👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

Midwest Region Picks: March Madness Bracket Predictions

NCAA Tournament bracket picks and team predictions for the Midwest Region. Read Seth's March Madness picks, sleepers and busts including teams to target and avoid.

March Madness is officially here, so let's fill out some winning brackets! RotoBaller will be bringing you a full breakdown on each tournament region, including some potential sleepers and busts. Today we'll be taking a look at the Midwest Region and my bracket picks.

I'm here to tell you some teams that I believe in to help you make the right tournament bracket decisions. Below I analyze the top four seeds, a potential bust, and a potential final four candidate. Hopefully my college basketball predictions can help you win your March Madness brackets. Now let's get to it.

Editor's Note: Be sure to check out the rest of our NCAA Tournament articles and analysis, including a guide on how to fill out your brackets. Read our March Madness picks, sleepers, busts and predictions for the East, South, and West regions.

 

Midwest Region Top Four Seeds 

Top four seeds: No. 1 North Carolina, No. 2 Kentucky, No. 3 Houston, No. 4 Kansas

Carolina is the final one seed and some think Michigan State should've gotten that nod. Nevertheless, here we are and Carolina greatly benefits with a seemingly clear path to the Elite Eight. They are led by freshman-phenom point guard Coby White and senior big man Luke Maye. They are a well-rounded team.

Kentucky has lost three times since February (twice to Tennessee and once to LSU). When both Reid Travis and P.J. Washington are healthy, they are tough to beat. They are a bruising physical bunch. Their loss to Tennessee in the SEC semis may be the best thing to happen to them.

The odds are stacked against Houston. Top-three seeds unranked before the season have made the Final Four just two times out of 53 since the field expanded in 1986. Houston falls under that category. They have only lost three times all season and they could very well make the Elite Eight, but I'd be hesitant to put them in the Final Four.

Watching Kansas on the road and at home is like watching two different teams. They were 17-0 at home this season and 3-8 on the road. Now you may be wondering, why I'm talking about home and road stats when the NCAA Tournament is played only at neutral-sites. Well, the committee placed Kansas in the Midwest region and the Sweet 16 and Elite Eight are in Kansas City, MO. So if Kansas can get through the first weekend in Salt Lake City, UT, they'll have a major home-court advantage for the Sweet 16 and Elite Eight.

 

Most Intriguing First-Round Matchup: No. 7 Wofford vs. No. 10 Seton Hall

The Southern conference champs are on a 20-game winning streak without a single loss in their conference. They also are second in the nation in team three-point percentage. Ken Pomeroy even has them as the 19th-rated team. But they are running into a well-coached, gritty, and scrappy Seton Hall squad.

The Pirates have a great scorer in Myles Powell and the big bodies down low to hang with anyone. They may get behind in the first half, but I've seen them battle back far too often to ever count them out. I think the fact that Seton Hall has played in more close, grind-it-out games in bigger moments, will be the deciding factor against Wofford.

 

Bust of the Region

Kansas. I don't think they're getting out of the first weekend so they won't have the chance to play with a massive home-court advantage. They're an underwhelming team that is not your typical Kansas team.

 

Final Four Pick

Kentucky. The Wildcats are really good and losing in the SEC semifinals is probably the best thing that happened to them. They'd face Wofford/Seton Hall in the second round and while both teams are good, Kentucky will be too much. In the Sweet 16, Houston or Iowa State don't have the bodies to hang with Kentucky. In the Elite Eight, they'd most probably face North Carolina and at that point, it comes down to the last possession.

More March Madness Brackets Advice




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Mika Zibanejad

Pots Two Goals Versus Toronto
Pavel Zacha

Adds Two More Points Against Buffalo
Jordan Addison

in Line for 2026 Resurgence with Improved Quarterback Play?
Landry Shamet

to Remain Out Thursday
Gunnar Helm

Appears Well-Positioned for 2026 Breakout
Vít Krejčí

Vit Krejci Misses Sixth Straight Game
Peyton Watson

Good to Go Wednesday
Dalton Kincaid

Facing Durability and Usage Questions Heading into 2026
Aaron Gordon

Misses Second Leg of Back-to-Back
Jakob Poeltl

Cleared to Play Against Clippers
Colston Loveland

Poised for Superstar Breakout in 2026?
Immanuel Quickley

Won't Play Wednesday
Brandon Ingram

Active Against Clippers
Khalil Shakir

Could See His Role in Buffalo Shrink in 2026
Myles Turner

Won't Play Against Trail Blazers
Bobby Portis

Kyle Kuzma Out Wednesday
Brandon Williams

Available Wednesday Night
Kawhi Leonard

Ready to Face Raptors
Daniel Gafford

Won't Play Wednesday
Jerami Grant

Returns to Action Wednesday
Robert Williams III

Active Wednesday Night
Trey Murphy III

Iffy to Face Pistons
Dejounte Murray

Questionable to Play Thursday
Christian Watson

Is Christian Watson's Breakout Season Coming in 2026?
Russell Westbrook

Out Indefinitely With Toe Injury
Pat Freiermuth

Should Have More Volume, but QB Situation Still a Mystery
Cody Williams

is Upgraded to Available
Jahmai Mashack

Remains Sidelined Wednesday
Jalen Smith

Won't Return to Wednesday's Game
Javon Small

Cleared to Play Wednesday
Nicolas Roy

to Be Out For "a Little Bit"
Anton Lundell

Likely Out for Rest of Regular Season
Anthony Mantha

Day-to-Day With Lower-Body Injury
Evgeni Malkin

to Remain Out Thursday
Mattias Samuelsson

a Game-Time Call Wednesday
Jonathan Quick

Remains Unavailable Wednesday
Victor Hedman

Takes Leave of Absence
Jake Bates

Lions Officially Re-Sign Jake Bates
Patrick Mahomes

Chiefs "Optimistic" That Patrick Mahomes Can Take Part in Offseason Practices
Najee Harris

Visits With Seahawks
Sean Murphy

Lands on 10-Day Injured List
Bryce Miller

Placed on 15-Day Injured List With Oblique Strain
Lars Nootbaar

Will Begin the Season on 60-Day Injured List
Jackson Holliday

Placed on 10-Day Injured List
New York Jets

Ty Simpson to Hold Private Workout With Jets on Friday
Ronnie Rivers

Rams Re-Sign Ronnie Rivers to One-Year Deal
Las Vegas Raiders

Raiders to Host Fernando Mendoza for a Top-30 Visit in Two Weeks
Tua Tagovailoa

Open to Being a QB Mentor in Atlanta
Zay Flowers

Ravens Want to Extend Zay Flowers Soon
Jeremy Peña

Jeremy Pena on the Astros Opening Day Roster
Blake Snell

Dodgers Place Blake Snell on 15-Day Injured List
John Carlson

Sets Up Three Goals Tuesday Night
Joel Hofer

Picks Up Sixth Shutout of the Season
John Tavares

Records Three Assists in Tuesday's Win
NJ

Arseni Gritsyuk Scheduled for Imaging Wednesday
Jordan Mason

Could Benefit from Quarterback Change
Tony DeAngelo

Suffers Lower-Body Injury Tuesday
Aaron Rodgers

Mike McCarthy Would Welcome an Aaron Rodgers Reunion
Emmitt Finnie

Enters Concussion Protocol
Ryan Fox

a High-Upside Value in Houston
Barrett Hayton

Sustains Upper-Body Injury Tuesday
Dak Prescott

Remains Egregiously Undervalued
Marco Penge

a Boom-or-Bust Option in Houston
CeeDee Lamb

Cowboys' Offensive Cohesion Could Lead to Another Big Year from CeeDee Lamb
NFL

Jeremiyah Love Does Not Participate at Notre Dame Pro Day
Puka Nacua

Accused of Biting a Woman, Making Antisemitic Remarks
Aaron Rai

Looks to Bounce Back in Houston
Jason Day

a Volatile Option at the Texas Children's Houston Open
Kirby Yates

Angels Place Kirby Yates on 15-Day Injured List
Harris English

Eyes a Bounce-Back at the Texas Children's Houston Open
Ben Griffin

Looks for Turnaround at the Texas Children's Houston Open
Rickie Fowler

Brings Strong Form Into Texas Children's Houston Open
Brady Tkachuk

Collects Two More Points on Tuesday
Martin Necas

Scores Twice Against Penguins
Nick Lodolo

Will Open 2026 on the Injured List Due to Finger Ailment
Pete Crow-Armstrong

Agrees to Six-Year, $115 Million Extension With the Cubs
Igor Chernyshov

Returns to Sharks Lineup
Dylan Larkin

Good to Go Tuesday
Ross Colton

Logan O'Connor, Ross Colton Available Tuesday
Francisco Lindor

Likely to be Ready for Opening Day
Ryan Gerard

Can Continue Rolling at Texas Children's Houston Open
Pierceson Coody

Bounces Back at Valspar Championship
Rasmus Hojgaard

Trying to Get Back on Track at Texas Children's Houston Open
Michael Thorbjornsen

Playing Well Heading to Texas Children's Houston Open
Harry Hall

Looking for Consistency at Texas Children's Houston Open
Brooks Koepka

Continues Building Momentum
Roki Sasaki

to Stick in Rotation Despite Spring Struggles
Kevin McGonigle

Makes Tigers Opening Day Roster
Scottie Scheffler

Withdraws From Texas Children's Houston Open
Ryan Pepiot

Placed on Injured List to Open the Season
J.J. Wetherholt

JJ Wetherholt Likely to Hit Leadoff on Opening Day
Connelly Early

to Make First Start on Sunday
Luke Clanton

Might Have a Problem in Houston
Sam Stevens

Happy to See Houston This Week
Keith Mitchell

Tries to Rebound After The Players Championship
Will Zalatoris

Returning This Week at Houston
Wyndham Clark

Trending in the Wrong Direction Heading to Houston
Shane Lowry

Seeking Better Luck in Houston This Weekend
Kurt Kitayama

Poised to Bounce Back at the Houston Open
Pete Crow-Armstrong

Cubs, Pete Crow-Armstrong Finalizing Long-Term Extension
Blake Snell

Targeting a May Return
Hunter Greene

Reds Place Hunter Greene on 60-Day Injured List
J.J. Wetherholt

JJ Wetherholt Makes Cardinals Opening Day Roster
Nick Pivetta

to Start on Opening Day for Padres
Brandon Woodruff

Makes Brewers Opening Day Rotation
Lerone Murphy

Suffers His First Loss
Movsar Evloev

Edges Out Lerone Murphy
CFB

Notre Dame Ranks No. 1 in Returning Production for 2026
Michael Aswell

Jr. Drops Decision At UFC London
Michael Aswell

Luke Riley Outclasses Michael Aswell Jr.
Sam Patterson

Suffers Unanimous-Decision Loss
Michael Page

Wins Lackluster Decision
Austen Lane

Suffers First-Round TKO Loss
Iwo Baraniewski

Delivers 28-Second TKO
Tyler Reddick

Overcomes Adversity for Fourth Victory of the Season At Darlington
Brad Keselowski

Falls Short of Darlington Victory Despite Domination
Ryan Blaney

Recovers From Pit-Road Struggles to Score Career-Best Darlington Finish
Carson Hocevar

Rallies to Finish Fourth at Darlington
Kyle Larson

Decent Performance Ends with Technical Issues At Darlington
Tyler Reddick

the Clear Favorite at Darlington
Kyle Larson

a High-Risk, High-Reward Driver at Darlington
Ryan Blaney

Is Getting Better at Darlington
NASCAR

Bubba Wallace Not Slowing Down at Darlington
Chris Buescher

Should be a Top-10 Contender at Darlington
Austin Cindric

a Sleeper at Darlington
Erik Jones

Quickest in Practice at Darlington
Denny Hamlin

Qualifies Ninth for this Week's Cup Race at Darlington
Chase Briscoe

Is One of the Top DFS Options of the Week for Darlington
William Byron

Is William Byron A Playable DFS Option for Darlington Lineups?
Christopher Bell

Could Christopher Bell be Considered A Decent DFS Option for Darlington?
Chase Elliott

Is Chase Elliott Worth Rostering At Darlington This Week For DFS?
Joey Logano

May Not Have the Speed to Warrant A Darlington DFS Lineup Spot
Ross Chastain

Should DFS Players Trust Ross Chastain at Darlington?
Kyle Busch

Could Kyle Busch Be A Worthy DFS Option for Darlington?
Brad Keselowski

May be A Contriarian DFS Tournament Option At Darlington
Lerone Murphy

Set For UFC London Main Event
Movsar Evloev

Looks To Remain Unbeaten
Michael Aswell

Jr. An Underdog At UFC London
Luke Riley

Set For UFC London Co-Main Event
Sam Patterson

Looks To Extend His Win Streak
Michael Page

Set For Welterweight Bout
Austen Lane

In Dire Need Of Victory
Iwo Baraniewski

A Favorite At UFC London
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF