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FanDuel MLB DFS Lineup Picks (4/21/19): Daily Fantasy Baseball Advice

Troy Klauder highlights the top FanDuel MLB DFS lineup picks for 4/21/19, and a couple of sleepers to consider while building daily rosters.

Today's main slate starts at 1:05 pm eastern and covers nine games. There's also an all day slate starting at the same time, featuring a glorious 15 game slate.

In this article, I will be providing you with my daily fantasy baseball lineup picks for FanDuel on 4/21/2019. The lineup picks will range from some of the elite players to mid-priced options and value plays.

If you have any questions or comments, feel free to hit me up on Twitter @TroyKlauder.

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FanDuel DFS Pitchers

James Paxton, NYY vs KC ($9,600)

Paxton was absolutely brilliant his last time out, throwing eight scoreless innings with twelve strikeouts against the Red Sox. He's now got a beastly 32.6% K-rate on the season and gets a very easy matchup in the Royals, who have just a .278 wOBA versus left-handed pitching this year. Paxton should be regarded as an ace, and this may be your last chance to get him at a discounted price.

Kyle Gibson, MIN at BAL ($6,100)

Gibson is the third-cheapest starter on FanDuel today because he's been downright awful this year. However, he's got serious upside in a matchup against the Orioles. Much of Baltimore's lineup simply isn't major league caliber, resulting in a .290 wOBA versus righties this season. It's worth noting that Gibson is coming off a year where he threw nearly 200 innings with a 3.62 ERA, so there's absolutely a chance for a bounce-back performance. Gibson is attractive in GPP contests, especially considering that he'll allow you to spend lots of salary on high-end hitters.

 

FanDuel DFS Infielders

Jose Abreu, CWS vs DET ($2,900)

Abreu is off to a rough start, but there's no reason to worry about a 19 game sample. He obliterated lefties last year with a 144 wRC+ and should have a big day against Tigers southpaw Daniel Norris. Norris has pitched poorly in 8 1/3 innings this season, with just four strikeouts and three walks, as well as three homers allowed. Abreu is a fantastic value at his price.

Robinson Cano, NYM at STL ($3,400)

Cano is another slow starter whose price we can take advantage of. He is in a great spot batting third for the Mets, where he will see lots of run and RBI opportunities against Dakota Hudson. Hudson has been chewed up by opposing lineups and has a 6.08 ERA, so Cano can certainly be used as part of a Mets stack.

Corey Seager, LAD at MIL ($3,400)

Seager is an exciting play in Miller Park, an extreme hitter's environment where the Dodgers can score lots of runs. Regardless of whether he's batting second or third in the Dodgers order, Seager will be in a position to produce at a low price.

Alex Bregman, HOU at TEX ($4,000)

Bregman is an elite fantasy commodity who has picked up right where he left off last year, entering Sunday with a .916 OPS. He is in line for a enormous game against Shelby Miller, who has had a catastrophic 2019 campaign consisting of 11 walks in 10 innings with a 9.00 ERA.

 

FanDuel DFS Outfielders

Mookie Betts, BOS at TB ($3,900)

It was just last year that Betts was fantasy baseball's top performer, and we're already seeing him below $4,000? It's only April! Slow start or not, tough matchup or not - Betts needs to be in your lineups at this price.

Nelson Cruz, MIN at BAL ($3,400)

While his teammate Eddie Rosario took the spotlight yesterday, Nelson Cruz had a monster day of his own with two home runs. Cruz will be at it again from the cleanup spot against Dylan Bundy, who is one of the most homer-prone pitchers in all of baseball. Cruz continues to be undervalued, as he's rocking an elite 179 wRC+.

Ian Desmond, COL vs PHI ($2,900)

Don't you wish you could get some high-scoring Coors Field action in your lineups without wasting away all of your payroll? In that case, Ian Desmond is the bat for you. Yes, Desmond does suck, but it doesn't take much to rack up fantasy points in Colorado.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

CFB

Virginia Tech Lands Commitment from Four-Star QB Peter Bourque
Kaytron Allen

Could Kaytron Allen Take on a Big Role Right Away?
Demond Claiborne

Has Long-Term Appeal in Minnesota
Byron Buxton

Scratched on Thursday With Hip Soreness
Cal Raleigh

Heading to Injured List With Oblique Strain
Adam Randall

to Contribute as a Pass-Catcher Right Away?
Francisco Alvarez

has Knee Surgery, Expected to Miss Eight Weeks
Nicholas Singleton

Could Contribute Right Away
Bryce Lance

a Perfect Fit in New Orleans?
Mike Washington Jr.

Can Mike Washington Jr. Force a Backfield Split in Vegas?
Paul Reed

Makes Big Impact Off the Bench Wednesday
Adonai Mitchell

Unlikely to be Phased Out of Jets Offense
Daniss Jenkins

Contributes 19 Points As Starter
Cade Cunningham

Tallies 39 Points in Losing Effort
Tony Pollard

an Affordable Add for Contending Dynasty Managers
Max Strus

Notches 20 Points With Six Triples
Evan Mobley

Close to Triple-Double Wednesday
Mason Taylor

How Much Dynasty Value Will Mason Taylor Hold After Offensive-Heavy Draft?
Jarrett Allen

Records Double-Double in Game 5 Win
De'Von Achane

a Dynasty Cornerstone
James Harden

Leads the Way for Cavaliers in Game 5 Victory
Quinn Hughes

Finishes Postseason With 15 Points
Matt Boldy

Posts Two Assists in Season-Ending Loss
Scott Wedgewood

Perfect in Relief Effort
Martin Necas

Records Another Multi-Point Game
Brett Kulak

Sends Avalanche Into Conference Finals
Brayden McNabb

Suspended for One Game
Cal Raleigh

Exits With Apparent Side Injury on Wednesday Night
Juan Soto

X-Rays Come Back Negative on Juan Soto's Ankle
Jacob Misiorowski

Pulled Early With Possible Leg Injury
Juan Soto

Exits Wednesday's Game Early with Ankle Injury
Tim Patrick

Jets Agree to Terms With Veteran Receiver Tim Patrick
Malik Nabers

Undergoes Second Knee Surgery
De'Von Achane

Dolphins, De'Von Achane Agree to Four-Year Contract Extension
Kevin Huerter

is Cleared to Return for Game 5
Caris LeVert

is Available for Game 5 on Wednesday
Duncan Robinson

is Out for Game 5
Keegan Murray

Undergoes Ankle Procedure
Josh Giddey

Undergoes Ankle Surgery
Pete Fairbanks

Returns From Injured List
Christian Yelich

Out With Back Tightness on Wednesday Night
Nathan MacKinnon

Chasing History Wednesday
Ryan Poehling

Won't Be an Option for Game 6
Sam Malinski

Set to Miss Second Straight Game
Artturi Lehkonen

Unlikely to Play Wednesday
Matthew Schaefer

Wins Calder Trophy
TOR

Maple Leafs Fire Head Coach Craig Berube
Jalen Hurts

Can Jalen Hurts Bounce Back as a Rusher in 2026?
Robby Snelling

Placed on 15-Day Injured List with Elbow Sprain
Zach Charbonnet

Dynasty Value in Question Entering 2026
DeVonta Smith

Poised to Reach a New Level of Production in 2026?
Chris Olave

Facing Increased Target Competition in New Orleans Entering 2026
Chris Bell

Dynasty Stock Rising Following NFL Draft
Ted Hurst

Facing Uphill Battle for Playing Time in Tampa Bay
Francisco Alvarez

Mets Place Francisco Alvarez on Injured List With Torn Meniscus
Max Fried

Dealing With Left Elbow Posterior Soreness
CFB

NFL Veteran Tom Moore Joins Iowa Coaching Staff
CFB

Can Cam Cook Dominate in Return to Big 12?
Chris Brazzell II

Is Chris Brazzell II the Top Deep Threat in Carolina's Receiver Room?
Kaelon Black

a Threat to Win Backup RB Job in San Fran?
CFB

ACC, Big 12 Support 24-Team College Football Playoff
CFB

Anthony Colandrea Looking to Elevate Nebraska Back to National Contention
CFB

Kwazi Gilmer Set for Big Impact at Nebraska
Justin Thomas

Trending Well Ahead of PGA Championship Despite Concerning Form
J.J. Spaun

Trending Up Ahead of PGA Championship
Adam Scott

Riding Strong Form Into PGA Championship
Patrick Reed

Looking to Make Another Run at PGA Championship
PGA

Sungjae Im Looks to Build on Strong Finish at Truist Championship
Sam Burns

Must Keep Ball in Play at PGA Championship
Jordan Spieth

Looks to Complete Career Grand Slam at Aronimink
Brandt Snedeker

Not the Best Option for the PGA Championship
Rasmus Hojgaard

a Volatile Option at PGA Championship
Ayo Dosunmu

Has Busy Night in Game 5
Maverick McNealy

Seeking Better Start in Philadelphia
Harry Hall

a Boom-or-Bust Option at Aronimink
Jaden McDaniels

Notches 17 Points in Game 5 Loss
Hideki Matsuyama

Attempts to Improve Over 2025 PGA Championship
Scottie Scheffler

Looks to Defend PGA Championship at Aronimink
Julius Randle

Posts a Double-Double in Losing Effort
Nicolai Hojgaard

Wants to Keep Momentum Rolling in Philadelphia
Anthony Edwards

Held to 20 Points in Game 5 Loss
Ben Griffin

Attempting to Bounce Back After Truist Championship
CFB

Transfer Defensive Lineman Devarrick Woods Commits to Clemson
Keldon Johnson

Comes Alive in Game 5 Against Timberwolves
Harris English

Will Need His Putter to Thrive at Aronimink
Stephon Castle

Makes All-Around Impact in Game 5
Victor Wembanyama

Leads Spurs to Big Win in Game 5
Akshay Bhatia

Creative Flair Could Show Itself in Philadelphia
Keegan Bradley

Knows the Aronimink Golf Club Well
Mason McTavish

Delivers Two Assists Tuesday Night
Pavel Dorofeyev

Pots Two Goals in Vital Game 5 Win
Josh Doan

Records Two Assists in Game 4 Victory
Evgeni Malkin

Penguins Want Evgeni Malkin Back
Sidney Crosby

Joins Team Canada for World Championship
Ryan Poehling

Suffers Upper-Body Injury in Game 5 Loss
Si Woo Kim

Struggles at Truist Championship
Gary Woodland

Can Continue Incredible 2026 Season at PGA Championship
Xander Schauffele

In Excellent Form Heading to PGA Championship
Brandon Nimmo

Leaves Game on Tuesday with Apparent Ankle Injury
Philadelphia 76ers

76ers Part Ways With Daryl Morey
Kevin Huerter

Iffy for Game 5 Against Cavaliers
Charlie McAvoy

Slapped With Six-Game Suspension
Jonas Brodin

Unavailable for Game 5 Against Avalanche
Joel Eriksson Ek

to Remain Out Wednesday
Jacob Wilson

A's Place Jacob Wilson on Injured List With Shoulder Subluxation
Christian Yelich

Brewers Reinstate Christian Yelich From Injured List
CFB

Isaac Brown Has All-American Upside in 2026
CFB

Nyck Harbor Heading into Breakout Year?
CFB

Notre Dame, USC in Discussions to Resume Rivalry Series
CFB

Jaron-Keawe Sagapolutele Has Eyes on ACC Title
CFB

Ahmad Hardy's Gunshot Wound Not Viewed as Career-Threatening
A.J. Ewing

Mets to Call Up Top Prospect A.J. Ewing
Mookie Betts

is Officially Back on Monday
Nathan Eovaldi

Scratched From Monday's Start With Side Tightness
Henry Bolte

Athletics to Promote Top Outfield Prospect Henry Bolte to Major Leagues
Khamzat Chimaev

Suffers his First Loss
Sean Strickland

Recaptures Middleweight Title
Tatsuro Taira

Suffers Fifth-Round TKO Loss
Joshua Van

Defends Flyweight Title
MMA

Waldo Cortes-Acosta Drops Decision
Alexander Volkov

Wins Back-To-Back Fights
Shane Van Gisbergen

Dominates Watkins Glen for First Win of 2026
Michael McDowell

Finishes Second for Best Run of the Year At Watkins Glen
Ty Gibbs

Scores New Career-Best Finish of Third at Watkins Glen
Tyler Reddick

Continues His Strong Season With Fifth-Place Run at Watkins Glen
Austin Dillon

Earns his First Top-10 Finish of 2026 at Watkins Glen
Mookie Betts

Dodgers Expect Mookie Betts to Return on Monday
CFB

Ahmad Hardy Sustains Gunshot Wound, in Stable Condition
Connor Zilisch

Will Start Fifth in his First Watkins Glen Cup Series Race
Tyler Reddick

Is A Top DFS Option for Watkins Glen Lineups
Christopher Bell

Is Likely to Bounce Back This Week at Watkins Glen
Carlos Rodón

Carlos Rodon Activated for Season Debut on Sunday
William Byron

Is William Byron Playable in DFS Lineups at Watkins Glen?
Kyle Larson

May have A Positive Day at Watkins Glen
Chase Briscoe

May Compete for A Top-10 Finish at Watkins Glen
NASCAR

A.J. Allmendinger May have Another Solid Outing at Watkins Glen
Ty Gibbs

Should Fantasy Managers Roster Ty Gibbs at Watkins Glen?
Ross Chastain

Is Ross Chastain Worth Rostering for Watkins Glen Lineups?
Austin Cindric

Could Austin Cindric be A Sneaky Tournament Play for Watkins Glen?
Shane Van Gisbergen

Shane van Gisbergen the Heavy Favorite at Watkins Glen
Chase Elliott

Is Chase Elliott a No-Brainer DFS Pick at Watkins Glen?
Chris Buescher

Qualifies 14th at Watkins Glen
Ryan Blaney

Has Upside at Watkins Glen After Signing Contract Extension
Michael McDowell

Still Searching for First Top-Five Finish at Watkins Glen
Carson Hocevar

Is Carson Hocevar Too Aggressive for Road-Course Racing?
Sean Strickland

An Underdog At UFC 328
Khamzat Chimaev

Set For UFC 328 Main Event
Tatsuro Taira

Can Become The New Flyweight Champion
Joshua Van

Set For His First Title Defense
Alexander Volkov

Looks To Win Back-To-Back Fights
MMA

Waldo Cortes-Acosta Looks To Extend His Win Streak
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF