👉 TAP TO SAVE 30% WITH CODE NEW
X
Lost password?

Don't have an account?
Gain Access Now

X

Receive free daily analysis

NFL
NBA
NHL
NASCAR
CFB
MLB
MMA
PGA
ESPORTS
BETTING

Already have an account? Log In

X

Forgot Password


POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

Midwest Region Picks: March Madness Bracket Predictions

NCAA Tournament bracket picks and team predictions for the Midwest Region. Read Seth's March Madness picks, sleepers and busts including teams to target and avoid.

March Madness is officially here, so let's fill out some winning brackets! RotoBaller will be bringing you a full breakdown on each tournament region, including some potential sleepers and busts. Today we'll be taking a look at the Midwest Region and my bracket picks.

I'm here to tell you some teams that I believe in to help you make the right tournament bracket decisions. Below I analyze the top four seeds, a potential bust, and a potential final four candidate. Hopefully my college basketball predictions can help you win your March Madness brackets. Now let's get to it.

Editor's Note: Be sure to check out the rest of our NCAA Tournament articles and analysis, including a guide on how to fill out your brackets. Read our March Madness picks, sleepers, busts and predictions for the East, South, and West regions.

 

Midwest Region Top Four Seeds 

Top four seeds: No. 1 North Carolina, No. 2 Kentucky, No. 3 Houston, No. 4 Kansas

Carolina is the final one seed and some think Michigan State should've gotten that nod. Nevertheless, here we are and Carolina greatly benefits with a seemingly clear path to the Elite Eight. They are led by freshman-phenom point guard Coby White and senior big man Luke Maye. They are a well-rounded team.

Kentucky has lost three times since February (twice to Tennessee and once to LSU). When both Reid Travis and P.J. Washington are healthy, they are tough to beat. They are a bruising physical bunch. Their loss to Tennessee in the SEC semis may be the best thing to happen to them.

The odds are stacked against Houston. Top-three seeds unranked before the season have made the Final Four just two times out of 53 since the field expanded in 1986. Houston falls under that category. They have only lost three times all season and they could very well make the Elite Eight, but I'd be hesitant to put them in the Final Four.

Watching Kansas on the road and at home is like watching two different teams. They were 17-0 at home this season and 3-8 on the road. Now you may be wondering, why I'm talking about home and road stats when the NCAA Tournament is played only at neutral-sites. Well, the committee placed Kansas in the Midwest region and the Sweet 16 and Elite Eight are in Kansas City, MO. So if Kansas can get through the first weekend in Salt Lake City, UT, they'll have a major home-court advantage for the Sweet 16 and Elite Eight.

 

Most Intriguing First-Round Matchup: No. 7 Wofford vs. No. 10 Seton Hall

The Southern conference champs are on a 20-game winning streak without a single loss in their conference. They also are second in the nation in team three-point percentage. Ken Pomeroy even has them as the 19th-rated team. But they are running into a well-coached, gritty, and scrappy Seton Hall squad.

The Pirates have a great scorer in Myles Powell and the big bodies down low to hang with anyone. They may get behind in the first half, but I've seen them battle back far too often to ever count them out. I think the fact that Seton Hall has played in more close, grind-it-out games in bigger moments, will be the deciding factor against Wofford.

 

Bust of the Region

Kansas. I don't think they're getting out of the first weekend so they won't have the chance to play with a massive home-court advantage. They're an underwhelming team that is not your typical Kansas team.

 

Final Four Pick

Kentucky. The Wildcats are really good and losing in the SEC semifinals is probably the best thing that happened to them. They'd face Wofford/Seton Hall in the second round and while both teams are good, Kentucky will be too much. In the Sweet 16, Houston or Iowa State don't have the bodies to hang with Kentucky. In the Elite Eight, they'd most probably face North Carolina and at that point, it comes down to the last possession.

More March Madness Brackets Advice




POPULAR FANTASY TOOLS

#1 Expert Projections
Save 30% Now
Import Your Leagues
Top-Rated Accuracy
Draft Simulator
Enter League Settings
Compare Any Players
Rookies & Call-Ups
24x7 News and Alerts

REAL-TIME FANTASY NEWS

Andrew Vaughn

Needs Hand Surgery, Expected to be Out 4-6 Weeks
Jacob deGrom

"Confident" he Will Make his Next Start
Trey Benson

Facing Uphill Battle for Playing Time in Arizona
Jacory Croskey-Merritt

Can Jacory Croskey-Merritt Emerge as the Clear RB1 in Washington?
Lamar Jackson

Looking for Return to Full Health in 2026
Sean Tucker

Remains Buried on Buccaneers' Running Back Depth Chart
Jake Tonges

Appears Likely to Enter 2026 Atop 49ers' Tight End Depth Chart
NFL

Can Ja'Kobi Lane Carve Out a Fantasy-Relevant Role as a Rookie?
Chig Okonkwo

Instantly Jumping to Fantasy Relevance in Washington?
Aaron Jones Sr.

Set for Familiar Role in 2026?
Brandon Aiyuk

a Buy-Low Candidate in Dynasty Leagues?
Romeo Doubs

the New No. 1 Target in New England?
Daniel Jones

a QB1 if Ready for Season Opener?
Jacob deGrom

Scratched From Saturday's Start Due to Neck Stiffness
Jeferson Quero

Brewers Calling Up Catching Prospect Jeferson Quero
Josh Allen

Still the Top Dog at QB in Fantasy
Jared Goff

Should Have Safe Floor as QB1 Again Under New Offensive Coordinator
Jacoby Brissett

Will Jacoby Brissett be on the Streaming Radar Again in 2026?
NFL

Kaytron Allen Should Attract Plenty of Interest in 2026 NFL Draft
NFL

Makai Lemon a Polarizing Receiver Prospect Heading into This Year's Draft
David Pastrnak

Riding 11-Game Point Streak
John Gibson

Gets Back on Track Friday
J.T. Miller

Bags Three Points Against Blackhawks
Tage Thompson

Picks Up 400th Career Point
Patrick Kane

Collects Two Points in Friday's Win
Nick Lardis

Pots Another Goal Friday Night
Shayne Gostisbehere

Could Be an Option Saturday
Nique Clifford

Could Return Saturday
Marcus Sasser

Probable Saturday
Caris LeVert

on Track to Return Saturday
Deyvison De Los Santos

Marlins Promote Deyvison De Los Santos to Major Leagues
Duncan Robinson

Listed as Questionable for Saturday
Ayo Dosunmu

Questionable to Play Saturday
Myles Turner

Iffy for Saturday
Kyle Kuzma

Questionable Saturday
Moritz Seider

Assists on Two Goals Against the Sabres
Shea Langeliers

Hits Two Home Runs on Opening Day
Kevin Gausman

Picks Up No-Decision But Strikes Out 11 on Opening Day
Mac Jones

Boosts his Dynasty Stock With Solid First Year in San Fran
Alex DeBrincat

Picks Up Three Points Versus Buffalo
Bobby Portis

May Miss Another Game Saturday
Tez Johnson

Could be Buried on the Depth Chart Again in Sophomore Season
Kevin Porter Jr.

Unavailable Against Spurs
Ka'imi Fairbairn

One of the NFL's Best Kickers Heading into His 10th Season
De'Aaron Fox

to Return to Action Saturday
Isaiah Jackson

Exits Early Friday
Kelly Oubre Jr.

Ready to Return Saturday
Michael Penix Jr.

Falcons Think Michael Penix Jr. Will be Healthy "At Some Point" in Training Camp
Al Horford

to Be Re-Evaluated in One Week
Vít Krejčí

Vit Krejci Remains Sidelined Friday
Robert Williams III

Will Suit Up Friday
Khris Middleton

Sits Out Friday's Game
Tre Johnson

Back From Three-Game Absence Friday
Isiah Pacheco

Can Isiah Pacheco Bounce Back in RB2 Role in Detroit?
Jarace Walker

Won't Return Friday
Tristan Vukcevic

Active Friday Night
Tanner Bibee

Day-to-Day, Could Make his Next Start
Alexandre Sarr

Returns to Action Friday
Ausar Thompson

Questionable Against Minnesota
Dylan Garand

Starts Friday
Noah Ostlund

Won't Play Friday
Connor Zary

Returns to Practice
Samuel Honzek

Won't Return This Season
Damon Severson

Labeled Week-to-Week
Sam Steel

Leaves Road Trip Due to Injury
Mikko Rantanen

Could Return Saturday
Shane Baz

Orioles Agree to Five-Year Extension
Jeremy Peña

Jeremy Pena Making Season Debut on Friday Against Angels
Tiger Woods

Involved In Rollover Car Crash
Tanner Bibee

Shoulder Issue Not Considered Serious
Barrett Hayton

Out Week-to-Week
Tony DeAngelo

to Miss 1-2 Weeks
Sam Steel

Makes Early Exit Against Islanders
Damon Severson

Exits With Upper-Body Injury Thursday
Joe Pyfer

Set For UFC Seattle Main Event
Yaroslav Askarov

Suffers New Injury Blow
Israel Adesanya

Returns At UFC Seattle
Maycee Barber

Looks To Extend Her Win Streak To Eight
Alexa Grasso

Looks To Get Back In The Win Column
Dominic Canzone

a Top Pickup After Two-Homer Game
Niko Price

In Dire Need Of Victory
Michael Chiesa

Set For Retirement Fight
Chase DeLauter

Launches Two Home Runs, Emerges as Top Waiver-Wire Target
Lerryan Douglas

Set For His UFC Debut
Julian Erosa

Looks To Bounce Back
Tanner Bibee

Leaves Opening Day Start Early With Shoulder Inflammation
Cristopher Sánchez

Cristopher Sanchez Makes a Statement on Opening Day With 10 Strikeouts
Kevin McGonigle

has Four Hits in Impressive MLB Debut
Nico Hoerner

Cubs Agree to Six-Year Deal With Nico Hoerner
Jacob Misiorowski

Shows Off his High-Strikeout Upside in Opening Day Win
Paul Skenes

Greeted Harshly by Mets on Opening Day
Brandon Lowe

Hits Two Home Runs on Opening Day
Ketel Marte

Active, Leading Off on Opening Day
Ryan Fox

a High-Upside Value in Houston
Marco Penge

a Boom-or-Bust Option in Houston
Aaron Rai

Looks to Bounce Back in Houston
Jason Day

a Volatile Option at the Texas Children's Houston Open
Harris English

Eyes a Bounce-Back at the Texas Children's Houston Open
Ben Griffin

Looks for Turnaround at the Texas Children's Houston Open
Rickie Fowler

Brings Strong Form Into Texas Children's Houston Open
Ryan Gerard

Can Continue Rolling at Texas Children's Houston Open
Pierceson Coody

Bounces Back at Valspar Championship
Rasmus Hojgaard

Trying to Get Back on Track at Texas Children's Houston Open
Michael Thorbjornsen

Playing Well Heading to Texas Children's Houston Open
Harry Hall

Looking for Consistency at Texas Children's Houston Open
Brooks Koepka

Continues Building Momentum
Scottie Scheffler

Withdraws From Texas Children's Houston Open
Luke Clanton

Might Have a Problem in Houston
Sam Stevens

Happy to See Houston This Week
Keith Mitchell

Tries to Rebound After The Players Championship
Will Zalatoris

Returning This Week at Houston
Wyndham Clark

Trending in the Wrong Direction Heading to Houston
Shane Lowry

Seeking Better Luck in Houston This Weekend
Lerone Murphy

Suffers His First Loss
Movsar Evloev

Edges Out Lerone Murphy
CFB

Notre Dame Ranks No. 1 in Returning Production for 2026
Michael Aswell

Jr. Drops Decision At UFC London
Michael Aswell

Luke Riley Outclasses Michael Aswell Jr.
Sam Patterson

Suffers Unanimous-Decision Loss
Michael Page

Wins Lackluster Decision
Austen Lane

Suffers First-Round TKO Loss
Iwo Baraniewski

Delivers 28-Second TKO
Tyler Reddick

Overcomes Adversity for Fourth Victory of the Season At Darlington
Brad Keselowski

Falls Short of Darlington Victory Despite Domination
Ryan Blaney

Recovers From Pit-Road Struggles to Score Career-Best Darlington Finish
Carson Hocevar

Rallies to Finish Fourth at Darlington
Kyle Larson

Decent Performance Ends with Technical Issues At Darlington
RANKINGS
C
1B
2B
3B
SS
OF
SP
RP

RANKINGS

QB
RB
WR
TE
K
DEF