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FanDuel MLB DFS Lineup Picks (4/21/19): Daily Fantasy Baseball Advice

Troy Klauder highlights the top FanDuel MLB DFS lineup picks for 4/21/19, and a couple of sleepers to consider while building daily rosters.

Today's main slate starts at 1:05 pm eastern and covers nine games. There's also an all day slate starting at the same time, featuring a glorious 15 game slate.

In this article, I will be providing you with my daily fantasy baseball lineup picks for FanDuel on 4/21/2019. The lineup picks will range from some of the elite players to mid-priced options and value plays.

If you have any questions or comments, feel free to hit me up on Twitter @TroyKlauder.

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FanDuel DFS Pitchers

James Paxton, NYY vs KC ($9,600)

Paxton was absolutely brilliant his last time out, throwing eight scoreless innings with twelve strikeouts against the Red Sox. He's now got a beastly 32.6% K-rate on the season and gets a very easy matchup in the Royals, who have just a .278 wOBA versus left-handed pitching this year. Paxton should be regarded as an ace, and this may be your last chance to get him at a discounted price.

Kyle Gibson, MIN at BAL ($6,100)

Gibson is the third-cheapest starter on FanDuel today because he's been downright awful this year. However, he's got serious upside in a matchup against the Orioles. Much of Baltimore's lineup simply isn't major league caliber, resulting in a .290 wOBA versus righties this season. It's worth noting that Gibson is coming off a year where he threw nearly 200 innings with a 3.62 ERA, so there's absolutely a chance for a bounce-back performance. Gibson is attractive in GPP contests, especially considering that he'll allow you to spend lots of salary on high-end hitters.

 

FanDuel DFS Infielders

Jose Abreu, CWS vs DET ($2,900)

Abreu is off to a rough start, but there's no reason to worry about a 19 game sample. He obliterated lefties last year with a 144 wRC+ and should have a big day against Tigers southpaw Daniel Norris. Norris has pitched poorly in 8 1/3 innings this season, with just four strikeouts and three walks, as well as three homers allowed. Abreu is a fantastic value at his price.

Robinson Cano, NYM at STL ($3,400)

Cano is another slow starter whose price we can take advantage of. He is in a great spot batting third for the Mets, where he will see lots of run and RBI opportunities against Dakota Hudson. Hudson has been chewed up by opposing lineups and has a 6.08 ERA, so Cano can certainly be used as part of a Mets stack.

Corey Seager, LAD at MIL ($3,400)

Seager is an exciting play in Miller Park, an extreme hitter's environment where the Dodgers can score lots of runs. Regardless of whether he's batting second or third in the Dodgers order, Seager will be in a position to produce at a low price.

Alex Bregman, HOU at TEX ($4,000)

Bregman is an elite fantasy commodity who has picked up right where he left off last year, entering Sunday with a .916 OPS. He is in line for a enormous game against Shelby Miller, who has had a catastrophic 2019 campaign consisting of 11 walks in 10 innings with a 9.00 ERA.

 

FanDuel DFS Outfielders

Mookie Betts, BOS at TB ($3,900)

It was just last year that Betts was fantasy baseball's top performer, and we're already seeing him below $4,000? It's only April! Slow start or not, tough matchup or not - Betts needs to be in your lineups at this price.

Nelson Cruz, MIN at BAL ($3,400)

While his teammate Eddie Rosario took the spotlight yesterday, Nelson Cruz had a monster day of his own with two home runs. Cruz will be at it again from the cleanup spot against Dylan Bundy, who is one of the most homer-prone pitchers in all of baseball. Cruz continues to be undervalued, as he's rocking an elite 179 wRC+.

Ian Desmond, COL vs PHI ($2,900)

Don't you wish you could get some high-scoring Coors Field action in your lineups without wasting away all of your payroll? In that case, Ian Desmond is the bat for you. Yes, Desmond does suck, but it doesn't take much to rack up fantasy points in Colorado.

MLB DFS News and Injury Alerts




REAL-TIME FANTASY NEWS

Drake Maye

Is Drake Maye Becoming the Most Valuable Player in Superflex Dynasty Leagues?
Vladimir Guerrero Jr.

Exits Sunday's Game Early with Elbow Contusion
MLB

Reds-Cardinals Game Postponed on Sunday
Denny Hamlin

the Favorite to Win at Charlotte
Tyler Reddick

on Pole for Coca-Cola 600
Christopher Bell

Could Break Out of Slump
Kyle Larson

May have A Solid Day at Charlotte
Ryan Blaney

Is A DFS Risk for Charlotte Lineups
William Byron

Could have A Great DFS Performance at Charlotte
Chase Briscoe

Is A Solid Tournament Option for Charlotte DFS Lineups
Pat Freiermuth

Steelers Restructure Pat Freiermuth's Contract
Ty Gibbs

May not be Worth his Salary for Charlotte DFS Lineups
Chris Buescher

May be a Sneaky Tournament Option for Charlotte Lineups
NASCAR

Bubba Wallace Has Favorable Upside for Charlotte DFS Lineups
Ross Chastain

Is A Strong Addition for DFS Lineups at Charlotte
Austin Dillon

Should Fantasy Managers Roster Austin Dillon for Charlotte DFS Lineups?
Chase Elliott

Should Be Strong at Charlotte
Carson Hocevar

Confident for Coca-Cola 600
Corey Heim

a Chalk DFS Pick at Charlotte
Michael McDowell

Is Michael McDowell A Tournament Option for Charlotte Lineups?
Jordan Mason

a Short-Term Dynasty Depth Piece
Dontayvion Wicks

Can Dontayvion Wicks Stand Out in Another Crowded Offense?
Chuba Hubbard

Dynasty Value Back on the Rise
Juwan Johnson

an Overlooked Buy Candidate for Contending Dynasty Managers
Kimani Vidal

Easily Acquirable as a High-Value Insurance Back
Evan Mobley

Tallies Series-High 24 Points on Saturday
Donovan Mitchell

Struggles at the Line Saturday
Karl-Anthony Towns

Continues Playmaking Surge on Saturday
OG Anunoby

Delivers Clean Shooting Line Saturday
Mikal Bridges

Fills Box Score in Game 3 Win
Jalen Brunson

Pushes Knicks Closer to NBA Finals
Orlando Magic

Magic Interview Jeff Van Gundy for Head-Coaching Position
Phillip Danault

Extends Point Streak to Three Games
Josh Anderson

Nets Two Goals in Painful Loss
Jalen Chatfield

Delivers Two Assists in Crucial Win
Mark Jankowski

Contributes Two Assists in Game 2 Victory
Eric Robinson

Scores in Second Consecutive Game
Nikolaj Ehlers

Tallies Two Goals as Hurricanes Bounce Back Saturday
Giannis Antetokounmpo

Magic Reportedly Have Giannis Antetokounmpo on Their Radar
Ajay Mitchell

Won't Play Sunday
Dylan Harper

Not on Injury Report for Game 4
De'Aaron Fox

Off the Injury Report Ahead of Game 4
Jalen Williams

Questionable for Sunday Night
Ja'Tavion Sanders

a Dynasty Dart Throw With Potential Untapped Upside
Geno Smith

a Low-Cost Dynasty Add Who Still Comes with Risk
C.J. Stroud

Still a Capable and Undervalued Dynasty QB2
Bhayshul Tuten

More Big Plays in 2026 Could Transform Bhayshul Tuten into a Dynasty Steal
Joe Mixon

Is Joe Mixon's NFL Career Over?
MLB

Orioles-Tigers Game Postponed on Saturday
RJ Harvey

to be Relegated to Third-Down Role After Rookie RB Addition?
Baker Mayfield

A Lot of Uncertainty Surrounding Baker Mayfield Going into Fourth Year in Tampa
Brian Robinson Jr.

a Must-Have Handcuff in Dynasty Leagues?
Sam LaPorta

Could be Excellent Buy-Low Candidate for Risk-Tolerant Managers
Jordyn Tyson

on a "Maintenance Plan" During Offseason Workouts
Kenneth Walker III

One of Dynasty's Biggest Risers for 2026
D'Andre Swift

an Underappreciated Dynasty Buy Candidate
Ray Davis

Still a Dynasty Stash Despite a Lack of Standalone Value
Travis Kelce

Now a Low-Cost Dynasty Rental
MLB

Rays-Yankees Postponed on Saturday
Devin Vassell

Posts 20 Points in Game 3 Loss
De'Aaron Fox

Struggles From Deep in Friday's Loss
Victor Wembanyama

Held to Four Rebounds in Game 3 Loss
Jaylin Williams

Catches Fire From Deep Friday
Jared McCain

Drops Playoff-High 24 Points in Game 3
Nazem Kadri

Contributes an Assist in Losing Effort
Shai Gilgeous-Alexander

Guides Thunder to 2-1 Series Lead
Ajay Mitchell

Does Not Return in Game 3 Win
Ross Colton

Nets Lone Avalanche Goal Friday Night
Rasmus Andersson

Extends Assist Streak to Four Games
Pavel Dorofeyev

Focuses on Playmaking in Friday's Win
Jack Eichel

Enjoys Multi-Point Outing in Game 2 Win Friday
Ivan Barbashev

Amasses Three Points as Golden Knights Grab 2-0 Series Lead
Mickey Moniak

Heads to Injured List With Ankle Sprain
Rudy Gobert

Earns Eighth All-Defensive First-Team Selection
Victor Wembanyama

Headlines 2025-26 All-Defensive First Team
Frederik Andersen

Hurricanes Keep Faith in Frederik Andersen
Devon Levi

Attracting Interest From Senators
Scott Wedgewood

Starting Game 2 Against Golden Knights
Ben Hutton

Scratched for Game 2 Against Avalanche
Mark Stone

Won't Play Friday
Jackson Merrill

has Sore Ribs, Expected to Avoid Injured List
Cale Makar

Remains Out Friday
CFB

Jaron-Keawe Sagapolutele Looking to Take Sophomore Leap
CFB

Jadan Baugh Primed to Lead Florida Offense in 2026
CFB

LSU Hires Ed Orgeron As Special Assistant
CFB

North Carolina and South Carolina Cancel Home-And-Home Series
CFB

Confidence High in Mississippi State's Kamario Taylor
MLB

Reds-Cardinals Game Postponed on Friday
Trevor Story

has Hernia Surgery, Expected to Miss 6-10 Weeks
Roman Anthony

Dealing With Sprained Ligament in his Finger
Sebastian Aho

Picks Up an Assist in Series-Opening Loss
Seth Jarvis

Needs 33 Seconds to Score in Game 1 Loss
Jaccob Slavin

Struggles in Game 1 Against Canadiens
Ronald Acuña Jr.

Ronald Acuna Jr. Exits Early, X-Rays Come Back Negative
Robby Snelling

Will Undergo Tommy John Surgery
Jackson Merrill

Tweaks his Back on Wednesday, Pulled Early
CFB

Lincoln Riley Believes USC is Ready for Playoff Run
CFB

Notre Dame-Stanford Rivalry Renewed Through 2028
CFB

Ahmad Hardy Says He's "Back to the Road to Success"
CFB

Texas Tech Graduate Judge Recuses Himself from Brendan Sorsby Case
CFB

UCLA Tackle Jordan Davis Officially Eligible for 2026 Season
CFB

Bret Bielema Supports Significant College Football Playoff Expansion
Michael Thorbjornsen

Brings High Upside to CJ Cup Byron Nelson
Luke List

Carrying Poor Form Into CJ Cup Byron Nelson
Tom Kim

Hoping to Build on Strong Myrtle Beach Finish
PGA

Sungjae Im Brings Upside to TPC Craig Ranch
Billy Horschel

Looking for Turnaround at CJ Cup Byron Nelson
Adam Hadwin

Difficult to Trust at TPC Craig Ranch
Tony Finau

Looking for Consistency at TPC Craig Ranch
Luke Clanton

Searching for Form at CJ Cup Byron Nelson
Aaron Rai

Withdraws From CJ Cup Byron Nelson
Wyndham Clark

Can Wyndham Clark Find Form at CJ Cup?
Si Woo Kim

Looks To Stay Hot at CJ Cup
Scottie Scheffler

to Defend CJ Cup Byron Nelson Title This Week
Jordan Spieth

Looking For Victory at TPC Craig Ranch
PGA

Matti Schmid Looks to Keep Recent Momentum Going at TPC Craig Ranch
Brooks Koepka

a High-Upside Play at CJ Cup Byron Nelson
Yandy Díaz

Yandy Diaz Exits Early on Tuesday After Being Hit By Pitch
Chris Kirk

Continues Search For Putting Form at TPC Craig Ranch
Rasmus Hojgaard

Looking to Shake Off Poor Major Showing at TPC Craig Ranch
Joel Dahmen

is of No DFS Consideration This Week in Dallas
Pierceson Coody

is Not The Fun DFS Play He Used to Be
Gerrit Cole

to Make Season Debut on Friday Against Rays
Drake Baldwin

Braves Place Drake Baldwin on Injured List With Oblique Strain
CFB

Ezavier Crowell has Immediate Opportunity at Alabama
CFB

Mark Bowman a Day 1 Impact Player for USC?
CFB

Bill Belichick Says Relationship with First North Carolina Team "Wasn't Great"
CFB

Kemario Taylor a Breakout Candidate at Quarterback
CFB

Trinidad Chambliss the Undisputed Top SEC Quarterback Entering 2026?
CFB

Rocco Becht The "Unifier" of Penn State's Roster
Jackson Holliday

Orioles Reinstate Jackson Holliday From Injured List on Monday
Ronald Acuña Jr.

Braves Reinstate Ronald Acuna Jr. From Injured List on Monday
Jose Altuve

Astros Put Jose Altuve on Injured List With Oblique Strain
Corey Seager

Going on Injured List With Back Injury
Jeremy Peña

Jeremy Pena Reinstated and Starting on Monday Against Twins
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF