scoring Coors Field action in your lineups without wasting away all of your payroll? In that case, Ian Desmond is the bat for you. Yes, Desmond does suck, but it doesn't take much to rack up fantasy points in Colorado.

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Peyton Watson

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Jason Day

has a Good Chance to Keep Momentum This Weekend
Keegan Bradley

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Billy Horschel

Isn't a Great DFS Option at Torrey Pines
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Mike McCarthy Says he Wants Aaron Rodgers to Return
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Adam Scott

Can Continue Hot Start to 2026 Season at Farmers Insurance Open
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Tom Hoge

Can Continue Hot Start to 2026 Season at Farmers Insurance Open
Harris English

Has a Chance to Repeat as Winner at the Farmers Insurance Open
Patrick Cantlay

Continues Playing Well and Can Compete at Farmers Insurance Open
Ludvig Aberg

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Drake Maye

Expected to be Fine for Super Bowl
Xander Schauffele

is The Best Fit at Torrey Pines This Week
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Titans Set to Hire Brian Daboll as New Offensive Coordinator
Justin Rose

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Maverick McNealy

is a Smart Play at Torrey Pines
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Bills Promote Joe Brady to Head Coach
Brooks Koepka

Making PGA Tour Return at Farmers Insurance Open
CFB

Quarterback Brayden Fowler-Nicolosi Signs with Michigan
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Zeev Buium

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Brock Boeser

Canucks Place Brock Boeser on Injured Reserve
Sean Durzi

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Eugenio Suárez

Eugenio Suarez Not Drawing Interest on Open Market?
Jonas Brodin

to Miss 6-8 Weeks
Kasperi Kapanen

Returns From Three-Game Absence Monday
Lawson Crouse

Available Against Lightning
Carson Soucy

Won't Play Monday
Rasmus Ristolainen

Returns to Flyers Lineup
Ryan Pulock

Misses Second Consecutive Game
Shedeur Sanders

Named as Pro Bowl Replacement
Simon Holmstrom

a Game-Time Call Monday
Framber Valdez

Among Many High-End Pitchers on Free-Agent Market
Jose Altuve

Won't Participate in World Baseball Classic
Harrison Bader

Agrees With Giants on Two-Year Deal
Paddy Pimblett

Drops Decision
Justin Gaethje

Becomes the New Interim-Lightweight Champion
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Suffers Unanimous Decision Loss
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Sean O'Malley Gets Back In The Win Column
Waldo Cortes-Acosta

Extends His Win Streak
Derrick Lewis

Suffers Second-Round TKO Loss
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Chargers Officially Hire Mike McDaniel as Offensive Coordinator
Nathan Eovaldi

Doesn't Expect Any Limitations in Spring Training
Jaxon Smith-Njigba

Dominates in NFC Championship Game Win
Scott Wedgewood

Activated From Non-Roster List
Matthew Stafford

Plans to Return in 2026
CFB

Arthur Smith to Become Ohio State's Offensive Coordinator
Bo Nix

Sidelined for 12 Weeks With Broken Ankle
Jose Altuve

to Mainly Play Second Base
Yu Darvish

Considering Retirement
Pittsburgh Steelers

Steelers Finalizing Deal to Make Mike McCarthy Their Head Coach
José Ramírez

Jose Ramirez Signs Seven-Year Extension With Guardians
Gunnar Henderson

is Fully Healthy Heading into Spring Training
Tyreek Hill

Dolphins Expected to Release Tyreek Hill
Paddy Pimblett

Set For Interim Lightweight Title Fight
Justin Gaethje

An Underdog At UFC 324
Song Yadong

Looks To Win Back-To-Back Fights
MMA

Sean O'Malley Looks To Get Back In The Win Column
Derrick Lewis

Returns At UFC 324
Waldo Cortes-Acosta

Looks For His Third Consecutive Win
Philip Rivers

Interviewing for Bills Head-Coaching Job
NFL

Fernando Mendoza Officially Declares for NFL Draft
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Arch Manning Undergoes Foot Surgery
Dalton Kincaid

Played Through Torn PCL
CFB

College Football Playoff Expected to Remain a 12-Team Field in 2026
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Ravens Hire Jesse Minter as Their Head Coach
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FBI Investigating the Death of Colts Owner Jim Irsay
MacKenzie Gore

Rangers Acquire MacKenzie Gore From the Nationals
Brandon Sproat

Dealt to Brewers in Four-Player Trade
Jett Williams

Brewers Acquire Jett Williams From Mets
Freddy Peralta

Mets Acquire Freddy Peralta From Brewers

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